Biomolecules with a broad range of structure and heteroatom-containing groups offer a great opportunity for rational design of promising electrocatalysts via versatile chemistry.In this study,uniform folic acid-Co nan...Biomolecules with a broad range of structure and heteroatom-containing groups offer a great opportunity for rational design of promising electrocatalysts via versatile chemistry.In this study,uniform folic acid-Co nanotubes(FA-Co NTs) were hydrothermally prepared as sacrificial templates for highly porous Co and N co-doped carbon nanotubes(Co-N/CNTs) with well-controlled size and morphology.The formation mechanism of FA-Co NTs was investigated and FA-Co-hydrazine coordination interaction together with the H-bond interaction between FA molecules was characterized to be the driving force for growth of one-dimensional nanotubes.Such distinct metal-ligand interaction afforded the resultant CNTs rich Co-N_x sites,hierarchically porous structure and Co nanoparticle-embedded conductive network,thus an overall good electrocatalytic activity for oxygen reduction.Electrochemical tests showed that Co-N/CNTs-900 promoted an efficient 4 e ORR process with an onset potential of 0.908 V vs.RHE,a limiting current density of 5.66 mA cm^(-2) at 0.6 V and a H_2 O_2 yield lower than 5%,comparable to that of 20%Pt/C catalyst.Moreover,the catalyst revealed very high stability upon continuous operation and remarkable tolerance to methanol.展开更多
Density functional calculations have been performed to investigate the adsorption of twenty two different kinds of metal adatoms on graphene-like BC3. In contrast to the graphene adsorbed with adatoms, the BC3 with ad...Density functional calculations have been performed to investigate the adsorption of twenty two different kinds of metal adatoms on graphene-like BC3. In contrast to the graphene adsorbed with adatoms, the BC3 with adatoms shows many interesting properties.（1） The interaction between the metal adatoms and the BC3 sheet is remarkably strong. The Li, Na, K, and Ca possess the binding energies larger than the cohesive energies of their corresponding bulk metals.（2）The Li, Na, and K adatoms form approximately ideal ionic bonds with BC3, while the Be, Mg, and Ca adatoms form ionic bonds with BC3 with slight hybridization of covalent bonds. The Al, Ga, In, Sn, and all transition metal adatoms form covalent bonds with BC3.（3） For all the structures studied, there exhibit metal, half-metal, semiconducting, and spin-semiconducting behaviors. Especially, the BC3 with Co adatom shows a quantum anomalous Hall（QAH） phase with a Chern number of -1 based on local density approximation calculations.（4） For Li, Na, K, Ca, Ga, In, Sn, Ti, V, Cr,Ni, Pd, and Pt, there exists a trend that the adatom species with lower ionization potential have lower work function. Our results indicate the potential applications of functionalization of BC3 with metal adatoms.展开更多
Regenerative responses are particularly important in the lungs,which are critical for gas exchange and frequently challenged by environmental insults.The lung progenitor cells play a central role in the lung regenerat...Regenerative responses are particularly important in the lungs,which are critical for gas exchange and frequently challenged by environmental insults.The lung progenitor cells play a central role in the lung regeneration response,and their dysfunction is associated with various lung diseases.Understanding the mechanisms regulating lung progenitor cell function is essential for developing new therapeutic approaches to promote lung regeneration.This review summarizes recent advancements in the field of lung regeneration,focusing on the metabolic control of lung progenitor cellfunction.We discuss cell lineage plasticity and cell-cell signaling under different physiological condi-tions.Additionally,we highlight the connection between progenitor cell dysfunction and lung diseases,emphasizing the need to develop new therapeutic strategies in regenerative medicine to improve lung regenerative capacity.展开更多
Functionalizing ligands on surface metal atoms has been implemented to tune the adsorption behaviors of intermediates in electrochemical CO_(2) reduction reaction(CO_(2)RR).However,it is always bound within an unfavor...Functionalizing ligands on surface metal atoms has been implemented to tune the adsorption behaviors of intermediates in electrochemical CO_(2) reduction reaction(CO_(2)RR).However,it is always bound within an unfavorable linear scaling relationship of the synchronously changed adsorption energies of intermediates.To break it,a win-win diethylamine(DEA)-mediated strategy was proposed to functionalize surface Pd atoms by exchanging the residual oleylamine(OAm) on ultrafine Pd nanoparticles(Pd NPs) with DEA.The molecular dynamics simulations,coupled with in situ Fourier transform infrared spectroscopy results,revealed that DEA hindered less toward CO_(2) than H_(2)O on Pd NPs surface,and induced more CO linear configuration intermediate(^(*)CO_L),indicative of ease CO_(2) transport and CO desorption.Additionally,computational calculations implied that-NH-in DEA delocalized more electrons to surface Pd atoms and formed H-bond with ^(*)COOH,asynchronously changing the adsorption energies of ^(*)COOH and ^(*)CO,which enabled a CO Faraday efficiency(FE_(CO)) close to 100% in an ultrawide potential window and a stability of over 50 h with a FE_(CO) over 90%.This study dexterously addresses the residual issue of end-blocking agents on metal nanostructures from synthesis,and synchronously realizes the surface molecular functionalization,paving a smart avenue to design high-performance electrocatalysts.展开更多
