Neutron time-of-flight(ToF)measurement is a highly accurate method for obtaining the kinetic energy of a neutron by measuring its velocity,but requires precise acquisition of the neutron signal arrival time.However,th...Neutron time-of-flight(ToF)measurement is a highly accurate method for obtaining the kinetic energy of a neutron by measuring its velocity,but requires precise acquisition of the neutron signal arrival time.However,the high hardware costs and data burden associated with the acquisition of neutron ToF signals pose significant challenges.Higher sampling rates increase the data volume,data processing,and storage hardware costs.Compressed sampling can address these challenges,but it faces issues regarding optimal sampling efficiency and high-quality reconstructed signals.This paper proposes a revolutionary deep learning-based compressed sampling(DL-CS)algorithm for reconstructing neutron ToF signals that outperform traditional compressed sampling methods.This approach comprises four modules:random projection,rising dimensions,initial reconstruction,and final reconstruction.Initially,the technique adaptively compresses neutron ToF signals sequentially using three convolutional layers,replacing random measurement matrices in traditional compressed sampling theory.Subsequently,the signals are reconstructed using a modified inception module,long short-term memory,and self-attention.The performance of this deep compressed sampling method was quantified using the percentage root-mean-square difference,correlation coefficient,and reconstruction time.Experimental results showed that our proposed DL-CS approach can significantly enhance signal quality compared with other compressed sampling methods.This is evidenced by a percentage root-mean-square difference,correlation coefficient,and reconstruction time results of 5%,0.9988,and 0.0108 s,respectively,obtained for sampling rates below 10%for the neutron ToF signal generated using an electron-beam-driven photoneutron source.The results showed that the proposed DL-CS approach significantly improves the signal quality compared with other compressed sampling methods,exhibiting excellent reconstruction accuracy and speed.展开更多
BACKGROUND Enhanced recovery after surgery(ERAS),a multidisciplinary and multimodal perioperative care protocol,has been widely used in several surgical fields.However,the effect of this care protocol on liver transpl...BACKGROUND Enhanced recovery after surgery(ERAS),a multidisciplinary and multimodal perioperative care protocol,has been widely used in several surgical fields.However,the effect of this care protocol on liver transplant recipients with endstage liver disease remains unclear.AIM To compare the clinical outcomes of the ERAS protocol and standard care(SC)for liver transplant recipients with end-stage liver disease.METHODS PubMed,Web of Science,Cochrane Library,and EMBASE databases were systematically searched to identify literature reporting the effects of the ERAS protocol on clinical outcomes in patients undergoing liver transplant recipients with endstage liver disease.All articles published to January 1,2025 were searched,followed by data extraction of the included literature and independent quality assessment.Then pooled mean difference(MD)and odds ratio(OR)with a 95%confidence interval(CI)were calculated by either a random-effects or fixed-effects model.RESULTS Overall,eight relevant studies(including two randomized controlled trials,two prospective cohort studies,and four retrospective cohort studies)involving 1220 patients(704 patients in the ERAS group and 516 patients in the SC group).The primary outcomes evaluated included intensive care unit(ICU)stay duration,hospital length of stay,overall complication rates,mortality,and 30-day readmission rates.Our findings showed that ERAS protocols significantly reduced ICU stay duration(MD:-1.21 days,95%CI:-2.08 to-0.34;P=0.006),hospital length of stay(MD:-4.91 days,95%CI:-7.45 to-2.37;P=0.0002),overall complication rates(OR=0.32,95%CI:0.22-0.46;P<0.0001),and mortality(OR=0.57,95%CI:0.33-0.98;P=0.04).However,ERAS was associated with an increased 30-day readmission rate(OR=3.20,95%CI:1.54-6.67;P=0.003).CONCLUSION The current meta-analysis indicated that ERAS protocols can significantly improve short-term clinical outcomes in liver transplant recipients,although the increased readmission rate requires further investigation.Future studies should aim to refine ERAS protocols and explore their long-term efficacy and underlying mechanisms.展开更多
AIM:To investigate the clinicopathological features of cranial-nasal-orbital communicating lesions and identify key diagnostic indicators for differentiating benign and malignant neoplasms.METHODS:The retrospective co...AIM:To investigate the clinicopathological features of cranial-nasal-orbital communicating lesions and identify key diagnostic indicators for differentiating benign and malignant neoplasms.METHODS:The retrospective cohort study analyzed 74 histologically confirmed cases stratified by anatomical involvement at the Wuhan Union Hospital between January 2010 and December 2020:Group A(orbital-nasal group,n=29),Group B(orbital-cranial group,n=27),and Group C(cranial-nasal-orbital group,n=18).Clinicopathological profiles including symptom presentation,histopathology,and invasion patterns were systematically evaluated.RESULTS:The cohort comprised 49(66.2%)benign and 25(33.8%)malignant lesions.Compared with benign lesions,malignant lesions had a shorter onset time(12mo vs 2.5mo,P=0.004)and resulted in poorer vision(0.6 vs 1.53,P=0.025).Headache was reported in 28.6%of patients with benign lesions,but none in those with malignant lesions(P=0.002).Conjunctival congestion and edema were observed in 32.7%of patients with benign lesions and 60%of patients with malignant lesions(P=0.028).The ethmoid sinus was the most frequently invaded site(35 cases).Malignant lesions showed greater invasion in the nasal cavity(28.0%vs 0,P=0.000)and anterior cranial fossa(40.0%vs 8.2%,P=0.003)than benign lesions.The orbital-cranial group was more likely to invade through osseous foramina compared with the orbitalnasal group(P=0.002).Neurogenic tumors predominated benign cases(34.7%),whereas blood derived(28%)and glandular tumors(28%)were most prevalent in malignant subgroups.The proportion of malignant tumors in multidisciplinary combined surgery was higher than that of benign lesions(61.5%vs 38.5%).CONCLUSION:Malignant cranial-nasal-orbital communicating lesions exhibit distinct clinicopathological signatures characterized by rapid progression,aggressive anterior fossa and nasal region,and severe visual morbidity.展开更多
