Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertensi...Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertension,jaundice,dysmenorrheal,gastrointestinal disorders and malaria.In order to reveal its full pharmacological and therapeutic potentials,die present review focuses on the current medicinal uses,phytochemistry,pharmacological and toxicological activities of this species.Literature survey on scientific journals,books as well as electronic sources have shown the isolation of alkaloids,tannins,polyphenols and steroids from different parts of the plant,pharmacological studies revealed that the extract or isolated compounds from this species posses analgesic,anti-inflammatory,hypoglyceamic,hypotensive,antiplasmodial,antimicrobial,antiulcer and antitumorigenic activities.Results from various scientific investigations to date have revealed the potential of the extract from the plant or isolated compounds for use in the treatment and prevention of various kinds of human diseases.However,further studies on the extracts and pure compounds from this species is required to completely assess its phytoc-hemical,pharmacological and toxicological profile as well as the mechanism of action behind these pharmacological activities exhibited by the compounds isolated from this species.展开更多
Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatroph...Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses lo obtain three known metabolites,microcyclic lathyrane dilerpenoids(1-3).Structures were confirmed by comparison of 1D and 2D spectral data with literature.Results:The three compounds exhibited inhibition of antileishmanial,antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC_(50)of 82 and 8.7 μg/ml,respectively.Conclusions:The research lends support to the ethnomedicinal use of the plant in combating microbial infections,leishmaniasis and malarial infections.展开更多
The title compound （E）-ethyl 2-fluoro-2-（3-oxoisobenzofuran-1（3H）-ylidene） aceta- te was synthesized as an unexpected product by the reaction ofphthalyl dichloride with bis-silylenol ether, which is not in accor...The title compound （E）-ethyl 2-fluoro-2-（3-oxoisobenzofuran-1（3H）-ylidene） aceta- te was synthesized as an unexpected product by the reaction ofphthalyl dichloride with bis-silylenol ether, which is not in accordance with our previous studies. The title compound was characterized by single-crystal X-ray diffraction, 1H NMR, 13C NMR, 19F NMR, GCMS, HRMS and IR. The crystal （C12HgFO4, Mr = 236.19） belongs to the monoclinic system, space group P21/c, a = 19.1609（8）, b = 7.9831（3）, c = 13.7715（6） A, V= 2106.13（15） A3, Z= 8, Dx = 1.490 Mg m-3, MoKa radiation, 2 = 0.71073 A,μ = 0.12 mm-1, F（000） = 976, the final R = 0.025 and wR = 0.1300 for 4505 observed reflections with I〉 2σ（I）.展开更多
The increase in natural gas production in North America resulting from the implementation of new technologies related to the fracturing (fracking) of natural gas-bearing shale reservoirs has enhanced the security of s...The increase in natural gas production in North America resulting from the implementation of new technologies related to the fracturing (fracking) of natural gas-bearing shale reservoirs has enhanced the security of supply and lowered energy costs in the continent. Yet the environmental impact associated with shale gas development has raised concerns and debate among energy and environmental policy makers as to how best to address these concerns. As Canada’s largest producer of natural gas, the Province of Alberta is an example of a jurisdiction with numerous regulations for dealing with such environmental risks. This paper applies the CO/RE model of Konschnik and Bolingin examining Alberta’s environmental regulatory framework and the impact;it will have on further shale gas production in the province. Aside from the identification of risks associated with increased seismicity, the results of this examination suggest that the current regulatory environment does not appear to have any adverse effect on current and future shale gas production within the province. Furthermore, Alberta’s environmental regulation has influenced shale gas producers to pursue innovation in technology and engineering practice and has helped establish a collaborative approach to mitigating environmental risk.展开更多
你眼前看到的是宝马新款概念车Concept Active Tourer的首张杂志照片，是我们在柏林的同事于9月早些时候拍摄的。这部车使我们首次得以一睹宝马新型1系GT的风采。作为梅赛德斯B级车型（MercedesB-Class）的竞争对手，它们的尺寸非常接...你眼前看到的是宝马新款概念车Concept Active Tourer的首张杂志照片，是我们在柏林的同事于9月早些时候拍摄的。这部车使我们首次得以一睹宝马新型1系GT的风采。作为梅赛德斯B级车型（MercedesB-Class）的竞争对手，它们的尺寸非常接近，但如你所见，宝马的这款车更有望打动人心。展开更多
基金supported by a US-Senior Fulbright Award granted to Dr.A.Falodun for study at University of Mississippi,USA,CIESCs for the Fulbright awardthe University of Benin(Nigeria)and Institute of Chemistry(University of Rostock,Germany),for their support
文摘Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertension,jaundice,dysmenorrheal,gastrointestinal disorders and malaria.In order to reveal its full pharmacological and therapeutic potentials,die present review focuses on the current medicinal uses,phytochemistry,pharmacological and toxicological activities of this species.Literature survey on scientific journals,books as well as electronic sources have shown the isolation of alkaloids,tannins,polyphenols and steroids from different parts of the plant,pharmacological studies revealed that the extract or isolated compounds from this species posses analgesic,anti-inflammatory,hypoglyceamic,hypotensive,antiplasmodial,antimicrobial,antiulcer and antitumorigenic activities.Results from various scientific investigations to date have revealed the potential of the extract from the plant or isolated compounds for use in the treatment and prevention of various kinds of human diseases.However,further studies on the extracts and pure compounds from this species is required to completely assess its phytoc-hemical,pharmacological and toxicological profile as well as the mechanism of action behind these pharmacological activities exhibited by the compounds isolated from this species.
