Currently,several disulfide-rich peptides have been officially approved as therapeutic medicines,such as w-conotoxin ziconotide[1],guanosine analogue linaclotide,and plecanatide.Peptides are predisposed to generate re...Currently,several disulfide-rich peptides have been officially approved as therapeutic medicines,such as w-conotoxin ziconotide[1],guanosine analogue linaclotide,and plecanatide.Peptides are predisposed to generate related substances(also termed as structurally related impurities)including amino acid deletion/insertion,diastereoisomerization,deamination/amination,oxidation,and succinimidation etc.展开更多
基金The authors thank the funding from the National Key R&D Program of China(Grant No.:2021YFF0600704 and 2021YFF0600701).
文摘Currently,several disulfide-rich peptides have been officially approved as therapeutic medicines,such as w-conotoxin ziconotide[1],guanosine analogue linaclotide,and plecanatide.Peptides are predisposed to generate related substances(also termed as structurally related impurities)including amino acid deletion/insertion,diastereoisomerization,deamination/amination,oxidation,and succinimidation etc.
