A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a mother.Several factors that influenced the success of the pregnancy in this...A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a mother.Several factors that influenced the success of the pregnancy in this case were analyzed.Favorable factors included:triple positive breast cancer[positive hormone receptors and positive human epidermal growth factor receptor 2],which is more hormosensitive and chemosensitive;absence of metastasis;correct endometrium preparation;and the patient's optimistic attitude and strict health habits.In contrast,the factors against success were:breast cancer;adjuvant breast cancer therapy gonadotoxicity;the age of the patient(>40-year-old);endometriosis;ovarian cyst;hydrosalpinx;submucosal fibroids and the respective associated surgery done for the above-mentioned pathology(all resolved prior to the embryo transfer);and a low quantity of ovules(low ovarian reserve)after ovarian stimulation.This is a very special clinical case of a patient with theoretically low pregnancy success probability due to the consecutive accumulation of gynecological and oncological pathologies,who nonetheless became pregnant and delivered a full-term infant and was able to provide adequate breastfeeding.展开更多
基金Supported by grants from the Instituto CarlosⅢ,Nos.PI11/01377 and ISCⅢ-RETICRD12/0036/0029Government of Catalonia,No.2017SGR-1014
文摘A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a mother.Several factors that influenced the success of the pregnancy in this case were analyzed.Favorable factors included:triple positive breast cancer[positive hormone receptors and positive human epidermal growth factor receptor 2],which is more hormosensitive and chemosensitive;absence of metastasis;correct endometrium preparation;and the patient's optimistic attitude and strict health habits.In contrast,the factors against success were:breast cancer;adjuvant breast cancer therapy gonadotoxicity;the age of the patient(>40-year-old);endometriosis;ovarian cyst;hydrosalpinx;submucosal fibroids and the respective associated surgery done for the above-mentioned pathology(all resolved prior to the embryo transfer);and a low quantity of ovules(low ovarian reserve)after ovarian stimulation.This is a very special clinical case of a patient with theoretically low pregnancy success probability due to the consecutive accumulation of gynecological and oncological pathologies,who nonetheless became pregnant and delivered a full-term infant and was able to provide adequate breastfeeding.
