Objective: to analyze the effect of rehabilitation nursing on neurological function of patients with epilepsy secondary to stroke. Methods: 74 patients with epilepsy secondary to stroke admitted to our hospital from M...Objective: to analyze the effect of rehabilitation nursing on neurological function of patients with epilepsy secondary to stroke. Methods: 74 patients with epilepsy secondary to stroke admitted to our hospital from March 2018 to April 2020 were included in the study and randomly divided into study group and control group with 37 patients with epilepsy secondary to stroke respectively. Routine nursing was given to the control group and rehabilitation nursing was given to the patients in the study group. Before and after nursing, the neurological function and health status, future view, cognitive function, physical function, emotional function and other dimensions of quality of life were compared between the two groups. Results: before nursing, there was no significant difference in neurological function between the two groups of patients with epilepsy secondary to stroke. After nursing, the improvement of neurological function in the study group was significantly better than that in the control group, with significant difference (P < 0.05). The scores of quality of life, health status, future view, cognitive function, physical function, emotional function and other dimensions of patients with epilepsy secondary to stroke in the study group were significantly better than those in the control group, the difference was statistically significant (P < 0.05). Conclusion: the application of rehabilitation nursing to the clinical nursing of patients with epilepsy secondary to stroke can effectively improve the neurological function of the patients and effectively improve the scores of all dimensions of the patient's quality of life. The application effect is excellent and should be popularized and applied in the future clinical nursing.展开更多
Objective: to analyze the application effect of personalized psychological nursing intervention in nursing care of senile cerebral infarction. Methods: many patients with cerebral infarction in our hospital since 2018...Objective: to analyze the application effect of personalized psychological nursing intervention in nursing care of senile cerebral infarction. Methods: many patients with cerebral infarction in our hospital since 2018 were selected and randomly classified. According to different treatment methods, they were treated and cared and their mental health level and treatment effect were compared. The first group was given some routine nursing intervention without extra treatment. The second group was given individualized nursing, and the differences between them were compared. The results showed that there was no significant difference in mental health level between the two groups before nursing, but the physical health level of patients who could receive special care after nursing was obviously better than that of those who did not receive special care, and the difference was relatively large. According to the statistical significance, some personalized nursing for the elderly can improve the mental health of patients to a certain extent, improve the treatment effect and relieve the pain of patients and their families. The application effect is particularly good, which can be applied and popularized in future clinical nursing.展开更多
Insulin-like growth factor 1(IGF1)is a regulator of both cellular hypertrophy and lipogenesis,which are two key processes for pathogenesis of obesity.However,the in vivo role of IGF1 in the development of obesity rema...Insulin-like growth factor 1(IGF1)is a regulator of both cellular hypertrophy and lipogenesis,which are two key processes for pathogenesis of obesity.However,the in vivo role of IGF1 in the development of obesity remains unclear.Here,we show that IGF1 expression is increased in adipose tissue in obese human patients and animal models.Elevation of IGF1 is associated with increased lipogenic gene expression and decreased energy expenditure.Genetic down-regulation of IGF1 normalizes lipogenic gene expression,restores aberrant energy metabolism and alleviates obese phenotype of a genetic mouse model with IGF1-hypersecretion.Importantly,genetic down-regulation of IGF1 exerts similar effects on development of diet-induced obesity.Furthermore,berberine that is an AMP-activated protein kinase(AMPK)activator in medicinal herbs inhibits IGF1 secretion,decreases lipogenic gene expression and alleviates diet-induced adiposity.Collectively,our findings demonstrate that hypersecretion of IGF1 is a critical factor for the development of obesity and can be targeted using AMPK activators to alleviate obesity.展开更多
目的目前关于医疗机构工作人员是否需要戴口罩仍存在较大争议,本研究意在评价和总结针对这一问题的现有最佳证据,以期为临床医务工作人员使用口罩提供参考。方法计算机检索PubMed、Cochrane图书馆、Web of Science、CINAHL、中国知网、...目的目前关于医疗机构工作人员是否需要戴口罩仍存在较大争议,本研究意在评价和总结针对这一问题的现有最佳证据,以期为临床医务工作人员使用口罩提供参考。方法计算机检索PubMed、Cochrane图书馆、Web of Science、CINAHL、中国知网、万方、维普、中国生物医学文献数据库,指南数据库平台及相关专业学会组织,检索时限为建库至2019年10月27日,以获取相关指南、专家共识、系统评价,应用国际公认的质量评价工具对纳入的证据进行质量评价,汇总现有证据对医疗机构人员是否需要戴口罩这一问题的相关推荐内容。结果共纳入35篇文献,其中6篇指南,27篇专家共识,2篇系统评价,证据质量整体较高。现有证据均推荐使用口罩作为个人防护措施之一,且与不使用呼吸防护设备相比,戴口罩在预防院内感染方面具有明显的优势,并根据不同的应用情景如手术区域、实验室区、产科等提出多项推荐意见。结论现有证据充分认可戴口罩作为个人防护措施之一在医疗机构中预防院内感染的重要作用。但本研究纳入的证据质量仍有一定的局限性。临床医务工作人员应当结合自身工作经验、临床实际情况等因素综合考虑,合理、规范使用口罩。展开更多
