Background:Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy.It is still unclear whether behavior phenotypes change at different developmental stages in ...Background:Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy.It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system.Methods:Sprague–Dawley rats received a single caudal vein injection of 10 mg/kg polyinosinic:polycytidylic acid(poly I:C)on gestational day 9 and the offspring were comprehensively tested for behaviors in adolescence and adulthood.Results:Maternal serum levels of interleukin(IL)-6,IL-1βand tumor necrosis factor-αwere elevated in poly I:C-treated dams.The offspring of maternal poly I:C-i nduced rats showed increased anxiety,impaired social approach,and progressive impaired cognitive and sensorimotor gating function.Conclusion:Maternal immune activation led to developmental specificity behavioral impairment in offspring.展开更多
基金Xinxiang Medical UniversityGrant/Award Number:2017ZDCG-04+2 种基金National Natural Science Foundation of ChinaGrant/Award Number:81972152 and 82171498Health Commission of Henan Province,Grant/Award Number:201300310200,212102310589 and LHGJ20190482。
文摘Background:Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy.It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system.Methods:Sprague–Dawley rats received a single caudal vein injection of 10 mg/kg polyinosinic:polycytidylic acid(poly I:C)on gestational day 9 and the offspring were comprehensively tested for behaviors in adolescence and adulthood.Results:Maternal serum levels of interleukin(IL)-6,IL-1βand tumor necrosis factor-αwere elevated in poly I:C-treated dams.The offspring of maternal poly I:C-i nduced rats showed increased anxiety,impaired social approach,and progressive impaired cognitive and sensorimotor gating function.Conclusion:Maternal immune activation led to developmental specificity behavioral impairment in offspring.