Objective The clinical features,disease course and visual outcomes of toxoplasmosis are less commonly reported in China than in other countries.To reduce misdiagnosis and improve visual function,the clinical character...Objective The clinical features,disease course and visual outcomes of toxoplasmosis are less commonly reported in China than in other countries.To reduce misdiagnosis and improve visual function,the clinical characteristics,management and visual outcomes of 13 cases of ocular toxoplasmosis(OT)were described.Methods This retrospective study included 14 eyes of 13 patients who were diagnosed with OT in Hubei,China.The clinical characteristics,course of treatment and outcomes are presented.There were 7 males and 6 females.Results The main form of OT was retinochoroiditis with vitritis or anterior uveitis.Next-generation sequencing was applied to 3 eyes,and positive results were found in those eyes.Thirteen patients were positive for Toxoplasma gondii IgG antibodies,and 3 of them were also positive for IgM T.gondii antibodies.One patient with acquired immune deficiency syndrome was diagnosed with coinfection with OT and cytomegalovirus,as evidenced by an aqueous humor etiological test.Three patients were misdiagnosed with noninfectious uveitis.Recurrence occurred in 3 eyes during the follow-up periods.One patient who received vitreous implantation of Ozurdex therapy at another hospital before referral relapsed.One patient who received sulfadiazine,azithromycin and glucocorticoid therapy relapsed.One patient who received sulfadiazine therapy experienced relapse.Patients who received clindamycin and sulfadiazine or who received clindamycin only did not experience recurrence during the follow-up period.The best corrected visual acuity was improved in 6 eyes after inflammation resolved.Conclusions Primary active retinochoroiditis is the main form of OT in Hubei,China.Timely correct diagnosis on the basis of ocular characteristics and aetiological test results and effective treatment should be adopted to prevent poor visual outcomes and recurrence.展开更多
The effects of the in-medium nucleon-nucleon(NN) elastic cross section on the observables in heavy ion collisions in the Fermi energy domain are investigated within the framework of the ultrarelativistic quantum molec...The effects of the in-medium nucleon-nucleon(NN) elastic cross section on the observables in heavy ion collisions in the Fermi energy domain are investigated within the framework of the ultrarelativistic quantum molecular dynamics model. The results simulated using medium correction factors of F=σ_(NN)^(in-medium)/σ_(NN)^(free)=0.2,0.3,0.5,and the density-and momentum-dependent factor obtained from the FU3 FP1 parametrization are compared with the FOPI and INDRA experimental data. It is found that the calculations using the correction factors F=0.2 and 0.5 reproduce the experimental data(i.e.,collective flow and nuclear stopping) at 40 and 150 MeV/nucleon, respectively. Calculations with the FU3 FP1 parametrization can best fit these experimental data. These conclusions can be confirmed in both^(197)Au+^(197)Au and^(129)Xe+^(120)Sn.展开更多
In this study, the rapidity distribution, collective flows, and nuclear stopping power in ^(197)Au+^(197)Au collisions at intermediate energies were investigated using the ultrarelativistic quantum molecular dynamics(...In this study, the rapidity distribution, collective flows, and nuclear stopping power in ^(197)Au+^(197)Au collisions at intermediate energies were investigated using the ultrarelativistic quantum molecular dynamics(UrQMD) model with GEMINI++ code. The UrQMD model was adopted to simulate the dynamic evolution of heavy-ion collisions, whereas the GEMINI++ code was used to simulate the decay of primary fragments produced by UrQMD. The calculated results were compared with the INDRA and FOPI experimental data. It was found that the rapidity distribution, collective flows, and nuclear stopping power were affected to a certain extent by the decay of primary fragments, especially at lower beam energies. Furthermore, the experimental data of the collective flows and nuclear stopping power at the investigated beam energies were better reproduced when the sequential decay effect was included.展开更多
Perylene-3,4-(dicarboxylic monoimide)-9,10-(dicarboxylic monoanhydrate)(PIA)is one key intermediate to construct functionalized perylene diimides(PDIs)for various applications.However,the difficulty in synthesizing ch...Perylene-3,4-(dicarboxylic monoimide)-9,10-(dicarboxylic monoanhydrate)(PIA)is one key intermediate to construct functionalized perylene diimides(PDIs)for various applications.However,the difficulty in synthesizing chlorinated PIA hinders the study of chlorinated PDIbased materials.Although chlorination has been widely used to modify the properties of organic semiconductors.We successfully synthesize chlorinated PIA via a simple hydrolysis reaction using LiOH as the base,then a PDI dimer connected at the imide position,N-di-PDI-4Cl,is synthesized as an application example of chlorinated PIA.The heavily chlorinated PDI dimer exhibits deeper energy levels,slightly blue-shifted UV-Vis absorption compared to the non-chlorinated analogue.In addition,the photovoltaic performance of N-di-PDI-4Cl is characterized.This study paves one easy way to synthesize chlorinated PIA and its more delicate derivatives.展开更多
BACKGROUND The global outbreak of human severe acute respiratory syndrome coronavirus(SARS-CoV)-2 infection represents an urgent need for readily available,accurate and rapid diagnostic tests.Nucleic acid testing of r...BACKGROUND The global outbreak of human severe acute respiratory syndrome coronavirus(SARS-CoV)-2 infection represents an urgent need for readily available,accurate and rapid diagnostic tests.Nucleic acid testing of respiratory tract specimens for SARS-CoV-2 is the current gold standard for diagnosis of coronavirus disease 2019(COVID-19).However,the diagnostic accuracy of reverse transcription polymerase chain reaction(RT-PCR)tests for detecting SARS-CoV-2 nucleic acid may be lower than optimal.The detection of SARS-CoV-2-specific antibodies should be used as a serological non-invasive tool for the diagnosis and management of SARS-CoV-2 infection.AIM To investigate the diagnostic value of SARS-CoV-2 IgM/IgG and nucleic acid detection in COVID-19.METHODS We retrospectively analyzed 652 suspected COVID-19 patients,and 206 non-COVID-19 patients in Wuhan Integrated TCM and Western Medicine Hospital.Data on SARS-CoV-2 nucleic acid tests and serum antibody tests were collected to investigate the diagnostic value of nucleic acid RT-PCR test kits and immunoglobulin(Ig)M/IgG antibody test kits.The j2 test was used to compare differences between categorical variables.A 95%confidence interval(CI)was provided by the Wilson score method.All analyses were performed with IBM SPSS Statistics version 22.0(IBM Corp.,Armonk,NY,United States).RESULTS Of the 652 suspected COVID-19 patients,237(36.3%)had positive nucleic acid tests,311(47.7%)were positive for IgM,and 592(90.8%)were positive for IgG.There was a significant difference in the positive detection rate between the IgM and IgG test groups(P<0.001).Using the RT-PCR results as a reference,the specificity,sensitivity,and accuracy of IgM/IgG combined tests for SARS-CoV-2 infection were 98.5%,95.8%,and 97.1%,respectively.Of the 415 suspected COVID-19 patients with negative nucleic acid test results,366 had positive IgM/IgG tests with a positive detection rate of 88.2%.CONCLUSION Our data indicate that serological IgM/IgG antibody combined test had high sensitivity and specificity for the diagnosis of SARS-CoV-2 infection,and can be used in combination with RT-PCR for the diagnosis of SARS-CoV-2 infection.展开更多
This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocul...This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic malignancies.Positron emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic metastases.Local treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and treatment.The challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.展开更多
