Helicobacter pylori(H.pylori)infection is one of the most widely spread infectious diseases in humans.It can cause chronic gastritis,peptic ulcer disease and gastric malignancies and has been associated with extra-gas...Helicobacter pylori(H.pylori)infection is one of the most widely spread infectious diseases in humans.It can cause chronic gastritis,peptic ulcer disease and gastric malignancies and has been associated with extra-gastric disorders.H.pylori elicit a chronic systemic inflammatory response which,under certain conditions,may trigger autoimmune reactions and may be implicated in the pathogenesis of autoimmune diseases.Although the pathogenesis of inflammatory bowel disease(IBD)is unknown,it is thought to result from complex interactions between environmental factors and microbiota in the gut of individuals who are genetically susceptible.Several bacterial and viral agents have been implicated in the aetiology of IBD.In theory,H.pylori infection could be involved in the pathogenesis of IBD by inducing alterations in gastric and/or intestinal permeability or by causing immunological derangements resulting in absorption of antigenic material and autoimmunity via various immunological pathways.Similar mechanisms may also be responsible for the co-existence of IBD with other autoimmune diseases and/or extra-intestinal manifestations.However,the epidemiological data fail to support this association.Infact,various studies indicate that the prevalence of H.pylori infection is low in patients with IBD,suggesting a protective role for this infection in the development of IBD.In this report,we aim to shed light on proposed mechanisms and confounding factors underlying the potential link between H.pylori infection and IBD.展开更多
Purpose: Serum calprotectin and prealbumin have been previously linked with ovarian cancer. However, to date, their effectiveness in the diagnosis of the disease remains uncertain. The purpose of the present study is ...Purpose: Serum calprotectin and prealbumin have been previously linked with ovarian cancer. However, to date, their effectiveness in the diagnosis of the disease remains uncertain. The purpose of the present study is to determine whether serum prealbumin and calprotectin correlate with the stage and type of histologic diagnosis. Materials-Methods: In the present study, we included 80 women aged 30 - 45 years that had either primary ovarian cancer (Stages 1 and 2) with elevated levels of CA-125 (n = 40) or were healthy (n = 40). Serum calprotectin and prealbumin levels were assessed using ELISA kits. Statistical analysis was performed with SPSS v.20.0 statistical software. Results: Both plasma prealbumin and calprotectin levels were significantly different in patients with ovarian cancer compared to healthy controls. Specifically, serum prealbumin levels showed a level towards decreasing as the stage of the disease advanced (21.2 (15.5 - 30.6) in healthy controls, 12.8 (6.9 - 16) for patients with stage 1 disease and 9.9 (4.0 - 15.5) for patients with stage 2 disease p p Conclusions: Both prealbumin and calprotectin seem to be useful markers for the identification of patients suffering from ovarian cancer.展开更多
The distribution of Eocene-Oligocene turbidite facies in the Pindos foreland and the paleocurrent directions of submarine fan deposits,of the Peloponnesus area,document the proximal part of an underfilled foreland bas...The distribution of Eocene-Oligocene turbidite facies in the Pindos foreland and the paleocurrent directions of submarine fan deposits,of the Peloponnesus area,document the proximal part of an underfilled foreland basin.The definition of Pindos foreland basin attributes sediment accommodation solely to flexural subsidence driven by topographic load of the thrust belt and sediment loads in the foreland basin.The restriction of the coarse grained deposits and the basin underfilled conditions are related to the Pindos foreland evolution,and especially to the internal thrusting and produced intrabasinal highs.The presence of strike-slip faults can affect the geometry of a basin by causing changes in depth and width,resulting in the transformation from a uniform to non-uniform configuration.This change has an intensive impact on depositional environments along the basin axis.Strike-slip faults that cross-cut intrabasinal highs produce pathways for the sediment distribution on both sides of the highs.Distributary channels that discharge into the basin are perpendicular to its axis and shift axially at the basin floor.The strikeslip and thrust faulting operated contemporaneously for much of their active periods,although it appears that thrust faulting,initiated slightly earlier than strike-slip faulting.展开更多
文摘Helicobacter pylori(H.pylori)infection is one of the most widely spread infectious diseases in humans.It can cause chronic gastritis,peptic ulcer disease and gastric malignancies and has been associated with extra-gastric disorders.H.pylori elicit a chronic systemic inflammatory response which,under certain conditions,may trigger autoimmune reactions and may be implicated in the pathogenesis of autoimmune diseases.Although the pathogenesis of inflammatory bowel disease(IBD)is unknown,it is thought to result from complex interactions between environmental factors and microbiota in the gut of individuals who are genetically susceptible.Several bacterial and viral agents have been implicated in the aetiology of IBD.In theory,H.pylori infection could be involved in the pathogenesis of IBD by inducing alterations in gastric and/or intestinal permeability or by causing immunological derangements resulting in absorption of antigenic material and autoimmunity via various immunological pathways.Similar mechanisms may also be responsible for the co-existence of IBD with other autoimmune diseases and/or extra-intestinal manifestations.However,the epidemiological data fail to support this association.Infact,various studies indicate that the prevalence of H.pylori infection is low in patients with IBD,suggesting a protective role for this infection in the development of IBD.In this report,we aim to shed light on proposed mechanisms and confounding factors underlying the potential link between H.pylori infection and IBD.
文摘Purpose: Serum calprotectin and prealbumin have been previously linked with ovarian cancer. However, to date, their effectiveness in the diagnosis of the disease remains uncertain. The purpose of the present study is to determine whether serum prealbumin and calprotectin correlate with the stage and type of histologic diagnosis. Materials-Methods: In the present study, we included 80 women aged 30 - 45 years that had either primary ovarian cancer (Stages 1 and 2) with elevated levels of CA-125 (n = 40) or were healthy (n = 40). Serum calprotectin and prealbumin levels were assessed using ELISA kits. Statistical analysis was performed with SPSS v.20.0 statistical software. Results: Both plasma prealbumin and calprotectin levels were significantly different in patients with ovarian cancer compared to healthy controls. Specifically, serum prealbumin levels showed a level towards decreasing as the stage of the disease advanced (21.2 (15.5 - 30.6) in healthy controls, 12.8 (6.9 - 16) for patients with stage 1 disease and 9.9 (4.0 - 15.5) for patients with stage 2 disease p p Conclusions: Both prealbumin and calprotectin seem to be useful markers for the identification of patients suffering from ovarian cancer.
文摘The distribution of Eocene-Oligocene turbidite facies in the Pindos foreland and the paleocurrent directions of submarine fan deposits,of the Peloponnesus area,document the proximal part of an underfilled foreland basin.The definition of Pindos foreland basin attributes sediment accommodation solely to flexural subsidence driven by topographic load of the thrust belt and sediment loads in the foreland basin.The restriction of the coarse grained deposits and the basin underfilled conditions are related to the Pindos foreland evolution,and especially to the internal thrusting and produced intrabasinal highs.The presence of strike-slip faults can affect the geometry of a basin by causing changes in depth and width,resulting in the transformation from a uniform to non-uniform configuration.This change has an intensive impact on depositional environments along the basin axis.Strike-slip faults that cross-cut intrabasinal highs produce pathways for the sediment distribution on both sides of the highs.Distributary channels that discharge into the basin are perpendicular to its axis and shift axially at the basin floor.The strikeslip and thrust faulting operated contemporaneously for much of their active periods,although it appears that thrust faulting,initiated slightly earlier than strike-slip faulting.
