This study examined how exploitative leadership undermines employees’experience of flow with work role overload and traditionalist values.Data were collected from 361 staff members across diverse industries in China(...This study examined how exploitative leadership undermines employees’experience of flow with work role overload and traditionalist values.Data were collected from 361 staff members across diverse industries in China(females=58.17%,mean age=32.14,SD=5.83).Structural equation modeling results indicated that exploitative leadership reduces employees’work-related flow via increased role overload.Furthermore,employees’traditionality level moderates the exploitative leadership effects on role overload.Specifically,employees with higher traditionality reported lower role overload when experiencing exploitative leadership,suggesting that cultural values may buffer its negative impact.This study contributes to understanding the mechanism and contextual factors linking exploitative leadership to work-related flow,filling a gap in the literature.Organizations are encouraged to reduce exploitative leadership behaviors through leadership development programs and to consider employees’value orientations when designing work environments.展开更多
Rechargeable aqueous zinc-ion batteries are recently gaining incremental attention because of low cost and material abundance,but their development is plagued by limited choices of cathode materials with satisfactory ...Rechargeable aqueous zinc-ion batteries are recently gaining incremental attention because of low cost and material abundance,but their development is plagued by limited choices of cathode materials with satisfactory cycling performance.The polyoxometalates perform formidable redox stability and able to participate in multi-electron transfer,which was well-suited for energy storage.Herein,a bicomponent polyoxometalate-derivative KNiVO(K_(2)[Ni(H_(2)O)_(6)]_(2)[V_(10)O_(28)]·_(4)H_(2)O polyoxometalates after annealing)is firstly demonstrated as a cathode material for aqueous ZIBs.The layered KV_(3)O_(8)(KVO)In the bi-component material constitutes Zn^(2+) migration and storage channels(K^(+) were substantially replaced by Zn^(2+) in the activation phase),and the three-dimensional NiV_(3)O_(8)(NiVO)part acts as skeleton to stabilize the ion channels,which assist the cell to demonstrate a high-rate capacity and specific energy of229.4 mAh/g and satisfactory cyclability(capacity retention of 99.1%after 4500 cycles at a current density of 4 A/g).These results prove the feasibility of POM as cathode materials precursor and put forward a novel pattern of the Zn^(2+)storage mechanism in the activated-KNiVO clusters,which also provide a new route for selecting or designing high-performance cathode for aqueous ZIBs and other advanced battery systems.展开更多
The pursuit-evasion game models the strategic interaction among players, attracting attention in many realistic scenarios, such as missile guidance, unmanned aerial vehicles, and target defense. Existing studies mainl...The pursuit-evasion game models the strategic interaction among players, attracting attention in many realistic scenarios, such as missile guidance, unmanned aerial vehicles, and target defense. Existing studies mainly concentrate on the cooperative pursuit of multiple players in two-dimensional pursuit-evasion games. However, these approaches can hardly be applied to practical situations where players usually move in three-dimensional space with a three-degree-of-freedom control. In this paper,we make the first attempt to investigate the equilibrium strategy of the realistic pursuit-evasion game, in which the pursuer follows a three-degree-of-freedom control, and the evader moves freely. First, we describe the pursuer's three-degree-of-freedom control and the evader's relative coordinate. We then rigorously derive the equilibrium strategy by solving the retrogressive path equation according to the Hamilton-Jacobi-Bellman-Isaacs(HJBI) method, which divides the pursuit-evasion process into the navigation and acceleration phases. Besides, we analyze the maximum allowable speed for the pursuer to capture the evader successfully and provide the strategy with which the evader can escape when the pursuer's speed exceeds the threshold. We further conduct comparison tests with various unilateral deviations to verify that the proposed strategy forms a Nash equilibrium.展开更多
