Purpose: To determine architectural differences between classic and occult choroidal neovascularization (CNV) in vivo. Design: Prospective observational case series. Methods: Twenty- two patients with acute CNV underw...Purpose: To determine architectural differences between classic and occult choroidal neovascularization (CNV) in vivo. Design: Prospective observational case series. Methods: Twenty- two patients with acute CNV underwent fluorescein angiography and optical coherence tomography (OCT), which were analyzed by separate blinded observers. Results: In 87.5% of angiographically labeled “ classic” CNV a discreet subretinal lesion corresponding to the neovascular complex could be seen above and separate to the retinal pigment epithelium on OCT. This was found in only 13.3% of “ occult” CNV. Conclusion: With the latest commercially availableOCT equipment it is now possible to confirm in vivo the previously proposed anatomic differences between fluorescein angiographically labeled classic and occultCNV. Classic CNVappear to growpredominantly in the subretinal space, whereas the majority of occult lesions do not. Optical coherence tomography features of CNV may correlate with response to photodynamic therapy or angiostatic treatments, as well as predicting the success of surgical removal.展开更多
Objective. To evaluate usability, accuracy, and hypoglycemia detection of the GlucoWatch G2 Biographer (GW2B) in children aged 1 to 17 years. Methods. After a 15-hour study of device accuracy, 46 children (15 < 7 y...Objective. To evaluate usability, accuracy, and hypoglycemia detection of the GlucoWatch G2 Biographer (GW2B) in children aged 1 to 17 years. Methods. After a 15-hour study of device accuracy, 46 children (15 < 7 years, 31 ≥7 years) with type 1 diabetes were enrolled for an extended-wear outcome study: 2 daytime and 2 nighttime 15-hr wear periods each week and blood glucose monitoring 4 times daily for 3 months. Results. A total of 531 paired GW2B/meter readings were available for accuracy assessment. The correlation coefficients were 0.58 and 0.74 (ages< 7 and ≥7 years, respectively). There was no significant change in hemoglobin A1C or weight-adjusted insulin dose at 3 months after biographer use. Forty-two episodes of hypoglycemia were detected by the GW2B, 33 of which were confirmed by blood glucose meters. Sensitivity and specificity of audible low-glucose alerts were ～79%and 83%, respectively. No significant side effects were reported. Conclusion. The GW2B is usable and safe in children who are < 7 years or older in the home setting. The GW2B can detect asymptomatic nocturnal hypoglycemia in younger children.展开更多
文摘Purpose: To determine architectural differences between classic and occult choroidal neovascularization (CNV) in vivo. Design: Prospective observational case series. Methods: Twenty- two patients with acute CNV underwent fluorescein angiography and optical coherence tomography (OCT), which were analyzed by separate blinded observers. Results: In 87.5% of angiographically labeled “ classic” CNV a discreet subretinal lesion corresponding to the neovascular complex could be seen above and separate to the retinal pigment epithelium on OCT. This was found in only 13.3% of “ occult” CNV. Conclusion: With the latest commercially availableOCT equipment it is now possible to confirm in vivo the previously proposed anatomic differences between fluorescein angiographically labeled classic and occultCNV. Classic CNVappear to growpredominantly in the subretinal space, whereas the majority of occult lesions do not. Optical coherence tomography features of CNV may correlate with response to photodynamic therapy or angiostatic treatments, as well as predicting the success of surgical removal.
文摘Objective. To evaluate usability, accuracy, and hypoglycemia detection of the GlucoWatch G2 Biographer (GW2B) in children aged 1 to 17 years. Methods. After a 15-hour study of device accuracy, 46 children (15 < 7 years, 31 ≥7 years) with type 1 diabetes were enrolled for an extended-wear outcome study: 2 daytime and 2 nighttime 15-hr wear periods each week and blood glucose monitoring 4 times daily for 3 months. Results. A total of 531 paired GW2B/meter readings were available for accuracy assessment. The correlation coefficients were 0.58 and 0.74 (ages< 7 and ≥7 years, respectively). There was no significant change in hemoglobin A1C or weight-adjusted insulin dose at 3 months after biographer use. Forty-two episodes of hypoglycemia were detected by the GW2B, 33 of which were confirmed by blood glucose meters. Sensitivity and specificity of audible low-glucose alerts were ～79%and 83%, respectively. No significant side effects were reported. Conclusion. The GW2B is usable and safe in children who are < 7 years or older in the home setting. The GW2B can detect asymptomatic nocturnal hypoglycemia in younger children.
