This study investigates the spatial distribution and regulatory mechanisms of dissolved inorganic carbon(DIC) in Xiangshan Bay, East China Sea, addressing critical gaps in carbon cycling research within semi-enclosed ...This study investigates the spatial distribution and regulatory mechanisms of dissolved inorganic carbon(DIC) in Xiangshan Bay, East China Sea, addressing critical gaps in carbon cycling research within semi-enclosed bays. Through isotopic analysis(δ~(13)C_(DIC), δD and δ18O) and hydrochemical measurements [salinity and dissolved oxygen(DO)] of surface and bottom seawater samples from 52 stations, we demonstrate that δ~(13)C_(DIC) values(surface:-3.6‰ to-2.1‰;bottom:-3.6‰ to-1.8‰) exhibit distinct vertical and spatial patterns, with higher values in surface waters and outer bay regions compared to bottom and inner bay areas. Conservative mixing between seawater(average contribution:56%) and freshwater dominates DIC dynamics, while tidal hydrodynamics amplify the imprint of riverine inputs during low tides. Nutrient gradients driven by saline-freshwater mixing enhance primary productivity in outer bay regions,resulting in 13C-enriched DIC and elevated dissolved organic carbon(DOC) concentrations. Conversely, bottom waters show 13C-depleted signatures(-2.75‰ mean δ~(13)C_(DIC)), reflecting organic matter degradation under oxygen-depleted conditions. Aquaculture activities exacerbate localized eutrophication, with monsoon-enhanced runoff amplifying anthropogenic impacts. This work underscores the sensitivity of coastal carbon cycling to both natural hydrodynamics and anthropogenic perturbations in semi-enclosed bays.展开更多
AIM:To rapidly detect molecular alterations in different malignancies and investigate the possible role of Tp53,C-myc,and CCND1 genes in development of tumors in human organs and their adjacent normal tissues,as well ...AIM:To rapidly detect molecular alterations in different malignancies and investigate the possible role of Tp53,C-myc,and CCND1 genes in development of tumors in human organs and their adjacent normal tissues,as well as the possible relation between well-and poorly-differentiated tumors.METHODS:A tissue array consisting of seven different tumors was generated.The tissue array included 120 points of esophagus,120 points of stomach,80 points of rectum,60 points of thyroid gland,100 points of mammary gland,80 points of liver,and 80 points of colon.Expressions of Tp53,C-myc,and CCND1 were determined by RNA in situ hybridization.3' terminal digoxin-labeled anti-sense single stranded oligonucleotide and locked nucleic acid modifying probe were used.RESULTS:The expression level of Tp53 gene was higher in six different carcinoma tissue samples than in paracancerous tissue samples with the exception in colon carcinoma tissue samples(P < 0.05).The expression level of CCND1 gene was significantly different in different carcinoma tissue samples with the exception in esophagus and colon carcinoma tissue samples.The expression level of C-myc gene was different in esophagus carcinoma tissue samples(c2 = 18.495,P = 0.000),stomach carcinoma tissue samples(c2 = 23.750,P = 0.000),and thyroid gland tissue samples(c2 = 10.999,P = 0.004).The intensity of signals was also different in different carcinoma tissue samples and paracancerous tissue samples.CONCLUSION:Over-expression of the Tp53,CCND1,and C-myc genes appears to play a role in development of human cancer by regulating the expression of mRNA.Tp53,CCND1 and C-myc genes are significantly correlated with the development of different carcinomas.展开更多
Body misperception plays an important role in the development of weight and dietary disorders among children and adolescents.A school-based health promotion program(2014-2015)was conducted to promote the school health...Body misperception plays an important role in the development of weight and dietary disorders among children and adolescents.A school-based health promotion program(2014-2015)was conducted to promote the school health education and improve the teenagers'physical health among Chinese children and adolescents.Based on this program,we intended to examine weight status and weight misperception among Chinese children and adolescents and to explore the relationship between weight misperception and lifestyle behaviors.A total of 10708 Chinese children and adolescents in 3rd and 7th grade from Shandong and Qinghai province participated in the program.The participants,dietary and activity patterns were clustered by latent class analysis(LCA).Logistic regression analysis was undertaken to explore the relationship between weight perception and demographic factors or dietary and activity patterns.Given the gender-specific difference of children and adolescents,analyses were separately conducted among boys and girls.The total prevalence of weight misperception was 44.50%.Boys,especially those in higher grade and living in wealthier district,were more likely to misperceive body weight.Girls were more likely to overestimate their weight(26.10%)while boys tended to underestimate the weight(28.32%).Three latent dietary and activity patterns including obesogenic pattern,malnourished pattern and healthy pattern were derived.The participants who had weight misperception were more likely to choose unhealthy dietary and exercise activities.The high prevalence of weight misperception was closely related to the unhealthy weight pattern and unhealthy dietary or exercise patterns.Our research found that most children and adolescents failed to perceive their weight correctly and boys tended to underestimate their weight while girls were subjected to overestimation.So,comprehensive intervention programs should focus on improving self-weight awareness,and appropriate guidance should be made to lead the adolescents to more healthy weight pattern.展开更多
Based on the 39 surface sediment samples collected in the flood season and the dry season in 2012 respectively and the measured hydrological data in October 2012, the sediment grain size characteristics has been analy...Based on the 39 surface sediment samples collected in the flood season and the dry season in 2012 respectively and the measured hydrological data in October 2012, the sediment grain size characteristics has been analyzed and the response mechanism of surface sediments to estuarine hydrodynamics was revealed by calculating the range of waves and tidal currents. The results show that:(1) The grain size of the surface sediment samples decreased gradually from land to sea in the flood season. The fine sediment was redistributed under marine hydrodynamics in the dry season and the sediments showed coarser tendency ingeneral;(2) tidal current stirring sediment was very obvious in Dagu River estuary area, and wave stirring sediments mainly occurred in the tidal flat area and estuary sand bar area;(3) in the flood season, surface sediment sat the estuary were transported towards south and southeast. In the dry season, surface sediments were transported towards southwest at the north area of Jiaozhou Bay Bridge, and sediments were transported towards northeast area at the south of Jiaozhou Bay Bridge.展开更多
