OBJECTIVE:To find alternatives to natural musk,this study compared the pharmacological effects of cultivated musk,synthetic musk,and natural musk.The aim is to address the dual challenge of clinical demand for muskbas...OBJECTIVE:To find alternatives to natural musk,this study compared the pharmacological effects of cultivated musk,synthetic musk,and natural musk.The aim is to address the dual challenge of clinical demand for muskbased medicines and the endangered status of the musk deer population.METHODS:This study aimed to establish a rat model of acute cerebral ischemia/reperfusion injury(CI/RI)by creating a middle cerebral artery occlusion and reperfusion model.Methods including enzyme-linked immunosorbent assay kits,hematoxylin and eosin staining,Nissl staining,immunohistochemistry,and Western blot were employed to compare the extent of brain tissue damage,inflammatory factor levels,and platelet-related indicators in rats treated with musk from different sources(natural musk,cultivated musk,and synthetic musk),thereby evaluating their differences in neuroprotection.Analysis was performed using one-way analysis of variance.RESULTS:Results indicated that pretreatment with musk demonstrated a positive impact on neurological function by reducing cerebral infarction size,decreasing cerebral edema severity,increasing calcitonin gene related peptide levels,inhibiting 5-hydroxytryptamine release,and preserving the blood-brain barrier integrity.Notably,natural musk exhibited superior antithrombotic properties compared to cultivated and synthetic musk,primarily evidenced by its ability to inhibit platelet aggregation rate,improve cerebral blood perfusion,reduce platelet activating factor receptor protein expression,and lower thromboxane A2 levels.Cultivated musk was observed to elevate catalase and superoxide dismutase levels while concurrently dampening inducible nitric oxide synthase activity,thereby mitigating oxidative damage and also diminishing tumor necrosis factor-αand interleukin-1βcontents along with Glial fibrillary acidic protein expression,enhancing anti-inflammatory capacity.CONCLUSION:Musk sourced from diverse origins exhibits profound neuroprotective qualities against acute CI/RI in rats.Particularly,natural musk demonstrated a specific propensity towards reinforcing antithrombotic effects,whereas cultivated musk excelled in augmenting anti-inflammatory and antioxidative defenses,offering efficacious protection against acute CI/RI.The findings bolster the credibility of strategically employing diverse sources of musk as a preventive strategy against ischemic strokes.展开更多
A rapidly growing field is piezoresistive sensor for accurate respiration rate monitoring to suppress the worldwide respiratory illness.However,a large neglected issue is the sensing durability and accuracy without in...A rapidly growing field is piezoresistive sensor for accurate respiration rate monitoring to suppress the worldwide respiratory illness.However,a large neglected issue is the sensing durability and accuracy without interference since the expiratory pressure always coupled with external humidity and temperature variations,as well as mechanical motion artifacts.Herein,a robust and biodegradable piezoresistive sensor is reported that consists of heterogeneous MXene/cellulose-gelation sensing layer and Ag-based interdigital electrode,featuring customizable cylindrical interface arrangement and compact hierarchical laminated architecture for collectively regulating the piezoresistive response and mechanical robustness,thereby realizing the long-term breath-induced pressure detection.Notably,molecular dynamics simulations reveal the frequent angle inversion and reorientation of MXene/cellulose in vacuum filtration,driven by shear forces and interfacial interactions,which facilitate the establishment of hydrogen bonds and optimize the architecture design in sensing layer.The resultant sensor delivers unprecedented collection features of superior stability for off-axis deformation(0-120°,~2.8×10^(-3) A)and sensing accuracy without crosstalk(humidity 50%-100%and temperature 30-80).Besides,the sensor-embedded mask together with machine learning models is achieved to train and classify the respiration status for volunteers with different ages(average prediction accuracy~90%).It is envisioned that the customizable architecture design and sensor paradigm will shed light on the advanced stability of sustainable electronics and pave the way for the commercial application in respiratory monitory.展开更多
A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha pr...A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.展开更多
