Thyroid cancer(TC)is one of the most common endocrine system tumors,and its incidence continues to increase worldwide.Although most TC patients have a good prognosis,especially with continuous advancements in surgery,...Thyroid cancer(TC)is one of the most common endocrine system tumors,and its incidence continues to increase worldwide.Although most TC patients have a good prognosis,especially with continuous advancements in surgery,radioactive iodine therapy,chemotherapy,endocrine therapy and targeted therapy,the effectiveness of disease treatment has significantly improved.However,there are still some cases with a higher risk of death and greater aggressiveness.In these more challenging advanced or highly aggressive cases,tyrosine kinase inhibitors appear to be an effective treatment option.Unfortunately,these drugs are less than ideal in terms of efficacy because of their toxicity and potential for intrinsic or acquired resistance.Therefore,exploring new strategies targeting the metabolic characteristics of TC cells and overcoming drug resistance barriers in existing treatments have become key topics in the current field of TC research.In recent years,lipid metabolic reprogramming has gained attention as an important aspect of cancer development.Lipid metabolic reprogramming not only participates in the formation of the cell membrane structure,but also plays an important role in signal transduction and promoting cell proliferation.In particular,fatty acid(FA)metabolic reprogramming has attracted widespread attention and plays an important role in multiple aspects such as tumor growth,metastasis,enhanced invasive ability,immune escape,and drug resistance.Although TC is considered a disease that is highly dependent on specific types of metabolic activities,a comprehensive understanding of the specific mechanism of action of FA metabolic reprogramming in this process is lacking.This article aims to review how FA metabolic reprogramming participates in the occurrence and development of TC,focusing on the impact of abnormal FA metabolic pathways and changes in the expression and regulation of related genes over the course of this disease.By examining the complex interactions between FA metabolic disorders and carcinogenic signaling pathways in depth,we aim to identify new therapeutic targets and develop more precise and effective treatments for TC.展开更多
Lipid metabolic reprogramming is considered one of the most prominent metabolic abnormalities in cancer,and fatty acid metabolism is a key aspect of lipid metabolism.Recent studies have shown that fatty acid metabolis...Lipid metabolic reprogramming is considered one of the most prominent metabolic abnormalities in cancer,and fatty acid metabolism is a key aspect of lipid metabolism.Recent studies have shown that fatty acid metabolism and its related lipid metabolic pathways play important roles in the malignant progression of nasopharyngeal carcinoma(NPC).NPC cells adapt to harsh environments by enhancing biological processes such as fatty acid metabolism,uptake,production,and oxidation,thereby accelerating their growth.In addition,the reprogramming of fatty acid metabolism plays a central role in the tumor microenvironment(TME)of NPC,and the phenotypic transformation of immune cells is closely related to fatty acid metabolism.Moreover,the reprogramming of fatty acid metabolism in NPC contributes to immune escape,which significantly affects disease treatment,progression,recurrence,and metastasis.This review explores recent advances in fatty acid metabolism in NPC and focuses on the interconnections among metabolic reprogramming,tumor immunity,and corresponding therapies.In conclusion,fatty acid metabolism represents a potential target for NPC treatment,and further exploration is needed to develop strategies that target the interaction between fatty acid metabolic reprogramming and immunotherapy.展开更多
文摘Thyroid cancer(TC)is one of the most common endocrine system tumors,and its incidence continues to increase worldwide.Although most TC patients have a good prognosis,especially with continuous advancements in surgery,radioactive iodine therapy,chemotherapy,endocrine therapy and targeted therapy,the effectiveness of disease treatment has significantly improved.However,there are still some cases with a higher risk of death and greater aggressiveness.In these more challenging advanced or highly aggressive cases,tyrosine kinase inhibitors appear to be an effective treatment option.Unfortunately,these drugs are less than ideal in terms of efficacy because of their toxicity and potential for intrinsic or acquired resistance.Therefore,exploring new strategies targeting the metabolic characteristics of TC cells and overcoming drug resistance barriers in existing treatments have become key topics in the current field of TC research.In recent years,lipid metabolic reprogramming has gained attention as an important aspect of cancer development.Lipid metabolic reprogramming not only participates in the formation of the cell membrane structure,but also plays an important role in signal transduction and promoting cell proliferation.In particular,fatty acid(FA)metabolic reprogramming has attracted widespread attention and plays an important role in multiple aspects such as tumor growth,metastasis,enhanced invasive ability,immune escape,and drug resistance.Although TC is considered a disease that is highly dependent on specific types of metabolic activities,a comprehensive understanding of the specific mechanism of action of FA metabolic reprogramming in this process is lacking.This article aims to review how FA metabolic reprogramming participates in the occurrence and development of TC,focusing on the impact of abnormal FA metabolic pathways and changes in the expression and regulation of related genes over the course of this disease.By examining the complex interactions between FA metabolic disorders and carcinogenic signaling pathways in depth,we aim to identify new therapeutic targets and develop more precise and effective treatments for TC.
文摘Lipid metabolic reprogramming is considered one of the most prominent metabolic abnormalities in cancer,and fatty acid metabolism is a key aspect of lipid metabolism.Recent studies have shown that fatty acid metabolism and its related lipid metabolic pathways play important roles in the malignant progression of nasopharyngeal carcinoma(NPC).NPC cells adapt to harsh environments by enhancing biological processes such as fatty acid metabolism,uptake,production,and oxidation,thereby accelerating their growth.In addition,the reprogramming of fatty acid metabolism plays a central role in the tumor microenvironment(TME)of NPC,and the phenotypic transformation of immune cells is closely related to fatty acid metabolism.Moreover,the reprogramming of fatty acid metabolism in NPC contributes to immune escape,which significantly affects disease treatment,progression,recurrence,and metastasis.This review explores recent advances in fatty acid metabolism in NPC and focuses on the interconnections among metabolic reprogramming,tumor immunity,and corresponding therapies.In conclusion,fatty acid metabolism represents a potential target for NPC treatment,and further exploration is needed to develop strategies that target the interaction between fatty acid metabolic reprogramming and immunotherapy.