Shandong has more than 70% of natural coasts are under erosion.Coastal erosion started from the 1970's and became a very serious problem at 1990 's.The dramatic decrease of sediment supplies from rivers caused...Shandong has more than 70% of natural coasts are under erosion.Coastal erosion started from the 1970's and became a very serious problem at 1990 's.The dramatic decrease of sediment supplies from rivers caused rapid erosion at the delta and estuary areas,especially in the abandoned Yellow River Delta.Most sandy coasts along the Peninsula were eroded due to lack of sand supply and interruption of alongshore sediment drift,sand dredging from the beach or the offshore area caused serious erosion during short time. Sea-level rise causes slow but constant shoreline retreats and became a more serious threat.Different types of hard solutions for coastal protection against erosion were used in Shandong.Seawalls are most widely used,especially at the Yellow River Delta and city center waterfront.Groynes,jetties and breakwater are used on the north and east sandy coast of the Peninsula.Hard approaches are effective to protect the coast erosion but not change the erosion causes and led secondary impact on the coast.Soft engineering solution or the combined solutions are taken into acts.Beach nourishment is mostly considered as the better soft solution,especially to those tourists attracting sandy beaches along the Shandong coast.Long term monitoring and continuous lessons learning from the coastal erosion management will be adaptive for better coast solution in the future.展开更多
The coastal cities are the most advanced regions in China.In the past few decades,the environment changed very significantly due to large scale human activities in the coastal regions.Polycyclic aromatic hydrocarbons ...The coastal cities are the most advanced regions in China.In the past few decades,the environment changed very significantly due to large scale human activities in the coastal regions.Polycyclic aromatic hydrocarbons (PAHs)in three dated sediment cores from the west coast of the Yellow Sea (core A01),the Yangtze River estuary (YRE;core A02)and the Oujiang River estuary (ORE;core A03)were analyzed to reconstruct the environmental evolutionary process of the east China coastal region over the past century. In the three cores,PAHs concentrations were increased rapidly.Lower concentrations of PAHs were measured in core A02 than in cores A01 and A03.The vertical variation of PAHs in the YRE Was dominated by the petrogenic sources.Historical records of PAHs in the ORE were controlled by pyrolytic sources.PAHs on the west coast of the Yellow Sea were contributed by the two sources.展开更多
Heterogeneous transition metal catalysts are indispensable in improving environmental pollution.However,their fabrication is often costly and cumbersome,and they can easily pollute the environment.This study proposed ...Heterogeneous transition metal catalysts are indispensable in improving environmental pollution.However,their fabrication is often costly and cumbersome,and they can easily pollute the environment.This study proposed using a natural Gabonese ore(GBO)containing Mn_(x)O_(y) and FexOy as catalysts to degrade orange Ⅱ(OII)via peroxymonosulfate(PMS)activation.The GBO+PMS system exhibited extraordinarily high stability and catalytic activity towards OII elimination(92.2%,0.0453 min^(−1)).The reactive oxygen species(ROS)generated in the system were identified using radical scavenging tests and electron spin-resonance(ESR)analysis.Singlet oxygen(^(1)O_(2))represented the dominant reactive species for OII degradation,while the system presented a lower reaction energy barrier and was effective in a broad pH range(2-10).This work also proposed the activation mechanism for the GBO+PMS system and OII degradation pathways.This study revealed a new approach for exploring inexpensive,eco-friendly,efficient,and stable heterogeneous transition metal catalysts.展开更多
Summary:Throughout the duration of the New Cooperative Medical Scheme(NCMS),it was found that an increasing number of rural patients were seeking out-of^county medical treatment,which posed a great burden on the NCMS ...Summary:Throughout the duration of the New Cooperative Medical Scheme(NCMS),it was found that an increasing number of rural patients were seeking out-of^county medical treatment,which posed a great burden on the NCMS fund.Our study was conducted to examine the prevalence of out-of^county hospitalizations and its related factors,and to provide a scientific basis for follow?up health insurance policies.A total of 215 counties in central and western China from 2008 to 2016 were selected.The total out-of-county hospitalization rate in nine years was 16.95%,which increased from 12.37%in 2008 to 19.21%in 2016 with an average annual growth rate of 5.66%.Its related expenses and compensations were shown to increase each year,with those in the central region being higher than those in the western region.Stepwise logistic regression reveals that the increase in out-of-county hospitalization rate was associated with region(XI),rural population(X2),per capita per year net income(X3),per capita gross domestic product(GDP)(X4),per capita funding amount of NCMS(X5),compensation ratio of out-of^county hospitalization cost(X6),per time average in-county(X7)and out-of-county hospitalization cost(X8).According to Bayesian network(BN),the marginal probability of high out-of^county hospitalization rate was as high as 81.7%.Out-of^county hospitalizations were directly related to X8,X3,X4 and X6.The probability of high out-of-county hospitalization obtained based on hospitalization expenses factors,economy factors,regional characteristics and NCMS policy factors was 95.7%,91.1%,93.0% and 88.8%,respectively.And how these factors affect out-of-county hospitalization and their interrelationships were found out.Our findings suggest that more attention should be paid to the influence mechanism of these factors on out-of-county hospitalizations,and the increase of hospitalizations outside the county should be reasonably supervised and controlled and our results will be used to help guide the formulation of proper intervention policies.展开更多
Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible p...Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible patients will be randomly assigned to the intervention group(acupuncture)or the control group(sham acupuncture).All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks(5 times per week in the first 2 weeks,3 times per week during weeks 3-6,and 2 times per week during weeks 7 and 8).Each treatment will last for 20 min.The primary outcome is the change in mean complete spontaneous bowel movements(CSBMs)per week.The secondary out?comes are patient assessment of constipation quality of life questionnaire(PAC-QOL),self-rating anxiety scale(SAS),and the dosage of the medication.All adverse events will be recorded in detail and managed by corresponding researchers as quickly as possible.Outcomes will be evaluated at baseline(1 week before treatment),2 weeks after intervention begins,6 weeks after intervention begins,8 weeks after intervention begins,4 weeks follow-up,and 12 weeks follow-up.Discussion:The results of this study will provide the evidence of the efficacy and safety of acupuncture as a traditional treatment methods for functional constipation.Trial registration:Chinese Clinical Trial Registry,ChiCTR-INR-17011472.Registered on 23 May 2017.展开更多
From the standpoint of chemical structures,the organic backbones of energetic materials can be classified into aromatic rings,nonaromatic rings,and open chains.Although the category of aromatic energetic compounds exh...From the standpoint of chemical structures,the organic backbones of energetic materials can be classified into aromatic rings,nonaromatic rings,and open chains.Although the category of aromatic energetic compounds exhibits several advantages in the regulation of energetic properties,the nonaromatic heterocycles,assembling nitramino explosophores with simple alkyl bridges,still have prevailed in benchmark materials.The methylene bridge plays a pivotal role in the constructions of the classic nonaromatic heterocycle-based energetic compounds,e.g.,hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX)and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),whereas ethylene bridge is the core moiety of state-of-the-art explosive 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20).In this context,it is of great interest to employ simple and practical bridges to assemble aromatic and nonaromatic nitrogen-rich heterocycles,thereby expanding the structural diversity of energetic materials,e.g.,bridged and fused nitrogen-rich poly-heterocycles.Furthermore,alkyl-bridged poly-heterocycles highlight the potential for the open chain type of energetic materials.In this review,the development of alkyl bridges in linking nitrogen-rich heterocycles is presented,and the perspective of the newly constructed energetic backbones is summarized for the future design of advanced energetic materials.展开更多
Neurological disorders,including headaches(tension-type headaches,medication-overuse headaches,and migraines)and dementias that include Alzheimer’s disease,are among the most prevalent and debilitating global conditi...Neurological disorders,including headaches(tension-type headaches,medication-overuse headaches,and migraines)and dementias that include Alzheimer’s disease,are among the most prevalent and debilitating global conditions.In 2016,these disorders affected 276 million people worldwide and were the second leading cause of death that year[1].This highlights the urgent need for effective prevention,treatment,and support strategies.The etiology of neurological disorders is multifaceted and involves genetic,environmental,physiological,and social factors[2].展开更多
BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary embolism.Traditional treatments like c...BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary embolism.Traditional treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and complications.AIM To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute LEDVT.METHODS A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August 2022.The patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two groups.The main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and PTS.RESULTS The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both groups.The complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(P<0.05).The average hospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT group.The incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(P<0.05).CONCLUSION Compared with CDT,treatment of LEDVT via PMT was associated with a better thrombus clearance rate,clinical therapeutic effect and PTS prevention function,but the difference was not statistically significant.Moreover,PMT was associated with a reduced urokinase dosage,shortened hospitalisation duration and reduced incidence of complications,such as infections and small haemorrhages.These results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.展开更多
The deltas serve as the primary interactive zone where terrestrial and marine environments converge,playing a pivotal role in the coastal deposition.In the Holocene,climate changes and sea level fluctuation are the pr...The deltas serve as the primary interactive zone where terrestrial and marine environments converge,playing a pivotal role in the coastal deposition.In the Holocene,climate changes and sea level fluctuation are the principal driving factors in the evolution of deltas.However,human activities such as the construction of dams and reservoirs in the Anthropocene have significantly altered sediment transport in rivers,leading to depositional pattern variation during deltaic evolution.In this study,we have conducted a comparative analysis of the morphological variations(1986-2021)in the barrier system of the Hanjiang River Delta(HRD)using satellite remote sensing(SRS)method.Additionally,we have examined the lithological changes and facies alterations observed in eight boreholes on the present barrier spit.Our findings indicate that the intensification of anthropogenic activities led to a significant reduction in the sediment flux of the Hanjiang River(HR),resulting in depocenter landward migration at the estuary.SRS analysis reveals their periodical morphological characteristics and spatial variations of estuarine sandbars(1986-1992),barrier islands-lagoons(1993-2009),and barrier spits(2010-2021)during 1986 to 2021.The stratigraphy of boreholes demonstrates a south-to-north facies transition from lagoon to lagoon-barrier spit and barrier spit in vertical lithology.Therefore,the depositional evolution of the HRD barrier system is categorized into three phases:estuarine sandbar-barrier island phase(1986-1998);barrier island-lagoon phase(1999-2009);and barrier spit phase(2010-2021).During the estuarine sandbar-barrier island phase,fluvial processes played a predominate role in the deposition.Consequently,with a significant decrease in river sediment load,the dominant factors driving depositional processes shifted towards wave action and alongshore current.Based on the conceptual model in the Holocene,we propose a modified depositional model of wave-dominated deltas during Anthropocene that encompasses three evolutionary phases:estuarine sandbars and delta front platforms,barrier island-lagoon formation and landward migration of barrier spits.This pattern highlights that human-induced reduction in river sediment flux has led to a seaward deltaic progradation driven by barrier landward migration.展开更多