Single-atom catalysts(SACs)have become an emerging frontier trend in the field of heterogeneous catalysis due to their high activity,selectivity and stability.SACs could greatly increase the availabilities of the acti...Single-atom catalysts(SACs)have become an emerging frontier trend in the field of heterogeneous catalysis due to their high activity,selectivity and stability.SACs could greatly increase the availabilities of the active metal atoms in many catalytic reactions by reducing the size to single atom scale.Graphene-supported metal SACs have also drawn considerable attention due to the unique lattice structure and physicochemical properties of graphene,resulting in superior activity and selectivity for several chemical reactions.In this paper,we review recent progress in the fabrications,advanced characterization tools and advantages of graphene-supported metal SACs,focusing on their applications in catalytic reactions such as CO oxidation,the oxidation of benzene to phenol,hydrogen evolution reaction,methanol oxidation reaction,oxygen reduction reaction,hydrogenation and photoelectrocatalysis.We also propose the development of SACs towards industrialization in the future.展开更多
Energy status is linked to the production of reactive oxygen species(ROS)in macrophages,which is elevated in obesity.However,it is unclear how ROS production is upregulated in macrophages in response to energy overloa...Energy status is linked to the production of reactive oxygen species(ROS)in macrophages,which is elevated in obesity.However,it is unclear how ROS production is upregulated in macrophages in response to energy overload for mediating the development of obesity.Here,we show that the Rab-GTPase activating protein(Rab GAP)TBC1D1,a substrate of the energy sensor AMP-activated protein kinase(AMPK),is a critical regulator of macrophage ROS production and consequent adipose inflammation for obesity development.TBC1D1 deletion decreases,whereas an energy overload-mimetic non-phosphorylatable TBC1D1^(S231A)Amutation increases,ROS production and M1-like polarization in macrophages.Mechanistically,TBC1D1 and its downstream target Rab8a form an energy-responsive complex with NOX2 for ROS generation.Transplantation of TBC1D1^(S231A)bone marrow aggravates diet-induced obesity whereas treatment with an ultra-stable Tt SOD for removal of ROS selectively in macrophages alleviates both TBC1D1~(S231A)mutation-and diet-induced obesity.Our findings therefore have implications for drug discovery to combat obesity.展开更多
Self-powered full-spectrum photodetectors(PDs)offer numerous advantages,such as broad application fields,high precision,efficiency,and multi-functionality,which represent a highly promising and potentially valuable cl...Self-powered full-spectrum photodetectors(PDs)offer numerous advantages,such as broad application fields,high precision,efficiency,and multi-functionality,which represent a highly promising and potentially valuable class of detectors for future development.However,insensitive response to solar-blind ultraviolet(UV)and complex and expensive preparation processes greatly limit their performance and practical application.In this study,a self-powered full-spectrum Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si heterojunction PD with high sensitivity for solar-blind UV band prepared by a simple and low-cost two-step synthesis method is presented.Experiments results reveal that the developed PD has an excellent performance,such as high sensitivity from 200 to 850 nm,and a responsivity of 1.38 mA/W as well as a detectivity of 3.22×10^(10) Jones under 254 nm light at zero bias.Additionally,the unencapsulated device displays exceptional stability and imaging capabilities.It is expected that Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si heterojunction PD with a simple and low-cost synthesis method has great potential for self-powered full-spectrum photodetectors.展开更多
The highly ordered film assembled by regularly 1D nanostructures has potentialprospects in electronic,photoelectronic and other fields because of its excellentlight-trapping effect and electronic transport property.Ho...The highly ordered film assembled by regularly 1D nanostructures has potentialprospects in electronic,photoelectronic and other fields because of its excellentlight-trapping effect and electronic transport property.However,the controlledgrowth of highly ordered film remains a great challenge.Herein,large-area andhighly ordered Bi_(2)S_(3) film is synthesized on fluorophlogopite mica substrate bychemical vapor deposition method.The Bi2S3 film features hollowed-outcrosslinked network structure,assembled by 1D nanobelts that regularly distributein three orientations,which agrees well with the first principles calculations.Based on the as-grown Bi_(2)S_(3) film,the broadband photodetector with a responserange from 365 to 940 nm is fabricated,exhibiting a maximum responsivity upto 98.51 mA W^(–1),specific detectivity of 2.03×10^(10)Jones and fast response timeof 35.19 ms.The stable instantaneous on/off behavior for 500 cycles and reliablephotoresponse characteristics of the Bi_(2)S_(3) photodetector after storage in air for6 months confirm its excellent long-term stability and air stability.Significantly,as sensing pixel and signal receiving terminal,the device successfully achieveshigh-resolution imaging of characters of“H”,“I”and“T”,and secure transmissionof confidential information.This work shows a great potential of the largeareaand highly ordered Bi_(2)S_(3) film toward the development of future multiplefunctional photoelectronic applications.展开更多
