Zero Trust Network(ZTN)enhances network security through strict authentication and access control.However,in the ZTN,optimizing flow control to improve the quality of service is still facing challenges.Software Define...Zero Trust Network(ZTN)enhances network security through strict authentication and access control.However,in the ZTN,optimizing flow control to improve the quality of service is still facing challenges.Software Defined Network(SDN)provides solutions through centralized control and dynamic resource allocation,but the existing scheduling methods based on Deep Reinforcement Learning(DRL)are insufficient in terms of convergence speed and dynamic optimization capability.To solve these problems,this paper proposes DRL-AMIR,which is an efficient flow scheduling method for software defined ZTN.This method constructs a flow scheduling optimization model that comprehensively considers service delay,bandwidth occupation,and path hops.Additionally,it balances the differentiated requirements of delay-critical K-flows,bandwidth-intensive D-flows,and background B-flows through adaptiveweighting.Theproposed framework employs a customized state space comprising node labels,link bandwidth,delaymetrics,and path length.It incorporates an action space derived fromnode weights and a hybrid reward function that integrates both single-step and multi-step excitation mechanisms.Based on these components,a hierarchical architecture is designed,effectively integrating the data plane,control plane,and knowledge plane.In particular,the adaptive expert mechanism is introduced,which triggers the shortest path algorithm in the training process to accelerate convergence,reduce trial and error costs,and maintain stability.Experiments across diverse real-world network topologies demonstrate that DRL-AMIR achieves a 15–20%reduction in K-flow transmission delays,a 10–15%improvement in link bandwidth utilization compared to SPR,QoSR,and DRSIR,and a 30%faster convergence speed via adaptive expert mechanisms.展开更多
Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water transfer across the intestinal epithelial membrane seems ...Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water transfer across the intestinal epithelial membrane seems to occur because of aquaporins(AQPs). Accumulating evidence indicates that alterations in AQPs may play an important role in pathogenesis. Here, we focus on changes in AQPs in a mouse model of rotavirus diarrhea. In the present study, 32 of 35 mice developed diarrhea and mild dehydration within 24 hours after infection with rotavirus strain SA11. Intestinal epithelial cells demonstrated cytoplasmic vacuolation, malaligned villi, and atrophy. AQP1 expression was significantly attenuated in the ileum and colon in comparison with controls; likewise, AQP4 and-8 protein expression were significantly decreased in the colon of rotavirus diarrhea-infected mice. In contrast, AQP3 protein expression was significantly increased in the colon of rotavirus-infected mice in comparison with controls. These results indicate that rotavirus diarrhea is associated with the downregulation of AQP1,-4, and-8 expression. Therefore, AQPs play an important role in rotavirus diarrhea.展开更多
Traditional seawater desalination requires high amounts of energy, with correspondingly high costs and limited benefits, hindering wider applications of the process. To further improve the comprehensive economic benef...Traditional seawater desalination requires high amounts of energy, with correspondingly high costs and limited benefits, hindering wider applications of the process. To further improve the comprehensive economic benefits of seawater desalination, the desalination load can be combined with renewable energy sources such as solar energy, wind energy, and ocean energy or with the power grid to ensure its effective regulation. Utilizing energy internet(EI) technology, energy balance demand of the regional power grid, and coordinated control between coastal multi-source multi-load and regional distribution network with desalination load is reviewed herein. Several key technologies, including coordinated control of coastal multi-source multi-load system with seawater desalination load, flexible interaction between seawater desalination and regional distribution network, and combined control of coastal multi-source multi-load storage system with seawater desalination load, are discussed in detail. Adoption of the flexible interaction between seawater desalination and regional distribution networks is beneficial for solving water resource problems, improving the ability to dissipate distributed renewable energy, balancing and increasing grid loads, improving the safety and economy of coastal power grids, and achieving coordinated and comprehensive application of power grids, renewable energy sources, and coastal loads.展开更多
