Low-density lipoprotein receptor-related protein 1(LRP1)is a multifunctional endocytic receptor whose dysfunction is linked to developmental dysplasia of the hip,osteoporosis and osteoarthritis.Our work addresses the ...Low-density lipoprotein receptor-related protein 1(LRP1)is a multifunctional endocytic receptor whose dysfunction is linked to developmental dysplasia of the hip,osteoporosis and osteoarthritis.Our work addresses the critical question of how these skeletal pathologies emerge.Here,we show the abundant expression of LRP1 in skeletal progenitor cells at mouse embryonic stage E10.5 and onwards,especially in the perichondrium,the stem cell layer surrounding developing limbs essential for bone formation.Lrp1 deficiency in these stem cells causes joint fusion,malformation of cartilage/bone template and markedly delayed or lack of primary ossification.展开更多
BACKGROUND Triclosan-coated vicryl plus suture(Ethicon,Inc.)was developed to reduce microbial colonisation during surgical procedures.However,its effect on wound healing and surgical site infections remain unclear aft...BACKGROUND Triclosan-coated vicryl plus suture(Ethicon,Inc.)was developed to reduce microbial colonisation during surgical procedures.However,its effect on wound healing and surgical site infections remain unclear after hip and knee arthroplasty surgery.AIM To determine the effect of triclosan-coated sutures(TCS)vs non-coated sutures on wound healing,following primary hip and knee arthroplasties.METHODS A single-centred,double-blind randomised controlled trial(RCT)was undertaken.We randomly allocated patients to receive either the triclosan-coated sutures(TCS vicryl plus)or non-coated sutures(NCS vicryl)during the closure of unilateral primary hip and knee arthroplasties.We utilised the ASEPSIS wound scoring system to evaluate wound healing for the first 6 weeks post-operatively.RESULTS One hundred and fifty patients undergoing primary total hip or knee arthroplasty over a one-year period were included.Eighty-one were randomised to the TCS group and 69 to the NCS group.Despite no statistically significant difference in the ASEPSIS scores among the study groups(P=0.75),sensitivity analysis using the Mann Whitney test(P=0.036)as well as assessment of the wound complications at 6 weeks follow up,demonstrated significantly higher wound complication rates in the TCS group(8 vs 1,P=0.03).CONCLUSION No clear advantage was demonstrated for using the TCS.However,larger multicentred RCTs are required to validate their use in hip and knee arthroplasty surgery.展开更多
This paper provides an implementation of a novel signal processing co-processor using a Geometric Algebra technique tailored for fast and complex geometric calculations in multiple dimensions. This is the first hardwa...This paper provides an implementation of a novel signal processing co-processor using a Geometric Algebra technique tailored for fast and complex geometric calculations in multiple dimensions. This is the first hardware implementation of Geometric Algebra to specifically address the issue of scalability to multiple (1 - 8) dimensions. This paper presents a detailed description of the implementation, with a particular focus on the techniques of optimization used to improve performance. Results are presented which demonstrate at least 3x performance improvements compared to previously published work.展开更多
This paper describes a novel time domain noise model for voltage controlled oscillators that accurately and efficiently predicts both tuning behavior and phase noise performance. The proposed method is based on device...This paper describes a novel time domain noise model for voltage controlled oscillators that accurately and efficiently predicts both tuning behavior and phase noise performance. The proposed method is based on device level flicker and thermal noise models that have been developed in Simulink and although the case study is a multiple feedback four delay cell architecture it could easily be extended to any similar topology. The strength of the approach is verified through comparison with post layout simulation results from a commercial simulator and measured results from a 120 nm fabricated prototype chip. Furthermore, the effect of control voltage flicker noise on oscillator output phase noise is also investigated as an example application of the model. Transient simulation based noise analysis has the strong advantage that noise performance of higher level systems such as phase locked loops can be easily determined over a realistic acquisition and locking process yielding more accurate and reliable results.展开更多
本文探讨在Microsonft Windows 2000和Windows 98第二版中并行共享组件的实现问题,同样在Windows认证规范方面进行了讨论。本文包括的内容涉及:新的并行组件的创建,以及使用DLL/COM重定向来处理同一组件的不同版本之间的不兼容问题。本...本文探讨在Microsonft Windows 2000和Windows 98第二版中并行共享组件的实现问题,同样在Windows认证规范方面进行了讨论。本文包括的内容涉及:新的并行组件的创建,以及使用DLL/COM重定向来处理同一组件的不同版本之间的不兼容问题。本文包括编写和安装并行组件,以及重新打包和测试应用程序的指导原则。展开更多
基金The Andor dragonfly Spinning Disk microscope in the CCI was funded by the BBSRC(BB/R01390X/1)This work was supported by the ministry of education of the Kingdom of Saudi Arabia(to M.Alhashmi)+6 种基金Libyan Ministry of Higher Education and Scientific Research and ECMage(to A.M.E.Gremida)Qatar National Research Fund(to N.A.Al-Maslamani)European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement(860635 to M.Antonaci and A.Kerr)BBSRC Grants(BB/T00715X/1 to S.K.Maharana and G.N.WheelerBB/X000907/1 to D.A.Turner)Versus Arthritis Career Development Fellowship(21447 to K.Yamamoto)Versus Arthritis Bridging Fellowship(23137 to K.Yamamoto).