BACKGROUND Gliomas are the most common primary central nervous system neoplasm.Despite recent advances in the diagnosis and treatment of gliomas,patient prognosis remains dismal.Therefore,it is imperative to identify ...BACKGROUND Gliomas are the most common primary central nervous system neoplasm.Despite recent advances in the diagnosis and treatment of gliomas,patient prognosis remains dismal.Therefore,it is imperative to identify novel diagnostic biomarkers and therapeutic targets of glioma to effectively improve treatment outcomes.AIM To investigate the association between oligodendrocyte transcription factor 2(Olig2)expression and the outcomes of glioma patients.METHODS The PubMed,Embase,Cochrane Library,and China National Knowledge Infrastructure databases were searched for studies(published up to October 2023)that investigated the relationship between Olig2 expression and prognosis of glioma patients.The quality of the studies was assessed using the Newcastle Ottawa Scale.Data analyses were performed using Stata Version 12.0 software.RESULTS A total of 1205 glioma patients from six studies were included in the metaanalysis.High Olig2 expression was associated with better outcomes in glioma patients[hazard ratio(HR):0.81;95%(confidence interval)CI:0.51-1.27;P=0.000].Furthermore,the results of subgroup meta-analysis showed that high expression of Olig2 was associated with poor overall survival in European patients(HR:1.34;95%CI:0.79-2.27)and better prognosis in Asian patients(HR:0.43;95%CI:0.22-0.84).The sensitivity analysis showed that no single study had a significant effect on pooled HR,and there was also no indication of publication bias according to the Egger’s and Begger’s P value test or funnel plot test.CONCLUSION High Olig2 expression may have a positive impact on the prognosis of glioma patients,and should be investigated further as a prognostic biomarker and therapeutic target for glioma.展开更多
目的探讨血清白细胞介素-6(IL-6)联合淋巴细胞/单核细胞比值(LMR)对严重烧伤患儿脓毒血症诊断及预后评估的临床意义。方法回顾性分析郑州大学附属儿童医院和郑州市第一人民医院2015年12月—2020年6月收治的78例重度及以上烧伤患儿的临...目的探讨血清白细胞介素-6(IL-6)联合淋巴细胞/单核细胞比值(LMR)对严重烧伤患儿脓毒血症诊断及预后评估的临床意义。方法回顾性分析郑州大学附属儿童医院和郑州市第一人民医院2015年12月—2020年6月收治的78例重度及以上烧伤患儿的临床资料,收集患儿入院时、伤后7 d、伤后14 d、伤后21 d的血常规及血清IL-6结果。根据患儿是否出现脓毒血症,分为脓毒血症组与非脓毒血症组;根据患儿预后结局,分为生存组和死亡组。同时综合考虑患儿性别、年龄、烧伤总面积(TBSA)、是否伴有吸入性损伤、是否行机械通气等指标,比较不同组之间的差异;受试者工作特征(ROC)曲线预测伤后7 d及伤后14 d IL-6联合LMR对脓毒血症的诊断价值;Kaplan-Meier法预测IL-6及LMR对严重烧伤患儿生存率的影响。结果脓毒血症组与非脓毒血症组患儿是否伴有吸入性损伤、是否行机械通气、TBSA、淋巴细胞绝对数及伤后7 d、伤后14 d、伤后21 d IL-6水平和LMR比较,差异有统计学意义(P<0.05);生存组与死亡组是否行机械通气、有无脓毒血症、TBSA、IL-6水平和LMR比较,差异有统计学意义(P<0.05);IL-6与TBSA呈正相关(P<0.05),LMR与TBSA呈负相关(P<0.05);伤后7 d ROC曲线分析结果显示,IL-6联合LMR诊断脓毒血症的曲线下面积(AUC)为0.767,敏感性为93.9%,特异性为59.3%,比单独IL-6诊断更有效(P<0.05);伤后14 d IL-6联合LMR的AUC为0.713,敏感性为93.9%,特异性为69.0%,比单独IL-6诊断更有效(P<0.05);Kaplan-Meier生存曲线显示,伤后7 d低LMR组和高LMR组患儿住院期间总生存率分别为54.0%和94.8%,伤后14 d低LMR组和高LMR组患儿住院期间总生存率分别为25.0%和98.4%。伤后7 d低IL-6组和高IL-6组严重烧伤患儿住院期间的总生存率分别为98.0%和55.6%,伤后14 d低IL-6组和高IL-6组总生存率分别为100.0%和45.8%。结论对严重烧伤患儿,伤后7 d、伤后14 d IL-6联合LMR对脓毒血症诊断及患儿预后评估具有更好的临床指导意义。展开更多
The development of narrow-bandgap polymer donors with complementary absorption and matched energy levels for perylene diimides(PDI)-based nonfullerene acceptors(NFAs)has received little attention.The high-lying highes...The development of narrow-bandgap polymer donors with complementary absorption and matched energy levels for perylene diimides(PDI)-based nonfullerene acceptors(NFAs)has received little attention.The high-lying highest occupied molecular orbital(HOMO)level and low degree of crystallinity of the star donor polymer PCE10 limit its application in PDI-based Organic solar cells(OSCs).In this study,two benzo[1,2-b:4,5-b′]difuran(BDF)-based narrow-bandgap polymer donors,PBDF and PBDFCl,were synthesized to improve the photovoltaic performance of PDI-based OSCs.The smaller BDF moiety with higher electronegativity endows the resulting polymers with stronger aggregation and lower HOMO energy levels.The power conversion efficiency(PCE)value of the PBDF:Ph(PDI)3-based OSCs was 7.24%,which is much higher than that of PCE10-based OSCs(6.09%).Further chlorination of the conjugated side chain elevated the PCE to 8.84%,which is 1.4 times higher than that of PCE10-based OSCs.These results demonstrate the significant contribution of designing novel narrow-bandgap polymer donors to boost the PCE of PDI-based OSCs and highlight the importance of matching the aggregation behaviors of polymeric donor materials with that of NFAs.展开更多
Based on the monthly precipitation and air temperature from 1960 to 1989 in the Luanhe River Basin, the standardized precipitation evapotranspiration index （SPEI） and standardized precipitation index （SPI） at thre...Based on the monthly precipitation and air temperature from 1960 to 1989 in the Luanhe River Basin, the standardized precipitation evapotranspiration index （SPEI） and standardized precipitation index （SPI） at three- and six-month time scales and the self-calibrating Palmer drought severity index （sc-PDSI） were calculated to evaluate droughts in the study area. Temporal variations of the drought severity from 1960 to 1989 were analyzed and compared based on the results of different drought indices, and some typical drought events were identified. Spatial distributions of the drought severity according to the indices were also plotted and investigated. The results reveal the following： the performances of different drought indices are closely associated with the drought duration and the dominant factors of droughts; the SPEI is more accurate than the SPI when both evaporation and precipitation play important roles in drought events; the drought severity shown by the sc-PDSI is generally milder than the actual drought severity from 1960 to 1989; and the evolution of the droughts is usually delayed according to the scPDSI. This study provides valuable references for building drought early warning and mitigation systems in the Luanhe River Basin.展开更多
High-order harmonic generation below ionization threshold of He atom in the laser field is investigated by solving the three-dimensional time-dependent Schrodinger equation. An angular momentum-dependent model potenti...High-order harmonic generation below ionization threshold of He atom in the laser field is investigated by solving the three-dimensional time-dependent Schrodinger equation. An angular momentum-dependent model potential of He atom was used for getting the accurate energy levels of singlet states. The satellite-peak structures of the below-threshold harmonic generation(BTHG) of He are observed. We analyze the emission properties of the BTHG by employing a synchrosqueezing transform technique. We find that the satellite-peak structures have two types related to two kinds of transitions. One is the transition of the dressed states of the excited states, the other is the transition between the excited states and the ground state in the field-free case. Furthermore, our results show that the maximum Stark shift of the 2 p state is about 0.9 Up(penderomotive energy), and that of the 4 p state is about 1.0 Up. It indicates that the energy difference between some satellite-and main-peaks of the BTHG can be used to measure the maximum Stark shift of the excited states of He atom in the laser field.展开更多