Background Youth suicide has been a pressing public mental health concern in China,yet there is a lack of gatekeeper intervention programmes developed locally to prevent suicide among Chinese adolescents.Aims The curr...Background Youth suicide has been a pressing public mental health concern in China,yet there is a lack of gatekeeper intervention programmes developed locally to prevent suicide among Chinese adolescents.Aims The current Delphi study was the first step in the systematic development of the Life Gatekeeper programme,the first gatekeeper programme to be developed locally in China that aims to equip teachers and parents with the knowledge,skills and ability to identify and intervene with students at high risk of suicide.Methods The Delphi method was used to elicit a consensus of experts who were invited to evaluate the importance of training content,the feasibility of the training delivery method,the possibility of achieving the training goals and,finally,the appropriateness of the training materials.Two Delphi rounds were conducted among local experts with diversified professional backgrounds in suicide research and practice.Statements were accepted for inclusion in the adjusted training programme if they were endorsed by at least 80%of the panel.Results Consensus was achieved on 201 out of 207 statements for inclusion into the adapted guidelines for the gatekeeper programme,with 151 from the original questionnaire and 50 generated from comments of the panel members.These endorsed statements were synthesised to develop the content of the Life Gatekeeper training programme.Conclusions This Delphi study provided an evidence base for developing the first gatekeeper training programme systematically and locally in China.We hope that the current study can pave the way for more evidence-based suicide prevention programmes in China.Further study is warranted to evaluate the effectiveness of the Life Gatekeeper training programme.展开更多
With the rapid developme nt of the economy, the continu ously in creasing populati on, and ongoing climate change, the shortage of freshwater resources has become an increasingly important global problem. Seawater des...With the rapid developme nt of the economy, the continu ously in creasing populati on, and ongoing climate change, the shortage of freshwater resources has become an increasingly important global problem. Seawater desalination tech no logy can effectively alleviate the pressure on freshwater supplies and has bee n in vestigated in many countries. However, the majority of existing projects focus on the research and development of desalination equipment and the use of new tech no logies and pay less atte ntion to the operation optimizati on of the desalinati on process. The micro energy n etwork (MEN) designed in this study is an efficient distributed energy supply system that can be used to simultaneously supply electricity, cooling, heating, and freshwater as photovoltaic power, wind power, combined heat and power (CHP), electric cooling and heating, and a seawater desalinati on device are in teg rated into the MEN. In this study, a model for operati on optimization of a MEN for seawater desalination was developed and the influences of the electric cooling and heating ratios and the operation optimization of the seawater desalination device were studied with the aim of minimizing the life cycle cost. Based on the results of this study, MENs can reduce the operation cost of desalination devices and improve the efficiency of renewable energy sources.展开更多
With increasing global shortage of fresh water resources,many countries are prioritizing desalination as a means of utilizing abundantly available seawater resources.Integrated energy efficiency evaluation is a scient...With increasing global shortage of fresh water resources,many countries are prioritizing desalination as a means of utilizing abundantly available seawater resources.Integrated energy efficiency evaluation is a scientific method for the quantitative analysis of energy efficiency based on multiple indicators and is very useful for investment,construction,and scientific decision-making for desalination projects.In this paper,the energy efficiency evaluation of the micro energy network (MEN) of desalination for multi-source and multi-load is studied,and the basic idea of comprehensive energy efficiency evaluation is analyzed.The process includes the use of a MEN model to establish an integrated energy efficiency evaluation index system,taking into consideration energy,equipment,economic,environmental,and social factors.A combined evaluation method considering subjective and objective comprehensive weights for multi-source multi-load desalination MENs is proposed to evaluate the energy efficiency of desalination and from multiple perspectives.展开更多