Pafuranones A(1)and B(2),a pair of new epimeric polyketide dimers,were isolated from the fungus Paraconiothyrium sp.OUCMDZ-3316 associated with the marine algae Enteromorpha prolifera.Their structures,including absolu...Pafuranones A(1)and B(2),a pair of new epimeric polyketide dimers,were isolated from the fungus Paraconiothyrium sp.OUCMDZ-3316 associated with the marine algae Enteromorpha prolifera.Their structures,including absolute configurations,were fully elucidated based on spectroscopic analysis,calculated ECD,and chemical methods.Pafuranones A(1)and B(2)possess a rare dimeric furanone skeleton,which might be formed through a conjugate addition of the monomeric units followed by an intramolecular cyclization.展开更多
Pyro-breaker is a fast-responding and high-reliable explosive-driven circuit breaker,which has been applied in several quench protection systems,such as International Thermonuclear Experimental Reactor and Experimenta...Pyro-breaker is a fast-responding and high-reliable explosive-driven circuit breaker,which has been applied in several quench protection systems,such as International Thermonuclear Experimental Reactor and Experimental Advanced Superconducting Tokamak.As an indispensable back-up switch,Pyro-breaker guarantees the reliability and safety of the system and avoids tremendous loss when quench happens.Electrical contact,a crucial part of an electrical device greatly determines the steady current capacity of a Pyro-breaker.However,due to the complexity of the model and the deficiency knowledge of the microstate of contact areas,an accurate calculation for contact resistance is difficult to acquire.A study of electrical contact in the design of a Pyro-breaker has been presented in this paper.An engineering calculation method is verified with experiments.Parameters are fitted for the presented model,which will be a significant theoretical basis for the future designing.展开更多
Using the operator correspondence of the real and fictious modes in the thermo entangled state representation, wesolve the quantum master equation describing the diffusion channel and obtain the Kraus operator-sum rep...Using the operator correspondence of the real and fictious modes in the thermo entangled state representation, wesolve the quantum master equation describing the diffusion channel and obtain the Kraus operator-sum representation ofits analytical solution. we find that the pure coherent states evolve into the new mixed thermal superposed states in thediffusion channel. Also, we investigate the statistical properties of the initial coherent states and their entropy evolutions inthe diffusion channel, and find that the entropy evolutions are only related to the decay time and without the amplitudes ofthe initial coherent states.展开更多
(±)-Pyriindolin(1)with a rare molecular backbone formed by fusing a 2,2'-bipyridine nucleus into a spiro[furan-3,3'-indoline]skeleton,was isolated from the Streptomyces albolongus EA12432.The constitution...(±)-Pyriindolin(1)with a rare molecular backbone formed by fusing a 2,2'-bipyridine nucleus into a spiro[furan-3,3'-indoline]skeleton,was isolated from the Streptomyces albolongus EA12432.The constitution and the relative configuration of(±)-1 were determined by extensive spectroscopic analyses,^(13)C calculation and DP4+probability analysis.The absolute configurations of optically pure(+)-1 and(-)-1 which were obtained after a chiral high performance liquid chromatography(HPLC)separation were further identified by electronic circular dichroism(ECD)calculations.(+)-and(-)-Pyriindolins displayed moderate cytotoxicity against HCT-116 cell line with the half-maximal inhibitory concentration(IC_(50))values of 2.89±0.17μmol/L and 4.47±0.26μmol/L,respectively.展开更多
A chemical investigation of Streptomyces sp.GZWMJZ-662,an endophytic actinomycete isolated from Houttuynia cordata Thunb.,has yielded eleven bohemamine dimers(1-11).Notably,the newly identified dibohemamines I-O(1-7)h...A chemical investigation of Streptomyces sp.GZWMJZ-662,an endophytic actinomycete isolated from Houttuynia cordata Thunb.,has yielded eleven bohemamine dimers(1-11).Notably,the newly identified dibohemamines I-O(1-7)have not been previously reported.Their structures were elucidated through detailed spectroscopic analysis,encompassing high-resolution electrospray ionization mass,nuclear magnetic resonance,infrared radiation,ultraviolet-visible,and electronic circular dichroism spectroscopy.Dibohemamine I(1)exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated,with the half-inhibitory concentration values of 3.24±0.20 and 7.36±0.41μM,respectively.展开更多
Correction to:Neurosci.Bull.December,2016,32(6):577–584.https://doi.org/10.1007/s12264-016-0068-z In this article,in Fig 5A,the picture of the Vector+Nogo-66 group was incorrect and should have appeared as shown below.