Geological Hazards Investigation and Evaluation is the core course of Environmental Geological Engineering,aiming to cultivate skilled talents with solid theoretical knowledge and excellent practical skills.At present...Geological Hazards Investigation and Evaluation is the core course of Environmental Geological Engineering,aiming to cultivate skilled talents with solid theoretical knowledge and excellent practical skills.At present,the course faces several issues,including a teaching environment disconnected from real-world work scenarios,course content that deviates from job-related tasks,a lack of digital teaching resources,and reliance on a single teaching method,leading to students’poor feedback from employers.Based on the concept of outcome-based education,the course team of Geological Hazards Investigation and Evaluation establishes a“five-step double-rotation”blended teaching model with the help of a Small Private Online Course platform.The program is designed to improve the teaching environment and expand the digitalized teaching resources in order to improve students’learning motivation,enhance learning effectiveness,and cultivate skillful talents who meet employers’satisfaction.展开更多
Scientific curriculum evaluation methods are critical for achieving talent training objectives.The Sydney Accord,one of the three major engineering education certification agreements,focuses on the training of“engine...Scientific curriculum evaluation methods are critical for achieving talent training objectives.The Sydney Accord,one of the three major engineering education certification agreements,focuses on the training of“engineering technologists.”Its logical system and three core principles align well with the connotation development of professional construction in China’s higher vocational colleges,offering significant insights for promoting reform and development in engineering education in Chinese colleges and universities.By incorporating the core principles,elements,and graduate quality defined in the Sydney Accord and focusing on the evaluation of curriculum achievement against“graduation requirements,”the quality of vocational education can be enhanced,making it an important direction for future teaching reforms in vocational education.展开更多
Colorectal cancer(CRC),recognized as one of the most commonly diagnosed cancers globally,is a complex disease influenced by various factors,including lifestyle,genetics,and the environment[1].Chronic bowel inflammatio...Colorectal cancer(CRC),recognized as one of the most commonly diagnosed cancers globally,is a complex disease influenced by various factors,including lifestyle,genetics,and the environment[1].Chronic bowel inflammation is one of the primary contributors to colorectal carcinogenesis[2].The persistent systemic inflammatory response associated with tumors contributes to cachexia and malnutrition in patient,leading to increased morbidity and mortality.展开更多
Background and Aims:Liver fibrosis is a key process in the progression of chronic liver diseases.However,there are currently no drugs specifically designed to treat liver fibrosis.Our Phase 2 trial of hydronidone for ...Background and Aims:Liver fibrosis is a key process in the progression of chronic liver diseases.However,there are currently no drugs specifically designed to treat liver fibrosis.Our Phase 2 trial of hydronidone for the treatment of chronic hepatitis B(CHB)-associated liver fibrosis showed that add-ing hydronidone to entecavir resulted in significant reversal of liver fibrosis.To further evaluate the efficacy of a 270 mg/day dose of hydronidone for treating liver fibrosis associated with CHB,we conducted this Phase 3 trial.Methods:This is a 52-week,randomized(1:1),double-blind,placebo-con-trolled,multicenter,entecavir-based Phase 3 clinical study conducted at 44 study centers across China.Adult patients aged 18 to 65 years with significant liver fibrosis(defined as an Ishak score≥3 on liver biopsy)associated with CHB were included.Results:The primary endpoint of the trial is to demonstrate the efficacy of fibrosis reversal,defined as a decrease in the Ishak stage score of liver fibrosis by≥1 after 52 weeks of treatment,compared to baseline.Conclusions:The results of this trial are expected to further support the antifibrotic indication for this novel drug.展开更多
基金The National Key R&D Program of China under contract No. 2022YFE0209300National Natural Science Foundation of China under contract No. 42176091+1 种基金Asia Cooperation Fund of China (Comparative Study of Geoenvironment and Geohazards in the Yangtze River Delta and the Red River Delta)China Geological Survey Project under contract No. DD20242714。
文摘This study investigates the spatial distribution and regulatory mechanisms of dissolved inorganic carbon(DIC) in Xiangshan Bay, East China Sea, addressing critical gaps in carbon cycling research within semi-enclosed bays. Through isotopic analysis(δ~(13)C_(DIC), δD and δ18O) and hydrochemical measurements [salinity and dissolved oxygen(DO)] of surface and bottom seawater samples from 52 stations, we demonstrate that δ~(13)C_(DIC) values(surface:-3.6‰ to-2.1‰;bottom:-3.6‰ to-1.8‰) exhibit distinct vertical and spatial patterns, with higher values in surface waters and outer bay regions compared to bottom and inner bay areas. Conservative mixing between seawater(average contribution:56%) and freshwater dominates DIC dynamics, while tidal hydrodynamics amplify the imprint of riverine inputs during low tides. Nutrient gradients driven by saline-freshwater mixing enhance primary productivity in outer bay regions,resulting in 13C-enriched DIC and elevated dissolved organic carbon(DOC) concentrations. Conversely, bottom waters show 13C-depleted signatures(-2.75‰ mean δ~(13)C_(DIC)), reflecting organic matter degradation under oxygen-depleted conditions. Aquaculture activities exacerbate localized eutrophication, with monsoon-enhanced runoff amplifying anthropogenic impacts. This work underscores the sensitivity of coastal carbon cycling to both natural hydrodynamics and anthropogenic perturbations in semi-enclosed bays.
