Bisphenol A(BPA)and its bisphenol analogs(BPs)serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins.However,due to BPA’s detrimental health effects,there has been a growing global co...Bisphenol A(BPA)and its bisphenol analogs(BPs)serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins.However,due to BPA’s detrimental health effects,there has been a growing global consensus to restrict its use.The elderly,being particularly susceptible to neurodegenerative disorders,represent a population of concern;yet,research exploring the association between BPs exposure and neurodegenerative diseases in the elderly remains scarce.In this study,the urinary levels of six BPs among 267 participants from the Shenzhen aging-related disorder cohort in China during 2017–2018 were measured.Cognitive status was evaluated using the Mini-Mental State Examination(MMSE),and the impact of sociodemographic factors,lifestyle habits,and dietary practices was analyzed through the Extreme Gradient Boosting(XGBoost)classifier.In this study,BPA was the highest urinary level of bisphenol compound detected in the high-risk group(2.10 ng/mL,95.2%).Significant differences in BPs levels were observed to the degree of education,tea consumption frequency,meat intake frequency,and distance of main road groups(P<0.05).Notably,the absence of a significant positive correlation between BPF and BPA levels in high-risk groups for cognitive impairment implies more findings may be needed to fully evaluate BPF’s actual human exposure levels.The XGBoost models have further revealed that BPA analogs exposure and certain housing characteristics were substantial contributors to the potential impact on cognitive impairment during aging not only BPA.展开更多
Cervical cancer is a major public health concern in China,accounting for almost one-fifth of the global incidence and mortality.The recently prequalified domestic bivalent human papillomavirus(HPV)vaccine offers a pra...Cervical cancer is a major public health concern in China,accounting for almost one-fifth of the global incidence and mortality.The recently prequalified domestic bivalent human papillomavirus(HPV)vaccine offers a practical and feasible preventive measure.In response to the global call for action,the National Health Commission issued an Action Plan to eliminate cervical cancer by 2030,with promotion of the HPV vaccination for school-aged girls as a critical step.Despite this,implementation of the vaccination has been patchy,with very low coverage among eligible girls.To address this,from December 2021 to December 2022,a demonstration project was launched in Shenzhen,Guangdong Province,to promote the inclusion of HPV vaccine in local immunisation programme and to address existing barriers to implementation.Using multiple sources of data,this article presents a case study of the demonstration project,analysing its impact on rolling out HPV vaccination among eligible girls and identifying any challenges encountered during implementation.The demonstration project has shown promising results in increasing the HPV vaccination rate,promoting public awareness and acceptance of the domestic HPV vaccine,and establishing a model for quickly scaling up the vaccination at the municipal level.The success of the project can be attributed to several factors,including strong governmental commitment,sufficient funding,multi-sectoral collaboration,ensured vaccine accessibility and affordability,improved vaccination services,and effective health education and communication strategies.Lessons learned from Shenzhen can provide valuable insights for future advocacy and implementation of the vaccination in other areas of China,but challenges must be addressed to achieve universal coverage.These include addressing vaccine hesitancy,expanding the programme to cover a broader age range,and ensuring consistent quality of vaccination services in primary care facilities.Overcoming these challenges will require innovative strategies,public-private partnerships,and sustained funding and resources.Future research should focus on evaluating the long-term effectiveness of the vaccination programme and identifying contextual factors that may impact its implementation in different settings.Overall,the effective control of cervical cancer in China will rely on the“political will”to ensure the incorporation of preventive interventions into policies and universal programme coverage.展开更多
HDAC6 is involved in several biological processes related to aging-associated diseases.However,it was unknown whether HDAC6 could directly regulate lifespan and healthspan.We found that HDAC6 knockdown induced transcr...HDAC6 is involved in several biological processes related to aging-associated diseases.However,it was unknown whether HDAC6 could directly regulate lifespan and healthspan.We found that HDAC6 knockdown induced transcriptome changes to attenuate the aging changes in the Drosophila head,particularly on the inflammation and innate immunity-related genes.Whole-body knockdown of HDAC6 extended lifespan in the fly,furthermore brain-specific knockdown of HDAC6 extended both lifespan and healthspan in the fly.Our results established HDAC6 as a lifespan regulator and provided a potential anti-aging target.展开更多
基金supported by the National Natural Science Foundation of China(No.42277424,No.42077385,and No.42477296)the Shenzhen Science and Technology Program(JCYJ20230807110903008 and JCYJ20240813150902004)+1 种基金Sanming Project of Medicine in Shenzhen(SZSM202211010)Shenzhen Key Medical Discipline Construction Fund(SZXK069).
