The potential of 2-amino-1-propanol(AP)as a novel depressant in selectively floating ilmenite from titanaugite under weakly acidic conditions was investigated.Micro-flotation results show that AP significantly reduces...The potential of 2-amino-1-propanol(AP)as a novel depressant in selectively floating ilmenite from titanaugite under weakly acidic conditions was investigated.Micro-flotation results show that AP significantly reduces the recovery of titanaugite while having no evident impact on ilmenite flotation.Subsequent bench-scale flotation tests further confirm a remarkable improvement in separation efficiency upon the introduction of AP.Contact angle and adsorption tests reveal a stronger affinity of AP towards the titanaugite surface in comparison to ilmenite.Zeta potential measurements and X-ray photoelectron spectroscopy(XPS)analyses exhibit favorable adsorption characteristics of AP on titanaugite,resulting from a synergy of electrostatic attraction and chemical interaction.In contrast,electrostatic repulsion hinders any significant interaction between AP and the ilmenite surface.These findings highlight the potential of AP as a highly efficient depressant for ilmenite flotation,paving the way for reduced reliance on sulfuric acid in the industry.展开更多
目的分析国内外文献报道免疫检查点抑制剂(Immune Checkpoint Inhibitors,ICIs)致肠炎的病例特征,为临床识别、诊断和管理此类免疫不良反应提供参考。方法通过检索中国知网、维普网、万方数据、PubMed、Web of Science、Embase、Cochran...目的分析国内外文献报道免疫检查点抑制剂(Immune Checkpoint Inhibitors,ICIs)致肠炎的病例特征,为临床识别、诊断和管理此类免疫不良反应提供参考。方法通过检索中国知网、维普网、万方数据、PubMed、Web of Science、Embase、Cochrane等数据库建库至2025年6月30日报道ICIs致肠炎的不良反应病例文献,提取相关信息并进行统计分析。结果共纳入98篇文献148例患者,其中男性108例,女性40例;中位年龄60(53.75,68.00)岁;原患肿瘤以肺癌(61例)和黑色素瘤(45例)为主,消化系统肿瘤和泌尿生殖系统肿瘤各15例,头颈部肿瘤8例,骨骼肌肉及其他(肩部、腹膜后、胸腺等)肿瘤4例;程序性死亡受体1(PD-1)抑制剂单药治疗121例,程序性死亡配体-1(PD-L1)抑制剂单药治疗2例,CTLA-4抑制剂单药治疗6例,联合治疗10例,不详9例;中位发病时间为当次用ICIs后20.50(7.00,41.00)d;G1~G2级不良反应40例,G3~G4级不良反应108例;肠炎治疗以糖皮质激素(87例)和英夫利西单抗(22例)为主;14例痊愈,103例好转,9例致死,不详22例。结论ICIs使用后若发生肠炎通常较严重,应警惕是否发生免疫性肠炎,密切监测腹泻特征,糖皮质激素冲击治疗有较好的疗效。展开更多
CO2 pyrolysis by thermal plasma was investigated,and a high conversion rate of 33% and energy efficiency of 17% were obtained.The high performance benefited from a novel quenching method,which synergizes the convergin...CO2 pyrolysis by thermal plasma was investigated,and a high conversion rate of 33% and energy efficiency of 17% were obtained.The high performance benefited from a novel quenching method,which synergizes the converging nozzle and cooling tube.To understand the synergy effect,a computational fluid dynamics simulation was carried out.A quick quenching rate of 10~7Ks（-1） could be expected when the pyrolysis gas temperature decreased from more than 3000 to 1000 K.According to the simulation results,the quenching mechanism was discussed as follows： first,the compressible fluid was adiabatically expanded in the converging nozzle and accelerated to sonic speed,and parts of the heat energy converted to convective kinetic energy; second,the sonic fluid jet into the cooling tube formed a strong eddy,which greatly enhanced the heat transfer between the inverse-flowing fluid and cooling tube.These two mechanisms ensure a quick quenching to prevent the reverse reaction of CO2 pyrolysis gas when it flows out from the thermal plasma reactor.展开更多
Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosp...Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic glycolysis.The present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring system.Methods Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was compared.Results The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy volunteers.Furthermore,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)group.All glycolysis-related molecules were positively correlated to the RAE scores.Among these,LAC had a strong correlation.The univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more time-consuming.Conclusion It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present study.The intervention of the glycolytic pathway may provide a potential therapeutic strategy.展开更多
目的分析肺移植后急性肾衰竭(acute renal failure,ARF)的危险因素并建立预测模型。方法本研究的数据来源于美国器官资源共享网络(UNOS)数据库,纳入2015—2022年间接受单侧或双侧肺移植的患者,分析患者在术前和术后的多项临床特征。结...目的分析肺移植后急性肾衰竭(acute renal failure,ARF)的危险因素并建立预测模型。方法本研究的数据来源于美国器官资源共享网络(UNOS)数据库,纳入2015—2022年间接受单侧或双侧肺移植的患者,分析患者在术前和术后的多项临床特征。结合随机森林算法和最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)回归,筛选出与肺移植术后ARF发生相关的关键因素,并据此建立列线图模型。在训练集和验证集中分别评估模型的预测性能,并使用受试者工作特征曲线和曲线下面积(area under the curve,AUC)等指标对模型的效果进行验证和比较。结果纳入15110例肺移植患者,其中男6041例、女9069例,中位年龄为62.00(54.00,67.00)岁。结果表明,术后肾透析与未透析患者术前肺部诊断、预计肾小球滤过率、机械通气、术前是否在ICU接受治疗、体外膜肺氧合支持、术前2周是否感染、Karnofsky功能状态评分、在等待名单上的时间、双肺移植、缺血时间差异均具有统计学意义(P<0.05)。通过随机森林和LASSO回归筛选出与肺移植后ARF相关的5个变量(受体预计肾小球滤过率、术前在ICU治疗、使用体外膜肺氧合、双肺移植和缺血时间),建立了列线图模型。模型评估结果显示,所构建的预测模型在训练集和验证集中均具有较高的准确性,且AUC值表现良好,验证了该模型的有效性和可靠性。结论根据肺移植后ARF常见的危险因素,开发了一个效能良好的预测模型,具有一定的临床应用价值。展开更多
基金supported by the National Key Research and Development Program of China(No.2019YFC1803501)the National Natural Science Foundation of China(No.52074357)+2 种基金the Natural Science Foundation of Hunan Province,China(No.2022JJ30713)the Vanadium Titanium Union Foundationthe Project of Technology Innovation Center for Comprehensive Utilization of Strategic Mineral Resources,Ministry of Natural Resources,China。
文摘The potential of 2-amino-1-propanol(AP)as a novel depressant in selectively floating ilmenite from titanaugite under weakly acidic conditions was investigated.Micro-flotation results show that AP significantly reduces the recovery of titanaugite while having no evident impact on ilmenite flotation.Subsequent bench-scale flotation tests further confirm a remarkable improvement in separation efficiency upon the introduction of AP.Contact angle and adsorption tests reveal a stronger affinity of AP towards the titanaugite surface in comparison to ilmenite.Zeta potential measurements and X-ray photoelectron spectroscopy(XPS)analyses exhibit favorable adsorption characteristics of AP on titanaugite,resulting from a synergy of electrostatic attraction and chemical interaction.In contrast,electrostatic repulsion hinders any significant interaction between AP and the ilmenite surface.These findings highlight the potential of AP as a highly efficient depressant for ilmenite flotation,paving the way for reduced reliance on sulfuric acid in the industry.