基金Supported by Foundation of Xiamen Science and Technology Bureau,Fujian Province,China,No.3502Z20074023
文摘AIM:To rapidly detect molecular alterations in different malignancies and investigate the possible role of Tp53,C-myc,and CCND1 genes in development of tumors in human organs and their adjacent normal tissues,as well as the possible relation between well-and poorly-differentiated tumors.METHODS:A tissue array consisting of seven different tumors was generated.The tissue array included 120 points of esophagus,120 points of stomach,80 points of rectum,60 points of thyroid gland,100 points of mammary gland,80 points of liver,and 80 points of colon.Expressions of Tp53,C-myc,and CCND1 were determined by RNA in situ hybridization.3' terminal digoxin-labeled anti-sense single stranded oligonucleotide and locked nucleic acid modifying probe were used.RESULTS:The expression level of Tp53 gene was higher in six different carcinoma tissue samples than in paracancerous tissue samples with the exception in colon carcinoma tissue samples(P < 0.05).The expression level of CCND1 gene was significantly different in different carcinoma tissue samples with the exception in esophagus and colon carcinoma tissue samples.The expression level of C-myc gene was different in esophagus carcinoma tissue samples(c2 = 18.495,P = 0.000),stomach carcinoma tissue samples(c2 = 23.750,P = 0.000),and thyroid gland tissue samples(c2 = 10.999,P = 0.004).The intensity of signals was also different in different carcinoma tissue samples and paracancerous tissue samples.CONCLUSION:Over-expression of the Tp53,CCND1,and C-myc genes appears to play a role in development of human cancer by regulating the expression of mRNA.Tp53,CCND1 and C-myc genes are significantly correlated with the development of different carcinomas.
基金This study was supported by grants from the National Natural Science Foundation of China(No.81573262)the Fundamental Research Funds for the Central Universities,HUST(No.2016YXZD042).
文摘Body misperception plays an important role in the development of weight and dietary disorders among children and adolescents.A school-based health promotion program(2014-2015)was conducted to promote the school health education and improve the teenagers'physical health among Chinese children and adolescents.Based on this program,we intended to examine weight status and weight misperception among Chinese children and adolescents and to explore the relationship between weight misperception and lifestyle behaviors.A total of 10708 Chinese children and adolescents in 3rd and 7th grade from Shandong and Qinghai province participated in the program.The participants,dietary and activity patterns were clustered by latent class analysis(LCA).Logistic regression analysis was undertaken to explore the relationship between weight perception and demographic factors or dietary and activity patterns.Given the gender-specific difference of children and adolescents,analyses were separately conducted among boys and girls.The total prevalence of weight misperception was 44.50%.Boys,especially those in higher grade and living in wealthier district,were more likely to misperceive body weight.Girls were more likely to overestimate their weight(26.10%)while boys tended to underestimate the weight(28.32%).Three latent dietary and activity patterns including obesogenic pattern,malnourished pattern and healthy pattern were derived.The participants who had weight misperception were more likely to choose unhealthy dietary and exercise activities.The high prevalence of weight misperception was closely related to the unhealthy weight pattern and unhealthy dietary or exercise patterns.Our research found that most children and adolescents failed to perceive their weight correctly and boys tended to underestimate their weight while girls were subjected to overestimation.So,comprehensive intervention programs should focus on improving self-weight awareness,and appropriate guidance should be made to lead the adolescents to more healthy weight pattern.
基金The authors are grateful to Lei Guo ,Xiao-lei Liu ,Yonggang Jia,Lu-lu Qiao,Bin Chen and others for discussions and help in this study. The authors are grateful to the anonymous reviewers and Dr. Yan Yang for their comments and suggestions,which significantly improved the quality of the manuscript. This study is supported financially by National Natural Science Foundation of China (41506107)Special Program for Basic Research of the Ministry of Science and Technology,China (2013FY112200),"China- ASEAN Marine Geoscience Research and Disaster Reduction and Prevention initiatives Project" Ministry of Foreign Affairs of China.
