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长期规律运动干预NAFLD患者肝损伤的作用机制 被引量:6
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作者 彭丹 王元 《晓庄学院自然科学学报》 CAS 北大核心 2019年第3期55-60,共6页
采用血生化、肝纤维化指标检测、观察长期规律运动对非酒精性脂肪肝(NAFLD)患者肝功能的影响,并通过比较TLR4/NF-KB信号通路相关细胞因子的差异表达,对其调控机制进行了研究。选取在晓庄学院校医院确诊的NAFLD患者40例,根据脂肪变... 采用血生化、肝纤维化指标检测、观察长期规律运动对非酒精性脂肪肝(NAFLD)患者肝功能的影响,并通过比较TLR4/NF-KB信号通路相关细胞因子的差异表达,对其调控机制进行了研究。选取在晓庄学院校医院确诊的NAFLD患者40例,根据脂肪变性程度及运动干预情况,将患者分为对照组(NAFLD患者组) 18例和长期规律运动组18例,另选取本院同期体检的健康者18例为正常对照组;检查所有受试者的一般资料、谷丙转氨酶ALT、谷草转氨酶AST、Y-谷氨酰基转移酶GGT、血清Ⅲ型前胶原肽(PCⅢ),透明质胶(HA),IV型胶原(CIV),层粘蛋白(LN),应用荧光定量PCR技术检测各组受试者血液中TLR4/NF-KB信号通路相关细胞因子及相应调控分子miR-146a的差异表达,揭示长期规律运动抗肝纤维化的作用及可能机制。与正常组比较,对照组血清中ALT,AST,GGT,PCⅢ,HA,CIV,LN的含量,长期规律运动组明显低于对照组。血液TLR4,NF-KB,MY-D88基因表达水平与对照组相比,长期规律运动组表达水平明显下调。研究发现长期规律运动能有效减轻非酒精性炎性肝损伤,并且具有明确的抗肝纤维化作用。其机制可能与长期规律运动通过调控TLR4/NF-KB信号通路相关因子及调控分子miR-146a,减轻炎症反应及阻止纤维化形成有关。 展开更多
关键词 非酒精性脂肪肝 患者 长期规律运动 TLR4 NF-KB
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Effects of afforestation on soil carbon and its fractions:a case study from the Loess Plateau,China 被引量:2
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作者 Yang Gao peng dang Zhong Zhao 《Journal of Forestry Research》 SCIE CAS CSCD 2018年第5期1291-1297,共7页
Afforestation has been implemented to reduce soil erosion and improve the environment of the Loess Plateau,China.Although it increased soil organic carbon(SOC),the stability of the increase is unknown.Additionally,t... Afforestation has been implemented to reduce soil erosion and improve the environment of the Loess Plateau,China.Although it increased soil organic carbon(SOC),the stability of the increase is unknown.Additionally,the variations of soil inorganic carbon(SIC) following afforestation needs to be reconfirmed.After planting Robinia pseudoacacia,Pinus tabuliformis,and Hippophae rhamnoides on bare land on the Loess Plateau,total soil carbon(TSC) was measured and its two components,SIC and SOC,as well as the light and heavy fractions within SOC under bare lands and woodlands at the soil surface(0–20 cm).The results show that TSC on bare land was 24.5 Mg ha^(-1) and significantly increased to 51.6 Mg ha^(-1) for R.pseudoacacia,47.0 Mg ha^(-1) for P.tabuliformis and 39.9 Mg ha^(-1) for H.rhamnoides.The accumulated total soil carbon under R.pseudoacacia,P.tabuliformis,and H.rhamnoides,the heavy fraction(HFSOC) accounted for 65.2,31.7 and 76.2%,respectively; the light fraction(LF-SOC) accounted for 18.0,52.0 and 4.0%,respectively; SIC occupied 15.6,15.3 and 19.7%,respectively.The accumulation rates of TSC under R.pseudoacacia,P.tabuliformis,and H.rhamnoides reached159.5,112.4 and 102.5 g m^(-2) a^(-1),respectively.The results demonstrate that afforestation on bare land has high potential for soil carbon accumulation on the Loess Plateau.Among the newly sequestrated total soil carbon,the heavy fraction(HF-SOC) with a slow turnover rate accounted for a considerably high percentage,suggesting that significant sequestrated carbon can be stored in soils following afforestation.Furthermore,afforestation induces SIC sequestration.Although its contribution to TSC accumulation was less than SOC,overlooking it may substantially underestimate the capacity of carbon sequestration after afforestation on the Loess Plateau. 展开更多
关键词 Soil carbon sequestration Soil organic carbon Organic carbon fractions Soil inorganic carbon AFFORESTATION
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Oxygen Metabolism-induced Stress Response Underlies Heartbrain Interaction Governing Human Consciousness-breaking and Attention 被引量:2
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作者 Xiao-Juan Xue Rui Su +9 位作者 Ze-Feng Li Xiao-Ou Bu peng dang Si-Fang Yu Zhi-Xin Wang Dong-Mei Chen Tong-Ao Zeng Ming Liu Hai-Lin Ma De-Long Zhang 《Neuroscience Bulletin》 SCIE CAS CSCD 2022年第2期166-180,共15页