Due to the solution processable nature,the prepared perovskite films are polycrystalline with considerable number of defects.These defects,especially defects at interface accelerate the carrier recombination and reduc...Due to the solution processable nature,the prepared perovskite films are polycrystalline with considerable number of defects.These defects,especially defects at interface accelerate the carrier recombination and reduce the carrier collection.Besides,the surface defects also affect the long-term stability of the perovskite solar cells(PVSCs).To solve this problem,surface passivation molecules are introduced at selective interface(the interface between perovskite and carrier selective layer).This review summarizes recent progress of small molecules used in PVSCs.Firstly,different types of defect states in perovskite films are introduced and their effects on device performance are discussed.Subsequently,surface passivation molecules are divided into four categories,and the interaction between the functional groups of the surface passivation molecules and selective defect states in perovskite films are highlighted.Finally,we look into the prospects and challenges in design noble small molecules for PVSCs applications.展开更多
Remarkable progress has been made in infection prevention and control(IPC)in many countries,but some gaps emerged in the context of the coronavirus disease 2019(COVID-19)pandemic.Core capabilities such as standard cli...Remarkable progress has been made in infection prevention and control(IPC)in many countries,but some gaps emerged in the context of the coronavirus disease 2019(COVID-19)pandemic.Core capabilities such as standard clinical precautions and tracing the source of infection were the focus of IPC in medical institutions during the pandemic.Therefore,the core competences of IPC professionals during the pandemic,and how these contributed to successful prevention and control of the epidemic,should be studied.To investigate,using a systematic review and cluster analysis,fundamental improvements in the competences of infection control and prevention professionals that may be emphasized in light of the COVID-19 pandemic.We searched the PubMed,Embase,Cochrane Library,Web of Science,CNKI,WanFang Data,and CBM databases for original articles exploring core competencies of IPC professionals during the COVID-19 pandemic(from January 1,2020 to February 7,2023).Weiciyun software was used for data extraction and the Donohue formula was followed to distinguish high-frequency technical terms.Cluster analysis was performed using the within-group linkage method and squared Euclidean distance as the metric to determine the priority competencies for development.We identified 46 studies with 29 high-frequency technical terms.The most common term was“infection prevention and control training”(184 times,17.3%),followed by“hand hygiene”(172 times,16.2%).“Infection prevention and control in clinical practice”was the most-reported core competency(367 times,34.5%),followed by“microbiology and surveillance”(292 times,27.5%).Cluster analysis showed two key areas of competence:Category 1(program management and leadership,patient safety and occupational health,education and microbiology and surveillance)and Category 2(IPC in clinical practice).During the COVID-19 pandemic,IPC program management and leadership,microbiology and surveillance,education,patient safety,and occupational health were the most important focus of development and should be given due consideration by IPC professionals.展开更多
The spherical crystal imaging system,noted for its high energy spectral resolution(monochromaticity)and spatial resolution,is extensively applied in high energy density physics and inertial confinement fusion research...The spherical crystal imaging system,noted for its high energy spectral resolution(monochromaticity)and spatial resolution,is extensively applied in high energy density physics and inertial confinement fusion research.This system supports studies on fast electron transport,hydrodynamic instabilities,and implosion dynamics.The x-ray source,produced through laser-plasma interaction,emits a limited number of photons within short time scales,resulting in predominantly photon-starved images.Through ray-tracing simulations,we investigated the impact of varying crystal dimensions on the performance of a spherical crystal self-emission imager.We observed that increasing the crystal dimension leads to higher imaging efficiency but at the expense of monochromaticity,causing broader spectral acceptance and reduced spatial resolution.Furthermore,we presented a theoretical model to estimate the spatial resolution of the imaging system within a specific energy spectrum range,detailing the expressions for the effective size of the crystal.The spatial resolution derived from the model closely matches the numerical simulations.展开更多
