Guajadials C-F(1-4),four sesquiterpenoid-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava.Their structures and relative configurations were established by extensive sp...Guajadials C-F(1-4),four sesquiterpenoid-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava.Their structures and relative configurations were established by extensive spectroscopic analysis.A possible biosynthetic pathway for 1-4 was also proposed.展开更多
Phytochemical investigation of the aerial parts of Dodonaea viscosa led to the isolation of six new compounds including four isoprenylated flavonoids,dodovisones A-D(1-4),and two clerodane diterpenoids,dodovislactones...Phytochemical investigation of the aerial parts of Dodonaea viscosa led to the isolation of six new compounds including four isoprenylated flavonoids,dodovisones A-D(1-4),and two clerodane diterpenoids,dodovislactones A and B(5 and 6).Their structures were established by extensive spectroscopic analysis.展开更多
Four new clerodane diterpenoids,tinosporols A–C(2–4)and tinosporoside A(5),together with six known analogues were isolated from the vines of Tinospora crispa.Their structures were established by extensive spectrosco...Four new clerodane diterpenoids,tinosporols A–C(2–4)and tinosporoside A(5),together with six known analogues were isolated from the vines of Tinospora crispa.Their structures were established by extensive spectroscopic analysis.The relative configuration at C-12 in the known diterpenoid borapetoside E(1),the major component of the plant,was firstly established with the aid of molecular model.Compound 1 significantly reduced serum glucose levels at dosedependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.展开更多
Three hitherto unknown taxane diterpenoids,namely baccatin Ⅷ(1),baccatin Ⅸ(2),and baccatin Ⅹ(3),along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis.The...Three hitherto unknown taxane diterpenoids,namely baccatin Ⅷ(1),baccatin Ⅸ(2),and baccatin Ⅹ(3),along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis.The new structures were characterized based on extensive spectroscopic analysis.Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines,and 1 exhibited inhibitory effects on HL-60 and MCF-7,with IC_(50) values of 3.44 and 9.67 μM,respectively.展开更多
Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety,namely rauvotetraphyllines F–H(1,3,4),17-epi-rauvotetraphylline F(2)and 21-epi-rauvotetraphylline H(5),were is...Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety,namely rauvotetraphyllines F–H(1,3,4),17-epi-rauvotetraphylline F(2)and 21-epi-rauvotetraphylline H(5),were isolated from the aerial parts of Rauvolfia tetraphylla.Their structures were established by extensive spectroscopic analysis.The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.展开更多
Four hitherto unknown 6a,11b-dihydroxypterocarpans,namely pterocarpadiols A–D(1–4),were isolated from the ethanol extract of the twigs and leaves of Derris robusta.Their structures were elucidated on the basis of ex...Four hitherto unknown 6a,11b-dihydroxypterocarpans,namely pterocarpadiols A–D(1–4),were isolated from the ethanol extract of the twigs and leaves of Derris robusta.Their structures were elucidated on the basis of extensive spectroscopic analysis.Pterocarpadiols A–D are a kind of very rare 6a,11b-dihydroxypterocarpans,and their presence as markers may be helpful in chemotaxonomical classification.展开更多
Five new indole alkaloids rauvotetraphyllines A-E(1-5),together with eight known analogues,were isolated from the aerial parts of Rauvolfia tetraphylla.The structures were established by means of spectroscopic methods.
基金The authors acknowledge the National Basic Research Program of China(973 Program,2009CB522300)the“West Light”program of Chinese Academy of Sciences,and the National Natural Science Foundation of China(U1132607).
文摘Guajadials C-F(1-4),four sesquiterpenoid-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava.Their structures and relative configurations were established by extensive spectroscopic analysis.A possible biosynthetic pathway for 1-4 was also proposed.
基金This work was financially supported by National Basic Research Program of China(973 Program,2009CB522300)the“West Light”program of Chinese Academy of Sciencesthe“Large-scale Compound Library”project of National Development Reform Commission.
文摘Phytochemical investigation of the aerial parts of Dodonaea viscosa led to the isolation of six new compounds including four isoprenylated flavonoids,dodovisones A-D(1-4),and two clerodane diterpenoids,dodovislactones A and B(5 and 6).Their structures were established by extensive spectroscopic analysis.
基金This work was financially supported by“Largescale Compound Library”Project of National Development Reform Commission of China,National Natural Science Foundation of China(81561148013 to J.L.)the Chinese Academy of Sciences(292013312 D11004 to W.X.)+1 种基金Yibin University(2015QD06 to Y.G.)Sciences Foundation of Yunnan Province(39Y33H521261 to W.X.).
文摘Four new clerodane diterpenoids,tinosporols A–C(2–4)and tinosporoside A(5),together with six known analogues were isolated from the vines of Tinospora crispa.Their structures were established by extensive spectroscopic analysis.The relative configuration at C-12 in the known diterpenoid borapetoside E(1),the major component of the plant,was firstly established with the aid of molecular model.Compound 1 significantly reduced serum glucose levels at dosedependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
基金financially supported by the "Large-scale Compound Library" project of National DevelopmentReform Commission of China and the"Western Light" talents training program of Chinese Academy of Sciences.
文摘Three hitherto unknown taxane diterpenoids,namely baccatin Ⅷ(1),baccatin Ⅸ(2),and baccatin Ⅹ(3),along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis.The new structures were characterized based on extensive spectroscopic analysis.Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines,and 1 exhibited inhibitory effects on HL-60 and MCF-7,with IC_(50) values of 3.44 and 9.67 μM,respectively.
基金This work was financially supported by “Largescale Compound Library” Project of National Development and Reform Commission of China.
文摘Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety,namely rauvotetraphyllines F–H(1,3,4),17-epi-rauvotetraphylline F(2)and 21-epi-rauvotetraphylline H(5),were isolated from the aerial parts of Rauvolfia tetraphylla.Their structures were established by extensive spectroscopic analysis.The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.
基金This work was financially supported by the“Large-scale Compound Library”project of National Development and Reform Commission of China.
文摘Four hitherto unknown 6a,11b-dihydroxypterocarpans,namely pterocarpadiols A–D(1–4),were isolated from the ethanol extract of the twigs and leaves of Derris robusta.Their structures were elucidated on the basis of extensive spectroscopic analysis.Pterocarpadiols A–D are a kind of very rare 6a,11b-dihydroxypterocarpans,and their presence as markers may be helpful in chemotaxonomical classification.
基金supported by National Basic Research Program of China(973 Program)2009CB522300,the“West Light”program of Chinese Academy of Sciences,and Natural Product Library Program of BioBioPha.
文摘Five new indole alkaloids rauvotetraphyllines A-E(1-5),together with eight known analogues,were isolated from the aerial parts of Rauvolfia tetraphylla.The structures were established by means of spectroscopic methods.
