From the cultured filtrates of fungus Aspergillus versicolor, isolated from marine sponge Xestospongia exigua, four novel secondary metabolites, namely aspergillone 1, aspergillodiol 2, aspergillol 3 and 12-acetyl-asp...From the cultured filtrates of fungus Aspergillus versicolor, isolated from marine sponge Xestospongia exigua, four novel secondary metabolites, namely aspergillone 1, aspergillodiol 2, aspergillol 3 and 12-acetyl-aspergillol 4, have been isolated by column chromatographic separation. The structures of all the new compounds are established on the basis of extensive 2D NMR spectroscopy in conjugation with MS, UV spectral analysis. The basic structure pattern of those compounds possessed an hydroindenoisopyran nucleus.展开更多
From the marine sponge Xestospongia exigua, fungal isolates of Aspergillus versicolor (Vuill)Triab were obtained. Isolation and purification of ethyl acetate extracts from culture filtrates of the fungus led to yield ...From the marine sponge Xestospongia exigua, fungal isolates of Aspergillus versicolor (Vuill)Triab were obtained. Isolation and purification of ethyl acetate extracts from culture filtrates of the fungus led to yield six new chromone derivatives namely aspergione A, aspergione B, aspergione C, aspergione D. aspergione E, aspergione F. The structures of all the new compounds were established on the basis of extensive spectroscopy (UV, MS, H-1 and C-13 NMR, COSY, HMQC and HMBC) analysis.展开更多
Objective:To provide further evidence for the ethnomedicinal use of the Eastern Nigeria mistletoe,Loranthus micranthus(L.micranthus),as an immunostimulant.Methods:Solvent fractions from the crude extract of the mistle...Objective:To provide further evidence for the ethnomedicinal use of the Eastern Nigeria mistletoe,Loranthus micranthus(L.micranthus),as an immunostimulant.Methods:Solvent fractions from the crude extract of the mistletoe plant was obtained and screened by the cell mediated delayed type hypersensitivity reaction(DTHR) model in mice.Then the immunomodulatory potentials of a major lupane triterpenoid ester isolated from an active hexane fraction of the Eastern Nigeria mistletoe was investigated.Three lupeol-based triterpenoid esters: 7β15α-dihydroxyl-lup-20(29)-ene-3β-palmitate(Ⅰ),7β,15α-dihydroxyl-lup-20(29)- ene-3β-stearate(Ⅱ) and 7β,15α-dihydroxyl-lup-20(29)-ene-3β-decadecanoate(Ⅲ) were isolated from the plant leaves epiphyting on a local kola nut tree and were characterized. Compound 1 was subjected to cell proliferation studies using C57H1/6 splenocvtes at three dose levels(5.25 and 100μg/mL) in presence of controls.Furthermore,the effect of this compound on IL-8 receptor expression was evaluated at three doses(1,5 and 10μg/mL) using the real time polymerase chain reaction assay.Results:This triterpenoid ester produced some enhancement of the splenocytes at the tested doses but at doses higher than 5μg/mL caused inhibition of the IL-8 receptor expression.Conclusions:The present findings support the ethnomedicinal use of the Eastern Nigeria Mistletoe in the management of diseases affecting the immune system.The trilerpenoid(s) have some immunomodulatory abilities on splenocytes and IL-8 receptors and may partly account lor the overall immunomodulatory activity of this plant.展开更多
The potential of mangrove-derived endophytic fungi as a promising source of diverse and structurally unprecedented bioactive natural products is unquestionable and continues to attract considerable attention.This revi...The potential of mangrove-derived endophytic fungi as a promising source of diverse and structurally unprecedented bioactive natural products is unquestionable and continues to attract considerable attention.This review highlights new bioactive mangrove fungal metabolites and known compounds with hitherto unreported biological activities described during the last 10 years.The compounds are categorized according to their reported biological activities,including cytotoxic,anti-infective,in addition to a wide range of miscellaneous activities such as protein kinase,αglucosidase,acetylcholinesterase and tyrosinase inhibitory activities,as well as antiangiogenic and neovascularisation effects,radical scavenging,DNA-binding affinity,and calcium and potassium channel blocking activity.展开更多
The potential of endophytes and algal or invertebrate associated marine derived fungi as promising sources of structurally unprecedented bioactive natural products is undeniable and continues to attract broad attentio...The potential of endophytes and algal or invertebrate associated marine derived fungi as promising sources of structurally unprecedented bioactive natural products is undeniable and continues to attract broad attention.This review highlights new bioactive fungal metabolites reported in 2011 until April 2012,as well as known compounds for which novel biological activities have been disclosed.All compounds are grouped according to their reported biological activities which include cytotoxic,anti-infective,as well as radical scavenging,enzyme inhibition,anti-fouling and anti-parasitic activities.Overall,178 fungal metabolites,including 138 new natural products are presented.Furthermore,new insights into fungal-host interaction,chemical communication,and chemo-ecological roles of fungal metabolites,as well as new strategies for bioprospecting are presented.展开更多
基金This project is supported by NNSF of China(No.29932030).
