The specific trigger of tumor cell ferroptosis is an effective way for precise cancer therapy with low side effects and high efficiency.However,the trigger reagents should be further developed.Herein,an ATT((E)-2,2...The specific trigger of tumor cell ferroptosis is an effective way for precise cancer therapy with low side effects and high efficiency.However,the trigger reagents should be further developed.Herein,an ATT((E)-2,2'-(((1,2-diphenylethene-1,2-diyl)bis(4,1-phenylene))bis(2-(4-(dicyanomethylene)-2,3,5,6-tetrafluorocyclohexa-2,5-dien-1-ylidene)-2-(4-(diphenylamino)phenyl)ethan-1-yl-1-ylidene))dimalononitrile)reagent bearing cyano and perfluorophenyl groups was found to be a capable reaction with cysteine(Cys)based on a single electron transfer(SET)mechanism in a concentration-dependent manner.Remarkably,with the depletion of Cys,the synthesis of glutathione(GSH)is inhibited intracellularly,which leads to ferroptosis and enhances the sensitivity of tumor cells towards paclitaxel,resulting in efficient inhibition of tumor cells.Meanwhile,the fluorescence of the system is enhanced significantly by destroying the intramolecular charge transfer process of ATT after its reaction with Cys,realizing the self-indication of the treatment.Based on this synergistic treatment,the efficient and specific suppression of tumor cells both in vitro and in vivo is realized,providing a reliable and promising strategy for cancer treatment in the clinic.展开更多
Organic light-emitting materials have attracted considerable attention because of their promising applications in diverse areas.Most fluorophores emit brightly in either dilute solutions or aggregate states;the former...Organic light-emitting materials have attracted considerable attention because of their promising applications in diverse areas.Most fluorophores emit brightly in either dilute solutions or aggregate states;the former generally suffer from aggregation-caused quenching problem,and the latter encounter intensity loss at low concentrations.Herein,we propose a new strategy to overcome these dilemmas by balancing the planar and distorted structures of terphenyl-based luminogens and obtain three luminogens,2PB-AC,2Me2PB-AC,and 2T2PB-AC,with bright emission in both solution and aggregate states.Among them,2PB-AC shows absolute photoluminescence quantum yields(ФPL)higher than 90%in both tetrahydrofuran solution(90.2%)and aggregate states(92.7%for powder and 95.3%for crystal).Thus,2PB-AC could be an efficient probe to realize dual-channel explosive detection in both solution and aggregate states.Moreover,it could be used to image live-cell lipid droplets at a wide range of concentrations.In addition,benefiting from its thermodynamically favorable intersystem crossing process,2Me2PB-AC could be doped in polymethyl methacrylate matrix to provide efficient room-temperature phosphorescence.Thus,this work provides a feasible strategy for the design of luminogens with highly efficient emission in both solution and aggregate states,greatly facilitating and broadening their practical applications.展开更多
基金supported by the Key-Area Research and Development Program of Guangdong Province(2024B0101040001)the National Natural Science Foundation of China(21788102,21907034)+1 种基金the Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates(2023B1212060003)the Innovation and Technology Commission of Hong Kong(ITC-CNERC14SC01).
文摘The specific trigger of tumor cell ferroptosis is an effective way for precise cancer therapy with low side effects and high efficiency.However,the trigger reagents should be further developed.Herein,an ATT((E)-2,2'-(((1,2-diphenylethene-1,2-diyl)bis(4,1-phenylene))bis(2-(4-(dicyanomethylene)-2,3,5,6-tetrafluorocyclohexa-2,5-dien-1-ylidene)-2-(4-(diphenylamino)phenyl)ethan-1-yl-1-ylidene))dimalononitrile)reagent bearing cyano and perfluorophenyl groups was found to be a capable reaction with cysteine(Cys)based on a single electron transfer(SET)mechanism in a concentration-dependent manner.Remarkably,with the depletion of Cys,the synthesis of glutathione(GSH)is inhibited intracellularly,which leads to ferroptosis and enhances the sensitivity of tumor cells towards paclitaxel,resulting in efficient inhibition of tumor cells.Meanwhile,the fluorescence of the system is enhanced significantly by destroying the intramolecular charge transfer process of ATT after its reaction with Cys,realizing the self-indication of the treatment.Based on this synergistic treatment,the efficient and specific suppression of tumor cells both in vitro and in vivo is realized,providing a reliable and promising strategy for cancer treatment in the clinic.
基金This work was financially supported by the National Natural Science Foundation of China(grant no.21788102)the Natural Science Foundation of Guangdong Province(grant nos.2019B030301003 and 2016A030312002)the Innovation and Technology Commission of Hong Kong(grant no.ITC-CNERC14S01).
文摘Organic light-emitting materials have attracted considerable attention because of their promising applications in diverse areas.Most fluorophores emit brightly in either dilute solutions or aggregate states;the former generally suffer from aggregation-caused quenching problem,and the latter encounter intensity loss at low concentrations.Herein,we propose a new strategy to overcome these dilemmas by balancing the planar and distorted structures of terphenyl-based luminogens and obtain three luminogens,2PB-AC,2Me2PB-AC,and 2T2PB-AC,with bright emission in both solution and aggregate states.Among them,2PB-AC shows absolute photoluminescence quantum yields(ФPL)higher than 90%in both tetrahydrofuran solution(90.2%)and aggregate states(92.7%for powder and 95.3%for crystal).Thus,2PB-AC could be an efficient probe to realize dual-channel explosive detection in both solution and aggregate states.Moreover,it could be used to image live-cell lipid droplets at a wide range of concentrations.In addition,benefiting from its thermodynamically favorable intersystem crossing process,2Me2PB-AC could be doped in polymethyl methacrylate matrix to provide efficient room-temperature phosphorescence.Thus,this work provides a feasible strategy for the design of luminogens with highly efficient emission in both solution and aggregate states,greatly facilitating and broadening their practical applications.
