Objective: To investigate the effect of dexmedetomidin combined with intraspinal anesthesia on perioperative brain injury, stress hormone and T lymphocyte subsets in elderly patients undergoing hip replacement. Method...Objective: To investigate the effect of dexmedetomidin combined with intraspinal anesthesia on perioperative brain injury, stress hormone and T lymphocyte subsets in elderly patients undergoing hip replacement. Methods: A total of 106 elderly patients undergoing hip replacement were randomly divided into the observation group and the control group, 53 cases in each group. All patients received intraspinal anesthesia, and the observation group was given dexmedetomidine assisted anesthesia. The detection results of perioperative jugular bulb venous oxygen saturation (SjvO2), jugular oxygen content (CjvO2), cerebral arterial-venous oxygen content difference (D (a-jv) O2), cerebral oxygen extraction rate (CERO2), cerebral arterial oxygen content (CaO2), S-100β protein of internal jugular vein, norepinephrine (NE), adrenaline (E), cortisol (Cor) and T lymphocyte subsets were compared between the two groups. Results: The SjvO2, CjvO2and CaO2in the observation group at the time of 30 min in the operation and immediately after operation were significantly higher than those in the control group, while the D (a-jv) O2and CERO2were significantly lower than those in the control group. The S-100β protein at the time of 30 min in the operation in the observation group was significantly lower than that in the control group. The NE, E and Cor in the observation group at the time of 30 min in the operation and immediately after operation were significantly lower than those in the control group. The CD3+, CD4+, CD8+ and CD4+/CD8+in the observation group at the time of immediately after operation and 24 h after operation were significantly higher than those in the control group. Conclusion: Dexmedetomidine combined with intraspinal anesthesia can reduce perioperative brain injury, relieve stress response and improve the immune function of the elderly patients with hip replacement.展开更多
In order to capture stable and realistic microscopic features of fluid surface, a surface tension and adhesion method based on implicit incompressible SPH （smoothed particle hydrodynamics） is presented in this paper...In order to capture stable and realistic microscopic features of fluid surface, a surface tension and adhesion method based on implicit incompressible SPH （smoothed particle hydrodynamics） is presented in this paper. It gives a steady and fast tension model and can solve the problem of not considering adhesion. Molecular cohesion and surface minimization are considered for surface tension, and adhesion is added to show the microscopic characteristics of the surface. To simulate surface tension and adhesion stably and efficiently, the surface tension and adhesion model is integrated to an implicit incompressible SPH method. The experimental results show that the method can better simulate surface features in a variety of scenarios compared with previous methods and meanwhile ensure stability and efficiency.展开更多
文摘Objective: To investigate the effect of dexmedetomidin combined with intraspinal anesthesia on perioperative brain injury, stress hormone and T lymphocyte subsets in elderly patients undergoing hip replacement. Methods: A total of 106 elderly patients undergoing hip replacement were randomly divided into the observation group and the control group, 53 cases in each group. All patients received intraspinal anesthesia, and the observation group was given dexmedetomidine assisted anesthesia. The detection results of perioperative jugular bulb venous oxygen saturation (SjvO2), jugular oxygen content (CjvO2), cerebral arterial-venous oxygen content difference (D (a-jv) O2), cerebral oxygen extraction rate (CERO2), cerebral arterial oxygen content (CaO2), S-100β protein of internal jugular vein, norepinephrine (NE), adrenaline (E), cortisol (Cor) and T lymphocyte subsets were compared between the two groups. Results: The SjvO2, CjvO2and CaO2in the observation group at the time of 30 min in the operation and immediately after operation were significantly higher than those in the control group, while the D (a-jv) O2and CERO2were significantly lower than those in the control group. The S-100β protein at the time of 30 min in the operation in the observation group was significantly lower than that in the control group. The NE, E and Cor in the observation group at the time of 30 min in the operation and immediately after operation were significantly lower than those in the control group. The CD3+, CD4+, CD8+ and CD4+/CD8+in the observation group at the time of immediately after operation and 24 h after operation were significantly higher than those in the control group. Conclusion: Dexmedetomidine combined with intraspinal anesthesia can reduce perioperative brain injury, relieve stress response and improve the immune function of the elderly patients with hip replacement.
基金This work was supported by the National Natural Science Foundation of China under Grant Nos. 61572075 and 61702036, the National Key Research and Development Program of China under Grant Nos. 2016YFB0700502 and 2016YFB1001404, and the Fun- damental Research Funds for the Central Universities of China under Grant No. 2302017FRF-TP-17-012A1.
文摘In order to capture stable and realistic microscopic features of fluid surface, a surface tension and adhesion method based on implicit incompressible SPH （smoothed particle hydrodynamics） is presented in this paper. It gives a steady and fast tension model and can solve the problem of not considering adhesion. Molecular cohesion and surface minimization are considered for surface tension, and adhesion is added to show the microscopic characteristics of the surface. To simulate surface tension and adhesion stably and efficiently, the surface tension and adhesion model is integrated to an implicit incompressible SPH method. The experimental results show that the method can better simulate surface features in a variety of scenarios compared with previous methods and meanwhile ensure stability and efficiency.
