Mitochondrial dysfunctions play major roles in ageing.How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered th...Mitochondrial dysfunctions play major roles in ageing.How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53 levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53 functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53 plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53 levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc^-/- cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals.展开更多
In this paper,finite element method is used to calculate the static performance of gas journal bearing,in which rotation speed term is introduced into the stiffness matrix of linear triangular element to realize the p...In this paper,finite element method is used to calculate the static performance of gas journal bearing,in which rotation speed term is introduced into the stiffness matrix of linear triangular element to realize the performance calculation of the bearing with rotation speed.The results indicate that the average gas film thicknesses corresponding to the maximum load capac-ity and stiffness,and the minimum attitude angle increase with the growth of orifice diameter.Load capacity and stiffness significantly improved with the increase of rotation speed,eccentricity ratio and supply pressure when the bearing has thin average gas film thickness.Attitude angle increases with the growth of rotation speed,while the growth rate slows down or even decreases at high speed.The most effective way of reducing attitude angle is to increase supply pressure.It can be found that rotation speed affects attitude angle through changing gas pressure difference between two orifices,while other parameters have the same effect by changing gas pressure at orifice outlet.展开更多
基金This research was supported by the Priority Research Program of the Ministry of Science and Tech no logy of the People's Republic of China 2017YFA0504600National Natural Science Foundation of the People's Republic of China grant 31371439,91649103Ministry of Education of the People's Republic of China 1000 Talents Youth program.
文摘Mitochondrial dysfunctions play major roles in ageing.How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53 levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53 functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53 plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53 levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc^-/- cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals.
基金supported by Natural Science Foundation of Zhejiang Province(LZ23E050002)the National Nature&Science Foundation of China under Grant 51675498,51905513.
文摘In this paper,finite element method is used to calculate the static performance of gas journal bearing,in which rotation speed term is introduced into the stiffness matrix of linear triangular element to realize the performance calculation of the bearing with rotation speed.The results indicate that the average gas film thicknesses corresponding to the maximum load capac-ity and stiffness,and the minimum attitude angle increase with the growth of orifice diameter.Load capacity and stiffness significantly improved with the increase of rotation speed,eccentricity ratio and supply pressure when the bearing has thin average gas film thickness.Attitude angle increases with the growth of rotation speed,while the growth rate slows down or even decreases at high speed.The most effective way of reducing attitude angle is to increase supply pressure.It can be found that rotation speed affects attitude angle through changing gas pressure difference between two orifices,while other parameters have the same effect by changing gas pressure at orifice outlet.
