目的:分析临床药师延伸性抗凝药学监护对房颤患者经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)临床效应的影响。方法:选取本院2017年1月~2020年5月收治的150例房颤合并急性冠脉综合征患者,随机分为研究组和对照组,各75...目的:分析临床药师延伸性抗凝药学监护对房颤患者经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)临床效应的影响。方法:选取本院2017年1月~2020年5月收治的150例房颤合并急性冠脉综合征患者,随机分为研究组和对照组,各75例,均给予PCI及抗血小板治疗。对照组接受抗凝药物常规使用指导;研究组接受延伸性抗凝药物使用监护。对比两组随访1年内全因死亡率,国际血栓形成与止血法学会(International Society on Thrombosis and Haemostasis,ISTH)大出血、临床相关非大出血(Clinically relevant non-major bleeding,CRNMB)、脑卒中、周围动脉栓塞、再发心肌梗死、支架内血栓发生率,以及随访期间再次住院时间。结果:研究组失访3例,对照组失访7例,其余140例均获得有效随访。研究组随访期间3例死亡,对照组随访期间4例死亡,研究组、对照组全因死亡率分别为4.17%、5.88%,组间比较差异无统计学意义(P>0.05)。随访期间研究组小出血发生率低于对照组,差异有统计学意义(P<0.05)。随访期间,两组在脑卒中、心肌梗死、支架内血栓、周围动脉栓塞发生率比较,差异无统计学意义(P>0.05)。随访期间研究组住院时间为(5.11±1.62)d,低于对照组的(8.07±1.95)d,差异有统计学意义(t=9.791,P<0.001)。随访期间,研究组华法林抗凝治疗达标率为68.75%,高于对照组的26.67%,差异有统计学意义(P<0.05)。结论:临床药师延伸性抗凝药物使用监护能够降低房颤患者PCI术后1年内小出血事件发生率、减少再住院时间、提高华法林抗凝的达标率。展开更多
Objective:The efficacy of monotherapy in alleviating psychological disorders like anxiety and depression among breast cancer patients is suboptimal,necessitating effective psychosocial interventions.Mindfulness-based ...Objective:The efficacy of monotherapy in alleviating psychological disorders like anxiety and depression among breast cancer patients is suboptimal,necessitating effective psychosocial interventions.Mindfulness-based interventions have been shown to mitigate anxiety-depression symptoms and encourage beneficial behaviors.The online mindfulness based cancer recovery(MBCR)offers flexibility and guides practice across various settings,facilitating full patient engagement.This study amis to analyze the impact of a 4-week internet-delivered mindfulness-based cancer recovery program on anxiety,depression,and mindfulness among Chinese patients with breast cancer,and to evaluate the degree of satisfaction breast cancer patients experienced after participating in this program.Methods:This study utilized a two-armed,parallel,randomized controlled trial design.A total of 103 patients with breast cancer from June 2020 to January 2021 in the ward of Breast and Thyroid Surgery of a tertiary hospital in Changsha,Hunan Province were selected and randomly assigned to an intervention group(n=51)and a control group(n=52).The intervention group participated in an internet-delivered mindfulness-based cancer recovery program,which was delivered once a week for 4 weeks.Meanwhile,the control group received weekly group health education for 4 weeks.The outcomes of hospital anxiety and depression scale and mindfulness Attention Awareness Scale were evaluated at 3 distinct time points:Baseline(T1),postintervention(T2),and 1-month follow-up(T3).The satisfaction questionnaire of 4-week mindful cancer rehabilitation training program was used at T2 to evaluate patients’satisfaction with the intervention program.Generalized estimation equations were used to assess differences in anxiety,depression and mindfulness levels between groups before and after the intervention.Results:There were no statistically significant differences in demographic data and outcome index scores between the 2 groups at T1(all P>0.05),indicating that the 2 groups were comparable.The generalized estimating equation analyses showed that the intervention group had significantly better improvement in outcomes compared to the control group,particularly for anxiety(T2β=−1.30,95%CI−1.87 to−0.72;T3β=−2.78,95%CI−3.51 to−2.05)and depression(T2β=−1.92,95%CI−2.78 to−1.06;T3β=−2.96,95%CI−4.05 to−1.87;all P<0.001).Moreover,the mindfulness score in the intervention group was significantly higher than that in the control group at T2(β=3.23,95%CI 0.73 to 5.72)and T3(β=8.06,95%CI 4.37 to 11.75;both P<0.05).In addition,patients in the intervention group were satisfied with the 4-week mindfulness-based cancer recovery intervention and teaching/learning activities used to implement the program.Conclusion:In patients with breast cancer,the 4-week internet-delivered mindfulness based cancer recovery program,as a low-threshold,short-term mental health intervention,has a positive effect on reducing anxiety and depression and improving mindfulness levels.This program holds great promise as a tool for clinical nursing practice,given the high satisfaction and applicability.展开更多
