Dear Editor,Significant progress has been made in understanding the genetics of amyotrophic lateral sclerosis(ALS),particularly in European populations.However,a substantial proportion of familial ALS(fALS)cases remai...Dear Editor,Significant progress has been made in understanding the genetics of amyotrophic lateral sclerosis(ALS),particularly in European populations.However,a substantial proportion of familial ALS(fALS)cases remaingenetically unexplained.Emerging evidence suggests that ALS phenotypes and genetic risk factors may vary across ethnicities and regions.Investigating the genetic architecture of ALS in understudied populations could uncover new pathwaysand mechanisms contributing to motor neuron degeneration.展开更多
文摘Dear Editor,Significant progress has been made in understanding the genetics of amyotrophic lateral sclerosis(ALS),particularly in European populations.However,a substantial proportion of familial ALS(fALS)cases remaingenetically unexplained.Emerging evidence suggests that ALS phenotypes and genetic risk factors may vary across ethnicities and regions.Investigating the genetic architecture of ALS in understudied populations could uncover new pathwaysand mechanisms contributing to motor neuron degeneration.