High temperature-induced hypocotyl elongation is a typical thermomorphogenesis trait that may significantly affect early seedling growth and subsequent crop yield.The ambient temperature and endogenous auxin are two c...High temperature-induced hypocotyl elongation is a typical thermomorphogenesis trait that may significantly affect early seedling growth and subsequent crop yield.The ambient temperature and endogenous auxin are two critical factors that regulate hypocotyl growth.However,the mechanism of temperature and auxin integration in horticultural plants remains poorly understood.In this study,the roles of the basic helix-loop-helix transcription factor CsPIF4 in regulating auxin biosynthesis genes and the auxin content in the hypocotyl of cucumber(Cucumis sativus L.)seedlings under high temperature were investigated.qRT-PCR and in situ hybridization analysis revealed that expression of CsPIF4 was enhanced in the epidermis and vascular bundles in the hypocotyl of cucumber seedlings in response to high temperature.qRT-PCR and HPLC analysis showed that CsPIF4 positively regulated transcription of the auxin biosynthesis gene CsYUC8 and the auxin content in the hypocotyl under high temperature(35℃).The CRISPR/Cas9-mediated knockout of CsPIF4 resulted in a shorter hypocotyl compared with that of the wild type,together with decreased expression of CsYUC8 and lower auxin content in response to high temperature.Furthermore,biochemical assays showed that CsPIF4 could bind directly to the G-box motif of the CsYUC8 promoter and thereby activate CsYUC8 expression.These findings provide insight into the molecular mechanism of high temperature-mediated hypocotyl elongation in cucumber.展开更多
[Objectives]To find out a suitable cultivation technique of Wangu 098 in Nanyang area,speed up the popularization,demonstration and application of Wangu 098,and provide a theoretical and practical basis for adjusting ...[Objectives]To find out a suitable cultivation technique of Wangu 098 in Nanyang area,speed up the popularization,demonstration and application of Wangu 098,and provide a theoretical and practical basis for adjusting the planting structure and realizing the matching of improved varieties and methods.[Methods]The new self-bred millet variety Wangu 098 was used as the material,and the two-factor split zone experimental design was adopted.The effects of different sowing dates and densities on the yield,growth period and agronomic characters of millet were studied.[Results]The interaction of seeding date and density had a great effect on the yield and plant traits of millet.Millet yield was significantly and positively correlated with plant height,panicle length,single panicle weight,panicle grain weight and tiller number.[Conclusions]The reasonable combination of seeding date and density could give full play to the yield potential of millet.According to the experimental results and cultivation experience,the suitable seeding date of millet in Nanyang area is in the first and middle ten days of June,and the best density is about 750000 plants/ha.However,after June 30,the seeding millet did not tiller,so the density should be increased to more than 900000 plants/ha to obtain higher yield.In terms of cultivation and management,timely seeding,reasonable close planting,and coordination of vegetative growth and reproductive growth can make the plant tall and strong,panicle long and thick,and improve the yield of millet.展开更多
The integration of atomically thin van der Waals(vd W)materials into next-generation electronic systems holds great promise for extending Moore's Law and enabling high-density,energy-efficient devices[1-4].These m...The integration of atomically thin van der Waals(vd W)materials into next-generation electronic systems holds great promise for extending Moore's Law and enabling high-density,energy-efficient devices[1-4].These materials,such as transition metal dichalcogenides,graphene,and hexagonal boron nitride,are ideal candidates for both front-end and back-end integration in siliconcompatible platforms[5].展开更多
Organic transistors,as a new generation of electronic technology,play a crucial role in the development of low-cost and flexible electronic applications,garnering extensive research interest.Two-dimensional organic se...Organic transistors,as a new generation of electronic technology,play a crucial role in the development of low-cost and flexible electronic applications,garnering extensive research interest.Two-dimensional organic semiconductors(2D-OSCs)with molecular layer thickness have shown important value in exploring the charge transfer mechanism of molecules,building high-performance transistor devices and large-scale flexible integrated circuits due to their advantages,such as long-range order of molecular arrangement,no grain boundaries,few impurities and defects,and high charge transfer efficiency.Currently,researchers are actively engaged in enhancing the performance of 2D organic field-effect transistors(2D-OFETs),which includes the design of high-performance molecular structures,controlled growth of large-area,high-quality crystals,and fabrication process.Therefore,this article focuses on the comprehensive performance optimization of 2D-OFETs,reviewing the relationship between key performance parameters and device structure,the latest research progress,and the main challenges currently faced.Furthermore,we delve into and summarize the optimization mechanisms and corresponding strategies for 2D-OFET mobility,dielectric layer performance,power consumption,and contact resistance.Lastly,we provide an outlook on the manufacturing technology of 2D-OFETs and their application prospects,aiming to guide future research and development.Ongoing research and development efforts in this area have the potential to make significant advances.展开更多