BACKGROUND Gastric cancer remains a leading cause of cancer-related mortality globally.Traditional open surgery for gastric cancer is often associated with significant morbidity and prolonged recovery.AIM To evaluate ...BACKGROUND Gastric cancer remains a leading cause of cancer-related mortality globally.Traditional open surgery for gastric cancer is often associated with significant morbidity and prolonged recovery.AIM To evaluate the effectiveness of laparoscopic minimally invasive surgery as an alternative to traditional open surgery for gastric cancer,focusing on its potential to reduce trauma,accelerate recovery,and achieve comparable oncological out-comes.METHODS This study retrospectively analyzed 203 patients with gastric cancer who underwent surgery at the Shanghai Health Medical College Affiliated Chongming Hospital from January 2020 to December 2023.The patients were divided into two groups:Minimally invasive surgery group(n=102),who underwent laparoscopic gastrectomy,and open surgery group(n=101),who underwent traditional open gastrectomy.We compared surgical indicators(surgical incision size,intraop-erative blood loss,surgical duration,and number of lymph nodes dissected),recovery parameters(time to first flatus,time to start eating,time to ambulation,and length of hospital stay),immune function(levels of IgA,IgG,and IgM),intestinal barrier function(levels of D-lactic acid and diamine oxidase),and stress response(levels of C-reactive protein,interleukin-6,and procalcitonin).RESULTS The minimally invasive surgery group demonstrated significantly better outcomes in terms of surgical indicators,including smaller incisions,less blood loss,shorter surgery time,and more lymph nodes dissected(P<0.05 for all).Recovery was also faster in the minimally invasive surgery group,with earlier return of bowel function,earlier initiation of diet,quicker mobilization,and shorter hospital stays(P<0.05 for all).Furthermore,patients in the minimally invasive surgery group had better preserved immune function,superior intestinal barrier function,and a less pronounced stress response postoperatively(P<0.05 for all).CONCLUSION Laparoscopic minimally invasive surgery for gastric cancer not only provides superior surgical indicators and faster recovery but also offers advantages in preserving immune function,protecting intestinal barrier function,and mitigating the stress response compared to traditional open surgery.These findings support the broader adoption of laparoscopic techniques in the management of gastric cancer.展开更多
Tetraspanin CD151 was found to be upregulated in malignant cell types and has been identified as a tumor metastasis promoter.In this study,we aimed to examine the role of the CD151-integrin complex in lung cancer meta...Tetraspanin CD151 was found to be upregulated in malignant cell types and has been identified as a tumor metastasis promoter.In this study,we aimed to examine the role of the CD151-integrin complex in lung cancer metastasis and the underlying mechanisms.CD151 QRD194–196→AAA194–196 mutant was generated and used to transfect A549 human lung adenocarcinoma cells.We found that there was no significant difference in CD151 protein expression between CD151 and CD151-AAA mutant groups.In vitro,CD151-AAA mutant delivery abrogated the migration and invasion of A549 cells,which was promoted by CD151 gene transfer.Furthermore,CD151-AAA delivery failed to activate FAK and p130Cas signaling pathways.Western blot and immunohistochemical staining showed strong CD151 expression in lung cancerous tissues but not in adjacent normal tissues.Increased level of CD151 protein was observed in 20 of the patients and the positive rate of CD151 protein in specimens was 62.5%(20/32).In addition,CD151 was co-localized withα3 integrin at the cell-cell contact site in carcinoma tissues.These results suggested that the disruption of the CD151-α3 integrin complex may impair the metastasis-promoting effects and signaling events induced by CD151 in lung cancer.Our findings identified a key role for CD151-α3 integrin complex as a promoter in the lung cancer.展开更多
Nuclear energy is a vital source of clean energy that will continue to play an essential role in global energy production for future generations.Nuclear fuel rods are core components of nuclear power plants,and their ...Nuclear energy is a vital source of clean energy that will continue to play an essential role in global energy production for future generations.Nuclear fuel rods are core components of nuclear power plants,and their safe utilization is paramount.Due to its inherent high radioactivity,indirect neutron radiography(INR)is currently the only viable technology for irradiated nuclear fuel rods in the field of energy production.This study explores the experimental technique of indirect neutron computed tomography(INCT)for radioactive samples.This project includes the development of indium and dysprosium conversion screens of different thicknesses and conducts resolution tests to assess their performance.Moreover,pressurized water reactor(PWR)dummy nuclear fuel rods have been fabricated by self-developing substitute materials for cores and outsourcing of mechanical processing.Experimental research on the INR is performed using the developed dummy nuclear fuel rods.The sparse reconstruction technique is used to reconstruct the INR results of 120 pairs of dummy nuclear fuel rods at different angles,achieving a resolution of 0.8 mm for defect detection using INCT.展开更多
The low-order harmonic generation of hydrogen molecular ion interacting with a linearly polarized laser field has been investigated theoretically by using a simple two-state model. The validity of the two-state model ...The low-order harmonic generation of hydrogen molecular ion interacting with a linearly polarized laser field has been investigated theoretically by using a simple two-state model. The validity of the two-state model is carefully examined by comparing the harmonic spectra of hydrogen molecular ion obtained from this model with those from the three-dimensional time-dependent Schr¨odinger equation. When combined with the Morlet transform of quantum time-frequency spectrum,the two-state model can be used to study the dynamical origin of the low-order harmonic generation of hydrogen molecular ion driven by low-frequency pulses. In addition, some interesting structures of the time profiles for low order harmonics are obtained.展开更多
Subcycle spectral structures and dynamics of high-order harmonic generation(HHG)processes of atoms and molecules driven by intense laser fields on the attosecond time scale have been originally studied theoretically a...Subcycle spectral structures and dynamics of high-order harmonic generation(HHG)processes of atoms and molecules driven by intense laser fields on the attosecond time scale have been originally studied theoretically and ex-perimentally.However,the time scale of HHG dynamics in crystals is in the order of sub-femtosecond,and the carrier dynamics of HHG in crystals driven by subcycle laser pulses are largely unexplored.Here we perform a theoretical study of subcycle structures,spectra,and dynamics of HHG of crystals in mid-infrared laser fields subject to excitation by a subcycle laser pulse with a time delay.The HHG spectra as a function of time delay between two laser fields are cal-culated by using a single-band model for the intra-band carrier dynamics in crystal momentum space and by solving the time-dependent Schr?dinger equation in velocity gauge for the treatment of multi-band crystal systems.The results exhibit a complex time-delay-dependent oscillatory pattern,and the enhancement and suppression of the HHG related to subcycle pulse are observed at the given time delay in either single-band or multi-band crystal systems.To understand oscillation structures with respect to the dependence for the subcycle laser fields,the time-frequency characteristics of the HHG as well as the probability density distribution of the radiation are analyzed in detail.展开更多
基金supported by the National Defense Technology Foundation Program of China(No.JSJT2022209A001-3)Sichuan Science and Technology Program(No.2021JDRC0011)+1 种基金Nuclear Energy Development Research Program of China(Research on High Energy X-ray Imaging of Nuclear Fuel)Scientific Research and Innovation Team Program of Sichuan University of Science and Engineering(No.SUSE652A001).
