Infections of Helicobacter pylori(H.pylori)affect 42.1%of Chinese and 43.1%of the world population.H.pylori inhabits the mucous sublayer at the pylorus,leading to gastric ulcers,gastritis,and even cancer.Oral antibiot...Infections of Helicobacter pylori(H.pylori)affect 42.1%of Chinese and 43.1%of the world population.H.pylori inhabits the mucous sublayer at the pylorus,leading to gastric ulcers,gastritis,and even cancer.Oral antibiotics are usually used to treat H.pylori infections,whereas traditional quadruple therapy has side effects including headaches,nausea,diarrhea,intestinal dysbacteriosis,antibiotic resistance,and repeat infections.Here,a drug-loaded magnetic microbullet was designed to realize long-term retention in the stomach for one-shot treatment for H.pylori infections.It comprises a hollow cylinder wherein eight microneedles homogenously distribute at the top and several round pores located at the bottom.Itwas three-dimensional(3D)-printed by stereolithography.A clarithromycin(CAM)ground mixture(CGM)was prepared to improve solubility.Enough CGM powders were filled into the cylinder,covered by a small round magnet,and sealed to form a CAM-loaded magnetic microbullet(CMMB).CAM continually released from CMMBs for>24 h.With outside magnetic guidance,an oral CMMB targeted the pylorus site and the microneedles immediately headed into the mucosa followed by long-term local drug release.The in vitro and in vivo safety of CMMBs was confirmed,where their swelling rates were low,and the oral CMMB was finally completely evacuated.An oral CMMB was administered to H.pylori-infected mice and maintained in the stomach for 36 h with magnetic guidance,and the successful eradication of H.pylori was confirmed after single-dose administration.Oral CMMBs are a convenient medication for the eradication of H.pylori.展开更多
Thermal conductivity is an important physical parameter in thermal equipment,in the blast furnace,rotary kiln and other equipment,multi-layer cylindrical wall is extremely important in industrial production of a therm...Thermal conductivity is an important physical parameter in thermal equipment,in the blast furnace,rotary kiln and other equipment,multi-layer cylindrical wall is extremely important in industrial production of a thermal conductivity model,its thermal conductivity coefficient determines the ability of the cylindrical wall,which results in the existence of a large number of multi-layer cylinder thermal conductivity problems of the pitfalls.This paper focuses on the establishment of a mathematical model of the multi-layer cylinder thermal conductivity problem,by applying different voltages to the multi-layer cylinder wall,study the temperature distribution of the multi-layer cylinder wall under the conditions of natural convection and forced convection,and draw the line graphs under the conditions of natural convection and forced convection by Origin software,and finally conclude that:under the same conditions,the forced convection is significantly stronger than the natural convection;under the conditions of different voltages,the multi-layer cylinder wall under the conditions of steady state convection,the forced convection is much stronger than natural convection.Under different voltage conditions,the temperature of the multilayer cylinder wall under steady state conditions increases with the increase of voltage,which provides a strong support for the related research.展开更多
China’s credit bond market has rapidly expanded in recent years.However,since 2014,the number of credit bond defaults has been increasing rapidly,posing enormous potential risks to the stability of the financial mark...China’s credit bond market has rapidly expanded in recent years.However,since 2014,the number of credit bond defaults has been increasing rapidly,posing enormous potential risks to the stability of the financial market.This study proposed a deep learning approach to predict credit bond defaults in the Chinese market.A convolutional neural network(CNN)was selected as the classification model and to reduce the extreme imbalance between defaulted and non-defaulted bonds,and a generative adversarial network(GAN)was used as the oversampling model.Based on 31 financial and 20 non-financial indicators,we collected Wind data on all credit bonds issued and matured or defaulted from 2014 to 2021.The experimental results showed that our GAN+CNN approach had superior predictive performance with an area under the curve(AUC)of 0.9157 and precision of 0.8871 compared to previous research and other commonly used classification models-including the logistic regression,support vector machine,and fully connected neural network models-and oversampling techniques-including the synthetic minority oversampling technique(SMOTE)and Borderline SMOTE model.For one-year predictions,indicators of solvency,capital structure,and fundamental properties of bonds are proved to be the most important indicators.展开更多
