Endoscopic ultrasonography is the most accurate procedure for the evaluation of subepithelial lesions. The finding of a homogeneous, hyperechoic, well-delimited lesion, originating from the third layer of the gastroin...Endoscopic ultrasonography is the most accurate procedure for the evaluation of subepithelial lesions. The finding of a homogeneous, hyperechoic, well-delimited lesion, originating from the third layer of the gastrointestinal tract(submucosa) suggests a benign tumor,generally lipoma. As other differential diagnoses have not been reported, echoendoscopists might not pursue a definitive pathological diagnosis or follow-up the patient. This case series aims to broaden the spectrum of differential diagnosis for duodenal hyperechoic third layer subepithelial lesions by providing four different and relevant pathologies with this echoendoscopic pattern.展开更多
Dysphagia is a common symptom in otolaryngology, but neuromuscular causes are rarely diagnostic hypotheses to be considered. The Myasthenia Gravis is an autoimmune disease which is characterized by muscle weakness tha...Dysphagia is a common symptom in otolaryngology, but neuromuscular causes are rarely diagnostic hypotheses to be considered. The Myasthenia Gravis is an autoimmune disease which is characterized by muscle weakness that can affect the muscles of the face, oral cavity, pharynx or esophagus and may present with swallowing disorders. The authors present the case of a 68-year-old man who went to the emergency department of otolaryngology complaining of dysphagia. After the examination and diagnostic exams, it was diagnosed as Myasthenia Gravis. The authors conclude that the clinical suspicion should not be forgotten in order to initiate timely treatment to the effective control of the disease and complement with functional tests according to the complaints, so that it can be followed up and start rehabilitation of the patient.展开更多
A petawatt facility fully based on noncollinear optical parametric chirped pulse amplification(NOPCPA)technology,Vulcan OPPEL(Vulcan OPCPA PEtawatt Laser),is presented.This system will be coupled with the existing hyb...A petawatt facility fully based on noncollinear optical parametric chirped pulse amplification(NOPCPA)technology,Vulcan OPPEL(Vulcan OPCPA PEtawatt Laser),is presented.This system will be coupled with the existing hybridCPA/OPCPA VULCAN laser system(500 J,500 fs beamline;250 J,ns regime beamline)based on Nd:glass amplification.Its pulse duration(20 times shorter)combined with the system design will allow the auxiliary beamline and its secondary sources to be used as probe beams for longer pulses and their interactions with targets.The newly designed system will be mainly dedicated to electron beam generation,but could also be used to perform a variety of particle acceleration and optical radiation detection experimental campaigns.In this communication,we present the entire beamline design discussing the technology choices and the design supported by extensive simulations for each system section.Finally,we present experimental results and details of our commissioned NOPCPA picosecond front end,delivering 1.5 mJ,~180 nm(1/e^(2))of bandwidth compressed to sub-15 fs.展开更多
We evaluate and demonstrate ultra-broadband near-infrared noncollinear optical parametric amplification in two nonlinear crystals,bismuth borate(Bi BO)and yttrium calcium oxyborate(YCOB),which are not commonly used fo...We evaluate and demonstrate ultra-broadband near-infrared noncollinear optical parametric amplification in two nonlinear crystals,bismuth borate(Bi BO)and yttrium calcium oxyborate(YCOB),which are not commonly used for this application.The spectral bandwidth is of the microjoule level;the amplified signal is≥200 nm,capable of supporting sub-10 fs pulses.These results,supported by numerical simulations,show that these crystals have a great potential as nonlinear media in both low-energy,few-cycle systems and high peak power amplifiers for terawatt to petawatt systems based on noncollinear optical parametric chirped pulse amplification(NOPCPA)or a hybrid.展开更多
文摘Endoscopic ultrasonography is the most accurate procedure for the evaluation of subepithelial lesions. The finding of a homogeneous, hyperechoic, well-delimited lesion, originating from the third layer of the gastrointestinal tract(submucosa) suggests a benign tumor,generally lipoma. As other differential diagnoses have not been reported, echoendoscopists might not pursue a definitive pathological diagnosis or follow-up the patient. This case series aims to broaden the spectrum of differential diagnosis for duodenal hyperechoic third layer subepithelial lesions by providing four different and relevant pathologies with this echoendoscopic pattern.
文摘Dysphagia is a common symptom in otolaryngology, but neuromuscular causes are rarely diagnostic hypotheses to be considered. The Myasthenia Gravis is an autoimmune disease which is characterized by muscle weakness that can affect the muscles of the face, oral cavity, pharynx or esophagus and may present with swallowing disorders. The authors present the case of a 68-year-old man who went to the emergency department of otolaryngology complaining of dysphagia. After the examination and diagnostic exams, it was diagnosed as Myasthenia Gravis. The authors conclude that the clinical suspicion should not be forgotten in order to initiate timely treatment to the effective control of the disease and complement with functional tests according to the complaints, so that it can be followed up and start rehabilitation of the patient.
基金financial support of the European Union’s Horizon 2020 research and innovation programme under grant agreement No.654148(Laserlab Europe)the Euratom research and training program 2014–2018 under grant agreement No.633053+1 种基金the Fundacao para a Ciencia e a Tecnologia(FCT,Lisboa)under grants No.PD/BD/114327/2016framework of the Advanced Program in Plasma Science and Engineering(APPLAuSE,sponsored by FCT under grant No.PD/00505/2012)at Instituto Superior Tecnico(IST)。
文摘A petawatt facility fully based on noncollinear optical parametric chirped pulse amplification(NOPCPA)technology,Vulcan OPPEL(Vulcan OPCPA PEtawatt Laser),is presented.This system will be coupled with the existing hybridCPA/OPCPA VULCAN laser system(500 J,500 fs beamline;250 J,ns regime beamline)based on Nd:glass amplification.Its pulse duration(20 times shorter)combined with the system design will allow the auxiliary beamline and its secondary sources to be used as probe beams for longer pulses and their interactions with targets.The newly designed system will be mainly dedicated to electron beam generation,but could also be used to perform a variety of particle acceleration and optical radiation detection experimental campaigns.In this communication,we present the entire beamline design discussing the technology choices and the design supported by extensive simulations for each system section.Finally,we present experimental results and details of our commissioned NOPCPA picosecond front end,delivering 1.5 mJ,~180 nm(1/e^(2))of bandwidth compressed to sub-15 fs.
基金the European Union’s Horizon 2020 research and innovation program under grant agreement No.871124(Laserlab-Europe)the Euratom research and training program 2014–2018 under grant agreement No.633053+1 种基金the Fundacao para a Ciencia e a Tecnologia(FCT,Lisboa)under grants Nos.PD/BD/114327/2016,PD/BD/135177/2017,PD/BD/135222/2017 and PINFRA/22124/2016the framework of the Advanced Program in Plasma Science and Engineering(APPLAu SE,sponsored by FCT under grant No.PD/00505/2012)at Instituto Superior Técnico(IST)。
文摘We evaluate and demonstrate ultra-broadband near-infrared noncollinear optical parametric amplification in two nonlinear crystals,bismuth borate(Bi BO)and yttrium calcium oxyborate(YCOB),which are not commonly used for this application.The spectral bandwidth is of the microjoule level;the amplified signal is≥200 nm,capable of supporting sub-10 fs pulses.These results,supported by numerical simulations,show that these crystals have a great potential as nonlinear media in both low-energy,few-cycle systems and high peak power amplifiers for terawatt to petawatt systems based on noncollinear optical parametric chirped pulse amplification(NOPCPA)or a hybrid.