Obesity is a major pathological factor that induces insulin resistance and consequent type 2 diabetes through multiple mechanisms.Inactivation of the insulin receptor(INSR)contributes to the development of insulin res...Obesity is a major pathological factor that induces insulin resistance and consequent type 2 diabetes through multiple mechanisms.Inactivation of the insulin receptor(INSR)contributes to the development of insulin resistance,whose protein level is down-regulated in obesity through as yet-undefined mechanisms.Here we show that the E3-ligase TRAF6 is a critical regulator of INSR maturation,whose inactivation prevents palmitic acid-or high-fat diet-induced diminution of the INSR.Consequently,genetic inactivation of TRAF6 enhances insulin signaling that further increases muscle glucose uptake and inhibits hepatic gluconeogenesis.TRAF6 inactivation increases the proprotein convertase FURIN that controls the processing of pro-INSR to mature INSR.Mechanistically,TRAF6 associates with the Golgi apparatus,where it ubiquitinates the cytosolic tail of FURIN,leading to its lysosomal degradation.This TRAF6-FURIN axis also regulates cholesterol metabolism via PCSK9 processing in the circulation.Collectively,our results reveal a critical role of TRAF6 in regulating proprotein processing and have therapeutic implications for metabolic control.展开更多
文摘Objective: to analyze the effect of rehabilitation nursing on neurological function of patients with epilepsy secondary to stroke. Methods: 74 patients with epilepsy secondary to stroke admitted to our hospital from March 2018 to April 2020 were included in the study and randomly divided into study group and control group with 37 patients with epilepsy secondary to stroke respectively. Routine nursing was given to the control group and rehabilitation nursing was given to the patients in the study group. Before and after nursing, the neurological function and health status, future view, cognitive function, physical function, emotional function and other dimensions of quality of life were compared between the two groups. Results: before nursing, there was no significant difference in neurological function between the two groups of patients with epilepsy secondary to stroke. After nursing, the improvement of neurological function in the study group was significantly better than that in the control group, with significant difference (P < 0.05). The scores of quality of life, health status, future view, cognitive function, physical function, emotional function and other dimensions of patients with epilepsy secondary to stroke in the study group were significantly better than those in the control group, the difference was statistically significant (P < 0.05). Conclusion: the application of rehabilitation nursing to the clinical nursing of patients with epilepsy secondary to stroke can effectively improve the neurological function of the patients and effectively improve the scores of all dimensions of the patient's quality of life. The application effect is excellent and should be popularized and applied in the future clinical nursing.
文摘Objective: to analyze the application effect of personalized psychological nursing intervention in nursing care of senile cerebral infarction. Methods: many patients with cerebral infarction in our hospital since 2018 were selected and randomly classified. According to different treatment methods, they were treated and cared and their mental health level and treatment effect were compared. The first group was given some routine nursing intervention without extra treatment. The second group was given individualized nursing, and the differences between them were compared. The results showed that there was no significant difference in mental health level between the two groups before nursing, but the physical health level of patients who could receive special care after nursing was obviously better than that of those who did not receive special care, and the difference was relatively large. According to the statistical significance, some personalized nursing for the elderly can improve the mental health of patients to a certain extent, improve the treatment effect and relieve the pain of patients and their families. The application effect is particularly good, which can be applied and popularized in future clinical nursing.