Walnut shell-kernel separation after cracking is crucial for providing raw materials for further processing.However,impurities and losses during separation limit complete separation.To address this,a two-stage tandem ...Walnut shell-kernel separation after cracking is crucial for providing raw materials for further processing.However,impurities and losses during separation limit complete separation.To address this,a two-stage tandem separation device was designed and optimized.Computational fluid dynamics(CFD)was used to analyze the effects of four bent duct structures on the flow field.Response surface methodology(RSM)and artificial neural networks(ANN)were employed to predict separation performance under various conditions.Both models accurately predicted performance,with ANN showing superior predictive ability.The optimal design was determined using non-dominated sorting genetic algorithm-II(NSGA-II)and technique for order preference by similarity to an ideal solution(TOPSIS):the inclination of the first stage deflector plate(x_(1))was 39°,the inclination of the second stage deflector plate(x_(2))was 36°,the wind speed of the first stage fan(x_(3))was 21 m/s,and the wind speed of the second stage fan(x_(4))was 13.5 m/s;impurity rate(y_(1))was 4.51%,and loss rate(y_(2))was 6.62%.Compared with traditional single-stage devices,the optimized device reduced impurity rate by 73.98%to 77.55%and loss rate by 9.44%to 53.96%,significantly improving separation efficiency and quality.This study provides theoretical guidance for designing and optimizing shell-kernel separation devices.展开更多
With the rapid development of artificial intelligence(AI)technology and its successful application in various fields,modeling and simulation technology,especially multi-agent modeling and simulation(MAMS),of complex s...With the rapid development of artificial intelligence(AI)technology and its successful application in various fields,modeling and simulation technology,especially multi-agent modeling and simulation(MAMS),of complex systems has rapidly advanced.In this study,we first describe the concept,technical advantages,research steps,and research status of MAMS.Then we review the development status of the hybrid modeling and simulation combining multi-agent and system dynamics,the modeling and simulation of multi-agent reinforcement learning,and the modeling and simulation of large-scale multi-agent.Lastly,we introduce existing MAMS platforms and their comparative studies.This work summarizes the current research situation of MAMS,thus helping scholars understand the systematic technology development of MAMS in the AI era.It also paves the way for further research on MAMS technology.展开更多
Breast cancer constitutes a significant global health burden,while conventional diagnosis approaches may lack precision and can be discomforting for patients.Exosomes have emerged as promising biomarkers for breast ca...Breast cancer constitutes a significant global health burden,while conventional diagnosis approaches may lack precision and can be discomforting for patients.Exosomes have emerged as promising biomarkers for breast cancer due to their participation in diverse pathological processes,and a convenient analysis platform is believed to greatly promote its application.In this study,we propose a novel digital PCR approach utilizing near-infrared(NIR)photo-responsive thermosensitive microcarriers integrated with black phosphorus for quantifying microRNA(miRNA)biomarkers within exosomes.Petal-like biomimetic nanomaterials were firstly assembled for nonspecific exosome capture based on the affinity effect of avidin and biotin.Photothermal-responsive microcarriers,fabricated using gelatin-based substrates blended with photothermal nanocomposite,exhibited NIRinduced heating and reversible phase transition properties.We optimized synthesis parameters on thermal response and established a programmable and controllable NIR light source module.The results indicated a significant elevation in the levels of biomarkers miRNA-1246 and miRNA-122,with fold increases ranging from 6.2 to 23.6 and 5.9 to 13.0,respectively,in breast cancer cell lines MCF-7 and MDA-MB-231 compared to healthy control cells HUVEC.This study offers broad prospects for utilizing exosomes to resolve predictive biomarkers.展开更多
基金supported in part by Scientific Research Fund of Zhejiang Provincial Education Department under Grant Y202351110in part by Huzhou Science and Technology Plan Project under Grant 2024YZ23+1 种基金in part by Research Fund of National Key Laboratory of Advanced Communication Networks under Grant SCX23641X004in part by Postgraduate Research and Innovation Project of Huzhou University under Grant 2024KYCX50.
