A growing number of skin laser treatments have rapidly evolved and increased their role in the field of dermatology,laser treatment is considered to be used for a variety of pigmentary dermatosis as well as aesthetic ...A growing number of skin laser treatments have rapidly evolved and increased their role in the field of dermatology,laser treatment is considered to be used for a variety of pigmentary dermatosis as well as aesthetic problems.The standardized assessment of laser treatment efficacy is crucial for the interpretation and comparison of studies related to laser treatment of skin disorders.In this study,we propose an evaluation method to quantitatively assess laser treatment efficacy based on the image segmentation technology.A tattoo model of Sprague Dawley(SD)rats was established and treated by picosecond laser treatments at varying energy levels.Images of the tattoo models were captured before and after laser treatment,and feature extraction was conducted to quantify the tattooed area and pigment gradation.Subsequently,the clearance rate,which has been a standardized parameter,was calculated.The results indicate that the clearance rates obtained through this quantitative algorithm are comparable and exhibit smaller standard deviations compared with scale scores(4.59%versus 7.93%in the low-energy group,4.01%versus 9.05%in the medium-energy group,and 4.29%versus 10.23%in the high-energy group).This underscores the greater accuracy,objectivity,and reproducibility in assessing treatment responses.The quantitative evaluation of pigment removal holds promise for facilitating faster and more robust assessments in research and development.Additionally,it may enable the optimization of treatments tailored to individual patients,thereby contributing to more effective and personalized dermatological care.展开更多
Rosacea presents as transient or persistent erythema,papules,pustules,fAushing,and telangi-ectasia on the middle of the face,which has some clinical similarity with act inic keratosis(AK).These two conditions can coex...Rosacea presents as transient or persistent erythema,papules,pustules,fAushing,and telangi-ectasia on the middle of the face,which has some clinical similarity with act inic keratosis(AK).These two conditions can coexist in the same patient.Dermoscopy and reflect ance confocal microscopy(RCM)could be useful methods for diagnosis and monitoring treatment efficacy.Novel intense pulsed light-photodynamic therapy(IPL-PDT)may have better tolerance and curative effect than traditional red-light 5-aminolevulinic acid photodynamic therapy(ALA-PDT).Herein,we present a case of facial AKs concomitant with rosacea where combination therapy of novel IPL-PDT and oral minocycline was effective in that AK lesions were eliminated and the patient's facial erythema and telangiectasia were significantly improved.展开更多
Acne conglobata(AC),perifolliculitis capitis abscedens et suffodiens(PCAS)and hidradenitis suppurativa(HS)are uncommon refractory chronic,inflammatory,scarring diseases but cause serious damage to the quality of life....Acne conglobata(AC),perifolliculitis capitis abscedens et suffodiens(PCAS)and hidradenitis suppurativa(HS)are uncommon refractory chronic,inflammatory,scarring diseases but cause serious damage to the quality of life.These three diseases are associated with follicular occlusion.Several studies indicated topical 5-aminolevulinic acid photodynamic therapy(ALA-PDT)improved follicular occlusion besides acne treatment.So we attempted to apply ALA-PDT to medicine resistant AC,PCAS and HS.Topical ALA-PDT was applied to 10 patients with AC,seven patients with PCAS and three patients with HS for more than three sessions.All the patients completed the dermatology life quality index(DLQI)questionnaire and were assessed for the efficacy at the baseline and on two weeks after each treatment.Adverse effects were recorded at each visit.The results showed 25.5%(5/20,two cases of AC and three cases of PCAS)of patients achieved excellent improvement after three sessions of PDT and another 60.0%(12/20,eight cases of AC and four cases of PCAS)of patients achieved good improvement.15.0%(3/20,three cases of HS)got poor response(<20%lesions clearance).Anotherfive cases(three cases of AC and two cases of PCAS)also achieved excellent response after 5–7 sessions of PDT.We also found that papular/nodular,cyst/abscess showed higher clearance rate than sinus/¯stula(88.5%,86.1%versus 11.1%).DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients.5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS.The e±cacy increased with more treatment sessions.展开更多
Using biodegradable material derived from renewable resources as petroleum-based plastics replacement is a promising way towards sustainable development.However,the insufficient mechanical properties and complex manuf...Using biodegradable material derived from renewable resources as petroleum-based plastics replacement is a promising way towards sustainable development.However,the insufficient mechanical properties and complex manufacturing process of bioplastics still need to be improved for high-quality food packages.Herein,we report a top-down strategy to transform natural wood into a clear wood packaging film through scalable delignification and polyvinyl alcohol(PVA)infiltration.The wood packaging film demonstrates a laminated structure with completely collapsed cell walls and PVA intertwined together after energy-saving air drying,resulting in high light transmittance with low haze,good mechanical performance,and high barrier performance for oxygen and water vapor.Molecular dynamics simulations reveal the underlying fracture mechanism between cellulose and PVA,which effectively enhances the Young’s modulus and strength of the wood packaging film.These findings contribute to the development of biodegradable and strong packaging materials,as well as other food-related applications,using sustainable wood.展开更多
基金supported by The Shanghai Science and Technology Commission(21S31902700)。
文摘A growing number of skin laser treatments have rapidly evolved and increased their role in the field of dermatology,laser treatment is considered to be used for a variety of pigmentary dermatosis as well as aesthetic problems.The standardized assessment of laser treatment efficacy is crucial for the interpretation and comparison of studies related to laser treatment of skin disorders.In this study,we propose an evaluation method to quantitatively assess laser treatment efficacy based on the image segmentation technology.A tattoo model of Sprague Dawley(SD)rats was established and treated by picosecond laser treatments at varying energy levels.Images of the tattoo models were captured before and after laser treatment,and feature extraction was conducted to quantify the tattooed area and pigment gradation.Subsequently,the clearance rate,which has been a standardized parameter,was calculated.The results indicate that the clearance rates obtained through this quantitative algorithm are comparable and exhibit smaller standard deviations compared with scale scores(4.59%versus 7.93%in the low-energy group,4.01%versus 9.05%in the medium-energy group,and 4.29%versus 10.23%in the high-energy group).This underscores the greater accuracy,objectivity,and reproducibility in assessing treatment responses.The quantitative evaluation of pigment removal holds promise for facilitating faster and more robust assessments in research and development.Additionally,it may enable the optimization of treatments tailored to individual patients,thereby contributing to more effective and personalized dermatological care.