文摘From the cultured filtrates of fungus Aspergillus versicolor, isolated from marine sponge Xestospongia exigua, four novel secondary metabolites, namely aspergillone 1, aspergillodiol 2, aspergillol 3 and 12-acetyl-aspergillol 4, have been isolated by column chromatographic separation. The structures of all the new compounds are established on the basis of extensive 2D NMR spectroscopy in conjugation with MS, UV spectral analysis. The basic structure pattern of those compounds possessed an hydroindenoisopyran nucleus.
文摘From the marine sponge Xestospongia exigua, fungal isolates of Aspergillus versicolor (Vuill)Triab were obtained. Isolation and purification of ethyl acetate extracts from culture filtrates of the fungus led to yield six new chromone derivatives namely aspergione A, aspergione B, aspergione C, aspergione D. aspergione E, aspergione F. The structures of all the new compounds were established on the basis of extensive spectroscopy (UV, MS, H-1 and C-13 NMR, COSY, HMQC and HMBC) analysis.
基金The NIH/NIPRD/FCN drug symposium travel grant award to the corresponding author in 2009the 2008 innovators of tomorrow(IOT) grant award from STEP-B project in Nigeria
文摘Objective:To provide further evidence for the ethnomedicinal use of the Eastern Nigeria mistletoe,Loranthus micranthus(L.micranthus),as an immunostimulant.Methods:Solvent fractions from the crude extract of the mistletoe plant was obtained and screened by the cell mediated delayed type hypersensitivity reaction(DTHR) model in mice.Then the immunomodulatory potentials of a major lupane triterpenoid ester isolated from an active hexane fraction of the Eastern Nigeria mistletoe was investigated.Three lupeol-based triterpenoid esters: 7β15α-dihydroxyl-lup-20(29)-ene-3β-palmitate(Ⅰ),7β,15α-dihydroxyl-lup-20(29)- ene-3β-stearate(Ⅱ) and 7β,15α-dihydroxyl-lup-20(29)-ene-3β-decadecanoate(Ⅲ) were isolated from the plant leaves epiphyting on a local kola nut tree and were characterized. Compound 1 was subjected to cell proliferation studies using C57H1/6 splenocvtes at three dose levels(5.25 and 100μg/mL) in presence of controls.Furthermore,the effect of this compound on IL-8 receptor expression was evaluated at three doses(1,5 and 10μg/mL) using the real time polymerase chain reaction assay.Results:This triterpenoid ester produced some enhancement of the splenocytes at the tested doses but at doses higher than 5μg/mL caused inhibition of the IL-8 receptor expression.Conclusions:The present findings support the ethnomedicinal use of the Eastern Nigeria Mistletoe in the management of diseases affecting the immune system.The trilerpenoid(s) have some immunomodulatory abilities on splenocytes and IL-8 receptors and may partly account lor the overall immunomodulatory activity of this plant.
基金Financial support to P.P.and A.D.by BMBF is gratefully acknowledged.
文摘The potential of mangrove-derived endophytic fungi as a promising source of diverse and structurally unprecedented bioactive natural products is unquestionable and continues to attract considerable attention.This review highlights new bioactive mangrove fungal metabolites and known compounds with hitherto unreported biological activities described during the last 10 years.The compounds are categorized according to their reported biological activities,including cytotoxic,anti-infective,in addition to a wide range of miscellaneous activities such as protein kinase,αglucosidase,acetylcholinesterase and tyrosinase inhibitory activities,as well as antiangiogenic and neovascularisation effects,radical scavenging,DNA-binding affinity,and calcium and potassium channel blocking activity.
基金Financial support to P.P.and A.D.by BMBF is gratefully acknowledged.
文摘The potential of endophytes and algal or invertebrate associated marine derived fungi as promising sources of structurally unprecedented bioactive natural products is undeniable and continues to attract broad attention.This review highlights new bioactive fungal metabolites reported in 2011 until April 2012,as well as known compounds for which novel biological activities have been disclosed.All compounds are grouped according to their reported biological activities which include cytotoxic,anti-infective,as well as radical scavenging,enzyme inhibition,anti-fouling and anti-parasitic activities.Overall,178 fungal metabolites,including 138 new natural products are presented.Furthermore,new insights into fungal-host interaction,chemical communication,and chemo-ecological roles of fungal metabolites,as well as new strategies for bioprospecting are presented.