文摘Zero Trust Network(ZTN)enhances network security through strict authentication and access control.However,in the ZTN,optimizing flow control to improve the quality of service is still facing challenges.Software Defined Network(SDN)provides solutions through centralized control and dynamic resource allocation,but the existing scheduling methods based on Deep Reinforcement Learning(DRL)are insufficient in terms of convergence speed and dynamic optimization capability.To solve these problems,this paper proposes DRL-AMIR,which is an efficient flow scheduling method for software defined ZTN.This method constructs a flow scheduling optimization model that comprehensively considers service delay,bandwidth occupation,and path hops.Additionally,it balances the differentiated requirements of delay-critical K-flows,bandwidth-intensive D-flows,and background B-flows through adaptiveweighting.Theproposed framework employs a customized state space comprising node labels,link bandwidth,delaymetrics,and path length.It incorporates an action space derived fromnode weights and a hybrid reward function that integrates both single-step and multi-step excitation mechanisms.Based on these components,a hierarchical architecture is designed,effectively integrating the data plane,control plane,and knowledge plane.In particular,the adaptive expert mechanism is introduced,which triggers the shortest path algorithm in the training process to accelerate convergence,reduce trial and error costs,and maintain stability.Experiments across diverse real-world network topologies demonstrate that DRL-AMIR achieves a 15–20%reduction in K-flow transmission delays,a 10–15%improvement in link bandwidth utilization compared to SPR,QoSR,and DRSIR,and a 30%faster convergence speed via adaptive expert mechanisms.
基金supported by funding from Guangdong Natural Science Foundation (grants:S2012010009211,S2012010009538)Key Specialty Projects of Guangzhou Board of Health (grant:20121A021014)
文摘Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water transfer across the intestinal epithelial membrane seems to occur because of aquaporins(AQPs). Accumulating evidence indicates that alterations in AQPs may play an important role in pathogenesis. Here, we focus on changes in AQPs in a mouse model of rotavirus diarrhea. In the present study, 32 of 35 mice developed diarrhea and mild dehydration within 24 hours after infection with rotavirus strain SA11. Intestinal epithelial cells demonstrated cytoplasmic vacuolation, malaligned villi, and atrophy. AQP1 expression was significantly attenuated in the ileum and colon in comparison with controls; likewise, AQP4 and-8 protein expression were significantly decreased in the colon of rotavirus diarrhea-infected mice. In contrast, AQP3 protein expression was significantly increased in the colon of rotavirus-infected mice in comparison with controls. These results indicate that rotavirus diarrhea is associated with the downregulation of AQP1,-4, and-8 expression. Therefore, AQPs play an important role in rotavirus diarrhea.
基金supported by the State Grid Science and Technology Project, “Study on Multi-source and Multiload Coordination and Optimization Technology Considering Desalination of Sea Water” (No. SGTJDK00DWJS1800011)
文摘Traditional seawater desalination requires high amounts of energy, with correspondingly high costs and limited benefits, hindering wider applications of the process. To further improve the comprehensive economic benefits of seawater desalination, the desalination load can be combined with renewable energy sources such as solar energy, wind energy, and ocean energy or with the power grid to ensure its effective regulation. Utilizing energy internet(EI) technology, energy balance demand of the regional power grid, and coordinated control between coastal multi-source multi-load and regional distribution network with desalination load is reviewed herein. Several key technologies, including coordinated control of coastal multi-source multi-load system with seawater desalination load, flexible interaction between seawater desalination and regional distribution network, and combined control of coastal multi-source multi-load storage system with seawater desalination load, are discussed in detail. Adoption of the flexible interaction between seawater desalination and regional distribution networks is beneficial for solving water resource problems, improving the ability to dissipate distributed renewable energy, balancing and increasing grid loads, improving the safety and economy of coastal power grids, and achieving coordinated and comprehensive application of power grids, renewable energy sources, and coastal loads.
基金funding from Research Fund of VankeSchool of Public Health(100009001)funding from Shuimu Tsinghua Scholarfunding from Beijing High Level Public HealthTechnical Specialist Development Fund(Discipline backbone-02-07).
文摘Background Youth suicide has been a pressing public mental health concern in China,yet there is a lack of gatekeeper intervention programmes developed locally to prevent suicide among Chinese adolescents.Aims The current Delphi study was the first step in the systematic development of the Life Gatekeeper programme,the first gatekeeper programme to be developed locally in China that aims to equip teachers and parents with the knowledge,skills and ability to identify and intervene with students at high risk of suicide.Methods The Delphi method was used to elicit a consensus of experts who were invited to evaluate the importance of training content,the feasibility of the training delivery method,the possibility of achieving the training goals and,finally,the appropriateness of the training materials.Two Delphi rounds were conducted among local experts with diversified professional backgrounds in suicide research and practice.Statements were accepted for inclusion in the adjusted training programme if they were endorsed by at least 80%of the panel.Results Consensus was achieved on 201 out of 207 statements for inclusion into the adapted guidelines for the gatekeeper programme,with 151 from the original questionnaire and 50 generated from comments of the panel members.These endorsed statements were synthesised to develop the content of the Life Gatekeeper training programme.Conclusions This Delphi study provided an evidence base for developing the first gatekeeper training programme systematically and locally in China.We hope that the current study can pave the way for more evidence-based suicide prevention programmes in China.Further study is warranted to evaluate the effectiveness of the Life Gatekeeper training programme.