In this paper,we propose a new non-Gaussian quantum state,termed the photon-modulated displaced thermal state(DTS).Using the operator ordering method,we obtain the normal ordering product of its density operator and t...In this paper,we propose a new non-Gaussian quantum state,termed the photon-modulated displaced thermal state(DTS).Using the operator ordering method,we obtain the normal ordering product of its density operator and then investigate its normalization,the negativity of its Wigner function and its non-Gaussianity.展开更多
基金Supported by Key Project of National Natural Science Foundation of Sichuan:Research on the Mechanism of Detoxification and Synergistic Effects of Sichuan-Produced Toxic Authentic Medicinal Herbs Croton Seed and Aconite Root(No.2024NSFSC0054)National Interdisciplinary Innovation Team of Traditional Chinese Medicine:Multidisciplinary Innovation Team for Multidimensional Evaluation of Southwest Chinese Characteristic Traditional Chinese Medicine Resources(No.ZYYCXTD-D-202209)Sichuan Chinese Medicine Science and Technology Industry Innovation Team:Innovative Team for Multidimensional Evaluation and Product Development of Characteristic Traditional Chinese Medicine Resources(No.2022C001)。
文摘OBJECTIVE:To find alternatives to natural musk,this study compared the pharmacological effects of cultivated musk,synthetic musk,and natural musk.The aim is to address the dual challenge of clinical demand for muskbased medicines and the endangered status of the musk deer population.METHODS:This study aimed to establish a rat model of acute cerebral ischemia/reperfusion injury(CI/RI)by creating a middle cerebral artery occlusion and reperfusion model.Methods including enzyme-linked immunosorbent assay kits,hematoxylin and eosin staining,Nissl staining,immunohistochemistry,and Western blot were employed to compare the extent of brain tissue damage,inflammatory factor levels,and platelet-related indicators in rats treated with musk from different sources(natural musk,cultivated musk,and synthetic musk),thereby evaluating their differences in neuroprotection.Analysis was performed using one-way analysis of variance.RESULTS:Results indicated that pretreatment with musk demonstrated a positive impact on neurological function by reducing cerebral infarction size,decreasing cerebral edema severity,increasing calcitonin gene related peptide levels,inhibiting 5-hydroxytryptamine release,and preserving the blood-brain barrier integrity.Notably,natural musk exhibited superior antithrombotic properties compared to cultivated and synthetic musk,primarily evidenced by its ability to inhibit platelet aggregation rate,improve cerebral blood perfusion,reduce platelet activating factor receptor protein expression,and lower thromboxane A2 levels.Cultivated musk was observed to elevate catalase and superoxide dismutase levels while concurrently dampening inducible nitric oxide synthase activity,thereby mitigating oxidative damage and also diminishing tumor necrosis factor-αand interleukin-1βcontents along with Glial fibrillary acidic protein expression,enhancing anti-inflammatory capacity.CONCLUSION:Musk sourced from diverse origins exhibits profound neuroprotective qualities against acute CI/RI in rats.Particularly,natural musk demonstrated a specific propensity towards reinforcing antithrombotic effects,whereas cultivated musk excelled in augmenting anti-inflammatory and antioxidative defenses,offering efficacious protection against acute CI/RI.The findings bolster the credibility of strategically employing diverse sources of musk as a preventive strategy against ischemic strokes.
基金supported by the National Natural Science Foundation of China(22074072,22274083,52376199)the Shandong Provincial Natural Science Foundation(ZR2023LZY005)+1 种基金the Exploration Project of the State Key Laboratory of BioFibers and EcoTextiles of Qingdao University(TSKT202101)the Fundamental Research Funds for the Central Universities(2022BLRD13,2023BLRD01).
文摘A rapidly growing field is piezoresistive sensor for accurate respiration rate monitoring to suppress the worldwide respiratory illness.However,a large neglected issue is the sensing durability and accuracy without interference since the expiratory pressure always coupled with external humidity and temperature variations,as well as mechanical motion artifacts.Herein,a robust and biodegradable piezoresistive sensor is reported that consists of heterogeneous MXene/cellulose-gelation sensing layer and Ag-based interdigital electrode,featuring customizable cylindrical interface arrangement and compact hierarchical laminated architecture for collectively regulating the piezoresistive response and mechanical robustness,thereby realizing the long-term breath-induced pressure detection.Notably,molecular dynamics simulations reveal the frequent angle inversion and reorientation of MXene/cellulose in vacuum filtration,driven by shear forces and interfacial interactions,which facilitate the establishment of hydrogen bonds and optimize the architecture design in sensing layer.The resultant sensor delivers unprecedented collection features of superior stability for off-axis deformation(0-120°,~2.8×10^(-3) A)and sensing accuracy without crosstalk(humidity 50%-100%and temperature 30-80).Besides,the sensor-embedded mask together with machine learning models is achieved to train and classify the respiration status for volunteers with different ages(average prediction accuracy~90%).It is envisioned that the customizable architecture design and sensor paradigm will shed light on the advanced stability of sustainable electronics and pave the way for the commercial application in respiratory monitory.
基金financially supported by NSFC (No. 21172204)&NSFS (No. ZR2009CQ014)863 Program of China (Nos. 2013AA092901, 2012AA092104 and 2011AA09070106)+1 种基金973 Program of China (No. 2010CB833804)Scientifc Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China (No. [2010]1174)
文摘A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.