文摘Based on the 39 surface sediment samples collected in the flood season and the dry season in 2012 respectively and the measured hydrological data in October 2012, the sediment grain size characteristics has been analyzed and the response mechanism of surface sediments to estuarine hydrodynamics was revealed by calculating the range of waves and tidal currents. The results show that:(1) The grain size of the surface sediment samples decreased gradually from land to sea in the flood season. The fine sediment was redistributed under marine hydrodynamics in the dry season and the sediments showed coarser tendency ingeneral;(2) tidal current stirring sediment was very obvious in Dagu River estuary area, and wave stirring sediments mainly occurred in the tidal flat area and estuary sand bar area;(3) in the flood season, surface sediment sat the estuary were transported towards south and southeast. In the dry season, surface sediments were transported towards southwest at the north area of Jiaozhou Bay Bridge, and sediments were transported towards northeast area at the south of Jiaozhou Bay Bridge.
文摘Shandong has more than 70% of natural coasts are under erosion.Coastal erosion started from the 1970's and became a very serious problem at 1990 's.The dramatic decrease of sediment supplies from rivers caused rapid erosion at the delta and estuary areas,especially in the abandoned Yellow River Delta.Most sandy coasts along the Peninsula were eroded due to lack of sand supply and interruption of alongshore sediment drift,sand dredging from the beach or the offshore area caused serious erosion during short time. Sea-level rise causes slow but constant shoreline retreats and became a more serious threat.Different types of hard solutions for coastal protection against erosion were used in Shandong.Seawalls are most widely used,especially at the Yellow River Delta and city center waterfront.Groynes,jetties and breakwater are used on the north and east sandy coast of the Peninsula.Hard approaches are effective to protect the coast erosion but not change the erosion causes and led secondary impact on the coast.Soft engineering solution or the combined solutions are taken into acts.Beach nourishment is mostly considered as the better soft solution,especially to those tourists attracting sandy beaches along the Shandong coast.Long term monitoring and continuous lessons learning from the coastal erosion management will be adaptive for better coast solution in the future.
文摘The coastal cities are the most advanced regions in China.In the past few decades,the environment changed very significantly due to large scale human activities in the coastal regions.Polycyclic aromatic hydrocarbons (PAHs)in three dated sediment cores from the west coast of the Yellow Sea (core A01),the Yangtze River estuary (YRE;core A02)and the Oujiang River estuary (ORE;core A03)were analyzed to reconstruct the environmental evolutionary process of the east China coastal region over the past century. In the three cores,PAHs concentrations were increased rapidly.Lower concentrations of PAHs were measured in core A02 than in cores A01 and A03.The vertical variation of PAHs in the YRE Was dominated by the petrogenic sources.Historical records of PAHs in the ORE were controlled by pyrolytic sources.PAHs on the west coast of the Yellow Sea were contributed by the two sources.
基金funding support from Talent Introduction Program of Xihua University(No.Z202117)。
文摘Heterogeneous transition metal catalysts are indispensable in improving environmental pollution.However,their fabrication is often costly and cumbersome,and they can easily pollute the environment.This study proposed using a natural Gabonese ore(GBO)containing Mn_(x)O_(y) and FexOy as catalysts to degrade orange Ⅱ(OII)via peroxymonosulfate(PMS)activation.The GBO+PMS system exhibited extraordinarily high stability and catalytic activity towards OII elimination(92.2%,0.0453 min^(−1)).The reactive oxygen species(ROS)generated in the system were identified using radical scavenging tests and electron spin-resonance(ESR)analysis.Singlet oxygen(^(1)O_(2))represented the dominant reactive species for OII degradation,while the system presented a lower reaction energy barrier and was effective in a broad pH range(2-10).This work also proposed the activation mechanism for the GBO+PMS system and OII degradation pathways.This study revealed a new approach for exploring inexpensive,eco-friendly,efficient,and stable heterogeneous transition metal catalysts.
基金This work was supported by the National Natural Science Foundation of China(No.71573192 and No.81573262)the Fundamental Research Funds for the Central Universities,HUST(No.2016YXZD042).
文摘Summary:Throughout the duration of the New Cooperative Medical Scheme(NCMS),it was found that an increasing number of rural patients were seeking out-of^county medical treatment,which posed a great burden on the NCMS fund.Our study was conducted to examine the prevalence of out-of^county hospitalizations and its related factors,and to provide a scientific basis for follow?up health insurance policies.A total of 215 counties in central and western China from 2008 to 2016 were selected.The total out-of-county hospitalization rate in nine years was 16.95%,which increased from 12.37%in 2008 to 19.21%in 2016 with an average annual growth rate of 5.66%.Its related expenses and compensations were shown to increase each year,with those in the central region being higher than those in the western region.Stepwise logistic regression reveals that the increase in out-of-county hospitalization rate was associated with region(XI),rural population(X2),per capita per year net income(X3),per capita gross domestic product(GDP)(X4),per capita funding amount of NCMS(X5),compensation ratio of out-of^county hospitalization cost(X6),per time average in-county(X7)and out-of-county hospitalization cost(X8).According to Bayesian network(BN),the marginal probability of high out-of^county hospitalization rate was as high as 81.7%.Out-of^county hospitalizations were directly related to X8,X3,X4 and X6.The probability of high out-of-county hospitalization obtained based on hospitalization expenses factors,economy factors,regional characteristics and NCMS policy factors was 95.7%,91.1%,93.0% and 88.8%,respectively.And how these factors affect out-of-county hospitalization and their interrelationships were found out.Our findings suggest that more attention should be paid to the influence mechanism of these factors on out-of-county hospitalizations,and the increase of hospitalizations outside the county should be reasonably supervised and controlled and our results will be used to help guide the formulation of proper intervention policies.
