Background The gut microbiome,colonizing the human gastrointestinal tract,is increasingly recognized for its symbiotic relationship with the immune system in maintaining overall host health.This emerging understanding...Background The gut microbiome,colonizing the human gastrointestinal tract,is increasingly recognized for its symbiotic relationship with the immune system in maintaining overall host health.This emerging understanding raises intriguing questions about potential connections between the gut microbiome and anatomically distant organs,such as the eye,possibly mediated through immune pathways.Main text This review synthesizes contemporary research on ocular diseases with the framework of the burgeoning"gut-eye axis"concept.Investigations spanning from the ocular surface to the fundus suggest correlations between the gut microbiome and various ocular disorders.By elucidating the putative pathogenic mechanisms underlying these ocular conditions,we offer novel perspectives to inform future diagnostic and therapeutic interventions in ophthalmology.Conclusions By presenting a critical analysis of current knowledge regarding the role of gastrointestinal microbiota in ocular health,this review shed light on the complex interplay between gut dysbiosis and eye disorders.Our work endeavors to catalyze interdisciplinary research and foster innovative clinical applications,thereby bridging the gap between the gut microbiota and the ocular well-being.展开更多
Background:The fast development of swept-source optical coherence tomography(SS-OCT)and swept-source optical coherence tomography angiography(SS-OCTA)enables both anterior and posterior imaging of the eye.These techni...Background:The fast development of swept-source optical coherence tomography(SS-OCT)and swept-source optical coherence tomography angiography(SS-OCTA)enables both anterior and posterior imaging of the eye.These techniques have evolved from a research tool to an essential clinical imaging modality.Main text:The longer wavelength and faster speed of SS-OCT and SS-OCTA facilitate better visualization of structure and vasculature below pigmented tissue with a larger field of view of the posterior segment and 360-degree visualization of the anterior segment.In the past 10 years,algorithms dealing with OCT and OCTA data also vastly improved the image quality and enabled the automated quantification of OCT-and OCTA-derived metrics.This technology has enriched our current understanding of healthy and diseased eyes.Even though the high cost of the systems currently limited the widespread use of SS-OCT and SS-OCTA at the first beginning,the gap between research and clinic practice got obviously shortened in the past few years.Conclusions:SS-OCT and SS-OCTA will continue to evolve rapidly,contributing to a paradigm shift toward more widespread adoption of new imaging technology in clinical practice.展开更多
基金supported by the Natural Science Foundation of Zhejiang Province(LTGY24H120002).
文摘Background The gut microbiome,colonizing the human gastrointestinal tract,is increasingly recognized for its symbiotic relationship with the immune system in maintaining overall host health.This emerging understanding raises intriguing questions about potential connections between the gut microbiome and anatomically distant organs,such as the eye,possibly mediated through immune pathways.Main text This review synthesizes contemporary research on ocular diseases with the framework of the burgeoning"gut-eye axis"concept.Investigations spanning from the ocular surface to the fundus suggest correlations between the gut microbiome and various ocular disorders.By elucidating the putative pathogenic mechanisms underlying these ocular conditions,we offer novel perspectives to inform future diagnostic and therapeutic interventions in ophthalmology.Conclusions By presenting a critical analysis of current knowledge regarding the role of gastrointestinal microbiota in ocular health,this review shed light on the complex interplay between gut dysbiosis and eye disorders.Our work endeavors to catalyze interdisciplinary research and foster innovative clinical applications,thereby bridging the gap between the gut microbiota and the ocular well-being.
基金supported by National Natural Youth Science Foundation Project of China(No.82201196).
文摘Background:The fast development of swept-source optical coherence tomography(SS-OCT)and swept-source optical coherence tomography angiography(SS-OCTA)enables both anterior and posterior imaging of the eye.These techniques have evolved from a research tool to an essential clinical imaging modality.Main text:The longer wavelength and faster speed of SS-OCT and SS-OCTA facilitate better visualization of structure and vasculature below pigmented tissue with a larger field of view of the posterior segment and 360-degree visualization of the anterior segment.In the past 10 years,algorithms dealing with OCT and OCTA data also vastly improved the image quality and enabled the automated quantification of OCT-and OCTA-derived metrics.This technology has enriched our current understanding of healthy and diseased eyes.Even though the high cost of the systems currently limited the widespread use of SS-OCT and SS-OCTA at the first beginning,the gap between research and clinic practice got obviously shortened in the past few years.Conclusions:SS-OCT and SS-OCTA will continue to evolve rapidly,contributing to a paradigm shift toward more widespread adoption of new imaging technology in clinical practice.