[Objectives]To isolate and identify characteristics of the cellulose-degrading bacteria.[Methods]In view of the poor effect of crop straw composting,the strains which can degrade cellulose were isolated and purified f...[Objectives]To isolate and identify characteristics of the cellulose-degrading bacteria.[Methods]In view of the poor effect of crop straw composting,the strains which can degrade cellulose were isolated and purified from the soil piled with rice straw,and the strains A2 and A5 with high efficiency of cellulose degradation were finally screened through the transparent circle,cellulase activity and filter paper disintegration experiments.[Results]It was confirmed that the strains A2 and A5 could degrade cellulose well.The results of 16s rDNA showed that A2 was Pseudoxanthomonas mexicana and A5 was Bacillus cibi.[Conclusions]The results of this study are expected to provide high-quality strain resources for the degradation of cellulose in straw,and have important application value for improving the efficiency of straw composting.展开更多
Background:To investigate the clinical medication approach of Professor Guiqi Xuan(Prof.Xuan)in treating pediatric patients with attention-deficit hyperactivity disorder(ADHD)and the potential mechanism of the core he...Background:To investigate the clinical medication approach of Professor Guiqi Xuan(Prof.Xuan)in treating pediatric patients with attention-deficit hyperactivity disorder(ADHD)and the potential mechanism of the core herbal prescription.Methods:Following medical record information pretreatment,the Traditional Chinese Medicine(TCM)inheritance computing platform system V3.0 was utilized to analyze the standardized data.The associate rules were summarized to identify the core prescription for treating ADHD.The extracted core herbal prescription’s active compounds and potential targets were used to establish a protein-protein interaction network of active ingredient-disease targets.Cytoscape 3.9.1 software was used to analyze the network’s topological parameters to obtain the key active ingredients and their targets.The Bioconductor data package of R4.0.2 was used to analyze the gene ontology biological functions and Kyoto Encyclopedia of Genes and Genomes pathways of key targets.Results:Two hundred and twenty-seven entries derived from TCM record information were selected.Through data mining,it was found that 62.5%of pediatric patients had short-tempered behavior,nearly half had sleep problems,and 30%-40%had picky eating and polyphagia issues.The highest-frequency syndrome type was kidney deficiency and liver hyperactivity.Deficiency,fire,phlegm,and dyspeptic food were the main pathological factors for ADHD.Prof.Xuan’s treatment of ADHD mainly focused on replenishing kidney essence and subduing Yang(active,external,ascending,warm,bright,functional and excited pertain to Yang).The core herbal prescription for ADHD included Yuan-zhi,Yi-zhi,Gui-jia,Bai-shao,Long-chi,Ci-shi,Shi-chang-pu,Yu-jin,Fu-shen,and Huang-jing.The protein-protein interaction network showed that MAOA,ADRB2,FOS,MAOB,and SLC6A3 were the five key targets essential in treating ADHD with core herbal prescriptions.The gene ontology biological function of crucial targets mainly involved G protein-coupled amine receptor activity,catecholamine binding,and neurotransmitter transmembrane transporter activity.Analysis of Kyoto Encyclopedia of Genes and Genomes pathways showed that the dopaminergic synapse signaling and neuroactive ligand-receptor interaction pathways were significantly enriched and may be the primary routes for the main treatment of ADHD.Conclusion:Prof.Xuan’s treatment of ADHD has achieved satisfactory clinical effects by supplementing the kidney,replenishing the essence,opening the orifices,nourishing the Yin(static,internal,descending,cold,dim,organic,depressed and pertain to Yin),and subduing the Yang.The major prescription predominantly affects catecholamine binding,neuroactive ligand-receptor interaction,G protein-coupled amine receptor function,and signaling pathways for dopaminergic synapses.Our findings showed that the methodology and software used in this research could explore and analyze the mechanism behind Prof.Xuan’s clinical medication rule for treating ADHD in children.展开更多
Slot-die coating with halogen-free solvents is a promising scalable fabrication strategy for organic solar cells(OSCs).However,the complex interplay between long-time-scale solute diffusion and microstructural evoluti...Slot-die coating with halogen-free solvents is a promising scalable fabrication strategy for organic solar cells(OSCs).However,the complex interplay between long-time-scale solute diffusion and microstructural evolution during the coating process remains poorly understood,limiting further optimization of morphology and device performance.In this study,we elucidate the critical role of solution viscosity in regulating phase separation and aggregation kinetics.Specifically,lower solution viscosity enhances solute diffusion,accelerating molecular aggregation while suppressing liquid-liquid phase separation(LLPS).Notably,we observe that in three different systems with varying crystallinity and