基金supported by the Shanghai Municipal Commission of Health and Family Planning(Grant No.2016LQ015)
文摘Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible patients will be randomly assigned to the intervention group(acupuncture)or the control group(sham acupuncture).All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks(5 times per week in the first 2 weeks,3 times per week during weeks 3-6,and 2 times per week during weeks 7 and 8).Each treatment will last for 20 min.The primary outcome is the change in mean complete spontaneous bowel movements(CSBMs)per week.The secondary out?comes are patient assessment of constipation quality of life questionnaire(PAC-QOL),self-rating anxiety scale(SAS),and the dosage of the medication.All adverse events will be recorded in detail and managed by corresponding researchers as quickly as possible.Outcomes will be evaluated at baseline(1 week before treatment),2 weeks after intervention begins,6 weeks after intervention begins,8 weeks after intervention begins,4 weeks follow-up,and 12 weeks follow-up.Discussion:The results of this study will provide the evidence of the efficacy and safety of acupuncture as a traditional treatment methods for functional constipation.Trial registration:Chinese Clinical Trial Registry,ChiCTR-INR-17011472.Registered on 23 May 2017.
基金National Natural Science Foundation of China(Grant Nos.22075023,22205022,and 22235003)to provide fund for conducting experiments。
文摘From the standpoint of chemical structures,the organic backbones of energetic materials can be classified into aromatic rings,nonaromatic rings,and open chains.Although the category of aromatic energetic compounds exhibits several advantages in the regulation of energetic properties,the nonaromatic heterocycles,assembling nitramino explosophores with simple alkyl bridges,still have prevailed in benchmark materials.The methylene bridge plays a pivotal role in the constructions of the classic nonaromatic heterocycle-based energetic compounds,e.g.,hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX)and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),whereas ethylene bridge is the core moiety of state-of-the-art explosive 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20).In this context,it is of great interest to employ simple and practical bridges to assemble aromatic and nonaromatic nitrogen-rich heterocycles,thereby expanding the structural diversity of energetic materials,e.g.,bridged and fused nitrogen-rich poly-heterocycles.Furthermore,alkyl-bridged poly-heterocycles highlight the potential for the open chain type of energetic materials.In this review,the development of alkyl bridges in linking nitrogen-rich heterocycles is presented,and the perspective of the newly constructed energetic backbones is summarized for the future design of advanced energetic materials.
基金supported by the National Key Research and Development Program of China[2018YFE0206900].
文摘Neurological disorders,including headaches(tension-type headaches,medication-overuse headaches,and migraines)and dementias that include Alzheimer’s disease,are among the most prevalent and debilitating global conditions.In 2016,these disorders affected 276 million people worldwide and were the second leading cause of death that year[1].This highlights the urgent need for effective prevention,treatment,and support strategies.The etiology of neurological disorders is multifaceted and involves genetic,environmental,physiological,and social factors[2].
基金the Health and Wellness Commission of Hebei Province,No.20160344the Health Commission of Shijiazhuang City,Hebei Province,No.221200763.
文摘BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary embolism.Traditional treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and complications.AIM To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute LEDVT.METHODS A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August 2022.The patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two groups.The main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and PTS.RESULTS The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both groups.The complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(P<0.05).The average hospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT group.The incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(P<0.05).CONCLUSION Compared with CDT,treatment of LEDVT via PMT was associated with a better thrombus clearance rate,clinical therapeutic effect and PTS prevention function,but the difference was not statistically significant.Moreover,PMT was associated with a reduced urokinase dosage,shortened hospitalisation duration and reduced incidence of complications,such as infections and small haemorrhages.These results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.
基金The Guangdong Basic and Applied Basic Research Foundation under contract Nos 2024A1515012628the National Natural Science Foundation of China under contract Nos 41876059 and 42372213+4 种基金the Open Research Fund Program of Zhoushan Field Scientific Observation and Research Station for Marine Geo-hazards,China Geological Survey under contract No.ZSORS-22-5the Shantou University Scientific Research Foundation for Talents under contract No.NTF20028China-Association of Southeast Asian Nations(ASEAN)Maritime Cooperation Fund Project under contract No.12120100500017001China Geological Survey Projects under contract Nos DD20211553,DD20221710,and DD20230415the Science and Technology Innovation Fund of Command Center of Integrated Natural Resources Survey Center under contract No.KC20230017.
