This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 pat...This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 patients with newly diagnosed MM;among which,270 received bortezomib-based therapies,and 141 received thalidomide-based therapies.Fluorescence in situ hybridization (FISH) was performed to detect six cytogenetic abnormalities,namely,del(1p32.3),gain(1q21),del(17p13),del(13q14),t(4;14),and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly more bone marrow plasma cells (P =0.025),higher β2-microglobulin levels (P =0.036),and higher lactate dehydrogenase levels (P =0.042) than those without del(1p32.3).Univariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies were strongly associated with short progression-free survival (PFS) (median PFS 11.6 vs.31.2 months,P =0.002) and overall survival (OS) (median OS 16.8 vs.45.9 months,P < 0.001).Multivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFS (P =0.006) and OS (P =0.016) for patients under thalidomide-based treatments.Patients with del(1 p32.3) under bortezomib-based treatments tended to have short PFS and OS.In conclusion,del(1p32.3) is associated with short PFS and OS in patients with MM who received thalidomide-or bortezomib-based treatments.展开更多
Pathogenic microorganisms pose a significant threat to water safety.Emerging disinfection processes that combine far-ultraviolet radiation with oxidants offer promising strategies for controlling these pathogens.This ...Pathogenic microorganisms pose a significant threat to water safety.Emerging disinfection processes that combine far-ultraviolet radiation with oxidants offer promising strategies for controlling these pathogens.This study investigated advanced disinfection processes(ADPs)that use 222 and 254 nm far-ultraviolet radiation in conjunction with hydrogen peroxide(H2O2),sodium percarbonate(SPC),and persulfate(PDS)to inactivate E.coli in water.The inactivation efficiencies of E.coli were measured as 6.50-log for UV_(222) alone and 2.50-log for UV_(254) alone at 0.0014 Einstein/L.When using UV_(222)-ADPs,the inactivation ranged from 5.20-log to 6.50-log,while UV_(254)-ADPs achieved inactivation levels of 2.55-log to 2.95-log.The inactivation occurred in the order of UV_(222)≥UV_(222)-ADPs>UV_(254)-ADPs>UV_(254),which was related to photon competition between E.coli and the oxidants,superiority of UV_(222) radiation compared with UV_(254) radiation,and the yields of radicals.When UV_(222) was combined with H2O2,SPC and PDS,the absorption fractions of 222 nm photons by E.coli reduced from 13.7%to 13.1%,12.4%,and 12.2%,respectively,and the actual inactivation also decreased.This reduction was attributed to the light shielding effect of the oxidants.In addition,intracellular organic matter released from ruptured bacterial cell membranes during UV_(222)-ADPs could be further damaged by UV_(222) photons and radicals.The effectiveness of UV_(222)-ADPs was also demonstrated in real water samples.Moreover,it was shown that UV_(222)-ADPs are less susceptible to dissolved organic matter(DOM)than UV_(222) alone.This study provides novel insights into disinfection by UV_(222)-ADPs in water.展开更多
基金We would like to thank the patients who donated multiple myeloma specimens.This work was partially supported by the National Natural Science Foundation of China(Nos.81400080 and 81470305)Leukemia Research Innovation Team of Zhejiang Province(No.2011R50015).
文摘This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 patients with newly diagnosed MM;among which,270 received bortezomib-based therapies,and 141 received thalidomide-based therapies.Fluorescence in situ hybridization (FISH) was performed to detect six cytogenetic abnormalities,namely,del(1p32.3),gain(1q21),del(17p13),del(13q14),t(4;14),and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly more bone marrow plasma cells (P =0.025),higher β2-microglobulin levels (P =0.036),and higher lactate dehydrogenase levels (P =0.042) than those without del(1p32.3).Univariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies were strongly associated with short progression-free survival (PFS) (median PFS 11.6 vs.31.2 months,P =0.002) and overall survival (OS) (median OS 16.8 vs.45.9 months,P < 0.001).Multivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFS (P =0.006) and OS (P =0.016) for patients under thalidomide-based treatments.Patients with del(1 p32.3) under bortezomib-based treatments tended to have short PFS and OS.In conclusion,del(1p32.3) is associated with short PFS and OS in patients with MM who received thalidomide-or bortezomib-based treatments.
基金supported by the National Key R&D Program of China(No.2023YFE0112100)the Marine and Fishery Development Special Fund of Xiamen(China)(No.23YYST064QCB36).
文摘Pathogenic microorganisms pose a significant threat to water safety.Emerging disinfection processes that combine far-ultraviolet radiation with oxidants offer promising strategies for controlling these pathogens.This study investigated advanced disinfection processes(ADPs)that use 222 and 254 nm far-ultraviolet radiation in conjunction with hydrogen peroxide(H2O2),sodium percarbonate(SPC),and persulfate(PDS)to inactivate E.coli in water.The inactivation efficiencies of E.coli were measured as 6.50-log for UV_(222) alone and 2.50-log for UV_(254) alone at 0.0014 Einstein/L.When using UV_(222)-ADPs,the inactivation ranged from 5.20-log to 6.50-log,while UV_(254)-ADPs achieved inactivation levels of 2.55-log to 2.95-log.The inactivation occurred in the order of UV_(222)≥UV_(222)-ADPs>UV_(254)-ADPs>UV_(254),which was related to photon competition between E.coli and the oxidants,superiority of UV_(222) radiation compared with UV_(254) radiation,and the yields of radicals.When UV_(222) was combined with H2O2,SPC and PDS,the absorption fractions of 222 nm photons by E.coli reduced from 13.7%to 13.1%,12.4%,and 12.2%,respectively,and the actual inactivation also decreased.This reduction was attributed to the light shielding effect of the oxidants.In addition,intracellular organic matter released from ruptured bacterial cell membranes during UV_(222)-ADPs could be further damaged by UV_(222) photons and radicals.The effectiveness of UV_(222)-ADPs was also demonstrated in real water samples.Moreover,it was shown that UV_(222)-ADPs are less susceptible to dissolved organic matter(DOM)than UV_(222) alone.This study provides novel insights into disinfection by UV_(222)-ADPs in water.