基金supported by the State Grid Corporation of China project:“Study on Multi-source and Multi-load Coordination and Optimization Technology Considering Desalination of Sea Water”(SGTJDK00DWJS1800011)
文摘With the rapid developme nt of the economy, the continu ously in creasing populati on, and ongoing climate change, the shortage of freshwater resources has become an increasingly important global problem. Seawater desalination tech no logy can effectively alleviate the pressure on freshwater supplies and has bee n in vestigated in many countries. However, the majority of existing projects focus on the research and development of desalination equipment and the use of new tech no logies and pay less atte ntion to the operation optimizati on of the desalinati on process. The micro energy n etwork (MEN) designed in this study is an efficient distributed energy supply system that can be used to simultaneously supply electricity, cooling, heating, and freshwater as photovoltaic power, wind power, combined heat and power (CHP), electric cooling and heating, and a seawater desalinati on device are in teg rated into the MEN. In this study, a model for operati on optimization of a MEN for seawater desalination was developed and the influences of the electric cooling and heating ratios and the operation optimization of the seawater desalination device were studied with the aim of minimizing the life cycle cost. Based on the results of this study, MENs can reduce the operation cost of desalination devices and improve the efficiency of renewable energy sources.
基金supported by the State Grid Corporation of China project titled “Study on Multisource and Multi-load Coordination and Optimization Technology Considering Desalination of Sea Water”(SGTJDK00DWJS1800011)
文摘With increasing global shortage of fresh water resources,many countries are prioritizing desalination as a means of utilizing abundantly available seawater resources.Integrated energy efficiency evaluation is a scientific method for the quantitative analysis of energy efficiency based on multiple indicators and is very useful for investment,construction,and scientific decision-making for desalination projects.In this paper,the energy efficiency evaluation of the micro energy network (MEN) of desalination for multi-source and multi-load is studied,and the basic idea of comprehensive energy efficiency evaluation is analyzed.The process includes the use of a MEN model to establish an integrated energy efficiency evaluation index system,taking into consideration energy,equipment,economic,environmental,and social factors.A combined evaluation method considering subjective and objective comprehensive weights for multi-source multi-load desalination MENs is proposed to evaluate the energy efficiency of desalination and from multiple perspectives.
基金the China Postdoctoral Science Foundation(Grant No.2021M703530)the National Natural Science Foundation of China(Grant No.31972398).
文摘High temperature-induced hypocotyl elongation is a typical thermomorphogenesis trait that may significantly affect early seedling growth and subsequent crop yield.The ambient temperature and endogenous auxin are two critical factors that regulate hypocotyl growth.However,the mechanism of temperature and auxin integration in horticultural plants remains poorly understood.In this study,the roles of the basic helix-loop-helix transcription factor CsPIF4 in regulating auxin biosynthesis genes and the auxin content in the hypocotyl of cucumber(Cucumis sativus L.)seedlings under high temperature were investigated.qRT-PCR and in situ hybridization analysis revealed that expression of CsPIF4 was enhanced in the epidermis and vascular bundles in the hypocotyl of cucumber seedlings in response to high temperature.qRT-PCR and HPLC analysis showed that CsPIF4 positively regulated transcription of the auxin biosynthesis gene CsYUC8 and the auxin content in the hypocotyl under high temperature(35℃).The CRISPR/Cas9-mediated knockout of CsPIF4 resulted in a shorter hypocotyl compared with that of the wild type,together with decreased expression of CsYUC8 and lower auxin content in response to high temperature.Furthermore,biochemical assays showed that CsPIF4 could bind directly to the G-box motif of the CsYUC8 promoter and thereby activate CsYUC8 expression.These findings provide insight into the molecular mechanism of high temperature-mediated hypocotyl elongation in cucumber.
