Fat is one of the three macronutrients and a significant energy source for piglets.It plays a positive role in maintaining intestinal health and improving production performance.During the weaning period,physiological...Fat is one of the three macronutrients and a significant energy source for piglets.It plays a positive role in maintaining intestinal health and improving production performance.During the weaning period,physiological,stress and diet-related factors influence the absorption of fat in piglets,leading to damage to the intestinal barrier,diarrhea and even death.Signaling pathways,such as fatty acid translocase(CD36),pregnane X receptor(PXR),and AMP-dependent protein kinase(AMPK),are responsible for regulating intestinal fat uptake and maintaining intestinal barrier function.Therefore,this review mainly elaborates on the reasons for diarrhea induced by insufficient fat absorption and related signaling pathways in weaned-piglets,with an emphasis on the intestinal fat absorption disorder.Moreover,we focus on introducing nutritional strategies that can promote intestinal fat absorption in piglets with insufficient fat absorption-related diarrhea,such as lipase,amino acids,and probiotics.展开更多
基金supported by the National Natural Science Foundation of China(U22A20517)National Key Research and Development Program of China(2022YFD1301500)+1 种基金Natural Science Foundation of Changsha Municipal(kq2208249)Agricultural Science and Technology Innovation Project Special Fund of Chinese Academy of Agricultural Sciences(ASTIP-IBFC)
文摘Fat is one of the three macronutrients and a significant energy source for piglets.It plays a positive role in maintaining intestinal health and improving production performance.During the weaning period,physiological,stress and diet-related factors influence the absorption of fat in piglets,leading to damage to the intestinal barrier,diarrhea and even death.Signaling pathways,such as fatty acid translocase(CD36),pregnane X receptor(PXR),and AMP-dependent protein kinase(AMPK),are responsible for regulating intestinal fat uptake and maintaining intestinal barrier function.Therefore,this review mainly elaborates on the reasons for diarrhea induced by insufficient fat absorption and related signaling pathways in weaned-piglets,with an emphasis on the intestinal fat absorption disorder.Moreover,we focus on introducing nutritional strategies that can promote intestinal fat absorption in piglets with insufficient fat absorption-related diarrhea,such as lipase,amino acids,and probiotics.