文摘目的分析国内外文献报道免疫检查点抑制剂(Immune Checkpoint Inhibitors,ICIs)致肠炎的病例特征,为临床识别、诊断和管理此类免疫不良反应提供参考。方法通过检索中国知网、维普网、万方数据、PubMed、Web of Science、Embase、Cochrane等数据库建库至2025年6月30日报道ICIs致肠炎的不良反应病例文献,提取相关信息并进行统计分析。结果共纳入98篇文献148例患者,其中男性108例,女性40例;中位年龄60(53.75,68.00)岁;原患肿瘤以肺癌(61例)和黑色素瘤(45例)为主,消化系统肿瘤和泌尿生殖系统肿瘤各15例,头颈部肿瘤8例,骨骼肌肉及其他(肩部、腹膜后、胸腺等)肿瘤4例;程序性死亡受体1(PD-1)抑制剂单药治疗121例,程序性死亡配体-1(PD-L1)抑制剂单药治疗2例,CTLA-4抑制剂单药治疗6例,联合治疗10例,不详9例;中位发病时间为当次用ICIs后20.50(7.00,41.00)d;G1~G2级不良反应40例,G3~G4级不良反应108例;肠炎治疗以糖皮质激素(87例)和英夫利西单抗(22例)为主;14例痊愈,103例好转,9例致死,不详22例。结论ICIs使用后若发生肠炎通常较严重,应警惕是否发生免疫性肠炎,密切监测腹泻特征,糖皮质激素冲击治疗有较好的疗效。
基金the funding of National Natural Science Foundation of China (Grant No.11775155)
文摘CO2 pyrolysis by thermal plasma was investigated,and a high conversion rate of 33% and energy efficiency of 17% were obtained.The high performance benefited from a novel quenching method,which synergizes the converging nozzle and cooling tube.To understand the synergy effect,a computational fluid dynamics simulation was carried out.A quick quenching rate of 10~7Ks（-1） could be expected when the pyrolysis gas temperature decreased from more than 3000 to 1000 K.According to the simulation results,the quenching mechanism was discussed as follows： first,the compressible fluid was adiabatically expanded in the converging nozzle and accelerated to sonic speed,and parts of the heat energy converted to convective kinetic energy; second,the sonic fluid jet into the cooling tube formed a strong eddy,which greatly enhanced the heat transfer between the inverse-flowing fluid and cooling tube.These two mechanisms ensure a quick quenching to prevent the reverse reaction of CO2 pyrolysis gas when it flows out from the thermal plasma reactor.
基金This work was supported by grants from the National Natural Science Foundation of China(No.62171193)the Natural Science Foundation of Hubei Province(No.2021CFB399)+1 种基金the Foundation of Health Commission of Hubei Province(No.WJ2021M125)the Key Research and Development Project of Hubei Province of China(No.2022BCA033).
文摘Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic glycolysis.The present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring system.Methods Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was compared.Results The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy volunteers.Furthermore,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)group.All glycolysis-related molecules were positively correlated to the RAE scores.Among these,LAC had a strong correlation.The univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more time-consuming.Conclusion It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present study.The intervention of the glycolytic pathway may provide a potential therapeutic strategy.
文摘目的分析肺移植后急性肾衰竭(acute renal failure,ARF)的危险因素并建立预测模型。方法本研究的数据来源于美国器官资源共享网络(UNOS)数据库,纳入2015—2022年间接受单侧或双侧肺移植的患者,分析患者在术前和术后的多项临床特征。结合随机森林算法和最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)回归,筛选出与肺移植术后ARF发生相关的关键因素,并据此建立列线图模型。在训练集和验证集中分别评估模型的预测性能,并使用受试者工作特征曲线和曲线下面积(area under the curve,AUC)等指标对模型的效果进行验证和比较。结果纳入15110例肺移植患者,其中男6041例、女9069例,中位年龄为62.00(54.00,67.00)岁。结果表明,术后肾透析与未透析患者术前肺部诊断、预计肾小球滤过率、机械通气、术前是否在ICU接受治疗、体外膜肺氧合支持、术前2周是否感染、Karnofsky功能状态评分、在等待名单上的时间、双肺移植、缺血时间差异均具有统计学意义(P<0.05)。通过随机森林和LASSO回归筛选出与肺移植后ARF相关的5个变量(受体预计肾小球滤过率、术前在ICU治疗、使用体外膜肺氧合、双肺移植和缺血时间),建立了列线图模型。模型评估结果显示,所构建的预测模型在训练集和验证集中均具有较高的准确性,且AUC值表现良好,验证了该模型的有效性和可靠性。结论根据肺移植后ARF常见的危险因素,开发了一个效能良好的预测模型,具有一定的临床应用价值。