文摘Neutron time-of-flight(ToF)measurement is a highly accurate method for obtaining the kinetic energy of a neutron by measuring its velocity,but requires precise acquisition of the neutron signal arrival time.However,the high hardware costs and data burden associated with the acquisition of neutron ToF signals pose significant challenges.Higher sampling rates increase the data volume,data processing,and storage hardware costs.Compressed sampling can address these challenges,but it faces issues regarding optimal sampling efficiency and high-quality reconstructed signals.This paper proposes a revolutionary deep learning-based compressed sampling(DL-CS)algorithm for reconstructing neutron ToF signals that outperform traditional compressed sampling methods.This approach comprises four modules:random projection,rising dimensions,initial reconstruction,and final reconstruction.Initially,the technique adaptively compresses neutron ToF signals sequentially using three convolutional layers,replacing random measurement matrices in traditional compressed sampling theory.Subsequently,the signals are reconstructed using a modified inception module,long short-term memory,and self-attention.The performance of this deep compressed sampling method was quantified using the percentage root-mean-square difference,correlation coefficient,and reconstruction time.Experimental results showed that our proposed DL-CS approach can significantly enhance signal quality compared with other compressed sampling methods.This is evidenced by a percentage root-mean-square difference,correlation coefficient,and reconstruction time results of 5%,0.9988,and 0.0108 s,respectively,obtained for sampling rates below 10%for the neutron ToF signal generated using an electron-beam-driven photoneutron source.The results showed that the proposed DL-CS approach significantly improves the signal quality compared with other compressed sampling methods,exhibiting excellent reconstruction accuracy and speed.
文摘BACKGROUND Enhanced recovery after surgery(ERAS),a multidisciplinary and multimodal perioperative care protocol,has been widely used in several surgical fields.However,the effect of this care protocol on liver transplant recipients with endstage liver disease remains unclear.AIM To compare the clinical outcomes of the ERAS protocol and standard care(SC)for liver transplant recipients with end-stage liver disease.METHODS PubMed,Web of Science,Cochrane Library,and EMBASE databases were systematically searched to identify literature reporting the effects of the ERAS protocol on clinical outcomes in patients undergoing liver transplant recipients with endstage liver disease.All articles published to January 1,2025 were searched,followed by data extraction of the included literature and independent quality assessment.Then pooled mean difference(MD)and odds ratio(OR)with a 95%confidence interval(CI)were calculated by either a random-effects or fixed-effects model.RESULTS Overall,eight relevant studies(including two randomized controlled trials,two prospective cohort studies,and four retrospective cohort studies)involving 1220 patients(704 patients in the ERAS group and 516 patients in the SC group).The primary outcomes evaluated included intensive care unit(ICU)stay duration,hospital length of stay,overall complication rates,mortality,and 30-day readmission rates.Our findings showed that ERAS protocols significantly reduced ICU stay duration(MD:-1.21 days,95%CI:-2.08 to-0.34;P=0.006),hospital length of stay(MD:-4.91 days,95%CI:-7.45 to-2.37;P=0.0002),overall complication rates(OR=0.32,95%CI:0.22-0.46;P<0.0001),and mortality(OR=0.57,95%CI:0.33-0.98;P=0.04).However,ERAS was associated with an increased 30-day readmission rate(OR=3.20,95%CI:1.54-6.67;P=0.003).CONCLUSION The current meta-analysis indicated that ERAS protocols can significantly improve short-term clinical outcomes in liver transplant recipients,although the increased readmission rate requires further investigation.Future studies should aim to refine ERAS protocols and explore their long-term efficacy and underlying mechanisms.
基金Supported by Natural Science Foundation of Hubei Province(No.2023BCB147,No.2023AFB1026).
文摘AIM:To investigate the clinicopathological features of cranial-nasal-orbital communicating lesions and identify key diagnostic indicators for differentiating benign and malignant neoplasms.METHODS:The retrospective cohort study analyzed 74 histologically confirmed cases stratified by anatomical involvement at the Wuhan Union Hospital between January 2010 and December 2020:Group A(orbital-nasal group,n=29),Group B(orbital-cranial group,n=27),and Group C(cranial-nasal-orbital group,n=18).Clinicopathological profiles including symptom presentation,histopathology,and invasion patterns were systematically evaluated.RESULTS:The cohort comprised 49(66.2%)benign and 25(33.8%)malignant lesions.Compared with benign lesions,malignant lesions had a shorter onset time(12mo vs 2.5mo,P=0.004)and resulted in poorer vision(0.6 vs 1.53,P=0.025).Headache was reported in 28.6%of patients with benign lesions,but none in those with malignant lesions(P=0.002).Conjunctival congestion and edema were observed in 32.7%of patients with benign lesions and 60%of patients with malignant lesions(P=0.028).The ethmoid sinus was the most frequently invaded site(35 cases).Malignant lesions showed greater invasion in the nasal cavity(28.0%vs 0,P=0.000)and anterior cranial fossa(40.0%vs 8.2%,P=0.003)than benign lesions.The orbital-cranial group was more likely to invade through osseous foramina compared with the orbitalnasal group(P=0.002).Neurogenic tumors predominated benign cases(34.7%),whereas blood derived(28%)and glandular tumors(28%)were most prevalent in malignant subgroups.The proportion of malignant tumors in multidisciplinary combined surgery was higher than that of benign lesions(61.5%vs 38.5%).CONCLUSION:Malignant cranial-nasal-orbital communicating lesions exhibit distinct clinicopathological signatures characterized by rapid progression,aggressive anterior fossa and nasal region,and severe visual morbidity.
基金Hubei Natural Science Foundation of China(No.2022CFB296).
文摘Objective The clinical features,disease course and visual outcomes of toxoplasmosis are less commonly reported in China than in other countries.To reduce misdiagnosis and improve visual function,the clinical characteristics,management and visual outcomes of 13 cases of ocular toxoplasmosis(OT)were described.Methods This retrospective study included 14 eyes of 13 patients who were diagnosed with OT in Hubei,China.The clinical characteristics,course of treatment and outcomes are presented.There were 7 males and 6 females.Results The main form of OT was retinochoroiditis with vitritis or anterior uveitis.Next-generation sequencing was applied to 3 eyes,and positive results were found in those eyes.Thirteen patients were positive for Toxoplasma gondii IgG antibodies,and 3 of them were also positive for IgM T.gondii antibodies.One patient with acquired immune deficiency syndrome was diagnosed with coinfection with OT and cytomegalovirus,as evidenced by an aqueous humor etiological test.Three patients were misdiagnosed with noninfectious uveitis.Recurrence occurred in 3 eyes during the follow-up periods.One patient who received vitreous implantation of Ozurdex therapy at another hospital before referral relapsed.One patient who received sulfadiazine,azithromycin and glucocorticoid therapy relapsed.One patient who received sulfadiazine therapy experienced relapse.Patients who received clindamycin and sulfadiazine or who received clindamycin only did not experience recurrence during the follow-up period.The best corrected visual acuity was improved in 6 eyes after inflammation resolved.Conclusions Primary active retinochoroiditis is the main form of OT in Hubei,China.Timely correct diagnosis on the basis of ocular characteristics and aetiological test results and effective treatment should be adopted to prevent poor visual outcomes and recurrence.