基金financially supported by the National Natural Science Foundation of China(Nos.41876172,41806086,U150122141376148&U1606403)the Fundamental Research Funds for the Central Universities(No.201841006)
文摘Pafuranones A(1)and B(2),a pair of new epimeric polyketide dimers,were isolated from the fungus Paraconiothyrium sp.OUCMDZ-3316 associated with the marine algae Enteromorpha prolifera.Their structures,including absolute configurations,were fully elucidated based on spectroscopic analysis,calculated ECD,and chemical methods.Pafuranones A(1)and B(2)possess a rare dimeric furanone skeleton,which might be formed through a conjugate addition of the monomeric units followed by an intramolecular cyclization.
文摘Pyro-breaker is a fast-responding and high-reliable explosive-driven circuit breaker,which has been applied in several quench protection systems,such as International Thermonuclear Experimental Reactor and Experimental Advanced Superconducting Tokamak.As an indispensable back-up switch,Pyro-breaker guarantees the reliability and safety of the system and avoids tremendous loss when quench happens.Electrical contact,a crucial part of an electrical device greatly determines the steady current capacity of a Pyro-breaker.However,due to the complexity of the model and the deficiency knowledge of the microstate of contact areas,an accurate calculation for contact resistance is difficult to acquire.A study of electrical contact in the design of a Pyro-breaker has been presented in this paper.An engineering calculation method is verified with experiments.Parameters are fitted for the presented model,which will be a significant theoretical basis for the future designing.
基金Collaborative Innovation Project of University,Anhui Province(Grant No.GXXT-2022-088).
文摘Using the operator correspondence of the real and fictious modes in the thermo entangled state representation, wesolve the quantum master equation describing the diffusion channel and obtain the Kraus operator-sum representation ofits analytical solution. we find that the pure coherent states evolve into the new mixed thermal superposed states in thediffusion channel. Also, we investigate the statistical properties of the initial coherent states and their entropy evolutions inthe diffusion channel, and find that the entropy evolutions are only related to the decay time and without the amplitudes ofthe initial coherent states.
基金financially supported by the National Key Research and Development Program of China(No.2019YFC0312504)the National Natural Science Foundation of China(Nos.41876172,U1906213)。
文摘(±)-Pyriindolin(1)with a rare molecular backbone formed by fusing a 2,2'-bipyridine nucleus into a spiro[furan-3,3'-indoline]skeleton,was isolated from the Streptomyces albolongus EA12432.The constitution and the relative configuration of(±)-1 were determined by extensive spectroscopic analyses,^(13)C calculation and DP4+probability analysis.The absolute configurations of optically pure(+)-1 and(-)-1 which were obtained after a chiral high performance liquid chromatography(HPLC)separation were further identified by electronic circular dichroism(ECD)calculations.(+)-and(-)-Pyriindolins displayed moderate cytotoxicity against HCT-116 cell line with the half-maximal inhibitory concentration(IC_(50))values of 2.89±0.17μmol/L and 4.47±0.26μmol/L,respectively.
基金The National Natural Science Foundation of China,82460684,Li-Ping WangWest Light Foundation,Chinese Academy of Sciences,RZ[2022]4,Li-Ping Wang+3 种基金Research Foundation for Advanced Talents(D.Wang),TCZJZ[2022]02,Dong-Yang WangProject of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,QJJ[2022]419,Peng FuCultivation project of National Natural Science Foundation of Guizhou Medical University,20NSP065,Li-Ping Wangthe 100 Leading Talents of Guizhou Province,W.Zhu,Wei-Ming Zhu.
文摘A chemical investigation of Streptomyces sp.GZWMJZ-662,an endophytic actinomycete isolated from Houttuynia cordata Thunb.,has yielded eleven bohemamine dimers(1-11).Notably,the newly identified dibohemamines I-O(1-7)have not been previously reported.Their structures were elucidated through detailed spectroscopic analysis,encompassing high-resolution electrospray ionization mass,nuclear magnetic resonance,infrared radiation,ultraviolet-visible,and electronic circular dichroism spectroscopy.Dibohemamine I(1)exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated,with the half-inhibitory concentration values of 3.24±0.20 and 7.36±0.41μM,respectively.
文摘Correction to:Neurosci.Bull.December,2016,32(6):577–584.https://doi.org/10.1007/s12264-016-0068-z In this article,in Fig 5A,the picture of the Vector+Nogo-66 group was incorrect and should have appeared as shown below.
基金supported by the Collaborative Innovation Project of University,Anhui Province(Grant No.GXXT-2022-088)。
文摘In this paper,we propose a new non-Gaussian quantum state,termed the photon-modulated displaced thermal state(DTS).Using the operator ordering method,we obtain the normal ordering product of its density operator and then investigate its normalization,the negativity of its Wigner function and its non-Gaussianity.
