Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the bo...Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the body and complex lesions,which may lead to misjudging in clinical diagnosis.Case report:A 69-year-old man presented with a seven-year history of recurrent generalized polymorphous mucocutaneous lesions(erythematous papules,nodules,ulcers,and necrosis)over his entire body,and the lesions had been painful for the past three years.Based on the past medical history,clinical presentation,histological examination excluded other diseases,and the 2014-amended International Criteria for Behget disease,the patient had a score of 6 points and was diagnosed as Behçet disease.Discussion:The common clinical feature in patients with Behçet syndrome is the presence of recurrent and usually painful mucocutaneous ulcers.Other clinical manifestations of this disorder are more variable among different patients.A diagnosis of generalized polymorphous cutaneous lesions should remain on the list of differential diagnosis of Behçet disease after excluding other diseases.Conclusion:The mucocutaneous lesions of Behçet disease are often preceded by other manifestations,and timely diagnosis may benefit early treatment and prognosis.展开更多
Introduction: Eruptive pruritic papular porokeratosis (EPPP) is a rare variant of porokeratosis. Several cases of this varient of porokeratosis had been reported.Here, we reported an old man with this rare kind of por...Introduction: Eruptive pruritic papular porokeratosis (EPPP) is a rare variant of porokeratosis. Several cases of this varient of porokeratosis had been reported.Here, we reported an old man with this rare kind of porokeratosis which is often eruptive and pruritic.Case report: A 72 years-old Chinese man presented to our hospital with intensively pruritic papular lesions on his trunk and limbs. Physical examination showed numerous scattered keratotic papules measuring 35 mm in diameter on his trunk and extremities. Some coalesced into anannular lesion with a slightly raised peripheral red rim. A tissue biopsy revealed the presence of a cornoid lamella. The patient was diagnosed with EPPP. After 3-months’ treatment of antihistamines and topical steroid agents, the lesions and the pruritus were diminished.Discussion: EPPP predominantly happens in an old male demographic. Patients with EPPP often develop pruritic papules spread on the body with or without preexisting typical porokeratosis lesions, and the lesions can subside within few months, leaving small brown spots or annular lesions. EPPP has the unique histological characteristic of porokeratosis cornoid lamella. The mechanism of EPPP is still unknown. It is important for clinicians to be aware of a disseminated pruritic papules as a manifestation of EPPP.Conclusion: The lesion of porokeratosis can be manifested as eruptive papules with intensive itch. When a patient develops eruptive pruritic papules, it is necessary to consider the possibility of EPPP. Histopathology is necessary for diagnosis.展开更多
Introduction Norwegian scabies is a rare and severe skin disorder caused by scabies mites.Severe public health problems resulted from Norwegian scabies outbreak,had been reported due to the highly contagious character...Introduction Norwegian scabies is a rare and severe skin disorder caused by scabies mites.Severe public health problems resulted from Norwegian scabies outbreak,had been reported due to the highly contagious characteristics[1-2].Also,severe complications such as secondary bacterial infections,severe water and electrolytic disorders,which could lead to fetal outcome,were reported recently in severe Norwegian scabies cases[3].Early diagnose may prevent scabies outbreak and longtime adverse events.However,crusted scabies may be misdiagnosed due to its various and atypical skin lesions.Here,we shared our experience on diagnosis of a patient with Norwegian scabies,who was misdiagnosed as psoriasis and eczema and treated with long term of oral prednisone and methotrexate.展开更多
Objective:Cutaneous and subcutaneous infectious granulorna(CSIG)is a broad group of inflammatory conditions that share important similarities in granulomatous reaction pattem and nonspecific clinical presentation.Here...Objective:Cutaneous and subcutaneous infectious granulorna(CSIG)is a broad group of inflammatory conditions that share important similarities in granulomatous reaction pattem and nonspecific clinical presentation.Here,we conducted the retrospective study to identify the clinical,pathological,and epidemiological correlations of CSIG cases at a signal center in China.Methods:Data of patients diagnosed with CSIG between January 1,2011 and December 31,2015 were retrospectively collected,including socio-demographic information,pathogen diagnosis,clinical features,pathological results,treatment,and prognosis.Results:This study included 256 patients(137 males and 119 females)with a mean age of 52 years.Infections were more common in those aged over 40 years old(76.17%).The most common pathogens were Mycobacterium leprae(26.56%),Sporothrix schenckii(23.83%),and Mycobacterium tuberculosis(15.63%).Mycobacterium marinum(8.98%)accounted for51.11%of nontuberculous mycobactedal contagion.Lesions were most common in the distal extremities(32.03%).The predominant clinical forms were plaques(61/142,42.96%)and nodules(41/142,28.87%).Conclusions:Various pathogens were responsible for the CSIG cases in this study,with M.leprae being the most common.CSIG should be considered as a likely diagnosis for patients with lesions on exposed parts of the body that present as plaques or nodules and has a history of trauma.展开更多
文摘Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the body and complex lesions,which may lead to misjudging in clinical diagnosis.Case report:A 69-year-old man presented with a seven-year history of recurrent generalized polymorphous mucocutaneous lesions(erythematous papules,nodules,ulcers,and necrosis)over his entire body,and the lesions had been painful for the past three years.Based on the past medical history,clinical presentation,histological examination excluded other diseases,and the 2014-amended International Criteria for Behget disease,the patient had a score of 6 points and was diagnosed as Behçet disease.Discussion:The common clinical feature in patients with Behçet syndrome is the presence of recurrent and usually painful mucocutaneous ulcers.Other clinical manifestations of this disorder are more variable among different patients.A diagnosis of generalized polymorphous cutaneous lesions should remain on the list of differential diagnosis of Behçet disease after excluding other diseases.Conclusion:The mucocutaneous lesions of Behçet disease are often preceded by other manifestations,and timely diagnosis may benefit early treatment and prognosis.