基金This research was financially funded by the National Natural Science Foundation of Shanghai(22ZR1455400)Shanghai Rising-Star Program(20QA1408600)Shanghai Sailing Program(21YF1441600).
文摘Rosacea presents as transient or persistent erythema,papules,pustules,fAushing,and telangi-ectasia on the middle of the face,which has some clinical similarity with act inic keratosis(AK).These two conditions can coexist in the same patient.Dermoscopy and reflect ance confocal microscopy(RCM)could be useful methods for diagnosis and monitoring treatment efficacy.Novel intense pulsed light-photodynamic therapy(IPL-PDT)may have better tolerance and curative effect than traditional red-light 5-aminolevulinic acid photodynamic therapy(ALA-PDT).Herein,we present a case of facial AKs concomitant with rosacea where combination therapy of novel IPL-PDT and oral minocycline was effective in that AK lesions were eliminated and the patient's facial erythema and telangiectasia were significantly improved.
基金This work was supported by grants from the National Natural Science Foundation of China (81402585)Advanced Suitable Technology Popularization Project of Shanghai Health System (2013SY007)the Natural Science Foundation of Shanghai Municipal Commission of Health and Family Planning (20144Y0216).
文摘Acne conglobata(AC),perifolliculitis capitis abscedens et suffodiens(PCAS)and hidradenitis suppurativa(HS)are uncommon refractory chronic,inflammatory,scarring diseases but cause serious damage to the quality of life.These three diseases are associated with follicular occlusion.Several studies indicated topical 5-aminolevulinic acid photodynamic therapy(ALA-PDT)improved follicular occlusion besides acne treatment.So we attempted to apply ALA-PDT to medicine resistant AC,PCAS and HS.Topical ALA-PDT was applied to 10 patients with AC,seven patients with PCAS and three patients with HS for more than three sessions.All the patients completed the dermatology life quality index(DLQI)questionnaire and were assessed for the efficacy at the baseline and on two weeks after each treatment.Adverse effects were recorded at each visit.The results showed 25.5%(5/20,two cases of AC and three cases of PCAS)of patients achieved excellent improvement after three sessions of PDT and another 60.0%(12/20,eight cases of AC and four cases of PCAS)of patients achieved good improvement.15.0%(3/20,three cases of HS)got poor response(<20%lesions clearance).Anotherfive cases(three cases of AC and two cases of PCAS)also achieved excellent response after 5–7 sessions of PDT.We also found that papular/nodular,cyst/abscess showed higher clearance rate than sinus/¯stula(88.5%,86.1%versus 11.1%).DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients.5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS.The e±cacy increased with more treatment sessions.
基金the support of the National Natural Science Foundation of China(No.32371790)the Fundamental Research Funds for the Central Universities(Nos.2572024AW61 and 2572023CT07)+4 种基金the National Key R&D Program of China(No.2023YFD2201404)China Postdoctoral Science Foundation(No.2020M681067)Special Funding Project of Postdoctoral in Heilongjiang Province(No.LBH-TZ2001)the National Natural Science Foundation of China(No.12302143)the National Key Research and Development Program of China(No.2023YFC3806300).
文摘Using biodegradable material derived from renewable resources as petroleum-based plastics replacement is a promising way towards sustainable development.However,the insufficient mechanical properties and complex manufacturing process of bioplastics still need to be improved for high-quality food packages.Herein,we report a top-down strategy to transform natural wood into a clear wood packaging film through scalable delignification and polyvinyl alcohol(PVA)infiltration.The wood packaging film demonstrates a laminated structure with completely collapsed cell walls and PVA intertwined together after energy-saving air drying,resulting in high light transmittance with low haze,good mechanical performance,and high barrier performance for oxygen and water vapor.Molecular dynamics simulations reveal the underlying fracture mechanism between cellulose and PVA,which effectively enhances the Young’s modulus and strength of the wood packaging film.These findings contribute to the development of biodegradable and strong packaging materials,as well as other food-related applications,using sustainable wood.
