A novel 5-（（4-（6,7-dihydrothieno[3,2-c]pyridin-5（4H）-ylsulfonyl）phenylamino）methyl）quinolin-8-ol（HTPSMQol） was synthesized by optimized reaction of 4-（6,7-dihydrothieno[3,2-c]pyridin-5（4H）-ylsulfonyl）ani...A novel 5-（（4-（6,7-dihydrothieno[3,2-c]pyridin-5（4H）-ylsulfonyl）phenylamino）methyl）quinolin-8-ol（HTPSMQol） was synthesized by optimized reaction of 4-（6,7-dihydrothieno[3,2-c]pyridin-5（4H）-ylsulfonyl）aniline with 5-chloromethyl-8-hydroxy-quinoline hydrochloride（CMHQ）.Also complexes of HTPSMQol were prepared by using various M（Ⅱ） metal salts.All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms.The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin.展开更多
A novel series of transition metal complexes have been synthesized from the reaction of 5-（（3-（methylthio）-5-（pyridin-4-yl）-4H- 1,2,4-triazol-4-ylamino）melhyl）quinolm-8-ol with transition metal salts.The struc...A novel series of transition metal complexes have been synthesized from the reaction of 5-（（3-（methylthio）-5-（pyridin-4-yl）-4H- 1,2,4-triazol-4-ylamino）melhyl）quinolm-8-ol with transition metal salts.The structures of these compounds have been elucidated by elemental and spectral analysis.Furthermore,compounds were screened for in vitro antimicrobial activity against the representative panel of two Gram-positive and two Gram-negative bacteria and two strains of fungus.The various compounds show potent inhibitory action against test organisms.展开更多
文摘A novel 5-（（4-（6,7-dihydrothieno[3,2-c]pyridin-5（4H）-ylsulfonyl）phenylamino）methyl）quinolin-8-ol（HTPSMQol） was synthesized by optimized reaction of 4-（6,7-dihydrothieno[3,2-c]pyridin-5（4H）-ylsulfonyl）aniline with 5-chloromethyl-8-hydroxy-quinoline hydrochloride（CMHQ）.Also complexes of HTPSMQol were prepared by using various M（Ⅱ） metal salts.All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms.The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin.
文摘A novel series of transition metal complexes have been synthesized from the reaction of 5-（（3-（methylthio）-5-（pyridin-4-yl）-4H- 1,2,4-triazol-4-ylamino）melhyl）quinolm-8-ol with transition metal salts.The structures of these compounds have been elucidated by elemental and spectral analysis.Furthermore,compounds were screened for in vitro antimicrobial activity against the representative panel of two Gram-positive and two Gram-negative bacteria and two strains of fungus.The various compounds show potent inhibitory action against test organisms.
