The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process,posing challenges in achieving stable osseointegration.It is thus critical to...The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process,posing challenges in achieving stable osseointegration.It is thus critical to tailor the biodegradation profiles of these implants to establish a conductive tissue microenvironment for bone tissue regeneration.In this study,we demonstrate that Zn-Li alloy forms a layer of Li-containing degradation products at the bone-implant interface to accommodate the bone regeneration process.During the early inflammatory phase,the controlled release of lithium ions(Li^(+))and zinc ions(Zn^(2+))from the alloy induces chemokine(C-C motif)ligand 5(CCL5)production from macrophages,which promotes the recruitment and differentiation of osteoblastic lineage cells.As a protective bone-implant interface is formed subsequently,the active Zn^(2+)release from Zn-Li alloy is suppressed while Li^(+)continues to exhibit anti-inflammatory effects and inhibit osteoclasto-genesis.Therefore,the presence of Li in Zn-based alloy prevents the prolonged inflammation and fibrous cap-sulation typically seen in pure Zn implants.Our findings offer valuable insights into the development of novel biodegradable implants aimed at achieving osseointegration through bioadaption.展开更多
基金supported by National Natural Science Foundation of China/Research Grants Council Joint Research Scheme(N_HKU721/23 to W.Q.and NSFC-RGC 5231101024 to Y.Z.)General Research Fund of the Research Grants Council(17207719,1711322,K.W.K.Y.and 17118425,W.Q.)+7 种基金Hong Kong Innovation Technology Fund(ITS/256/22,W.Q.)Health and Medical Research Fund(21200592,22210832,23220925,K.W.K.Y.,09201466,W.Q.)Collaborative Research Fund of the Research Grants Council(C5044-21G,K.W.K.Y.,C7003-22Y,W.Q.)National Key R&D Program of China(2023YFB3810203,K.W.K.Y)National Natural Sci-ence Foundation of China(U22A20121,51931001,Y.Z.,82201124,W.Q.,32301098,D.S.)Beijing Natural Science Foundation Haidian Orig-inal Innovation Joint Fund(L212014,Y.Z.)Shenzhen Science and Technology Innovation Committee Projects(SGDX20220530111405038 to W.Q.,JCYJ20210324120009026,JCYJ20210324120012034 to K.W.W.Y.)Guangdong Basic and Applied Basic Research Foundation(2023A1515011963,W.Q.).
文摘The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process,posing challenges in achieving stable osseointegration.It is thus critical to tailor the biodegradation profiles of these implants to establish a conductive tissue microenvironment for bone tissue regeneration.In this study,we demonstrate that Zn-Li alloy forms a layer of Li-containing degradation products at the bone-implant interface to accommodate the bone regeneration process.During the early inflammatory phase,the controlled release of lithium ions(Li^(+))and zinc ions(Zn^(2+))from the alloy induces chemokine(C-C motif)ligand 5(CCL5)production from macrophages,which promotes the recruitment and differentiation of osteoblastic lineage cells.As a protective bone-implant interface is formed subsequently,the active Zn^(2+)release from Zn-Li alloy is suppressed while Li^(+)continues to exhibit anti-inflammatory effects and inhibit osteoclasto-genesis.Therefore,the presence of Li in Zn-based alloy prevents the prolonged inflammation and fibrous cap-sulation typically seen in pure Zn implants.Our findings offer valuable insights into the development of novel biodegradable implants aimed at achieving osseointegration through bioadaption.
