Background The triglyceride-glucose(TyG)index has been widely studied in metabolic and cardiovascular diseases.ST-segment elevation myocardial infarction(STEMI)patients undergoing percutaneous coronary inter-vention(P...Background The triglyceride-glucose(TyG)index has been widely studied in metabolic and cardiovascular diseases.ST-segment elevation myocardial infarction(STEMI)patients undergoing percutaneous coronary inter-vention(PCI)are at increased risk of pulmonary infection due to their stressful conditions.While previous studies have confirmed the predictive role of TyG index in the prognosis of STEMI patients,its potential association with pulmonary infection remains unclear.This study was to explored the relationship between the TyG index and pul-monary infection in STEMI patients PCI.Methods STEMI patients who underwent PCI were enrolled and strati-fied into three tertiles based on the TyG index measured after receiving PCI.Primary outcome was pulmonary infec-tion during hospitalization.Secondary outcomes were in-hospital bleeding,all-cause mortality and major adverse cardiac events(MACE)as well as MACE during follow-up.Logistic regression and Cox proportional hazard re-gression were mainly used to estimate outcomes.Results 3652 patients were enrolled in this study.In multivari-ate logistic regression,the TyG index was associated with in-hospital pulmonary infection[adjusted odds ratio(aOR):1.29,95%CI:1.05-1.58,P=0.014],mortality(aOR:2.27,95%CI:1.64-3.15,P<0.001),MACE(aOR:1.81,95%CI:1.39-2.37,P<0.001),and any bleeding(aOR:1.22,95%CI:1.04-1.43,P=0.013).The median follow-up was 1.70 years.After adjusting for potential confounders,the TyG index was positively related to long-term MACE(aHR:1.26,95%CI:1.06-1.49,P=0.009).Conclusions A high TyG index was associated with in-hospital pulmo-nary infection,bleeding,mortality and MACE in patients with STEMI undergoing PCI.Additionally,it is also asso-ciated with long-term MACE.展开更多
基金supported by the Shuangqing Talent Program Project of Guangdong Provincial People′s Hospital(No.KJ012019084)and(No.KJ012019095)High-level Hospital Construction Project(No.DFJH2020021)Basic and Applied Basic Research Fund of Guangdong Province(No.2023A1515220174)。
文摘Background The triglyceride-glucose(TyG)index has been widely studied in metabolic and cardiovascular diseases.ST-segment elevation myocardial infarction(STEMI)patients undergoing percutaneous coronary inter-vention(PCI)are at increased risk of pulmonary infection due to their stressful conditions.While previous studies have confirmed the predictive role of TyG index in the prognosis of STEMI patients,its potential association with pulmonary infection remains unclear.This study was to explored the relationship between the TyG index and pul-monary infection in STEMI patients PCI.Methods STEMI patients who underwent PCI were enrolled and strati-fied into three tertiles based on the TyG index measured after receiving PCI.Primary outcome was pulmonary infec-tion during hospitalization.Secondary outcomes were in-hospital bleeding,all-cause mortality and major adverse cardiac events(MACE)as well as MACE during follow-up.Logistic regression and Cox proportional hazard re-gression were mainly used to estimate outcomes.Results 3652 patients were enrolled in this study.In multivari-ate logistic regression,the TyG index was associated with in-hospital pulmonary infection[adjusted odds ratio(aOR):1.29,95%CI:1.05-1.58,P=0.014],mortality(aOR:2.27,95%CI:1.64-3.15,P<0.001),MACE(aOR:1.81,95%CI:1.39-2.37,P<0.001),and any bleeding(aOR:1.22,95%CI:1.04-1.43,P=0.013).The median follow-up was 1.70 years.After adjusting for potential confounders,the TyG index was positively related to long-term MACE(aHR:1.26,95%CI:1.06-1.49,P=0.009).Conclusions A high TyG index was associated with in-hospital pulmo-nary infection,bleeding,mortality and MACE in patients with STEMI undergoing PCI.Additionally,it is also asso-ciated with long-term MACE.