Dear Editor, Histone H3 lysine 36 （H3K36） methylation is a conserved epigenetic mark in all eukaryotes （Berr et al., 2011; Wagner and Carpenter, 2012）. Reverse genetic analysis in Arabidopsis had uncovered a cruc...Dear Editor, Histone H3 lysine 36 （H3K36） methylation is a conserved epigenetic mark in all eukaryotes （Berr et al., 2011; Wagner and Carpenter, 2012）. Reverse genetic analysis in Arabidopsis had uncovered a crucial role of H3K36 di- and tri-methylation （H3K36me2 and H3K36me3） in flowering-time regulation （reviewed in Berr et al., 2011）.展开更多
Regenerative responses are particularly important in the lungs,which are critical for gas exchange and frequently challenged by environmental insults.The lung progenitor cells play a central role in the lung regenerat...Regenerative responses are particularly important in the lungs,which are critical for gas exchange and frequently challenged by environmental insults.The lung progenitor cells play a central role in the lung regeneration response,and their dysfunction is associated with various lung diseases.Understanding the mechanisms regulating lung progenitor cell function is essential for developing new therapeutic approaches to promote lung regeneration.This review summarizes recent advancements in the field of lung regeneration,focusing on the metabolic control of lung progenitor cell function.We discuss cell lineage plasticity and cell–cell signaling under different physiological condi-tions.Additionally,we highlight the connection between progenitor cell dysfunction and lung diseases,emphasizing the need to develop new therapeutic strategies in regenerative medicine to improve lung regenerative capacity.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 51902204, 21975163)the Bureau of Industry and Information Technology of Shenzhen (No. 201901171518)the support provided by Instrumental Analysis Center of Shenzhen University (Xili Campus)。
文摘Biomolecules with a broad range of structure and heteroatom-containing groups offer a great opportunity for rational design of promising electrocatalysts via versatile chemistry.In this study,uniform folic acid-Co nanotubes(FA-Co NTs) were hydrothermally prepared as sacrificial templates for highly porous Co and N co-doped carbon nanotubes(Co-N/CNTs) with well-controlled size and morphology.The formation mechanism of FA-Co NTs was investigated and FA-Co-hydrazine coordination interaction together with the H-bond interaction between FA molecules was characterized to be the driving force for growth of one-dimensional nanotubes.Such distinct metal-ligand interaction afforded the resultant CNTs rich Co-N_x sites,hierarchically porous structure and Co nanoparticle-embedded conductive network,thus an overall good electrocatalytic activity for oxygen reduction.Electrochemical tests showed that Co-N/CNTs-900 promoted an efficient 4 e ORR process with an onset potential of 0.908 V vs.RHE,a limiting current density of 5.66 mA cm^(-2) at 0.6 V and a H_2 O_2 yield lower than 5%,comparable to that of 20%Pt/C catalyst.Moreover,the catalyst revealed very high stability upon continuous operation and remarkable tolerance to methanol.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11774396 and 11704322)Shandong Natural Science Funds for Doctoral Program,China(Grant No.ZR2017BA017)
文摘Density functional calculations have been performed to investigate the adsorption of twenty two different kinds of metal adatoms on graphene-like BC3. In contrast to the graphene adsorbed with adatoms, the BC3 with adatoms shows many interesting properties.（1） The interaction between the metal adatoms and the BC3 sheet is remarkably strong. The Li, Na, K, and Ca possess the binding energies larger than the cohesive energies of their corresponding bulk metals.（2）The Li, Na, and K adatoms form approximately ideal ionic bonds with BC3, while the Be, Mg, and Ca adatoms form ionic bonds with BC3 with slight hybridization of covalent bonds. The Al, Ga, In, Sn, and all transition metal adatoms form covalent bonds with BC3.（3） For all the structures studied, there exhibit metal, half-metal, semiconducting, and spin-semiconducting behaviors. Especially, the BC3 with Co adatom shows a quantum anomalous Hall（QAH） phase with a Chern number of -1 based on local density approximation calculations.（4） For Li, Na, K, Ca, Ga, In, Sn, Ti, V, Cr,Ni, Pd, and Pt, there exists a trend that the adatom species with lower ionization potential have lower work function. Our results indicate the potential applications of functionalization of BC3 with metal adatoms.