文摘Low-density lipoprotein receptor-related protein 1(LRP1)is a multifunctional endocytic receptor whose dysfunction is linked to developmental dysplasia of the hip,osteoporosis and osteoarthritis.Our work addresses the critical question of how these skeletal pathologies emerge.Here,we show the abundant expression of LRP1 in skeletal progenitor cells at mouse embryonic stage E10.5 and onwards,especially in the perichondrium,the stem cell layer surrounding developing limbs essential for bone formation.Lrp1 deficiency in these stem cells causes joint fusion,malformation of cartilage/bone template and markedly delayed or lack of primary ossification.
文摘BACKGROUND Triclosan-coated vicryl plus suture(Ethicon,Inc.)was developed to reduce microbial colonisation during surgical procedures.However,its effect on wound healing and surgical site infections remain unclear after hip and knee arthroplasty surgery.AIM To determine the effect of triclosan-coated sutures(TCS)vs non-coated sutures on wound healing,following primary hip and knee arthroplasties.METHODS A single-centred,double-blind randomised controlled trial(RCT)was undertaken.We randomly allocated patients to receive either the triclosan-coated sutures(TCS vicryl plus)or non-coated sutures(NCS vicryl)during the closure of unilateral primary hip and knee arthroplasties.We utilised the ASEPSIS wound scoring system to evaluate wound healing for the first 6 weeks post-operatively.RESULTS One hundred and fifty patients undergoing primary total hip or knee arthroplasty over a one-year period were included.Eighty-one were randomised to the TCS group and 69 to the NCS group.Despite no statistically significant difference in the ASEPSIS scores among the study groups(P=0.75),sensitivity analysis using the Mann Whitney test(P=0.036)as well as assessment of the wound complications at 6 weeks follow up,demonstrated significantly higher wound complication rates in the TCS group(8 vs 1,P=0.03).CONCLUSION No clear advantage was demonstrated for using the TCS.However,larger multicentred RCTs are required to validate their use in hip and knee arthroplasty surgery.
文摘This paper provides an implementation of a novel signal processing co-processor using a Geometric Algebra technique tailored for fast and complex geometric calculations in multiple dimensions. This is the first hardware implementation of Geometric Algebra to specifically address the issue of scalability to multiple (1 - 8) dimensions. This paper presents a detailed description of the implementation, with a particular focus on the techniques of optimization used to improve performance. Results are presented which demonstrate at least 3x performance improvements compared to previously published work.
文摘This paper describes a novel time domain noise model for voltage controlled oscillators that accurately and efficiently predicts both tuning behavior and phase noise performance. The proposed method is based on device level flicker and thermal noise models that have been developed in Simulink and although the case study is a multiple feedback four delay cell architecture it could easily be extended to any similar topology. The strength of the approach is verified through comparison with post layout simulation results from a commercial simulator and measured results from a 120 nm fabricated prototype chip. Furthermore, the effect of control voltage flicker noise on oscillator output phase noise is also investigated as an example application of the model. Transient simulation based noise analysis has the strong advantage that noise performance of higher level systems such as phase locked loops can be easily determined over a realistic acquisition and locking process yielding more accurate and reliable results.
文摘本文探讨在Microsonft Windows 2000和Windows 98第二版中并行共享组件的实现问题,同样在Windows认证规范方面进行了讨论。本文包括的内容涉及:新的并行组件的创建,以及使用DLL/COM重定向来处理同一组件的不同版本之间的不兼容问题。本文包括编写和安装并行组件,以及重新打包和测试应用程序的指导原则。
