目的评价健心平律丸结合西医常规疗法治疗糖尿病室性心律失常的疗效。方法将符合入选标准的2019年6月-2020年12月本院92例T2DM合并室性心律失常(ventricular arhythmia,VA)患者,按随机数字表法分为2组,每组46例。对照组应用常规治疗方案...目的评价健心平律丸结合西医常规疗法治疗糖尿病室性心律失常的疗效。方法将符合入选标准的2019年6月-2020年12月本院92例T2DM合并室性心律失常(ventricular arhythmia,VA)患者,按随机数字表法分为2组,每组46例。对照组应用常规治疗方案,观察组在对照组基础上服用健心平律丸。2组均连续治疗2个月。分别于治疗前后从胸痛心悸、胸闷气短、口干口渴、神疲乏力4个方面进行中医症状评分,指尖采血检测患者空腹血糖、2 hPG水平;佩戴心电测量仪完成24 h动态心电图监测,统计全部窦性心搏RR间期标准差(standard diviation of NN intervals,SDNN)、RR间期平均值标准差(standard diviation average of NN intervals,SDANN)、相邻RR间期差值均方根(the root mean square of successive R-R interval,RMSSD)、相邻NN间期之差>50 ms的个数占比(the percentage of adjacent NN intervals over 50 ms,PNN50);采用生化分析仪检测肌酸激酶(creatine kinase,CK)、肌酸激酶同工酶(creatine kinase isoenzymes,CK-MB);采用化学发光免疫法测定血浆脑利尿钠肽(brain natriuretic peptide,BNP),记录不良反应,评价临床疗效。结果观察组总有效率为93.5%(43/46)、对照组为78.3%(36/46),2组比较差异有统计学意义(χ^(2)=4.390,P=0.036)。观察组治疗后胸痛心悸、胸闷气短、口干口渴、神疲乏力评分低于对照组(t值分别为4.319、2.714、3.196、4.667,P<0.01或P<0.05)。观察组治疗后空腹血糖、2 hPG水平低于对照组(t值分别为2.025、6.462,P<0.05或P<0.01)。治疗后,观察组SDNN[(119.72±5.86)ms比(115.27±6.10)ms,t=3.568]、SDANN[(112.80±13.36)ms比(98.62±14.51)ms,t=4.876]、RMSSD[(46.87±5.44)ms比(42.58±5.73)ms,t=3.683]、PNN50[(6.84±0.66)%比(6.21±0.64)%,t=4.648]水平高于对照组(P<0.01);CK[(263.82±52.18)U/L比(306.59±48.45)U/L,t=4.074]、CK-MB[(2.02±0.62)g/L比(3.25±0.49)g/L,t=10.556]水平低于对照组(P<0.01);血浆BNP[(126.99±49.02)ng/L比(188.26±54.30)ng/L,t=5.681]水平低于对照组(P<0.01)。治疗期间,观察组不良反应发生率为10.9%(5/46)、对照组为4.3%(2/46),2组比较差异无统计学意义(χ^(2)=0.619,P=0.432)。结论健心平律丸结合西医常规疗法可有效缓解T2DM合并VA患者临床症状,控制血糖水平,改善心率变异性,控制心肌酶谱及血浆BNP水平,且药物安全性较好。展开更多
The response and recovery mechanisms of forests to damage from freezing rain and snow events are a key topic in forest research and management. However, the relationship between the degree of damage and tree age, i.e....The response and recovery mechanisms of forests to damage from freezing rain and snow events are a key topic in forest research and management. However, the relationship between the degree of damage and tree age, i.e., whether seedlings, young trees, or adult trees are most vulnerable, remains unclear and is rarely reported. We investigated the effect of tree age on the degrees of vegetation damage and subsequent recovery in three subtropical forest types-coniferous, mixed, and broad-leaved —in the Tianjing Mountains, South China, after a series of rare icy rain and freezing snow events in 2008. The results showed that damage and recovery rates were both dependent on tree age, with the proportion of damaged vegetation increasing with age(estimated by diameter at breast height, DBH) in all three forest types and gradually plateauing. Significant variation occurred among forest types. Young trees in the coniferous forest were more vulnerable than those in the broad-leaved forest. The type of damage also varied with tree age in different ways in the three forest types. The proportion of young seedlings that were uprooted(the most severe type of damage) was highest in the coniferous forest. In the mixed forest, young trees were significantly more likely to be uprooted than seedlings and adult trees, while in the broad-leaved forest, the proportion of uprooted adult trees was significantly higher than that of seedlings and young trees. There were also differences among forest types in how tree age affected damage recovery. In the coniferous forest, the recovery rate of trees with broken trunks or crowns(DBH > 2.5 cm) increased with tree age. However, in the mixed and broad-leaved forests, no obvious correlation between the recovery rate of trees with broken trunks or crowns and tree age was observed. Trees with severe root damage did not recover; they were uprooted and died. In these forests, vegetation damage and recovery showed tree age dependencies, which varied with tree shape, forest type, and damage type. Understanding this dependency will guide restoration after freezing rain and snow disturbances.展开更多