基金supported by the National Natural Science Foundation of China(Nos.11875125,11747312,11675066,and 11505057)the Zhejiang Provincial Natural Science Foundation of China(No.LY18A050002)
文摘The effects of the in-medium nucleon-nucleon(NN) elastic cross section on the observables in heavy ion collisions in the Fermi energy domain are investigated within the framework of the ultrarelativistic quantum molecular dynamics model. The results simulated using medium correction factors of F=σ_(NN)^(in-medium)/σ_(NN)^(free)=0.2,0.3,0.5,and the density-and momentum-dependent factor obtained from the FU3 FP1 parametrization are compared with the FOPI and INDRA experimental data. It is found that the calculations using the correction factors F=0.2 and 0.5 reproduce the experimental data(i.e.,collective flow and nuclear stopping) at 40 and 150 MeV/nucleon, respectively. Calculations with the FU3 FP1 parametrization can best fit these experimental data. These conclusions can be confirmed in both^(197)Au+^(197)Au and^(129)Xe+^(120)Sn.
基金partly supported by the National Natural Science Foundation of China (Nos. U2032145 and 11875125)the National Key Research and Development Program of China (No. 2020YFE0202002)。
文摘In this study, the rapidity distribution, collective flows, and nuclear stopping power in ^(197)Au+^(197)Au collisions at intermediate energies were investigated using the ultrarelativistic quantum molecular dynamics(UrQMD) model with GEMINI++ code. The UrQMD model was adopted to simulate the dynamic evolution of heavy-ion collisions, whereas the GEMINI++ code was used to simulate the decay of primary fragments produced by UrQMD. The calculated results were compared with the INDRA and FOPI experimental data. It was found that the rapidity distribution, collective flows, and nuclear stopping power were affected to a certain extent by the decay of primary fragments, especially at lower beam energies. Furthermore, the experimental data of the collective flows and nuclear stopping power at the investigated beam energies were better reproduced when the sequential decay effect was included.
基金the National Natural Science Foundation of China(Nos.51973169,51703172 and 52273195)Key R&D program of Hubei Province(No.2021BAA014)+2 种基金the Natural Science Foundation of Hubei Province(No.2022CFB097)the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2020WNLOKF015)the science foundation of Wuhan Institute of Technology(No.K202025)。
文摘Perylene-3,4-(dicarboxylic monoimide)-9,10-(dicarboxylic monoanhydrate)(PIA)is one key intermediate to construct functionalized perylene diimides(PDIs)for various applications.However,the difficulty in synthesizing chlorinated PIA hinders the study of chlorinated PDIbased materials.Although chlorination has been widely used to modify the properties of organic semiconductors.We successfully synthesize chlorinated PIA via a simple hydrolysis reaction using LiOH as the base,then a PDI dimer connected at the imide position,N-di-PDI-4Cl,is synthesized as an application example of chlorinated PIA.The heavily chlorinated PDI dimer exhibits deeper energy levels,slightly blue-shifted UV-Vis absorption compared to the non-chlorinated analogue.In addition,the photovoltaic performance of N-di-PDI-4Cl is characterized.This study paves one easy way to synthesize chlorinated PIA and its more delicate derivatives.
基金Natural Science Foundation of Hubei Province,China,No.2016CFB596and Wuhan City Medical Research Project,China,No.WX17Q39 and No.WX15B14.
文摘BACKGROUND The global outbreak of human severe acute respiratory syndrome coronavirus(SARS-CoV)-2 infection represents an urgent need for readily available,accurate and rapid diagnostic tests.Nucleic acid testing of respiratory tract specimens for SARS-CoV-2 is the current gold standard for diagnosis of coronavirus disease 2019(COVID-19).However,the diagnostic accuracy of reverse transcription polymerase chain reaction(RT-PCR)tests for detecting SARS-CoV-2 nucleic acid may be lower than optimal.The detection of SARS-CoV-2-specific antibodies should be used as a serological non-invasive tool for the diagnosis and management of SARS-CoV-2 infection.AIM To investigate the diagnostic value of SARS-CoV-2 IgM/IgG and nucleic acid detection in COVID-19.METHODS We retrospectively analyzed 652 suspected COVID-19 patients,and 206 non-COVID-19 patients in Wuhan Integrated TCM and Western Medicine Hospital.Data on SARS-CoV-2 nucleic acid tests and serum antibody tests were collected to investigate the diagnostic value of nucleic acid RT-PCR test kits and immunoglobulin(Ig)M/IgG antibody test kits.The j2 test was used to compare differences between categorical variables.A 95%confidence interval(CI)was provided by the Wilson score method.All analyses were performed with IBM SPSS Statistics version 22.0(IBM Corp.,Armonk,NY,United States).RESULTS Of the 652 suspected COVID-19 patients,237(36.3%)had positive nucleic acid tests,311(47.7%)were positive for IgM,and 592(90.8%)were positive for IgG.There was a significant difference in the positive detection rate between the IgM and IgG test groups(P<0.001).Using the RT-PCR results as a reference,the specificity,sensitivity,and accuracy of IgM/IgG combined tests for SARS-CoV-2 infection were 98.5%,95.8%,and 97.1%,respectively.Of the 415 suspected COVID-19 patients with negative nucleic acid test results,366 had positive IgM/IgG tests with a positive detection rate of 88.2%.CONCLUSION Our data indicate that serological IgM/IgG antibody combined test had high sensitivity and specificity for the diagnosis of SARS-CoV-2 infection,and can be used in combination with RT-PCR for the diagnosis of SARS-CoV-2 infection.
基金Supported by the National Natural Science Foundation of China (No.81900912)Fundamental Research Funds for the Central Universities (No.YCJJ20230109).
文摘This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic malignancies.Positron emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic metastases.Local treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and treatment.The challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.
文摘BACKGROUND Gliomas are the most common primary central nervous system neoplasm.Despite recent advances in the diagnosis and treatment of gliomas,patient prognosis remains dismal.Therefore,it is imperative to identify novel diagnostic biomarkers and therapeutic targets of glioma to effectively improve treatment outcomes.AIM To investigate the association between oligodendrocyte transcription factor 2(Olig2)expression and the outcomes of glioma patients.METHODS The PubMed,Embase,Cochrane Library,and China National Knowledge Infrastructure databases were searched for studies(published up to October 2023)that investigated the relationship between Olig2 expression and prognosis of glioma patients.The quality of the studies was assessed using the Newcastle Ottawa Scale.Data analyses were performed using Stata Version 12.0 software.RESULTS A total of 1205 glioma patients from six studies were included in the metaanalysis.High Olig2 expression was associated with better outcomes in glioma patients[hazard ratio(HR):0.81;95%(confidence interval)CI:0.51-1.27;P=0.000].Furthermore,the results of subgroup meta-analysis showed that high expression of Olig2 was associated with poor overall survival in European patients(HR:1.34;95%CI:0.79-2.27)and better prognosis in Asian patients(HR:0.43;95%CI:0.22-0.84).The sensitivity analysis showed that no single study had a significant effect on pooled HR,and there was also no indication of publication bias according to the Egger’s and Begger’s P value test or funnel plot test.CONCLUSION High Olig2 expression may have a positive impact on the prognosis of glioma patients,and should be investigated further as a prognostic biomarker and therapeutic target for glioma.
