张量转置(tensor transposition)作为基础张量运算原语,广泛应用于信号处理、科学计算以及深度学习等各种领域,在张量数据密集型应用及高性能计算中具有重要作用。随着能效指标在高性能计算系统中的重要性日益凸显,基于数字信号处理器(d...张量转置(tensor transposition)作为基础张量运算原语,广泛应用于信号处理、科学计算以及深度学习等各种领域,在张量数据密集型应用及高性能计算中具有重要作用。随着能效指标在高性能计算系统中的重要性日益凸显,基于数字信号处理器(digital signal processors,DSPs)的加速器已被集成至通用计算系统。然而,传统面向多核CPU和GPU的张量转置库因架构差异无法充分适配DSP架构。一方面,DSP架构的向量化计算潜力尚未得到充分挖掘;另一方面,其复杂的片上存储体系与多层次共享内存结构为张量并行程序设计带来了显著挑战。针对国产多核DSP的架构特点,提出ftmTT算法,并设计实现了一个面向多核DSP架构的通用张量转置库。ftmTT算法通过设计适配DSP架构的高效内存访问模式充分挖掘其并行化和向量化潜力,其核心创新包括:1)采用分块策略将高维张量转置转化为多核DSP平台所提供的矩阵转置内核操作;2)提出基于DMA点对点传输的张量数据块访存合并方案来降低数据搬运开销;3)通过双缓冲设计异步重叠转置计算与DMA传输实现计算通信隐藏,最终面向多核DSP实现高性能并行张量转置。在国产多核DSP平台FT-M7032的实验表明,ftmTT张量转置算法取得了最高达理论带宽75.96%的性能,达到FT-M7032平台STREAM带宽99.23%的性能。展开更多
Traditional psychiatric diagnosis relies on subjective symptom assessment,lacking objective biomarkers that hinder early detection and personalized treatment.Plasma proteins and polygenic risk score(PRS),as potential ...Traditional psychiatric diagnosis relies on subjective symptom assessment,lacking objective biomarkers that hinder early detection and personalized treatment.Plasma proteins and polygenic risk score(PRS),as potential predictive tools,hold promise for advancing early diagnosis of mental disorders.This study aims to evaluate the predictive potential of proteomic features and PRS in multiple mental illnesses(depression,schizophrenia,and post-traumatic stress disorder(PTSD)).Using participant data from the UK Biobank-Pharma Proteomics Project,we screen protein associations with mental disorders through least absolute shrinkage and selection operator(LASSO)analysis and construct a Cox regression risk prediction model by integrating the PRS.Additionally,we evaluate predictive performance using 6 machine learning methods and Kaplan-Meier survival curves.Our findings reveal distinct predictive patterns across dis-orders.For depression,integrating plasma proteins with PRS significantly improves prediction beyond the clinical model(C-index=0.6322).For schizophrenia,adding plasma proteins enhances predictive performance,whereas PRS provides no significant improvement.For PTSD,neither plasma proteins nor PRS add substantial predictive value beyond clinical variables.Risk stratification analysis demonstrat that all three mental disorders models can clearly distinguish high-risk from low-risk groups(depression:HR=2.34,P<0.001;schizophrenia:HR=5.47,P<0.001;PTSD:HR=3.02,P<0.001).Al-though it shows good performance in short-term prediction,its long-term prediction ability has decreased,and it needs to be further optimized in the future.This study underscores the differential utility of biomarkers across mental disorders and provides a rationale for disorder-specific predictive modeling in precision psychiatry.展开更多
文摘张量转置(tensor transposition)作为基础张量运算原语,广泛应用于信号处理、科学计算以及深度学习等各种领域,在张量数据密集型应用及高性能计算中具有重要作用。随着能效指标在高性能计算系统中的重要性日益凸显,基于数字信号处理器(digital signal processors,DSPs)的加速器已被集成至通用计算系统。然而,传统面向多核CPU和GPU的张量转置库因架构差异无法充分适配DSP架构。一方面,DSP架构的向量化计算潜力尚未得到充分挖掘;另一方面,其复杂的片上存储体系与多层次共享内存结构为张量并行程序设计带来了显著挑战。针对国产多核DSP的架构特点,提出ftmTT算法,并设计实现了一个面向多核DSP架构的通用张量转置库。ftmTT算法通过设计适配DSP架构的高效内存访问模式充分挖掘其并行化和向量化潜力,其核心创新包括:1)采用分块策略将高维张量转置转化为多核DSP平台所提供的矩阵转置内核操作;2)提出基于DMA点对点传输的张量数据块访存合并方案来降低数据搬运开销;3)通过双缓冲设计异步重叠转置计算与DMA传输实现计算通信隐藏,最终面向多核DSP实现高性能并行张量转置。在国产多核DSP平台FT-M7032的实验表明,ftmTT张量转置算法取得了最高达理论带宽75.96%的性能,达到FT-M7032平台STREAM带宽99.23%的性能。
基金The National Natural Science Foundation of China-Regional Science“Identification of novel drug targets for lung cancer via Mendelian randomization analysis based on blood proteomics”(62362062)The 2025 Xinjiang University Excellent Graduate Innovation Project“Research on identification of therapeutic targets and predictive factors for mental disorders based on proteomics”(XJDX2025YJS151)。
文摘Traditional psychiatric diagnosis relies on subjective symptom assessment,lacking objective biomarkers that hinder early detection and personalized treatment.Plasma proteins and polygenic risk score(PRS),as potential predictive tools,hold promise for advancing early diagnosis of mental disorders.This study aims to evaluate the predictive potential of proteomic features and PRS in multiple mental illnesses(depression,schizophrenia,and post-traumatic stress disorder(PTSD)).Using participant data from the UK Biobank-Pharma Proteomics Project,we screen protein associations with mental disorders through least absolute shrinkage and selection operator(LASSO)analysis and construct a Cox regression risk prediction model by integrating the PRS.Additionally,we evaluate predictive performance using 6 machine learning methods and Kaplan-Meier survival curves.Our findings reveal distinct predictive patterns across dis-orders.For depression,integrating plasma proteins with PRS significantly improves prediction beyond the clinical model(C-index=0.6322).For schizophrenia,adding plasma proteins enhances predictive performance,whereas PRS provides no significant improvement.For PTSD,neither plasma proteins nor PRS add substantial predictive value beyond clinical variables.Risk stratification analysis demonstrat that all three mental disorders models can clearly distinguish high-risk from low-risk groups(depression:HR=2.34,P<0.001;schizophrenia:HR=5.47,P<0.001;PTSD:HR=3.02,P<0.001).Al-though it shows good performance in short-term prediction,its long-term prediction ability has decreased,and it needs to be further optimized in the future.This study underscores the differential utility of biomarkers across mental disorders and provides a rationale for disorder-specific predictive modeling in precision psychiatry.
