Pneumoconiosis refers to a group of interstitial lung diseases that arise from the prolonged inhalation of occupational dust,resulting in chronic inflammation,immune dysregulation,and lung fibrosis[1].According to the...Pneumoconiosis refers to a group of interstitial lung diseases that arise from the prolonged inhalation of occupational dust,resulting in chronic inflammation,immune dysregulation,and lung fibrosis[1].According to the 2019 Burden of Disease database,there are currently 3.1 million cases of pneumoconiosis worldwide,with developing countries such as China experiencing a particularly significant burden.The complex pathogenesis of pneumoconiosis,along with the irreversible nature of pulmonary fibrosis,has led to a scarcity of effective therapeutic options.While the aetiology of pneumoconiosis is well established,additional factors,including diet,genetic susceptibility,and lifestyle habits,may influence an individual’s risk of developing the disease or its progression.Notably,moderate intake of polyunsaturated fatty acids(PUFAs)has been associated with a reduced risk of chronic respiratory diseases and the modulation of lung inflammation through the regulation of antioxidant signaling pathways[2].However,the potential impact of PUFAs on pneumoconiosis remains an area requiring further investigation.展开更多
基金the Central Guidance for Regional Science and Technology Development Projects(YDZJSX2024B010)Research project of Shanxi Provincial Health Commission(2023XG019).
文摘Pneumoconiosis refers to a group of interstitial lung diseases that arise from the prolonged inhalation of occupational dust,resulting in chronic inflammation,immune dysregulation,and lung fibrosis[1].According to the 2019 Burden of Disease database,there are currently 3.1 million cases of pneumoconiosis worldwide,with developing countries such as China experiencing a particularly significant burden.The complex pathogenesis of pneumoconiosis,along with the irreversible nature of pulmonary fibrosis,has led to a scarcity of effective therapeutic options.While the aetiology of pneumoconiosis is well established,additional factors,including diet,genetic susceptibility,and lifestyle habits,may influence an individual’s risk of developing the disease or its progression.Notably,moderate intake of polyunsaturated fatty acids(PUFAs)has been associated with a reduced risk of chronic respiratory diseases and the modulation of lung inflammation through the regulation of antioxidant signaling pathways[2].However,the potential impact of PUFAs on pneumoconiosis remains an area requiring further investigation.
