Background:Prostate cancer is one of the most common diagnosed cancers globally,with early detection crucial for reducing mortality and morbidity.However existing screening methods have limitations,such as invasivenes...Background:Prostate cancer is one of the most common diagnosed cancers globally,with early detection crucial for reducing mortality and morbidity.However existing screening methods have limitations,such as invasiveness and patient discomfort.Spectral detector computed tomography(SDCT)could be an alternative or complementary test for prostate cancer diagnosis because of its material decomposition capabilities.The purpose of this experimental study was to explore the capability of SDCT to accurately measure zinc(Zn)and magnesium(Mg)levels in solutions that simulate clinically relevant concentrations of these elements.Methods:Solutions of zinc and magnesium chloride(50-1200μg/g)were prepared in 10 mL test tubes and scanned using SDCT.A region of interest was selected,and average effective atomic numbers(Z‐effective[Z‐eff])were obtained using IntelliSpace Discovery.Linear regression assessed the relationship between concentration and Z‐eff,with p<0.05.Regression lines,R2 values,and 95%prediction intervals evaluated measurement variability and precision.Results:A strong positive correlation was observed between Zn concentration and Z‐eff(R2=0.99),with the regression equation Z‐eff=7.17þ0.0010�concentration.Similarly,Mg concentration demonstrated a positive correlation with Z‐eff(R2=0.97),with the regression equation Z‐eff=7.14þ0.0002�concentration.The 95%prediction interval showed minimal variability in the data.Conclusions:SDCT effectively differentiates between Zn and Mg within clinically relevant concentration ranges,providing a foundation for further research into its clinical application for prostate cancer diagnosis.展开更多
基金This PhD research project titled Mapping Zinc and Magnesium to Better Evaluate Prostate Health was supported by funding from the School of Medicine at Deakin University.
文摘Background:Prostate cancer is one of the most common diagnosed cancers globally,with early detection crucial for reducing mortality and morbidity.However existing screening methods have limitations,such as invasiveness and patient discomfort.Spectral detector computed tomography(SDCT)could be an alternative or complementary test for prostate cancer diagnosis because of its material decomposition capabilities.The purpose of this experimental study was to explore the capability of SDCT to accurately measure zinc(Zn)and magnesium(Mg)levels in solutions that simulate clinically relevant concentrations of these elements.Methods:Solutions of zinc and magnesium chloride(50-1200μg/g)were prepared in 10 mL test tubes and scanned using SDCT.A region of interest was selected,and average effective atomic numbers(Z‐effective[Z‐eff])were obtained using IntelliSpace Discovery.Linear regression assessed the relationship between concentration and Z‐eff,with p<0.05.Regression lines,R2 values,and 95%prediction intervals evaluated measurement variability and precision.Results:A strong positive correlation was observed between Zn concentration and Z‐eff(R2=0.99),with the regression equation Z‐eff=7.17þ0.0010�concentration.Similarly,Mg concentration demonstrated a positive correlation with Z‐eff(R2=0.97),with the regression equation Z‐eff=7.14þ0.0002�concentration.The 95%prediction interval showed minimal variability in the data.Conclusions:SDCT effectively differentiates between Zn and Mg within clinically relevant concentration ranges,providing a foundation for further research into its clinical application for prostate cancer diagnosis.
