Pemphigus is amucocutaneous intraepithelial blistering disease caused by autoantibodies to epithelial cell adhesion molecules (desmoglein). The association between pemphigus and malignant neoplasm is well recognized. ...Pemphigus is amucocutaneous intraepithelial blistering disease caused by autoantibodies to epithelial cell adhesion molecules (desmoglein). The association between pemphigus and malignant neoplasm is well recognized. We present the case of a 62-year-old woman with pemphigus vulgaris accompanied by multiple myeloma. To the best of our knowledge, this is the first report of a case of pemphigus v ulgaris concomitant with multiple myeloma. From the results of immunoblotting us ing normal human epidermal extracts and indirect immunofluorescence using rat bl adder sections,and her clinical manifestations, our case does not seem to be one of paraneoplastic pemphigus.展开更多
文摘Pemphigus is amucocutaneous intraepithelial blistering disease caused by autoantibodies to epithelial cell adhesion molecules (desmoglein). The association between pemphigus and malignant neoplasm is well recognized. We present the case of a 62-year-old woman with pemphigus vulgaris accompanied by multiple myeloma. To the best of our knowledge, this is the first report of a case of pemphigus v ulgaris concomitant with multiple myeloma. From the results of immunoblotting us ing normal human epidermal extracts and indirect immunofluorescence using rat bl adder sections,and her clinical manifestations, our case does not seem to be one of paraneoplastic pemphigus.