基金supported by grants from the National Key Research and Development Program of China 2022YFA0806200"Strategic Priority Research Program"of the Chinese Academy of Sciences(CAS)(XDB1030000)+1 种基金National Natural Science Foundation of China 82070042CAS Youth Interdisciplinary Team(to P.S.).
文摘Regenerative responses are particularly important in the lungs,which are critical for gas exchange and frequently challenged by environmental insults.The lung progenitor cells play a central role in the lung regeneration response,and their dysfunction is associated with various lung diseases.Understanding the mechanisms regulating lung progenitor cell function is essential for developing new therapeutic approaches to promote lung regeneration.This review summarizes recent advancements in the field of lung regeneration,focusing on the metabolic control of lung progenitor cellfunction.We discuss cell lineage plasticity and cell-cell signaling under different physiological condi-tions.Additionally,we highlight the connection between progenitor cell dysfunction and lung diseases,emphasizing the need to develop new therapeutic strategies in regenerative medicine to improve lung regenerative capacity.
基金supported by the Pilot Group Program of the Research Fund for International Senior Scientists (No.22350710789)the Start-up Funding of Central South University (No.206030104)。
文摘Functionalizing ligands on surface metal atoms has been implemented to tune the adsorption behaviors of intermediates in electrochemical CO_(2) reduction reaction(CO_(2)RR).However,it is always bound within an unfavorable linear scaling relationship of the synchronously changed adsorption energies of intermediates.To break it,a win-win diethylamine(DEA)-mediated strategy was proposed to functionalize surface Pd atoms by exchanging the residual oleylamine(OAm) on ultrafine Pd nanoparticles(Pd NPs) with DEA.The molecular dynamics simulations,coupled with in situ Fourier transform infrared spectroscopy results,revealed that DEA hindered less toward CO_(2) than H_(2)O on Pd NPs surface,and induced more CO linear configuration intermediate(^(*)CO_L),indicative of ease CO_(2) transport and CO desorption.Additionally,computational calculations implied that-NH-in DEA delocalized more electrons to surface Pd atoms and formed H-bond with ^(*)COOH,asynchronously changing the adsorption energies of ^(*)COOH and ^(*)CO,which enabled a CO Faraday efficiency(FE_(CO)) close to 100% in an ultrawide potential window and a stability of over 50 h with a FE_(CO) over 90%.This study dexterously addresses the residual issue of end-blocking agents on metal nanostructures from synthesis,and synchronously realizes the surface molecular functionalization,paving a smart avenue to design high-performance electrocatalysts.
文摘Dear Editor, Histone H3 lysine 36 （H3K36） methylation is a conserved epigenetic mark in all eukaryotes （Berr et al., 2011; Wagner and Carpenter, 2012）. Reverse genetic analysis in Arabidopsis had uncovered a crucial role of H3K36 di- and tri-methylation （H3K36me2 and H3K36me3） in flowering-time regulation （reviewed in Berr et al., 2011）.
基金National Key Research and Development Program of China 2022YFA0806200“Strategic Priority Research Program”of the Chinese Academy of Sciences(CAS)(XDB1030000)+1 种基金National Natural Science Foundation of China 82070042CAS Youth Interdisciplinary Team(to P.S.).
文摘Regenerative responses are particularly important in the lungs,which are critical for gas exchange and frequently challenged by environmental insults.The lung progenitor cells play a central role in the lung regeneration response,and their dysfunction is associated with various lung diseases.Understanding the mechanisms regulating lung progenitor cell function is essential for developing new therapeutic approaches to promote lung regeneration.This review summarizes recent advancements in the field of lung regeneration,focusing on the metabolic control of lung progenitor cell function.We discuss cell lineage plasticity and cell–cell signaling under different physiological condi-tions.Additionally,we highlight the connection between progenitor cell dysfunction and lung diseases,emphasizing the need to develop new therapeutic strategies in regenerative medicine to improve lung regenerative capacity.
