Unfermented jujube pulp(UFJP),fermented jujube pulp(FJP)in high and low doses were fed to constipated ICR mice.Defecation function,serum gastrointestinal regulatory peptide,fecal short-chain fatty acids(SCFAs)and gut ...Unfermented jujube pulp(UFJP),fermented jujube pulp(FJP)in high and low doses were fed to constipated ICR mice.Defecation function,serum gastrointestinal regulatory peptide,fecal short-chain fatty acids(SCFAs)and gut microbial composition were assessed.Results showed that high-dose FJP could protect intestinal mucosa tissue,shorten the first black feces defecating time by 17%and increase the number and wet weights of black feces by 72%and 71%,respectively,within 6 h.High-dose FJP signifi cantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice,compared with low-dose FJP and UFJP.The high-dose FJP intervention regulated the microbiota profi le,which afterwards restored microbiota,like Bacteroidetes,Bifi dobacterium and Lactobacillus,to a less unhealthy state.This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.展开更多
This paper proposes a variational binary level set method for shape and topology optimization of structural.First,a topology optimization problem is presented based on the level set method and an algorithm based on bi...This paper proposes a variational binary level set method for shape and topology optimization of structural.First,a topology optimization problem is presented based on the level set method and an algorithm based on binary level set method is proposed to solve such problem.Considering the difficulties of coordination between the various parameters and efficient implementation of the proposed method,we present a fast algorithm by reducing several parameters to only one parameter,which would substantially reduce the complexity of computation and make it easily and quickly to get the optimal solution.The algorithm we constructed does not need to re-initialize and can produce many new holes automatically.Furthermore,the fast algorithm allows us to avoid the update of Lagrange multiplier and easily deal with constraints,such as piecewise constant,volume and length of the interfaces.Finally,we show several optimum design examples to confirm the validity and efficiency of our method.展开更多
基金supported by the Chinese Universities Scientific Fund(2022TC124)open foundation of Beijing Advanced Innovation Center for Food Nutrition and Human Health.
文摘Unfermented jujube pulp(UFJP),fermented jujube pulp(FJP)in high and low doses were fed to constipated ICR mice.Defecation function,serum gastrointestinal regulatory peptide,fecal short-chain fatty acids(SCFAs)and gut microbial composition were assessed.Results showed that high-dose FJP could protect intestinal mucosa tissue,shorten the first black feces defecating time by 17%and increase the number and wet weights of black feces by 72%and 71%,respectively,within 6 h.High-dose FJP signifi cantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice,compared with low-dose FJP and UFJP.The high-dose FJP intervention regulated the microbiota profi le,which afterwards restored microbiota,like Bacteroidetes,Bifi dobacterium and Lactobacillus,to a less unhealthy state.This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.
基金the support of Zhejiang Provincial Natural Science Foundation of China(No.LQ12A01012)Key Project of the Major Research Plan of NSFC(No.91130004)the Major Projects on Control and Rectification of Water Body Pollution of China(No.2009ZX07424-001).
文摘This paper proposes a variational binary level set method for shape and topology optimization of structural.First,a topology optimization problem is presented based on the level set method and an algorithm based on binary level set method is proposed to solve such problem.Considering the difficulties of coordination between the various parameters and efficient implementation of the proposed method,we present a fast algorithm by reducing several parameters to only one parameter,which would substantially reduce the complexity of computation and make it easily and quickly to get the optimal solution.The algorithm we constructed does not need to re-initialize and can produce many new holes automatically.Furthermore,the fast algorithm allows us to avoid the update of Lagrange multiplier and easily deal with constraints,such as piecewise constant,volume and length of the interfaces.Finally,we show several optimum design examples to confirm the validity and efficiency of our method.
