The"one drug-multiple targets"paradigm has revolutionized therapeutic development for complex diseases by addressing the limitations of single-target approaches[1].However,elucidating multi-target synergism ...The"one drug-multiple targets"paradigm has revolutionized therapeutic development for complex diseases by addressing the limitations of single-target approaches[1].However,elucidating multi-target synergism remains a major challenge.Network pharmacology(NP)enables polypharmacological investigations through biological networks[2].展开更多
基金supported by the National Key R&D Program of China(2022YFF1203304)the National Natural Science Foundation of China(92474204,32070670,and 32341019)+5 种基金the Ningbo Top Medical and Health Research Program(2023030615 and 2024020919)the Beijing Natural Science Foundation Haidian Origination and Innovation Joint Fund(L222007)the Ningbo Science and Technology Innovation Yongjiang 2035 Project(2023Z226 and 2024Z229)the Major Project of Guangzhou National Laboratory(GZNL2023A03001)the Beijing Nova Program(20240484661)the State Key Laboratory of Systems Medicine for Cancer(KF2422-93).
文摘The"one drug-multiple targets"paradigm has revolutionized therapeutic development for complex diseases by addressing the limitations of single-target approaches[1].However,elucidating multi-target synergism remains a major challenge.Network pharmacology(NP)enables polypharmacological investigations through biological networks[2].