基金supported by the Ministry of Science and Technology of China(2021YFF0702100 and 2018YFA0801100 to S.C.and H.Y.W.)the National Natural Science Foundation of China(32025019 to S.C.,32400986 to P.R.)+2 种基金the Science and Technology Foundation of Jiangsu Province of China(BK20243041(Key Research Program))the Fundamental Research Funds for the Central Universities(021414380533 to S.C.)the Program A for Outstanding Ph D candidates of Nanjing University(202001A013 to P.R.)。
文摘Insulin-like growth factor 1(IGF1)is a regulator of both cellular hypertrophy and lipogenesis,which are two key processes for pathogenesis of obesity.However,the in vivo role of IGF1 in the development of obesity remains unclear.Here,we show that IGF1 expression is increased in adipose tissue in obese human patients and animal models.Elevation of IGF1 is associated with increased lipogenic gene expression and decreased energy expenditure.Genetic down-regulation of IGF1 normalizes lipogenic gene expression,restores aberrant energy metabolism and alleviates obese phenotype of a genetic mouse model with IGF1-hypersecretion.Importantly,genetic down-regulation of IGF1 exerts similar effects on development of diet-induced obesity.Furthermore,berberine that is an AMP-activated protein kinase(AMPK)activator in medicinal herbs inhibits IGF1 secretion,decreases lipogenic gene expression and alleviates diet-induced adiposity.Collectively,our findings demonstrate that hypersecretion of IGF1 is a critical factor for the development of obesity and can be targeted using AMPK activators to alleviate obesity.
文摘目的目前关于医疗机构工作人员是否需要戴口罩仍存在较大争议,本研究意在评价和总结针对这一问题的现有最佳证据,以期为临床医务工作人员使用口罩提供参考。方法计算机检索PubMed、Cochrane图书馆、Web of Science、CINAHL、中国知网、万方、维普、中国生物医学文献数据库,指南数据库平台及相关专业学会组织,检索时限为建库至2019年10月27日,以获取相关指南、专家共识、系统评价,应用国际公认的质量评价工具对纳入的证据进行质量评价,汇总现有证据对医疗机构人员是否需要戴口罩这一问题的相关推荐内容。结果共纳入35篇文献,其中6篇指南,27篇专家共识,2篇系统评价,证据质量整体较高。现有证据均推荐使用口罩作为个人防护措施之一,且与不使用呼吸防护设备相比,戴口罩在预防院内感染方面具有明显的优势,并根据不同的应用情景如手术区域、实验室区、产科等提出多项推荐意见。结论现有证据充分认可戴口罩作为个人防护措施之一在医疗机构中预防院内感染的重要作用。但本研究纳入的证据质量仍有一定的局限性。临床医务工作人员应当结合自身工作经验、临床实际情况等因素综合考虑,合理、规范使用口罩。
基金This work was financially supported by the National Natural Science Foundation of China(51502166 and 51881220658)the Scientific Research Program Funded by Shaanxi Provincial Department(17JK0130).
文摘Single-atom catalysts(SACs)have become an emerging frontier trend in the field of heterogeneous catalysis due to their high activity,selectivity and stability.SACs could greatly increase the availabilities of the active metal atoms in many catalytic reactions by reducing the size to single atom scale.Graphene-supported metal SACs have also drawn considerable attention due to the unique lattice structure and physicochemical properties of graphene,resulting in superior activity and selectivity for several chemical reactions.In this paper,we review recent progress in the fabrications,advanced characterization tools and advantages of graphene-supported metal SACs,focusing on their applications in catalytic reactions such as CO oxidation,the oxidation of benzene to phenol,hydrogen evolution reaction,methanol oxidation reaction,oxygen reduction reaction,hydrogenation and photoelectrocatalysis.We also propose the development of SACs towards industrialization in the future.
基金the Ministry of Science and Technology of China(Grant Nos.2018YFA0801100 and 2021YFF0702100)the National Natural Science Foundation of China(Grant Nos.32025019 and 31970719 to S.C.,31971067)the Fundamental Research Funds for the Central Universities(021414380533,021414380505)for financial support。
文摘Energy status is linked to the production of reactive oxygen species(ROS)in macrophages,which is elevated in obesity.However,it is unclear how ROS production is upregulated in macrophages in response to energy overload for mediating the development of obesity.Here,we show that the Rab-GTPase activating protein(Rab GAP)TBC1D1,a substrate of the energy sensor AMP-activated protein kinase(AMPK),is a critical regulator of macrophage ROS production and consequent adipose inflammation for obesity development.TBC1D1 deletion decreases,whereas an energy overload-mimetic non-phosphorylatable TBC1D1^(S231A)Amutation increases,ROS production and M1-like polarization in macrophages.Mechanistically,TBC1D1 and its downstream target Rab8a form an energy-responsive complex with NOX2 for ROS generation.Transplantation of TBC1D1^(S231A)bone marrow aggravates diet-induced obesity whereas treatment with an ultra-stable Tt SOD for removal of ROS selectively in macrophages alleviates both TBC1D1~(S231A)mutation-and diet-induced obesity.Our findings therefore have implications for drug discovery to combat obesity.