Neuroscientists have emphasized visceral influences on consciousness and attention,but the potential neurophysiological pathways remain under exploration.Here,we found two neurophysiological pathways of heartbrain int... Neuroscientists have emphasized visceral influences on consciousness and attention,but the potential neurophysiological pathways remain under exploration.Here,we found two neurophysiological pathways of heartbrain interaction based on the relationship between oxygen-transport by red blood cells(RBCs)and consciousness/attention.To this end,we collected a dataset based on the routine physical examination,the breaking continuous flash suppression(b-CFS)paradigm,and an attention network test(ANT)in 140 immigrants under the hypoxic Tibetan environment.We combined electroencephalography and multilevel mediation analysis to investigate the relationship between RBC properties and consciousness/attention.The results showed that RBC function,via two independent neurophysiological pathways,not only triggered interoceptive re-representations in the insula and awareness connected to orienting attention but also induced an immune response corresponding to consciousness and executive control.Importantly,consciousness played a fundamental role in executive function which might be associated with the level of perceived stress.These results indicated the important role of oxygen-transport in heart-brain interactions,in which the related stress response affected consciousness and executive control.The findings provide new insights into the neurophysiological schema of heartbrain interactions. 展开更多
关键词 Heart-brain interaction Breaking continuous flash suppression Executive attention Stress response
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Effect of boiling time on radionuclide concentration in seafood
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作者 Xiaolei Shen Yue Feng +3 位作者 Yuyang Yao Feng Tian peng dang Qinghua Li 《Radiation Medicine and Protection》 2025年第6期343-350,共8页
Objective:To reveal the effect of boiling time on radionuclide concentrations in seafood by investigating boilingrepresented cooking practices,in order to fill the knowledge gap on how boiling time affects human radia... Objective:To reveal the effect of boiling time on radionuclide concentrations in seafood by investigating boilingrepresented cooking practices,in order to fill the knowledge gap on how boiling time affects human radiation exposure.-Methods:A total of 13 seafood species of four categories(fish,crustacean,mollusk and algae)were collected from the coastal areas of China and analyzed for radionuclide contents left after boiling at 5,10,20 and^(40)min under 100◦C.Grossαandβ,^(40)K,^(226)Ra,^(232)Th,^(137)Cs were measured using the low backgroundαandβcounter and the gamma-spectrometer.Results:The contents of radionuclides decreased significantly with the increasing boiling time.The average retention rate ofα-emitting radionuclide in in fish,crustacean,mollusk,and algae decreased to 64.47%,53.34%,84.12%and 62.63%after 5 min of boiling,respectively,and then to 15.46%,14.21%,71.94%,and 27.27%after^(40)min,respectively.The average retention rate ofβ-emitting radionuclide in in fish,crustacean,mollusk,and algae decreased to 64.89%,43.43%,66.55%and 63.30%after 5 min,respectively,and then to 47.90%,29.01%,45.96%,and 53.24%after^(40)min.The greatest loss of solubility was observed for^(40)K with the average retention rate of 47.16%after 10 min,and higher retention rate of 87.86%and 90.03%in^(226)Ra and^(232)Th,respectively.Conclusion:Boiling is effective in reducing the radionuclide content,with the committed effective dose(CED)reduction of 44.6%achieved by boiling for 10 min,mainly due to the reduction in^(40)K.A full assessment will also be needed to incorporate more radionuclides(^(210)Po,^(210)Pb,^(228)Ra)into the calculations. 展开更多
关键词 SEAFOOD Radionuclides Ingestion dose Marine contamination Grossαandβactivities Seafood cooking
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