文摘Introduction: Eruptive pruritic papular porokeratosis (EPPP) is a rare variant of porokeratosis. Several cases of this varient of porokeratosis had been reported.Here, we reported an old man with this rare kind of porokeratosis which is often eruptive and pruritic.Case report: A 72 years-old Chinese man presented to our hospital with intensively pruritic papular lesions on his trunk and limbs. Physical examination showed numerous scattered keratotic papules measuring 35 mm in diameter on his trunk and extremities. Some coalesced into anannular lesion with a slightly raised peripheral red rim. A tissue biopsy revealed the presence of a cornoid lamella. The patient was diagnosed with EPPP. After 3-months’ treatment of antihistamines and topical steroid agents, the lesions and the pruritus were diminished.Discussion: EPPP predominantly happens in an old male demographic. Patients with EPPP often develop pruritic papules spread on the body with or without preexisting typical porokeratosis lesions, and the lesions can subside within few months, leaving small brown spots or annular lesions. EPPP has the unique histological characteristic of porokeratosis cornoid lamella. The mechanism of EPPP is still unknown. It is important for clinicians to be aware of a disseminated pruritic papules as a manifestation of EPPP.Conclusion: The lesion of porokeratosis can be manifested as eruptive papules with intensive itch. When a patient develops eruptive pruritic papules, it is necessary to consider the possibility of EPPP. Histopathology is necessary for diagnosis.
文摘Introduction Norwegian scabies is a rare and severe skin disorder caused by scabies mites.Severe public health problems resulted from Norwegian scabies outbreak,had been reported due to the highly contagious characteristics[1-2].Also,severe complications such as secondary bacterial infections,severe water and electrolytic disorders,which could lead to fetal outcome,were reported recently in severe Norwegian scabies cases[3].Early diagnose may prevent scabies outbreak and longtime adverse events.However,crusted scabies may be misdiagnosed due to its various and atypical skin lesions.Here,we shared our experience on diagnosis of a patient with Norwegian scabies,who was misdiagnosed as psoriasis and eczema and treated with long term of oral prednisone and methotrexate.
基金supported by grants from Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS-2016-I2M-1–005)National Natural Science Foundation of China(81371751)Natural Science Foundation of Jiangsu Province of China(BK20141065)
文摘Objective:Cutaneous and subcutaneous infectious granulorna(CSIG)is a broad group of inflammatory conditions that share important similarities in granulomatous reaction pattem and nonspecific clinical presentation.Here,we conducted the retrospective study to identify the clinical,pathological,and epidemiological correlations of CSIG cases at a signal center in China.Methods:Data of patients diagnosed with CSIG between January 1,2011 and December 31,2015 were retrospectively collected,including socio-demographic information,pathogen diagnosis,clinical features,pathological results,treatment,and prognosis.Results:This study included 256 patients(137 males and 119 females)with a mean age of 52 years.Infections were more common in those aged over 40 years old(76.17%).The most common pathogens were Mycobacterium leprae(26.56%),Sporothrix schenckii(23.83%),and Mycobacterium tuberculosis(15.63%).Mycobacterium marinum(8.98%)accounted for51.11%of nontuberculous mycobactedal contagion.Lesions were most common in the distal extremities(32.03%).The predominant clinical forms were plaques(61/142,42.96%)and nodules(41/142,28.87%).Conclusions:Various pathogens were responsible for the CSIG cases in this study,with M.leprae being the most common.CSIG should be considered as a likely diagnosis for patients with lesions on exposed parts of the body that present as plaques or nodules and has a history of trauma.