文摘目的评价健心平律丸结合西医常规疗法治疗糖尿病室性心律失常的疗效。方法将符合入选标准的2019年6月-2020年12月本院92例T2DM合并室性心律失常(ventricular arhythmia,VA)患者,按随机数字表法分为2组,每组46例。对照组应用常规治疗方案,观察组在对照组基础上服用健心平律丸。2组均连续治疗2个月。分别于治疗前后从胸痛心悸、胸闷气短、口干口渴、神疲乏力4个方面进行中医症状评分,指尖采血检测患者空腹血糖、2 hPG水平;佩戴心电测量仪完成24 h动态心电图监测,统计全部窦性心搏RR间期标准差(standard diviation of NN intervals,SDNN)、RR间期平均值标准差(standard diviation average of NN intervals,SDANN)、相邻RR间期差值均方根(the root mean square of successive R-R interval,RMSSD)、相邻NN间期之差>50 ms的个数占比(the percentage of adjacent NN intervals over 50 ms,PNN50);采用生化分析仪检测肌酸激酶(creatine kinase,CK)、肌酸激酶同工酶(creatine kinase isoenzymes,CK-MB);采用化学发光免疫法测定血浆脑利尿钠肽(brain natriuretic peptide,BNP),记录不良反应,评价临床疗效。结果观察组总有效率为93.5%(43/46)、对照组为78.3%(36/46),2组比较差异有统计学意义(χ^(2)=4.390,P=0.036)。观察组治疗后胸痛心悸、胸闷气短、口干口渴、神疲乏力评分低于对照组(t值分别为4.319、2.714、3.196、4.667,P<0.01或P<0.05)。观察组治疗后空腹血糖、2 hPG水平低于对照组(t值分别为2.025、6.462,P<0.05或P<0.01)。治疗后,观察组SDNN[(119.72±5.86)ms比(115.27±6.10)ms,t=3.568]、SDANN[(112.80±13.36)ms比(98.62±14.51)ms,t=4.876]、RMSSD[(46.87±5.44)ms比(42.58±5.73)ms,t=3.683]、PNN50[(6.84±0.66)%比(6.21±0.64)%,t=4.648]水平高于对照组(P<0.01);CK[(263.82±52.18)U/L比(306.59±48.45)U/L,t=4.074]、CK-MB[(2.02±0.62)g/L比(3.25±0.49)g/L,t=10.556]水平低于对照组(P<0.01);血浆BNP[(126.99±49.02)ng/L比(188.26±54.30)ng/L,t=5.681]水平低于对照组(P<0.01)。治疗期间,观察组不良反应发生率为10.9%(5/46)、对照组为4.3%(2/46),2组比较差异无统计学意义(χ^(2)=0.619,P=0.432)。结论健心平律丸结合西医常规疗法可有效缓解T2DM合并VA患者临床症状,控制血糖水平,改善心率变异性,控制心肌酶谱及血浆BNP水平,且药物安全性较好。
基金financially supported by the National Natural Science Foundation of China(31300401,31030015,31100402)the Forestry Science and Technology Innovative Foundation of Guangdong Province(2008KJCX012,2009KJCX015)+1 种基金the Guangdong Natural Science Foundation(S2012040007896)the Fundamental Research Funds for the Central Universities
文摘The response and recovery mechanisms of forests to damage from freezing rain and snow events are a key topic in forest research and management. However, the relationship between the degree of damage and tree age, i.e., whether seedlings, young trees, or adult trees are most vulnerable, remains unclear and is rarely reported. We investigated the effect of tree age on the degrees of vegetation damage and subsequent recovery in three subtropical forest types-coniferous, mixed, and broad-leaved —in the Tianjing Mountains, South China, after a series of rare icy rain and freezing snow events in 2008. The results showed that damage and recovery rates were both dependent on tree age, with the proportion of damaged vegetation increasing with age(estimated by diameter at breast height, DBH) in all three forest types and gradually plateauing. Significant variation occurred among forest types. Young trees in the coniferous forest were more vulnerable than those in the broad-leaved forest. The type of damage also varied with tree age in different ways in the three forest types. The proportion of young seedlings that were uprooted(the most severe type of damage) was highest in the coniferous forest. In the mixed forest, young trees were significantly more likely to be uprooted than seedlings and adult trees, while in the broad-leaved forest, the proportion of uprooted adult trees was significantly higher than that of seedlings and young trees. There were also differences among forest types in how tree age affected damage recovery. In the coniferous forest, the recovery rate of trees with broken trunks or crowns(DBH > 2.5 cm) increased with tree age. However, in the mixed and broad-leaved forests, no obvious correlation between the recovery rate of trees with broken trunks or crowns and tree age was observed. Trees with severe root damage did not recover; they were uprooted and died. In these forests, vegetation damage and recovery showed tree age dependencies, which varied with tree shape, forest type, and damage type. Understanding this dependency will guide restoration after freezing rain and snow disturbances.