BACKGROUND Gastric oxyntic gland adenoma is a rare neoplasm often misdiagnosed as a hyperplastic or fundic gland polyp due to nonspecific endoscopic features and the limitations of superficial biopsies,leading to diag...BACKGROUND Gastric oxyntic gland adenoma is a rare neoplasm often misdiagnosed as a hyperplastic or fundic gland polyp due to nonspecific endoscopic features and the limitations of superficial biopsies,leading to diagnostic delays.CASE SUMMARY In 2020,a gastroscopy of a 47-year-old man revealed a 0.5 cm lesion that was diagnosed as a hyperplastic polyp by superficial biopsy.By 2022,the lesion had enlarged to 1.0 cm exhibiting firmness,bleeding tendency,and disrupted sub-mucosal layers on endoscopic ultrasound.Repeat biopsies again suggested hyperplasia.Endoscopic submucosal dissection was performed,confirming the diagnosis of gastric oxyntic gland adenoma.Additional surgical resection con-firmed negative margins,and no recurrence at the three-year postoperative follow-up.However,endoscopic ultrasound revealed localized thickening(1.2 mm)of the muscularis mucosae at the gastric lesser curvature,likely repres-enting post-procedural fibrosis.The patient was clinically asymptomatic,and was advised to continue annual endoscopic monitoring.CONCLUSION This case highlights the necessity of deep biopsy or complete resection for diagnosis.We recommend long-term endoscopic surveillance post-resection and heightened clinical vigilance to mitigate misdiagnosis risks.展开更多
Mucosa-associated lymphoid tissue （MALT） lymphoma has previously been diagnosed only by a histological examination of gastric specimens, which made the diagnosis of MALT lymphoma very difficult. Endoscopic findings ...Mucosa-associated lymphoid tissue （MALT） lymphoma has previously been diagnosed only by a histological examination of gastric specimens, which made the diagnosis of MALT lymphoma very difficult. Endoscopic findings of gastric MALT lymphoma are variable, and current conventional white-light endoscopy cannot distinguish the cancerous tissue of MALT lymphoma frorn inflammation due to its histomorphological similarities. A new endoscopic modality known as linked color imaging （LCI） has been developed that may help in the diagnosis of gastric MALT lymphoma. Here,展开更多
A stable and recyclable of BiOBr/silk fibroincellulose acetate composite film was prepared by blendingwet phase transformation and in situ precipitate technology.The cellulose acetate film modified by silk fibroin for...A stable and recyclable of BiOBr/silk fibroincellulose acetate composite film was prepared by blendingwet phase transformation and in situ precipitate technology.The cellulose acetate film modified by silk fibroin formed a finger-shaped porous structure,which provided a large space for the uniform growth of BiOBr nanosheets and facilitated the shuttle flow of dyes in film.The morphology,phase structure,and optical properties of the composite films were characterized using various techniques,and their photocatalytic performance for dye wastewater was evaluated under visible light irradiation.Results showed that the BiOBr/SF-CA composite film exhibited efficient photocatalytic activity with 99.9%of rhodamine B degradation rate.Moreover,the composite film maintained high catalytic stability because Bi as the active species deposited on the film showed almost no loss.Finally,the possible photocatalytic mechanisms in the BiOBr/SF-CA composite film were speculated through radical-trapping experiments and electron spin resonance testing.展开更多
基金supported by the National Natural Science Foundation of China(82073791).
文摘Infections of Helicobacter pylori(H.pylori)affect 42.1%of Chinese and 43.1%of the world population.H.pylori inhabits the mucous sublayer at the pylorus,leading to gastric ulcers,gastritis,and even cancer.Oral antibiotics are usually used to treat H.pylori infections,whereas traditional quadruple therapy has side effects including headaches,nausea,diarrhea,intestinal dysbacteriosis,antibiotic resistance,and repeat infections.Here,a drug-loaded magnetic microbullet was designed to realize long-term retention in the stomach for one-shot treatment for H.pylori infections.It comprises a hollow cylinder wherein eight microneedles homogenously distribute at the top and several round pores located at the bottom.Itwas three-dimensional(3D)-printed by stereolithography.A clarithromycin(CAM)ground mixture(CGM)was prepared to improve solubility.Enough CGM powders were filled into the cylinder,covered by a small round magnet,and sealed to form a CAM-loaded magnetic microbullet(CMMB).CAM continually released from CMMBs for>24 h.With outside magnetic guidance,an oral CMMB targeted the pylorus site and the microneedles immediately headed into the mucosa followed by long-term local drug release.The in vitro and in vivo safety of CMMBs was confirmed,where their swelling rates were low,and the oral CMMB was finally completely evacuated.An oral CMMB was administered to H.pylori-infected mice and maintained in the stomach for 36 h with magnetic guidance,and the successful eradication of H.pylori was confirmed after single-dose administration.Oral CMMBs are a convenient medication for the eradication of H.pylori.
基金The Natural Science Foundation of Liaoning Province of China(Grant No.2023-MSLH-314)he 2024 Yingkou Institute of Technology Campus level Scientific Research Project(FDL202408)+1 种基金The Foundation of Liaoning Provincial Key Laboratoryof Energy Storageand Utilization(GrantNo.CNNK202406)Yingkou Instituteof Technology campus level research project-Development of food additive supercriticalextraction equipment and fluid transmission systemresearch(Grant No.HX202427).