基金supported by the Fulbright Senior Scholar program granted to Dr A.Falodun to study at the School of Pharmacy,University of Mississippisupported by NIH,NIAID,Division of AIDS.Grant No.Al 27094(antifungal)+1 种基金the USDA Agricultural Research Service Specific Cooperative Agreement No.58-6408-1-603(antibacterial)TETFUND/DESS/RP/UNIV/BENIN/VOL.111 2013 and URPC VC.23
文摘Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses lo obtain three known metabolites,microcyclic lathyrane dilerpenoids(1-3).Structures were confirmed by comparison of 1D and 2D spectral data with literature.Results:The three compounds exhibited inhibition of antileishmanial,antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC_(50)of 82 and 8.7 μg/ml,respectively.Conclusions:The research lends support to the ethnomedicinal use of the plant in combating microbial infections,leishmaniasis and malarial infections.
文摘The title compound （E）-ethyl 2-fluoro-2-（3-oxoisobenzofuran-1（3H）-ylidene） aceta- te was synthesized as an unexpected product by the reaction ofphthalyl dichloride with bis-silylenol ether, which is not in accordance with our previous studies. The title compound was characterized by single-crystal X-ray diffraction, 1H NMR, 13C NMR, 19F NMR, GCMS, HRMS and IR. The crystal （C12HgFO4, Mr = 236.19） belongs to the monoclinic system, space group P21/c, a = 19.1609（8）, b = 7.9831（3）, c = 13.7715（6） A, V= 2106.13（15） A3, Z= 8, Dx = 1.490 Mg m-3, MoKa radiation, 2 = 0.71073 A,μ = 0.12 mm-1, F（000） = 976, the final R = 0.025 and wR = 0.1300 for 4505 observed reflections with I〉 2σ（I）.
文摘The increase in natural gas production in North America resulting from the implementation of new technologies related to the fracturing (fracking) of natural gas-bearing shale reservoirs has enhanced the security of supply and lowered energy costs in the continent. Yet the environmental impact associated with shale gas development has raised concerns and debate among energy and environmental policy makers as to how best to address these concerns. As Canada’s largest producer of natural gas, the Province of Alberta is an example of a jurisdiction with numerous regulations for dealing with such environmental risks. This paper applies the CO/RE model of Konschnik and Bolingin examining Alberta’s environmental regulatory framework and the impact;it will have on further shale gas production in the province. Aside from the identification of risks associated with increased seismicity, the results of this examination suggest that the current regulatory environment does not appear to have any adverse effect on current and future shale gas production within the province. Furthermore, Alberta’s environmental regulation has influenced shale gas producers to pursue innovation in technology and engineering practice and has helped establish a collaborative approach to mitigating environmental risk.
文摘你眼前看到的是宝马新款概念车Concept Active Tourer的首张杂志照片，是我们在柏林的同事于9月早些时候拍摄的。这部车使我们首次得以一睹宝马新型1系GT的风采。作为梅赛德斯B级车型（MercedesB-Class）的竞争对手，它们的尺寸非常接近，但如你所见，宝马的这款车更有望打动人心。