基金Supported by Key R&D Project of Henan Province(231111110300)National Modern Agricultural Industry Technology System Special Fund Project of Ministry of Finance/Ministry of Agriculture and Rural Affairs(nycytx-CARS-06)+1 种基金Science and Technology Innovation Team Project of Henan Academy of Agricultural Sciences(2022KJCHXTD33)Henan Provincial Agricultural Seed Research Project(2022010401).
文摘[Objectives]To find out a suitable cultivation technique of Wangu 098 in Nanyang area,speed up the popularization,demonstration and application of Wangu 098,and provide a theoretical and practical basis for adjusting the planting structure and realizing the matching of improved varieties and methods.[Methods]The new self-bred millet variety Wangu 098 was used as the material,and the two-factor split zone experimental design was adopted.The effects of different sowing dates and densities on the yield,growth period and agronomic characters of millet were studied.[Results]The interaction of seeding date and density had a great effect on the yield and plant traits of millet.Millet yield was significantly and positively correlated with plant height,panicle length,single panicle weight,panicle grain weight and tiller number.[Conclusions]The reasonable combination of seeding date and density could give full play to the yield potential of millet.According to the experimental results and cultivation experience,the suitable seeding date of millet in Nanyang area is in the first and middle ten days of June,and the best density is about 750000 plants/ha.However,after June 30,the seeding millet did not tiller,so the density should be increased to more than 900000 plants/ha to obtain higher yield.In terms of cultivation and management,timely seeding,reasonable close planting,and coordination of vegetative growth and reproductive growth can make the plant tall and strong,panicle long and thick,and improve the yield of millet.
文摘The integration of atomically thin van der Waals(vd W)materials into next-generation electronic systems holds great promise for extending Moore's Law and enabling high-density,energy-efficient devices[1-4].These materials,such as transition metal dichalcogenides,graphene,and hexagonal boron nitride,are ideal candidates for both front-end and back-end integration in siliconcompatible platforms[5].
基金support from the National Key R&D Program of China(Nos.2024YFB4405300 and 2024YFB4405203)the Natural Science Foundation of Jiangsu Province(No.BK20220397)+6 种基金the National Natural Science Foundation of China(Nos.62204130,62474094,and T2322014)NSFC-DFG“Mobility”project(No.M0604)Guangdong Province Research and Development in Key Fields from Guangdong Greater Bay Area Institute of Integrated Circuit and System(No.2021B0101280002)Guangzhou City Research and Development Program in Key Field(No.20210302001)in part by Guangdong Key Laboratory of Integrated Circuit Technology and Products Based on Fully Depleted Silicon On Insulator,the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(No.22KJB510010)Guangdong Provincial Key Laboratory of Integrated Circuit Technology and Products Based on Fully Depleted Silicon On Insulator(2024)(No.2024B1212020005)Guangdong Province Pearl-River Talent Program(No.2023JC11X250).
文摘Organic transistors,as a new generation of electronic technology,play a crucial role in the development of low-cost and flexible electronic applications,garnering extensive research interest.Two-dimensional organic semiconductors(2D-OSCs)with molecular layer thickness have shown important value in exploring the charge transfer mechanism of molecules,building high-performance transistor devices and large-scale flexible integrated circuits due to their advantages,such as long-range order of molecular arrangement,no grain boundaries,few impurities and defects,and high charge transfer efficiency.Currently,researchers are actively engaged in enhancing the performance of 2D organic field-effect transistors(2D-OFETs),which includes the design of high-performance molecular structures,controlled growth of large-area,high-quality crystals,and fabrication process.Therefore,this article focuses on the comprehensive performance optimization of 2D-OFETs,reviewing the relationship between key performance parameters and device structure,the latest research progress,and the main challenges currently faced.Furthermore,we delve into and summarize the optimization mechanisms and corresponding strategies for 2D-OFET mobility,dielectric layer performance,power consumption,and contact resistance.Lastly,we provide an outlook on the manufacturing technology of 2D-OFETs and their application prospects,aiming to guide future research and development.Ongoing research and development efforts in this area have the potential to make significant advances.
