Metal-bio-oxygen batteries establish a paradigmshifting energy architecture for biomedical implants,endowing these devices with extended service life in continuous physiological surveillance and precision theranostic ...Metal-bio-oxygen batteries establish a paradigmshifting energy architecture for biomedical implants,endowing these devices with extended service life in continuous physiological surveillance and precision theranostic operations.However,the conventional electrolytes in these semi-opened batteries fail to meet the requirements in biocompatibility and bio-safety for in vivo applications.Herein,we report a bio-compatible composite gel electrolyte for implanted Zn-O_(2) battery(ZOB),while also sustainably powering a mechanical sensor in vivo.This electrolyte composes a poly(L-lactide-co-epsilon-caprolactone)(PLCL)framework with a gelatin methacryloyl(GelMA)modification layer,and the salt in body fluid serves as ion transport carriers in the electrolyte.It displays an O_(2) impermeable property and lower polarization potentials as electrolyte in Zn||Zn symmetric cell.In vitro assay results demonstrate that the battery components illustrate excellent biocompatibility with negligible cytotoxicity.In vivo histopathological and hematological analyses further verified the biosafety of ZOB during operation,while capillary regeneration around the cathode ensured adequate oxygen supply for sustained performance.The assembled ZOB delivers a power density of 1.96μW/cm^(2) at 0.98 V in vivo,which also successfully powers an integrated hydrogel mechanical sensor and monitors cardiac signals in rats.The unique two-electron transfer pathway of oxygen reduction in blood has also been elucidated.This work offers a new insight into bio-compatible electrolyte design for next-generation implantable power sources,enabling robust implantable devices for healthcare technologies.展开更多
Urea/urine as a renewable energy source is attracting extensive attention,which represents a promising prospect toward ensuring a clean environment and energy utilization.We herein report a new Li-urea battery archite...Urea/urine as a renewable energy source is attracting extensive attention,which represents a promising prospect toward ensuring a clean environment and energy utilization.We herein report a new Li-urea battery architecture with organic and aqueous hybrid electrolytes.The concept of urea decomposition was first proposed in a Li-fuel battery.展开更多
The progress of biomaterials and tissue engineering has led to significant advances in wound healing,but the clinical therapy to regenerate perfect skin remains a great challenge.The implantation of biomaterial scaffo...The progress of biomaterials and tissue engineering has led to significant advances in wound healing,but the clinical therapy to regenerate perfect skin remains a great challenge.The implantation of biomaterial scaffolds to heal wounds inevitably leads to a host immune response.Many recent studies revealed that the immune system plays a significant role in both the healing process and the outcome.Immunomodulation or immuno-engineering has thus become a promising approach to develop pro-regenerative scaffolds for perfect skin regeneration.In this paper,we will review recent advancements in immunomodulating biomaterials in the field of skin repair and regeneration,and discuss strategies to modulate the immune response by tailoring the chemical,physical and biological properties of the biomaterials.Understanding the important role of immune responses and manipulating the inherent properties of biomaterials to regulate the immune reaction are approaches to overcome the current bottleneck of skin repair and regeneration.展开更多
基金supported by the National Natural Science Foundation of China(No.22179095)the Graduate Scientific Research Foundation of Jianghan University(No.KYCXJJ202423).
文摘Metal-bio-oxygen batteries establish a paradigmshifting energy architecture for biomedical implants,endowing these devices with extended service life in continuous physiological surveillance and precision theranostic operations.However,the conventional electrolytes in these semi-opened batteries fail to meet the requirements in biocompatibility and bio-safety for in vivo applications.Herein,we report a bio-compatible composite gel electrolyte for implanted Zn-O_(2) battery(ZOB),while also sustainably powering a mechanical sensor in vivo.This electrolyte composes a poly(L-lactide-co-epsilon-caprolactone)(PLCL)framework with a gelatin methacryloyl(GelMA)modification layer,and the salt in body fluid serves as ion transport carriers in the electrolyte.It displays an O_(2) impermeable property and lower polarization potentials as electrolyte in Zn||Zn symmetric cell.In vitro assay results demonstrate that the battery components illustrate excellent biocompatibility with negligible cytotoxicity.In vivo histopathological and hematological analyses further verified the biosafety of ZOB during operation,while capillary regeneration around the cathode ensured adequate oxygen supply for sustained performance.The assembled ZOB delivers a power density of 1.96μW/cm^(2) at 0.98 V in vivo,which also successfully powers an integrated hydrogel mechanical sensor and monitors cardiac signals in rats.The unique two-electron transfer pathway of oxygen reduction in blood has also been elucidated.This work offers a new insight into bio-compatible electrolyte design for next-generation implantable power sources,enabling robust implantable devices for healthcare technologies.
基金supported by the National Natural Science Foundation of China(21603162 and U1804255)Tianjin Sci.&Tech.Program(17JCYBJC21500).
文摘Urea/urine as a renewable energy source is attracting extensive attention,which represents a promising prospect toward ensuring a clean environment and energy utilization.We herein report a new Li-urea battery architecture with organic and aqueous hybrid electrolytes.The concept of urea decomposition was first proposed in a Li-fuel battery.
基金This work was supported by the National Natural Science Foundation of China(No.31700845)Hebei DHRSS Research Fund,China(No.E2019100005)the High-level Talents Research Start-up Project of Hebei University,China(Nos.521000981393,521000981336).
文摘The progress of biomaterials and tissue engineering has led to significant advances in wound healing,but the clinical therapy to regenerate perfect skin remains a great challenge.The implantation of biomaterial scaffolds to heal wounds inevitably leads to a host immune response.Many recent studies revealed that the immune system plays a significant role in both the healing process and the outcome.Immunomodulation or immuno-engineering has thus become a promising approach to develop pro-regenerative scaffolds for perfect skin regeneration.In this paper,we will review recent advancements in immunomodulating biomaterials in the field of skin repair and regeneration,and discuss strategies to modulate the immune response by tailoring the chemical,physical and biological properties of the biomaterials.Understanding the important role of immune responses and manipulating the inherent properties of biomaterials to regulate the immune reaction are approaches to overcome the current bottleneck of skin repair and regeneration.