文摘目的探讨血清白细胞介素-6(IL-6)联合淋巴细胞/单核细胞比值(LMR)对严重烧伤患儿脓毒血症诊断及预后评估的临床意义。方法回顾性分析郑州大学附属儿童医院和郑州市第一人民医院2015年12月—2020年6月收治的78例重度及以上烧伤患儿的临床资料,收集患儿入院时、伤后7 d、伤后14 d、伤后21 d的血常规及血清IL-6结果。根据患儿是否出现脓毒血症,分为脓毒血症组与非脓毒血症组;根据患儿预后结局,分为生存组和死亡组。同时综合考虑患儿性别、年龄、烧伤总面积(TBSA)、是否伴有吸入性损伤、是否行机械通气等指标,比较不同组之间的差异;受试者工作特征(ROC)曲线预测伤后7 d及伤后14 d IL-6联合LMR对脓毒血症的诊断价值;Kaplan-Meier法预测IL-6及LMR对严重烧伤患儿生存率的影响。结果脓毒血症组与非脓毒血症组患儿是否伴有吸入性损伤、是否行机械通气、TBSA、淋巴细胞绝对数及伤后7 d、伤后14 d、伤后21 d IL-6水平和LMR比较,差异有统计学意义(P<0.05);生存组与死亡组是否行机械通气、有无脓毒血症、TBSA、IL-6水平和LMR比较,差异有统计学意义(P<0.05);IL-6与TBSA呈正相关(P<0.05),LMR与TBSA呈负相关(P<0.05);伤后7 d ROC曲线分析结果显示,IL-6联合LMR诊断脓毒血症的曲线下面积(AUC)为0.767,敏感性为93.9%,特异性为59.3%,比单独IL-6诊断更有效(P<0.05);伤后14 d IL-6联合LMR的AUC为0.713,敏感性为93.9%,特异性为69.0%,比单独IL-6诊断更有效(P<0.05);Kaplan-Meier生存曲线显示,伤后7 d低LMR组和高LMR组患儿住院期间总生存率分别为54.0%和94.8%,伤后14 d低LMR组和高LMR组患儿住院期间总生存率分别为25.0%和98.4%。伤后7 d低IL-6组和高IL-6组严重烧伤患儿住院期间的总生存率分别为98.0%和55.6%,伤后14 d低IL-6组和高IL-6组总生存率分别为100.0%和45.8%。结论对严重烧伤患儿,伤后7 d、伤后14 d IL-6联合LMR对脓毒血症诊断及患儿预后评估具有更好的临床指导意义。
基金supported by the National Natural Science Foundation of China(Nos.52273195 and 51973169)Young Top-notch Talent Cultivation Program of Hubei Province,Natural Science Foundation of Hubei Province(No.2022CFB097)。
文摘The development of narrow-bandgap polymer donors with complementary absorption and matched energy levels for perylene diimides(PDI)-based nonfullerene acceptors(NFAs)has received little attention.The high-lying highest occupied molecular orbital(HOMO)level and low degree of crystallinity of the star donor polymer PCE10 limit its application in PDI-based Organic solar cells(OSCs).In this study,two benzo[1,2-b:4,5-b′]difuran(BDF)-based narrow-bandgap polymer donors,PBDF and PBDFCl,were synthesized to improve the photovoltaic performance of PDI-based OSCs.The smaller BDF moiety with higher electronegativity endows the resulting polymers with stronger aggregation and lower HOMO energy levels.The power conversion efficiency(PCE)value of the PBDF:Ph(PDI)3-based OSCs was 7.24%,which is much higher than that of PCE10-based OSCs(6.09%).Further chlorination of the conjugated side chain elevated the PCE to 8.84%,which is 1.4 times higher than that of PCE10-based OSCs.These results demonstrate the significant contribution of designing novel narrow-bandgap polymer donors to boost the PCE of PDI-based OSCs and highlight the importance of matching the aggregation behaviors of polymeric donor materials with that of NFAs.
基金financial supports from the National Natural Science Foundation of China(Nos.52075250,52175468)the China Postdoctoral Science Foundation(No.2020M683376)+1 种基金State Key Laboratory of Advanced Welding and Joining,Harbin Institute of Technology,China(No.AWJ-22M13)the Fundamental Research Funds for the Central Universities,China(No.NT2021018)。
基金supported by the National Natural Science Foundation of China(Grant No.41171220)the Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education of China(Grant No.IRT13062)+2 种基金the Programme of Introducing Talents of Discipline to Universities(the 111 Project,Grant No.B08048)the Jiangsu Provincial Collaborative Innovation Center for World Water Valley and Water Ecological Civilizationthe National Cooperative Innovation Center for Water Safety and Hydro-Science
文摘Based on the monthly precipitation and air temperature from 1960 to 1989 in the Luanhe River Basin, the standardized precipitation evapotranspiration index （SPEI） and standardized precipitation index （SPI） at three- and six-month time scales and the self-calibrating Palmer drought severity index （sc-PDSI） were calculated to evaluate droughts in the study area. Temporal variations of the drought severity from 1960 to 1989 were analyzed and compared based on the results of different drought indices, and some typical drought events were identified. Spatial distributions of the drought severity according to the indices were also plotted and investigated. The results reveal the following： the performances of different drought indices are closely associated with the drought duration and the dominant factors of droughts; the SPEI is more accurate than the SPI when both evaporation and precipitation play important roles in drought events; the drought severity shown by the sc-PDSI is generally milder than the actual drought severity from 1960 to 1989; and the evolution of the droughts is usually delayed according to the scPDSI. This study provides valuable references for building drought early warning and mitigation systems in the Luanhe River Basin.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11674268,11764038,and 11765018)the Scientific Research Foundation of Physics of CPEE–NWNU and NWNU-LKQN-17-1,China
文摘High-order harmonic generation below ionization threshold of He atom in the laser field is investigated by solving the three-dimensional time-dependent Schrodinger equation. An angular momentum-dependent model potential of He atom was used for getting the accurate energy levels of singlet states. The satellite-peak structures of the below-threshold harmonic generation(BTHG) of He are observed. We analyze the emission properties of the BTHG by employing a synchrosqueezing transform technique. We find that the satellite-peak structures have two types related to two kinds of transitions. One is the transition of the dressed states of the excited states, the other is the transition between the excited states and the ground state in the field-free case. Furthermore, our results show that the maximum Stark shift of the 2 p state is about 0.9 Up(penderomotive energy), and that of the 4 p state is about 1.0 Up. It indicates that the energy difference between some satellite-and main-peaks of the BTHG can be used to measure the maximum Stark shift of the excited states of He atom in the laser field.