基金This work has been financially supported and encouraged by the National Science Foundation for Young Scientists of China(Grant No.12002229)the Key R&D Program Projects of Xinjiang Uygur Autonomous Region(2024B02017)+2 种基金the Bingtuan Science and Technology Program(Grant No.2022CB008,2018CB014)the Science and Technology Research Project of the Presidential Foundation of Tarim University(Grant No.TDZKBS202414)the National Forestry and Grassland Equipment Science and Technology Innovation Park’s“Challenge System”Major Breakthrough Project(2024YG06).
文摘Walnut shell-kernel separation after cracking is crucial for providing raw materials for further processing.However,impurities and losses during separation limit complete separation.To address this,a two-stage tandem separation device was designed and optimized.Computational fluid dynamics(CFD)was used to analyze the effects of four bent duct structures on the flow field.Response surface methodology(RSM)and artificial neural networks(ANN)were employed to predict separation performance under various conditions.Both models accurately predicted performance,with ANN showing superior predictive ability.The optimal design was determined using non-dominated sorting genetic algorithm-II(NSGA-II)and technique for order preference by similarity to an ideal solution(TOPSIS):the inclination of the first stage deflector plate(x_(1))was 39°,the inclination of the second stage deflector plate(x_(2))was 36°,the wind speed of the first stage fan(x_(3))was 21 m/s,and the wind speed of the second stage fan(x_(4))was 13.5 m/s;impurity rate(y_(1))was 4.51%,and loss rate(y_(2))was 6.62%.Compared with traditional single-stage devices,the optimized device reduced impurity rate by 73.98%to 77.55%and loss rate by 9.44%to 53.96%,significantly improving separation efficiency and quality.This study provides theoretical guidance for designing and optimizing shell-kernel separation devices.
文摘With the rapid development of artificial intelligence(AI)technology and its successful application in various fields,modeling and simulation technology,especially multi-agent modeling and simulation(MAMS),of complex systems has rapidly advanced.In this study,we first describe the concept,technical advantages,research steps,and research status of MAMS.Then we review the development status of the hybrid modeling and simulation combining multi-agent and system dynamics,the modeling and simulation of multi-agent reinforcement learning,and the modeling and simulation of large-scale multi-agent.Lastly,we introduce existing MAMS platforms and their comparative studies.This work summarizes the current research situation of MAMS,thus helping scholars understand the systematic technology development of MAMS in the AI era.It also paves the way for further research on MAMS technology.
基金National Key Research and Development Program of China,Grant/Award Number:2022YFA1405002National Natural Science Foundation of China,Grant/Award Numbers:12325405,22307098+6 种基金Wenzhou Institute,University of Chinese Academy of Sciences,Grant/Award Number:WIUCASQD2021012Wenzhou high‐level innovation teamDevelopment and application team of functional livKey Projects of Wenzhou Science and Technology Bureau,Grant/Award Number:ZG2023013Wenzhou Basic Research Projects,Grant/Award Number:Y2023147Zhejiang Provincial Natural Science Foundation of China,Grant/Award Number:LGF22C100003Key Laboratory of Structural Malformations in Children of Zhejiang Province,Grant/Award Number:ZJET2301Z。
文摘Breast cancer constitutes a significant global health burden,while conventional diagnosis approaches may lack precision and can be discomforting for patients.Exosomes have emerged as promising biomarkers for breast cancer due to their participation in diverse pathological processes,and a convenient analysis platform is believed to greatly promote its application.In this study,we propose a novel digital PCR approach utilizing near-infrared(NIR)photo-responsive thermosensitive microcarriers integrated with black phosphorus for quantifying microRNA(miRNA)biomarkers within exosomes.Petal-like biomimetic nanomaterials were firstly assembled for nonspecific exosome capture based on the affinity effect of avidin and biotin.Photothermal-responsive microcarriers,fabricated using gelatin-based substrates blended with photothermal nanocomposite,exhibited NIRinduced heating and reversible phase transition properties.We optimized synthesis parameters on thermal response and established a programmable and controllable NIR light source module.The results indicated a significant elevation in the levels of biomarkers miRNA-1246 and miRNA-122,with fold increases ranging from 6.2 to 23.6 and 5.9 to 13.0,respectively,in breast cancer cell lines MCF-7 and MDA-MB-231 compared to healthy control cells HUVEC.This study offers broad prospects for utilizing exosomes to resolve predictive biomarkers.