基金support from the National Key R&D Program of China(No.2019YFA0705201)the National Natural Science Foundation of China(No.62174042)the Heilongjiang Touyan Team.
文摘Self-powered full-spectrum photodetectors(PDs)offer numerous advantages,such as broad application fields,high precision,efficiency,and multi-functionality,which represent a highly promising and potentially valuable class of detectors for future development.However,insensitive response to solar-blind ultraviolet(UV)and complex and expensive preparation processes greatly limit their performance and practical application.In this study,a self-powered full-spectrum Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si heterojunction PD with high sensitivity for solar-blind UV band prepared by a simple and low-cost two-step synthesis method is presented.Experiments results reveal that the developed PD has an excellent performance,such as high sensitivity from 200 to 850 nm,and a responsivity of 1.38 mA/W as well as a detectivity of 3.22×10^(10) Jones under 254 nm light at zero bias.Additionally,the unencapsulated device displays exceptional stability and imaging capabilities.It is expected that Bi_(2)Se_(3)/a-Ga_(2)O_(3)/p-Si heterojunction PD with a simple and low-cost synthesis method has great potential for self-powered full-spectrum photodetectors.
基金National Key Research and Development Program of China,Grant/Award Number:2019YFA0705201National Natural Science Foundation of China,Grant/Award Number:12074095+1 种基金Natural Science Foundation of Heilongjiang Province of China,Grant/Award Number:LH2020E033Heilongjiang Touyan Team。
文摘The highly ordered film assembled by regularly 1D nanostructures has potentialprospects in electronic,photoelectronic and other fields because of its excellentlight-trapping effect and electronic transport property.However,the controlledgrowth of highly ordered film remains a great challenge.Herein,large-area andhighly ordered Bi_(2)S_(3) film is synthesized on fluorophlogopite mica substrate bychemical vapor deposition method.The Bi2S3 film features hollowed-outcrosslinked network structure,assembled by 1D nanobelts that regularly distributein three orientations,which agrees well with the first principles calculations.Based on the as-grown Bi_(2)S_(3) film,the broadband photodetector with a responserange from 365 to 940 nm is fabricated,exhibiting a maximum responsivity upto 98.51 mA W^(–1),specific detectivity of 2.03×10^(10)Jones and fast response timeof 35.19 ms.The stable instantaneous on/off behavior for 500 cycles and reliablephotoresponse characteristics of the Bi_(2)S_(3) photodetector after storage in air for6 months confirm its excellent long-term stability and air stability.Significantly,as sensing pixel and signal receiving terminal,the device successfully achieveshigh-resolution imaging of characters of“H”,“I”and“T”,and secure transmissionof confidential information.This work shows a great potential of the largeareaand highly ordered Bi_(2)S_(3) film toward the development of future multiplefunctional photoelectronic applications.
基金supported by the National Natural Science Foundation of China(32025019)the Ministry of Science and Technology of China(2021YFF0702100,2018YFA0801100)+2 种基金the Science and Technology Foundation of Jiangsu Province of China(BK20243041)the Fundamental Research Funds for the Central Universities(021414380533)Wellcome Trust Investigator Award(209380/Z/17/Z).
文摘Obesity is a major pathological factor that induces insulin resistance and consequent type 2 diabetes through multiple mechanisms.Inactivation of the insulin receptor(INSR)contributes to the development of insulin resistance,whose protein level is down-regulated in obesity through as yet-undefined mechanisms.Here we show that the E3-ligase TRAF6 is a critical regulator of INSR maturation,whose inactivation prevents palmitic acid-or high-fat diet-induced diminution of the INSR.Consequently,genetic inactivation of TRAF6 enhances insulin signaling that further increases muscle glucose uptake and inhibits hepatic gluconeogenesis.TRAF6 inactivation increases the proprotein convertase FURIN that controls the processing of pro-INSR to mature INSR.Mechanistically,TRAF6 associates with the Golgi apparatus,where it ubiquitinates the cytosolic tail of FURIN,leading to its lysosomal degradation.This TRAF6-FURIN axis also regulates cholesterol metabolism via PCSK9 processing in the circulation.Collectively,our results reveal a critical role of TRAF6 in regulating proprotein processing and have therapeutic implications for metabolic control.