immiscibility(PM6:Y6,PTQ10:Y6,and D18:Y6),the optimal processing conditions for peak device efficiency consistently correspond to a nearly identical solution viscosity(∼0.8 mPa s),despite variations in optimal processing temperatures.In situ characterizations reveal that at this viscosity,all three systems exhibit constrained LLPS and rapid molecular aggregation,promoting the formation of finely structured,continuous nanoscale domains.These findings establish solution viscosity as a universal governing parameter for morphology control in printed active layers.By providing a fundamental framework for understanding viscosity-mediated phase separation,this work offers valuable insights for advancing high-throughput,environmentally friendly printing techniques for high-efficiency OSCs.展开更多
The disturbance of the human microbiota influences the occurrence and progression of many diseases.Live therapeutic bacteria,with their genetic manipulability,anaerobic tendencies,and immunomodulatory properties,are e...The disturbance of the human microbiota influences the occurrence and progression of many diseases.Live therapeutic bacteria,with their genetic manipulability,anaerobic tendencies,and immunomodulatory properties,are emerging as promising therapeutic agents.However,their clinical applications face challenges in maintaining activity and achieving precise spatiotemporal release,particularly in the harsh gastrointestinal environment.This review highlights the innovative bacterial functionalized encapsulation strategies developed through advances in physicochemical and biological techniques.We comprehensively review how bacterial encapsulation strategies can be used to provide physical barriers and enhanced adhesion properties to live microorganisms,while introducing superior material properties to live bacteria.In addition,this review outlines how bacterial surface coating can facilitate targeted delivery and precise spatiotemporal release of live bacteria.Furthermore,it elucidates their potential applications for treating different diseases,along with critical perspectives on challenges in clinical translation.This review comprehensively analyzes the connection between functionalized bacterial encapsulation and innovative biomedical applications,providing a theoretical reference for the development of next-generation bacterial therapies.展开更多
Short-chain fatty acids(SCFAs)have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiot...Short-chain fatty acids(SCFAs)have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiota-gut-brain axis.However,the precise mechanism by which brain SCFAs extert multiple beneficial effects is not completely understood.Our previous research has demonstrated that the acetyl-coenzyme A synthetase short-chain family member 2(ACSS2)is a novel target of the rapid and long-lasting antidepressant responses.Here,we show that micromolar SCFAs significantly augment both total cellular and nuclear ACSS2 to trigger tryptophan hydroxylase 2(TPH2)promoter histone acetylation and its transcription in SH-SY5Y cells.In chronic-restraint-stress-induced depression mice,neuronal ACSS2 knockdown by stereotaxic injection of adeno-associated virus in the hippocampus abolished SCFA-mediated improvements in depressive-like behaviors of mice,supporting that ACSS2 is required for SCFA-mediated antidepressant responses.Mechanistically,the peroxisome-proliferator-activated receptor gamma(PPARγ)is identified as a novel partner of ACSS2 to activate TPH2 transcription.Importantly,PPARγis also responsible for SCFA-mediated antidepressant-like effects via ACSS2-TPH2 axis.To further support brain SCFAs as a therapeutic target for antidepressant effects,d-mannose,which is a naturally present hexose,can significantly reverse the dysbiosis of gut microbiota in the chronic-restraint-stress-exposure mice and augment brain SCFAs to protect against the depressive-like behaviors via ACSS2-PPARγ-TPH2 axis.In summary,brain SCFAs can activate ACSS2-PPARγ-TPH2 axis to play the antidepressive-like effects,and d-mannose is suggested to be an inducer of brain SCFAs in resisting depression.展开更多