文摘The deltas serve as the primary interactive zone where terrestrial and marine environments converge,playing a pivotal role in the coastal deposition.In the Holocene,climate changes and sea level fluctuation are the principal driving factors in the evolution of deltas.However,human activities such as the construction of dams and reservoirs in the Anthropocene have significantly altered sediment transport in rivers,leading to depositional pattern variation during deltaic evolution.In this study,we have conducted a comparative analysis of the morphological variations(1986-2021)in the barrier system of the Hanjiang River Delta(HRD)using satellite remote sensing(SRS)method.Additionally,we have examined the lithological changes and facies alterations observed in eight boreholes on the present barrier spit.Our findings indicate that the intensification of anthropogenic activities led to a significant reduction in the sediment flux of the Hanjiang River(HR),resulting in depocenter landward migration at the estuary.SRS analysis reveals their periodical morphological characteristics and spatial variations of estuarine sandbars(1986-1992),barrier islands-lagoons(1993-2009),and barrier spits(2010-2021)during 1986 to 2021.The stratigraphy of boreholes demonstrates a south-to-north facies transition from lagoon to lagoon-barrier spit and barrier spit in vertical lithology.Therefore,the depositional evolution of the HRD barrier system is categorized into three phases:estuarine sandbar-barrier island phase(1986-1998);barrier island-lagoon phase(1999-2009);and barrier spit phase(2010-2021).During the estuarine sandbar-barrier island phase,fluvial processes played a predominate role in the deposition.Consequently,with a significant decrease in river sediment load,the dominant factors driving depositional processes shifted towards wave action and alongshore current.Based on the conceptual model in the Holocene,we propose a modified depositional model of wave-dominated deltas during Anthropocene that encompasses three evolutionary phases:estuarine sandbars and delta front platforms,barrier island-lagoon formation and landward migration of barrier spits.This pattern highlights that human-induced reduction in river sediment flux has led to a seaward deltaic progradation driven by barrier landward migration.
基金Scientific Research Fund of Hunan Provincial Education Department Excellent Youth Project(23B0953)Hunan Province Vocational College Education and Teaching Reform Research Project(ZJGB2022427)。
文摘Geological Hazards Investigation and Evaluation is the core course of Environmental Geological Engineering,aiming to cultivate skilled talents with solid theoretical knowledge and excellent practical skills.At present,the course faces several issues,including a teaching environment disconnected from real-world work scenarios,course content that deviates from job-related tasks,a lack of digital teaching resources,and reliance on a single teaching method,leading to students’poor feedback from employers.Based on the concept of outcome-based education,the course team of Geological Hazards Investigation and Evaluation establishes a“five-step double-rotation”blended teaching model with the help of a Small Private Online Course platform.The program is designed to improve the teaching environment and expand the digitalized teaching resources in order to improve students’learning motivation,enhance learning effectiveness,and cultivate skillful talents who meet employers’satisfaction.
基金Hunan Province Vocational College Education and Teaching Reform Research Project(ZJGB2023323)Hunan Provincial Department of Education Scientific Research Funding Excellent Youth Project(23B0953)Natural Science Foundation of Hunan Province(2023JJ60189,2024JJ8105)。
文摘Scientific curriculum evaluation methods are critical for achieving talent training objectives.The Sydney Accord,one of the three major engineering education certification agreements,focuses on the training of“engineering technologists.”Its logical system and three core principles align well with the connotation development of professional construction in China’s higher vocational colleges,offering significant insights for promoting reform and development in engineering education in Chinese colleges and universities.By incorporating the core principles,elements,and graduate quality defined in the Sydney Accord and focusing on the evaluation of curriculum achievement against“graduation requirements,”the quality of vocational education can be enhanced,making it an important direction for future teaching reforms in vocational education.
基金supported by National Institutes of Health funding R01CA224921supported by National Institute of General Medical Sciences T32GM65841.
文摘Colorectal cancer(CRC),recognized as one of the most commonly diagnosed cancers globally,is a complex disease influenced by various factors,including lifestyle,genetics,and the environment[1].Chronic bowel inflammation is one of the primary contributors to colorectal carcinogenesis[2].The persistent systemic inflammatory response associated with tumors contributes to cachexia and malnutrition in patient,leading to increased morbidity and mortality.
基金supported by GNI Group Ltd,Beijing Continent Pharmaceuticals,Shanghai Genomics,Inc.,and the State Project for Essential Drug Research and Development of China(2019ZX09302024).
文摘Background and Aims:Liver fibrosis is a key process in the progression of chronic liver diseases.However,there are currently no drugs specifically designed to treat liver fibrosis.Our Phase 2 trial of hydronidone for the treatment of chronic hepatitis B(CHB)-associated liver fibrosis showed that add-ing hydronidone to entecavir resulted in significant reversal of liver fibrosis.To further evaluate the efficacy of a 270 mg/day dose of hydronidone for treating liver fibrosis associated with CHB,we conducted this Phase 3 trial.Methods:This is a 52-week,randomized(1:1),double-blind,placebo-con-trolled,multicenter,entecavir-based Phase 3 clinical study conducted at 44 study centers across China.Adult patients aged 18 to 65 years with significant liver fibrosis(defined as an Ishak score≥3 on liver biopsy)associated with CHB were included.Results:The primary endpoint of the trial is to demonstrate the efficacy of fibrosis reversal,defined as a decrease in the Ishak stage score of liver fibrosis by≥1 after 52 weeks of treatment,compared to baseline.Conclusions:The results of this trial are expected to further support the antifibrotic indication for this novel drug.
