Background and Objective Marfan syndrome,a variable and heritable disorder of fibrous connective tissue,characterized by affecting skeletal,ocular and cardiovascular systems.With the research advancement of genetic me...Background and Objective Marfan syndrome,a variable and heritable disorder of fibrous connective tissue,characterized by affecting skeletal,ocular and cardiovascular systems.With the research advancement of genetic mechanism,the diagnosis of Marfan syndrome,based on clinical manifestations and genetic evidence,is more accurate.The aim of this study is identification of genetic pathogenesis in a Chinese family.展开更多
Objective To report the clinical features and the screening Results of the pathogenic gene in type 2 Marfan syndrome patients,and the relationship between the transmembrane domain of TGFBR2 gene and the clinical pheno...Objective To report the clinical features and the screening Results of the pathogenic gene in type 2 Marfan syndrome patients,and the relationship between the transmembrane domain of TGFBR2 gene and the clinical phenotype.Methods The FBN1 and TGFBR2 genes were sequenced in the genomic DNA by Sanger sequence of type 2 Marfan syndrome pedigrees,and the protein structure prediction and genotype phenotypic analysis of the TGFBR2 gene transmembrane domain termination mutation were carried out.展开更多
Objective causing mutation in a Marfan syndrome(MFS)family with a proband,and to establish genotype-phenotype correlations.Methods Genomic DNA from peripheral blood leukocytes of a Chinese Marfan syndrome familial wer...Objective causing mutation in a Marfan syndrome(MFS)family with a proband,and to establish genotype-phenotype correlations.Methods Genomic DNA from peripheral blood leukocytes of a Chinese Marfan syndrome familial were isolated and screened for fibrillin-1(FBN1)mutations by direct sequencing,and a genotypephenotype study was carried out following a review of the literature on mutations in the searched area.展开更多
随着汽车技术的不断发展,汽车的电气设备种类越来越多,电器消耗的电能占整车能量比重不断上升,对汽车低压电源管理提出更高要求。为满足用户日益增长的汽车电子设备用电需求,达到减少整车能量消耗、提高电池充电效率的目的,在对纯电动...随着汽车技术的不断发展,汽车的电气设备种类越来越多,电器消耗的电能占整车能量比重不断上升,对汽车低压电源管理提出更高要求。为满足用户日益增长的汽车电子设备用电需求,达到减少整车能量消耗、提高电池充电效率的目的,在对纯电动汽车负载进行分类的基础上,利用遗传算法对用于电量安全分级的低压电池荷电状态(state of charge,SOC)进行优化,并提出一种基于SOC的4级恒流低压锂电池充电管理策略;利用AVL-Cruise和MATLAB-Simulink软件联合仿真搭建车辆模型,采用不同工况进行仿真验证和对比分析。结果表明,低压锂电池电源管理策略能够满足纯电动汽车的电量安全性要求,在一定程度上提高了整车经济性;优化后的锂电池充电效率有一定的提高,充电时间也有所减少。展开更多
文摘Background and Objective Marfan syndrome,a variable and heritable disorder of fibrous connective tissue,characterized by affecting skeletal,ocular and cardiovascular systems.With the research advancement of genetic mechanism,the diagnosis of Marfan syndrome,based on clinical manifestations and genetic evidence,is more accurate.The aim of this study is identification of genetic pathogenesis in a Chinese family.
文摘Objective To report the clinical features and the screening Results of the pathogenic gene in type 2 Marfan syndrome patients,and the relationship between the transmembrane domain of TGFBR2 gene and the clinical phenotype.Methods The FBN1 and TGFBR2 genes were sequenced in the genomic DNA by Sanger sequence of type 2 Marfan syndrome pedigrees,and the protein structure prediction and genotype phenotypic analysis of the TGFBR2 gene transmembrane domain termination mutation were carried out.
文摘Objective causing mutation in a Marfan syndrome(MFS)family with a proband,and to establish genotype-phenotype correlations.Methods Genomic DNA from peripheral blood leukocytes of a Chinese Marfan syndrome familial were isolated and screened for fibrillin-1(FBN1)mutations by direct sequencing,and a genotypephenotype study was carried out following a review of the literature on mutations in the searched area.
文摘随着汽车技术的不断发展,汽车的电气设备种类越来越多,电器消耗的电能占整车能量比重不断上升,对汽车低压电源管理提出更高要求。为满足用户日益增长的汽车电子设备用电需求,达到减少整车能量消耗、提高电池充电效率的目的,在对纯电动汽车负载进行分类的基础上,利用遗传算法对用于电量安全分级的低压电池荷电状态(state of charge,SOC)进行优化,并提出一种基于SOC的4级恒流低压锂电池充电管理策略;利用AVL-Cruise和MATLAB-Simulink软件联合仿真搭建车辆模型,采用不同工况进行仿真验证和对比分析。结果表明,低压锂电池电源管理策略能够满足纯电动汽车的电量安全性要求,在一定程度上提高了整车经济性;优化后的锂电池充电效率有一定的提高,充电时间也有所减少。
