In the first application of bio-layer interferometry in medicinal inorganic chemistry,Fe(Ⅲ)-transferrin(Tf)binds strongly to Tf receptor 1(TfR1),but an apo-Tf adduct of the anti-metastatic prodrug,NAMI-A does not bin...In the first application of bio-layer interferometry in medicinal inorganic chemistry,Fe(Ⅲ)-transferrin(Tf)binds strongly to Tf receptor 1(TfR1),but an apo-Tf adduct of the anti-metastatic prodrug,NAMI-A does not bind specifically to TfR1.Binding of NAMI-A to albumin affects its interactions with other blood proteins,such as immunoglobulins.展开更多
基金Financial support of this work has been provided by the Australian Research Council(ARC)Discovery grant,including an ARC Professorial Fellowship,to P.A.L.(DP0984722)funding for an ARC Senior Research Associate for A.L.(DP130103566).
文摘In the first application of bio-layer interferometry in medicinal inorganic chemistry,Fe(Ⅲ)-transferrin(Tf)binds strongly to Tf receptor 1(TfR1),but an apo-Tf adduct of the anti-metastatic prodrug,NAMI-A does not bind specifically to TfR1.Binding of NAMI-A to albumin affects its interactions with other blood proteins,such as immunoglobulins.
