Heavy metal contamination in water sources is a widespread global concern,particularly in developing nations,with various treatment approaches under extensive scientific investigation.In the present study,we fabricate...Heavy metal contamination in water sources is a widespread global concern,particularly in developing nations,with various treatment approaches under extensive scientific investigation.In the present study,we fabricated electrospun composite polyvinylidene fluoride(PVDF)nanofibrous membranes exhibiting hierarchical surface roughness and superhydrophobicity for the removal of heavy metal ions via vacuum membrane distillation(VMD)process.The membranes were prepared by incorporating optimized dosing of silica nanoparticles,followed by a two-step membrane modification approach.These membranes exhibited notable characteristics,including elevated water contact angle(152.8±3.2°),increased liquid entry pressure(127±6 kPa),and reduced average pore size(0.28±0.03μm).The study demonstrated the efficacy of fabricated membranes in VMD process,specifically for the removal of heavy metals such as arsenic and iron from aqueous solutions.The membrane produced stable permeate flux of 12.7 kg⋅m^(-2)⋅h^(-1) for arsenic-containing feed and 13.2 kg⋅m^(-2)⋅h^(-1) for iron-containing feed,and excellent rejection of>99.9%over a 12-h testing period without any observed wetting of membrane pores.These performance results were compared with those of typical commercial PVDF and pristine electrospun PVDF membranes.Consequently,the developed membrane demonstrated high efficiency and scalability as a water treatment option,showing significant potential for industrial heavy metal removal and the treatment of contaminated groundwater.展开更多
A diverse array of microbes in and on the human body constitute the microbiota.These micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in h...A diverse array of microbes in and on the human body constitute the microbiota.These micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and illnesses.Any biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human diseases.Plant metabolites are continually being used to treat various illnesses.These metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human diseases.Despite the paramount therapeutic significance of the factors affecting host-microbiota interactions,a comprehensive overview of the modulatory role of plant-derived metabolites in host-microbiota interactions is lacking.The current review puts an effort into comprehending the role of medicinal plants in gut microbiota modulation to mitigate various human illnesses.It would develop a holistic understanding of hostmicrobiota interactions and the role of effectors in health and diseases.展开更多
Metabolic dysfunction-associated steatotic liver disease(MASLD)is a widespread and potentially severe liver condition characterized by abnormal fat accumulation in the liver unrelated to alcohol consumption.According ...Metabolic dysfunction-associated steatotic liver disease(MASLD)is a widespread and potentially severe liver condition characterized by abnormal fat accumulation in the liver unrelated to alcohol consumption.According to the World Health Organization,MASLD is the most prevalent liver disease globally,it affects approximately 25% of the world’s population,nearly two billion individuals.This staggering prevalence underscores the urgent need for effective and safe therapeutic approaches to address this escalating global health concern.Natural products have emerged as promising candidates for preventing and treating MASLD in recent years because of their diverse bioactive compounds and minimal side effects.Well-known natural products such as curcumin,resveratrol,green tea polyphenols,and silymarin exhibit notable hepatoprotective effects by influencing lipid metabolism,mitigating oxidative stress,and reducing inflammation.Ongoing research highlights the potential of phytochemicals from traditional medicinal plants,such as Phyllanthus and Salvia,in ameliorating liver steatosis and fibrosis.These natural products demonstrate the capacity to impede fibrogenesis by interfering with hepatic stellate cell activation,which is pivotal in liver fibrosis development.Recent studies underscore the significance of natural products in modulating the gut-liver axis,where they restore balance to the gut microbiota and enhance intestinal barrier function,which slows the progression of MASLD.Moreover,advancements in nanotechnology facilitate the targeted delivery of natural product-derived compounds,which enhances their bioavailability and therapeutic efficacy.Harnessing the potency of natural products offers a promising avenue for developing novel,safer therapies for MASLD and addressing a critical global health concern with far-reaching implications for public well-being.展开更多
文摘Heavy metal contamination in water sources is a widespread global concern,particularly in developing nations,with various treatment approaches under extensive scientific investigation.In the present study,we fabricated electrospun composite polyvinylidene fluoride(PVDF)nanofibrous membranes exhibiting hierarchical surface roughness and superhydrophobicity for the removal of heavy metal ions via vacuum membrane distillation(VMD)process.The membranes were prepared by incorporating optimized dosing of silica nanoparticles,followed by a two-step membrane modification approach.These membranes exhibited notable characteristics,including elevated water contact angle(152.8±3.2°),increased liquid entry pressure(127±6 kPa),and reduced average pore size(0.28±0.03μm).The study demonstrated the efficacy of fabricated membranes in VMD process,specifically for the removal of heavy metals such as arsenic and iron from aqueous solutions.The membrane produced stable permeate flux of 12.7 kg⋅m^(-2)⋅h^(-1) for arsenic-containing feed and 13.2 kg⋅m^(-2)⋅h^(-1) for iron-containing feed,and excellent rejection of>99.9%over a 12-h testing period without any observed wetting of membrane pores.These performance results were compared with those of typical commercial PVDF and pristine electrospun PVDF membranes.Consequently,the developed membrane demonstrated high efficiency and scalability as a water treatment option,showing significant potential for industrial heavy metal removal and the treatment of contaminated groundwater.
基金financial support under Maharshi Dayanand University Rohtak for a Post-Seed Research Grant(DRD/23/75)sanctioned to Dr.NS Chauhan.
文摘A diverse array of microbes in and on the human body constitute the microbiota.These micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and illnesses.Any biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human diseases.Plant metabolites are continually being used to treat various illnesses.These metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human diseases.Despite the paramount therapeutic significance of the factors affecting host-microbiota interactions,a comprehensive overview of the modulatory role of plant-derived metabolites in host-microbiota interactions is lacking.The current review puts an effort into comprehending the role of medicinal plants in gut microbiota modulation to mitigate various human illnesses.It would develop a holistic understanding of hostmicrobiota interactions and the role of effectors in health and diseases.
文摘Metabolic dysfunction-associated steatotic liver disease(MASLD)is a widespread and potentially severe liver condition characterized by abnormal fat accumulation in the liver unrelated to alcohol consumption.According to the World Health Organization,MASLD is the most prevalent liver disease globally,it affects approximately 25% of the world’s population,nearly two billion individuals.This staggering prevalence underscores the urgent need for effective and safe therapeutic approaches to address this escalating global health concern.Natural products have emerged as promising candidates for preventing and treating MASLD in recent years because of their diverse bioactive compounds and minimal side effects.Well-known natural products such as curcumin,resveratrol,green tea polyphenols,and silymarin exhibit notable hepatoprotective effects by influencing lipid metabolism,mitigating oxidative stress,and reducing inflammation.Ongoing research highlights the potential of phytochemicals from traditional medicinal plants,such as Phyllanthus and Salvia,in ameliorating liver steatosis and fibrosis.These natural products demonstrate the capacity to impede fibrogenesis by interfering with hepatic stellate cell activation,which is pivotal in liver fibrosis development.Recent studies underscore the significance of natural products in modulating the gut-liver axis,where they restore balance to the gut microbiota and enhance intestinal barrier function,which slows the progression of MASLD.Moreover,advancements in nanotechnology facilitate the targeted delivery of natural product-derived compounds,which enhances their bioavailability and therapeutic efficacy.Harnessing the potency of natural products offers a promising avenue for developing novel,safer therapies for MASLD and addressing a critical global health concern with far-reaching implications for public well-being.
