目的探讨维持性血液透析患者慢性牙周炎与蛋白质能量消耗相关性。方法纳入新疆医科大学第一附属医院98例维持性血液透析(maintenance hemodialysis,MHD)患者,采用患者自评-主观全面评定量表诊断不同程度蛋白质能量消耗(Protein energy w...目的探讨维持性血液透析患者慢性牙周炎与蛋白质能量消耗相关性。方法纳入新疆医科大学第一附属医院98例维持性血液透析(maintenance hemodialysis,MHD)患者,采用患者自评-主观全面评定量表诊断不同程度蛋白质能量消耗(Protein energy wasting,PEW),采用社区牙周指数常规口腔检查方法诊断慢性牙周炎(Chronic periodontitis,CP),并检测超敏C反应蛋白(Hypersensitive c-reactive protein,hs-CRP)、白介素6(Interleukin-6,IL-6)及相关营养检测指标,建立多因素回归模型分析PEW的危险因素。结果MHD患者CP检出率为94.9%,重度CP组PEW的检出率为93.3%,重度PEW的患者均患牙周炎,中度牙周炎占35.3%,重度牙周炎64.7%。超敏C反应蛋白和铁蛋白随着牙周炎程度的加重而升高,重度牙周炎的MHD患者血肌酐、前白蛋白、总铁结合力较非CP组明显降低,多因素Logistic回归模型显示牙周炎为PEW的危险因素,合并牙周炎的MHD患者较无牙周炎的患者PEW的发生风险增加3倍。结论MHD患者慢性牙周炎检出率高,PEW与慢性牙周炎密切相关,临床工作中应该重视MHD患者牙周炎与PEW的综合干预和治疗。展开更多
This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphoc...This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members.展开更多
基金This work was supported by the Science Foundation of Civil Aviation Administration of China (Grant No. 99-3-3).
文摘This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members.