基金Shanghai Chongming District Sustainable Development Science and Technology Innovation Action Plan,No.CKY2020-11.
文摘BACKGROUND Gastric cancer remains a leading cause of cancer-related mortality globally.Traditional open surgery for gastric cancer is often associated with significant morbidity and prolonged recovery.AIM To evaluate the effectiveness of laparoscopic minimally invasive surgery as an alternative to traditional open surgery for gastric cancer,focusing on its potential to reduce trauma,accelerate recovery,and achieve comparable oncological out-comes.METHODS This study retrospectively analyzed 203 patients with gastric cancer who underwent surgery at the Shanghai Health Medical College Affiliated Chongming Hospital from January 2020 to December 2023.The patients were divided into two groups:Minimally invasive surgery group(n=102),who underwent laparoscopic gastrectomy,and open surgery group(n=101),who underwent traditional open gastrectomy.We compared surgical indicators(surgical incision size,intraop-erative blood loss,surgical duration,and number of lymph nodes dissected),recovery parameters(time to first flatus,time to start eating,time to ambulation,and length of hospital stay),immune function(levels of IgA,IgG,and IgM),intestinal barrier function(levels of D-lactic acid and diamine oxidase),and stress response(levels of C-reactive protein,interleukin-6,and procalcitonin).RESULTS The minimally invasive surgery group demonstrated significantly better outcomes in terms of surgical indicators,including smaller incisions,less blood loss,shorter surgery time,and more lymph nodes dissected(P<0.05 for all).Recovery was also faster in the minimally invasive surgery group,with earlier return of bowel function,earlier initiation of diet,quicker mobilization,and shorter hospital stays(P<0.05 for all).Furthermore,patients in the minimally invasive surgery group had better preserved immune function,superior intestinal barrier function,and a less pronounced stress response postoperatively(P<0.05 for all).CONCLUSION Laparoscopic minimally invasive surgery for gastric cancer not only provides superior surgical indicators and faster recovery but also offers advantages in preserving immune function,protecting intestinal barrier function,and mitigating the stress response compared to traditional open surgery.These findings support the broader adoption of laparoscopic techniques in the management of gastric cancer.
基金The project was supported by a grant from the National Natural Science Foundation of China(No.81873535)the Natural Science Foundation of Hubei Province(No.2020CFB573).
文摘Tetraspanin CD151 was found to be upregulated in malignant cell types and has been identified as a tumor metastasis promoter.In this study,we aimed to examine the role of the CD151-integrin complex in lung cancer metastasis and the underlying mechanisms.CD151 QRD194–196→AAA194–196 mutant was generated and used to transfect A549 human lung adenocarcinoma cells.We found that there was no significant difference in CD151 protein expression between CD151 and CD151-AAA mutant groups.In vitro,CD151-AAA mutant delivery abrogated the migration and invasion of A549 cells,which was promoted by CD151 gene transfer.Furthermore,CD151-AAA delivery failed to activate FAK and p130Cas signaling pathways.Western blot and immunohistochemical staining showed strong CD151 expression in lung cancerous tissues but not in adjacent normal tissues.Increased level of CD151 protein was observed in 20 of the patients and the positive rate of CD151 protein in specimens was 62.5%(20/32).In addition,CD151 was co-localized withα3 integrin at the cell-cell contact site in carcinoma tissues.These results suggested that the disruption of the CD151-α3 integrin complex may impair the metastasis-promoting effects and signaling events induced by CD151 in lung cancer.Our findings identified a key role for CD151-α3 integrin complex as a promoter in the lung cancer.
基金supported in part by the National Key R&D Program of China (No. 2022YFA1604002)the Sichuan Postdoctoral Research Program (No. TB2022035)+1 种基金the Nuclear Energy Development Research Program of Chinathe Scientific Research and Innovation Team Program of Sichuan University of Science and Engineering (No. SUSE652A001)
文摘Nuclear energy is a vital source of clean energy that will continue to play an essential role in global energy production for future generations.Nuclear fuel rods are core components of nuclear power plants,and their safe utilization is paramount.Due to its inherent high radioactivity,indirect neutron radiography(INR)is currently the only viable technology for irradiated nuclear fuel rods in the field of energy production.This study explores the experimental technique of indirect neutron computed tomography(INCT)for radioactive samples.This project includes the development of indium and dysprosium conversion screens of different thicknesses and conducts resolution tests to assess their performance.Moreover,pressurized water reactor(PWR)dummy nuclear fuel rods have been fabricated by self-developing substitute materials for cores and outsourcing of mechanical processing.Experimental research on the INR is performed using the developed dummy nuclear fuel rods.The sparse reconstruction technique is used to reconstruct the INR results of 120 pairs of dummy nuclear fuel rods at different angles,achieving a resolution of 0.8 mm for defect detection using INCT.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11465016,11674268,and 11764038)
文摘The low-order harmonic generation of hydrogen molecular ion interacting with a linearly polarized laser field has been investigated theoretically by using a simple two-state model. The validity of the two-state model is carefully examined by comparing the harmonic spectra of hydrogen molecular ion obtained from this model with those from the three-dimensional time-dependent Schr¨odinger equation. When combined with the Morlet transform of quantum time-frequency spectrum,the two-state model can be used to study the dynamical origin of the low-order harmonic generation of hydrogen molecular ion driven by low-frequency pulses. In addition, some interesting structures of the time profiles for low order harmonics are obtained.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12074239 and 91850209)the Natural Science Foundation of Guangdong Province,China(Grant Nos.2020A1515010927 and 2020ST084)+3 种基金Department of Education of Guangdong Province,China(Grant Nos.2019KTSCX038 and 2020KCXTD012)Shantou University(Grant No.NTF18030)the Natural Science basic Research Program of Shaanxi Province,China(Grant No.2022JM-015)Scientific Research Foundation of SUST(Grant No.2017BJ-30).
文摘Subcycle spectral structures and dynamics of high-order harmonic generation(HHG)processes of atoms and molecules driven by intense laser fields on the attosecond time scale have been originally studied theoretically and ex-perimentally.However,the time scale of HHG dynamics in crystals is in the order of sub-femtosecond,and the carrier dynamics of HHG in crystals driven by subcycle laser pulses are largely unexplored.Here we perform a theoretical study of subcycle structures,spectra,and dynamics of HHG of crystals in mid-infrared laser fields subject to excitation by a subcycle laser pulse with a time delay.The HHG spectra as a function of time delay between two laser fields are cal-culated by using a single-band model for the intra-band carrier dynamics in crystal momentum space and by solving the time-dependent Schr?dinger equation in velocity gauge for the treatment of multi-band crystal systems.The results exhibit a complex time-delay-dependent oscillatory pattern,and the enhancement and suppression of the HHG related to subcycle pulse are observed at the given time delay in either single-band or multi-band crystal systems.To understand oscillation structures with respect to the dependence for the subcycle laser fields,the time-frequency characteristics of the HHG as well as the probability density distribution of the radiation are analyzed in detail.
