Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection,resulting in very high mortality.Dysfunction of the tightly regulated immune response occurs when the body exerts an exacerbate...Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection,resulting in very high mortality.Dysfunction of the tightly regulated immune response occurs when the body exerts an exacerbated hyperinflammatory response that is counteracted by an anti-inflammatory response,which results in immune paralysis if it is sustained for long.Innate lymphoid cells(ILCs)are immune effector cells of lymphoid origin that are devoid of recombination-activating gene-dependent rearranged antigen receptors,as in T and B cells.1 This evolutionary adaptation eliminates the necessity for antigen presentation to activate these cells,and therefore,these cells can rapidly sense and respond to infection and inflammation.ILCs sense tissue injury and pathogen infiltration through numerous cytokine,chemokine,and pattern recognition receptors.ILCs are of lymphoid origin and arise from a common lymphoid progenitor(CLP).展开更多
文摘Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection,resulting in very high mortality.Dysfunction of the tightly regulated immune response occurs when the body exerts an exacerbated hyperinflammatory response that is counteracted by an anti-inflammatory response,which results in immune paralysis if it is sustained for long.Innate lymphoid cells(ILCs)are immune effector cells of lymphoid origin that are devoid of recombination-activating gene-dependent rearranged antigen receptors,as in T and B cells.1 This evolutionary adaptation eliminates the necessity for antigen presentation to activate these cells,and therefore,these cells can rapidly sense and respond to infection and inflammation.ILCs sense tissue injury and pathogen infiltration through numerous cytokine,chemokine,and pattern recognition receptors.ILCs are of lymphoid origin and arise from a common lymphoid progenitor(CLP).