文摘Bisphenol A(BPA)and its bisphenol analogs(BPs)serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins.However,due to BPA’s detrimental health effects,there has been a growing global consensus to restrict its use.The elderly,being particularly susceptible to neurodegenerative disorders,represent a population of concern;yet,research exploring the association between BPs exposure and neurodegenerative diseases in the elderly remains scarce.In this study,the urinary levels of six BPs among 267 participants from the Shenzhen aging-related disorder cohort in China during 2017–2018 were measured.Cognitive status was evaluated using the Mini-Mental State Examination(MMSE),and the impact of sociodemographic factors,lifestyle habits,and dietary practices was analyzed through the Extreme Gradient Boosting(XGBoost)classifier.In this study,BPA was the highest urinary level of bisphenol compound detected in the high-risk group(2.10 ng/mL,95.2%).Significant differences in BPs levels were observed to the degree of education,tea consumption frequency,meat intake frequency,and distance of main road groups(P<0.05).Notably,the absence of a significant positive correlation between BPF and BPA levels in high-risk groups for cognitive impairment implies more findings may be needed to fully evaluate BPF’s actual human exposure levels.The XGBoost models have further revealed that BPA analogs exposure and certain housing characteristics were substantial contributors to the potential impact on cognitive impairment during aging not only BPA.
文摘Cervical cancer is a major public health concern in China,accounting for almost one-fifth of the global incidence and mortality.The recently prequalified domestic bivalent human papillomavirus(HPV)vaccine offers a practical and feasible preventive measure.In response to the global call for action,the National Health Commission issued an Action Plan to eliminate cervical cancer by 2030,with promotion of the HPV vaccination for school-aged girls as a critical step.Despite this,implementation of the vaccination has been patchy,with very low coverage among eligible girls.To address this,from December 2021 to December 2022,a demonstration project was launched in Shenzhen,Guangdong Province,to promote the inclusion of HPV vaccine in local immunisation programme and to address existing barriers to implementation.Using multiple sources of data,this article presents a case study of the demonstration project,analysing its impact on rolling out HPV vaccination among eligible girls and identifying any challenges encountered during implementation.The demonstration project has shown promising results in increasing the HPV vaccination rate,promoting public awareness and acceptance of the domestic HPV vaccine,and establishing a model for quickly scaling up the vaccination at the municipal level.The success of the project can be attributed to several factors,including strong governmental commitment,sufficient funding,multi-sectoral collaboration,ensured vaccine accessibility and affordability,improved vaccination services,and effective health education and communication strategies.Lessons learned from Shenzhen can provide valuable insights for future advocacy and implementation of the vaccination in other areas of China,but challenges must be addressed to achieve universal coverage.These include addressing vaccine hesitancy,expanding the programme to cover a broader age range,and ensuring consistent quality of vaccination services in primary care facilities.Overcoming these challenges will require innovative strategies,public-private partnerships,and sustained funding and resources.Future research should focus on evaluating the long-term effectiveness of the vaccination programme and identifying contextual factors that may impact its implementation in different settings.Overall,the effective control of cervical cancer in China will rely on the“political will”to ensure the incorporation of preventive interventions into policies and universal programme coverage.
基金This work was supported by grants from the National Natural Science Foundation of China(31771545,92049301,31821002,91329302,and 31210103916)China Ministry of Science and Technology(2015CB964803,2016YFE0108700,and 2016YFA0500600),and Max Planck fellowship to J.D.J.H.
文摘HDAC6 is involved in several biological processes related to aging-associated diseases.However,it was unknown whether HDAC6 could directly regulate lifespan and healthspan.We found that HDAC6 knockdown induced transcriptome changes to attenuate the aging changes in the Drosophila head,particularly on the inflammation and innate immunity-related genes.Whole-body knockdown of HDAC6 extended lifespan in the fly,furthermore brain-specific knockdown of HDAC6 extended both lifespan and healthspan in the fly.Our results established HDAC6 as a lifespan regulator and provided a potential anti-aging target.
