Severe forms of coronavirus disease 2019(COVID-19)have been associated with a cytokine storm mainly involving interleukin(IL)-6,IL-1β,and TNF.1,2 Several authors have reported features of macrophage activation,thus c...Severe forms of coronavirus disease 2019(COVID-19)have been associated with a cytokine storm mainly involving interleukin(IL)-6,IL-1β,and TNF.1,2 Several authors have reported features of macrophage activation,thus comparing the cytokine storm of COVID-19 to reactive hemophagocytic lymphohistiocytosis(reHLH).3,4 However,these data have been balanced by other studies primarily involving IL-6 and,therefore,a mechanism closer to the complex immune dysregulation observed in sepsis.5,6 Considering these discrepancies,serum cytokine profiling may not be the best option for assessing COVID-19 severity and prognosis.Serum ferritin,an inflammatory biomarker,is elevated in most COVID-19 patients and has been correlated with severity and mortality.展开更多
文摘Severe forms of coronavirus disease 2019(COVID-19)have been associated with a cytokine storm mainly involving interleukin(IL)-6,IL-1β,and TNF.1,2 Several authors have reported features of macrophage activation,thus comparing the cytokine storm of COVID-19 to reactive hemophagocytic lymphohistiocytosis(reHLH).3,4 However,these data have been balanced by other studies primarily involving IL-6 and,therefore,a mechanism closer to the complex immune dysregulation observed in sepsis.5,6 Considering these discrepancies,serum cytokine profiling may not be the best option for assessing COVID-19 severity and prognosis.Serum ferritin,an inflammatory biomarker,is elevated in most COVID-19 patients and has been correlated with severity and mortality.