文摘Thermal conductivity is an important physical parameter in thermal equipment,in the blast furnace,rotary kiln and other equipment,multi-layer cylindrical wall is extremely important in industrial production of a thermal conductivity model,its thermal conductivity coefficient determines the ability of the cylindrical wall,which results in the existence of a large number of multi-layer cylinder thermal conductivity problems of the pitfalls.This paper focuses on the establishment of a mathematical model of the multi-layer cylinder thermal conductivity problem,by applying different voltages to the multi-layer cylinder wall,study the temperature distribution of the multi-layer cylinder wall under the conditions of natural convection and forced convection,and draw the line graphs under the conditions of natural convection and forced convection by Origin software,and finally conclude that:under the same conditions,the forced convection is significantly stronger than the natural convection;under the conditions of different voltages,the multi-layer cylinder wall under the conditions of steady state convection,the forced convection is much stronger than natural convection.Under different voltage conditions,the temperature of the multilayer cylinder wall under steady state conditions increases with the increase of voltage,which provides a strong support for the related research.
基金supported in part by the Emerging Interdisciplinary Project of Central University of Finance and Economics,Beijing,China.
文摘China’s credit bond market has rapidly expanded in recent years.However,since 2014,the number of credit bond defaults has been increasing rapidly,posing enormous potential risks to the stability of the financial market.This study proposed a deep learning approach to predict credit bond defaults in the Chinese market.A convolutional neural network(CNN)was selected as the classification model and to reduce the extreme imbalance between defaulted and non-defaulted bonds,and a generative adversarial network(GAN)was used as the oversampling model.Based on 31 financial and 20 non-financial indicators,we collected Wind data on all credit bonds issued and matured or defaulted from 2014 to 2021.The experimental results showed that our GAN+CNN approach had superior predictive performance with an area under the curve(AUC)of 0.9157 and precision of 0.8871 compared to previous research and other commonly used classification models-including the logistic regression,support vector machine,and fully connected neural network models-and oversampling techniques-including the synthetic minority oversampling technique(SMOTE)and Borderline SMOTE model.For one-year predictions,indicators of solvency,capital structure,and fundamental properties of bonds are proved to be the most important indicators.
基金Supported by the National High Level Chinese Medicine Hospital Clinical Research Funding,No.2025XZYJ04.
文摘BACKGROUND Gastric oxyntic gland adenoma is a rare neoplasm often misdiagnosed as a hyperplastic or fundic gland polyp due to nonspecific endoscopic features and the limitations of superficial biopsies,leading to diagnostic delays.CASE SUMMARY In 2020,a gastroscopy of a 47-year-old man revealed a 0.5 cm lesion that was diagnosed as a hyperplastic polyp by superficial biopsy.By 2022,the lesion had enlarged to 1.0 cm exhibiting firmness,bleeding tendency,and disrupted sub-mucosal layers on endoscopic ultrasound.Repeat biopsies again suggested hyperplasia.Endoscopic submucosal dissection was performed,confirming the diagnosis of gastric oxyntic gland adenoma.Additional surgical resection con-firmed negative margins,and no recurrence at the three-year postoperative follow-up.However,endoscopic ultrasound revealed localized thickening(1.2 mm)of the muscularis mucosae at the gastric lesser curvature,likely repres-enting post-procedural fibrosis.The patient was clinically asymptomatic,and was advised to continue annual endoscopic monitoring.CONCLUSION This case highlights the necessity of deep biopsy or complete resection for diagnosis.We recommend long-term endoscopic surveillance post-resection and heightened clinical vigilance to mitigate misdiagnosis risks.
文摘Mucosa-associated lymphoid tissue （MALT） lymphoma has previously been diagnosed only by a histological examination of gastric specimens, which made the diagnosis of MALT lymphoma very difficult. Endoscopic findings of gastric MALT lymphoma are variable, and current conventional white-light endoscopy cannot distinguish the cancerous tissue of MALT lymphoma frorn inflammation due to its histomorphological similarities. A new endoscopic modality known as linked color imaging （LCI） has been developed that may help in the diagnosis of gastric MALT lymphoma. Here,
基金the financial support by the National Natural Science Foundation of China(Grant No.22202068)Natural Science Foundation in Hunan Province(Grant No.2021JJ30239)Natural Science Foundation for Distinguished Young Scholars in Hunan Province(Grant No.2020JJ2014).
文摘A stable and recyclable of BiOBr/silk fibroincellulose acetate composite film was prepared by blendingwet phase transformation and in situ precipitate technology.The cellulose acetate film modified by silk fibroin formed a finger-shaped porous structure,which provided a large space for the uniform growth of BiOBr nanosheets and facilitated the shuttle flow of dyes in film.The morphology,phase structure,and optical properties of the composite films were characterized using various techniques,and their photocatalytic performance for dye wastewater was evaluated under visible light irradiation.Results showed that the BiOBr/SF-CA composite film exhibited efficient photocatalytic activity with 99.9%of rhodamine B degradation rate.Moreover,the composite film maintained high catalytic stability because Bi as the active species deposited on the film showed almost no loss.Finally,the possible photocatalytic mechanisms in the BiOBr/SF-CA composite film were speculated through radical-trapping experiments and electron spin resonance testing.