文摘目的:分析临床药师延伸性抗凝药学监护对房颤患者经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)临床效应的影响。方法:选取本院2017年1月~2020年5月收治的150例房颤合并急性冠脉综合征患者,随机分为研究组和对照组,各75例,均给予PCI及抗血小板治疗。对照组接受抗凝药物常规使用指导;研究组接受延伸性抗凝药物使用监护。对比两组随访1年内全因死亡率,国际血栓形成与止血法学会(International Society on Thrombosis and Haemostasis,ISTH)大出血、临床相关非大出血(Clinically relevant non-major bleeding,CRNMB)、脑卒中、周围动脉栓塞、再发心肌梗死、支架内血栓发生率,以及随访期间再次住院时间。结果:研究组失访3例,对照组失访7例,其余140例均获得有效随访。研究组随访期间3例死亡,对照组随访期间4例死亡,研究组、对照组全因死亡率分别为4.17%、5.88%,组间比较差异无统计学意义(P>0.05)。随访期间研究组小出血发生率低于对照组,差异有统计学意义(P<0.05)。随访期间,两组在脑卒中、心肌梗死、支架内血栓、周围动脉栓塞发生率比较,差异无统计学意义(P>0.05)。随访期间研究组住院时间为(5.11±1.62)d,低于对照组的(8.07±1.95)d,差异有统计学意义(t=9.791,P<0.001)。随访期间,研究组华法林抗凝治疗达标率为68.75%,高于对照组的26.67%,差异有统计学意义(P<0.05)。结论:临床药师延伸性抗凝药物使用监护能够降低房颤患者PCI术后1年内小出血事件发生率、减少再住院时间、提高华法林抗凝的达标率。
基金supported by the National Science Fund for Distinguished Young Scholars(81703084)the National Natural Science Foundation of General Program(82272924),and the Hunan Women’s Federation(19WTB03),China.
文摘Objective:The efficacy of monotherapy in alleviating psychological disorders like anxiety and depression among breast cancer patients is suboptimal,necessitating effective psychosocial interventions.Mindfulness-based interventions have been shown to mitigate anxiety-depression symptoms and encourage beneficial behaviors.The online mindfulness based cancer recovery(MBCR)offers flexibility and guides practice across various settings,facilitating full patient engagement.This study amis to analyze the impact of a 4-week internet-delivered mindfulness-based cancer recovery program on anxiety,depression,and mindfulness among Chinese patients with breast cancer,and to evaluate the degree of satisfaction breast cancer patients experienced after participating in this program.Methods:This study utilized a two-armed,parallel,randomized controlled trial design.A total of 103 patients with breast cancer from June 2020 to January 2021 in the ward of Breast and Thyroid Surgery of a tertiary hospital in Changsha,Hunan Province were selected and randomly assigned to an intervention group(n=51)and a control group(n=52).The intervention group participated in an internet-delivered mindfulness-based cancer recovery program,which was delivered once a week for 4 weeks.Meanwhile,the control group received weekly group health education for 4 weeks.The outcomes of hospital anxiety and depression scale and mindfulness Attention Awareness Scale were evaluated at 3 distinct time points:Baseline(T1),postintervention(T2),and 1-month follow-up(T3).The satisfaction questionnaire of 4-week mindful cancer rehabilitation training program was used at T2 to evaluate patients’satisfaction with the intervention program.Generalized estimation equations were used to assess differences in anxiety,depression and mindfulness levels between groups before and after the intervention.Results:There were no statistically significant differences in demographic data and outcome index scores between the 2 groups at T1(all P>0.05),indicating that the 2 groups were comparable.The generalized estimating equation analyses showed that the intervention group had significantly better improvement in outcomes compared to the control group,particularly for anxiety(T2β=−1.30,95%CI−1.87 to−0.72;T3β=−2.78,95%CI−3.51 to−2.05)and depression(T2β=−1.92,95%CI−2.78 to−1.06;T3β=−2.96,95%CI−4.05 to−1.87;all P<0.001).Moreover,the mindfulness score in the intervention group was significantly higher than that in the control group at T2(β=3.23,95%CI 0.73 to 5.72)and T3(β=8.06,95%CI 4.37 to 11.75;both P<0.05).In addition,patients in the intervention group were satisfied with the 4-week mindfulness-based cancer recovery intervention and teaching/learning activities used to implement the program.Conclusion:In patients with breast cancer,the 4-week internet-delivered mindfulness based cancer recovery program,as a low-threshold,short-term mental health intervention,has a positive effect on reducing anxiety and depression and improving mindfulness levels.This program holds great promise as a tool for clinical nursing practice,given the high satisfaction and applicability.
