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GABA能抑制调制大棕蝠下丘听神经元时间编码模式 被引量:5
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作者 栾瑞红 p.h.s.jen 孙心德 《生物物理学报》 CAS CSCD 北大核心 2002年第4期399-403,共5页
大棕蝠(Eptesicusfuscus)下丘神经元对重复率为10 pps(pulse per second)、30 pps的串声刺激均产生跟随反应,但对90 pps串声刺激的跟随反应则不尽相同。微电泳bicuculline阻断GABA能抑制作用后,所记录的58个神经元中,有13个(22%)放电率... 大棕蝠(Eptesicusfuscus)下丘神经元对重复率为10 pps(pulse per second)、30 pps的串声刺激均产生跟随反应,但对90 pps串声刺激的跟随反应则不尽相同。微电泳bicuculline阻断GABA能抑制作用后,所记录的58个神经元中,有13个(22%)放电率及串声刺激反应模式无变化;45个(78%)神经元放电率有不同程度的增加,对10 pps、30 pps串声刺激仍能产生跟随反应,但对90 pps串声刺激的跟随反应模式有多种变化。其中: 17个(29%)神经元为放电率增加的跟随反应;9个(15%)神经元放电率增加,对前100 ms的串刺激产生反应且放电密集,而对随后200 ms的串刺激只产生少量的放电;15个(26%)神经元放电率增加,在前几十毫秒范围内有较多的放电反应,后续的反应很弱;4个(7%)神经元只对第一个声刺激产生反应,且放电率增加,随后放电急剧减少。结果提示中脑下丘神经元对听觉信息的时间编码可能具有更复杂的机理。 展开更多
关键词 GABA GABAA受体 串刺激重复率 回声定位
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Effects of forward masking on the responses of the inferior collicular neurons in the big brown bats, Eptesicus fuscus 被引量:6
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作者 LUANRuihong WUFeijian +1 位作者 p.h.s.jen SUNXinde 《Chinese Science Bulletin》 SCIE EI CAS 2003年第16期1748-1752,共5页
The present study explores the forward mask-ing of the two-tone stimuli in sequence that evoked responses in the inferior colliculus (IC) of the echolocating bats. The results indicate that forward masking is obvious ... The present study explores the forward mask-ing of the two-tone stimuli in sequence that evoked responses in the inferior colliculus (IC) of the echolocating bats. The results indicate that forward masking is obvious in the acoustic responses of the IC neurons to the two-tone stimuli. Meanwhile the intensity sensitivity of the neurons respond-ing to the probe increases with the inter-tone interval de-creasing. The effects of forward masking are correlated with the relative intensity and the interval between the masker and probe. That is, the effects of forward masking are re-duced with the masker intensity decreasing and enhanced with the probe intensity decreasing and the inter-tone inter-val shortened. The present study suggests that there is a cor-relation between the characteristics of the response to the probe and the dynamic conditions of the postsynaptic cur-rents in the IC neurons. 展开更多
关键词 神经元 回音 声音间隔 声音探测器 前掩蔽 IC 回声定位 生理学 多突触传递
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