Food-derived polysaccharides are gaining popularity across diverse food applications due to their wideranging bioactivities and distinctive properties.The specific targeting of glycoside hydrolases towards glycosidic ...Food-derived polysaccharides are gaining popularity across diverse food applications due to their wideranging bioactivities and distinctive properties.The specific targeting of glycoside hydrolases towards glycosidic bonds lays the groundwork for synthesizing and exploring specific structural segments of polysaccharides,offering crucial implications in the food industry.However,macromolecular polysaccharides demonstrate limited biological activities as their active centers are tightly enveloped,posing challenges for traversing cell membrane barriers.By selectively cleaving partial glycosidic linkages in polysaccharides,glycoside hydrolases decrease the polymerization of polysaccharide molecules and effectively change the structural characteristics,where a series of smaller polysaccharide fragments can be generated for improving the bioactivities and properties in some respects.This review examines the role of glycoside hydrolases in degrading food-derived polysaccharides,the structure-function relationships,reaction conditions,and the current application status of degraded polysaccharides is discussed in particular.In addition,we also highlight challenges and future directions worth attention in the application of enzymes and polysaccharides.Overall,the present review will provide an efficient method for producing bioactivity-enhanced polysaccharides,which can improve the effectiveness and safety of functional foods to safeguard human wellness.展开更多
Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental e...Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.展开更多
The outbreak and spreading of the COVID-19 pandemic have had a significant impact on transportation system.By analyzing the impact of the pandemic on the transportation system,the impact of the pandemic on the social ...The outbreak and spreading of the COVID-19 pandemic have had a significant impact on transportation system.By analyzing the impact of the pandemic on the transportation system,the impact of the pandemic on the social economy can be reflected to a certain extent,and the effect of anti-pandemic policy implementation can also be evaluated.In addition,the analysis results are expected to provide support for policy optimization.Currently,most of the relevant studies analyze the impact of the pandemic on the overall transportation system from the macro perspective,while few studies quantitatively analyze the impact of the pandemic on individual spatiotemporal travel behavior.Based on the license plate recognition(LPR)data,this paper analyzes the spatiotemporal travel patterns of travelers in each stage of the pandemic progress,quantifies the change of travelers'spatiotemporal behaviors,and analyzes the adjustment of travelers'behaviors under the influence of the pandemic.There are three different behavior adjustment strategies under the influence of the pandemic,and the behavior adjustment is related to the individual's past travel habits.The paper quantitatively assesses the impact of the COVID-19 pandemic on individual travel behavior.And the method proposed in this paper can be used to quantitatively assess the impact of any long-term emergency on individual micro travel behavior.展开更多
The authors regret that Eq.(5)in the paper is wrongly written and should be revised as follows:s_(p)(a_(i),a_(j))=len(a_(i))×Ratio(LCS(a_(i),a_(j)),a_(i))+len(a_(j))×Ratio(LCS(a_(i),a_(j)),a_(j))/len(a_(i))+...The authors regret that Eq.(5)in the paper is wrongly written and should be revised as follows:s_(p)(a_(i),a_(j))=len(a_(i))×Ratio(LCS(a_(i),a_(j)),a_(i))+len(a_(j))×Ratio(LCS(a_(i),a_(j)),a_(j))/len(a_(i))+len(a_(j))(5)The authors would like to apologise for any inconvenience caused.展开更多
Nonlinear optical signal processing(NOSP)has the potential to significantly improve the throughput,flexibility,and cost-efficiency of optical communication networks by exploiting the intrinsically ultrafast optical no...Nonlinear optical signal processing(NOSP)has the potential to significantly improve the throughput,flexibility,and cost-efficiency of optical communication networks by exploiting the intrinsically ultrafast optical nonlinear wave mixing.It can support digital signal processing speeds of up to terabits per second,far exceeding the line rate of the electronic counterpart.In NOSP,high-intensity light fields are used to generate nonlinear optical responses,which can be used to process optical signals.Great efforts have been devoted to developing new materials and structures for NOSP.However,one of the challenges in implementing NOSP is the requirement of high-intensity light fields,which is difficult to generate and maintain.This has been a major roadblock to realize practical NOSP systems for high-speed,high-capacity optical communications.Here,we propose using a parity-time(PT)symmetric microresonator system to significantly enhance the light intensity and support high-speed operation by relieving the bandwidth-efficiency limit imposed on conventional single resonator systems.The design concept is the coexistence of a PT symmetry broken regime for a narrow-linewidth pump wave and near-exceptional point operation for broadband signal and idler waves.This enables us to achieve a new NOSP system with two orders of magnitude improvement in efficiency compared to a single resonator.With a highly nonlinear AlGaAs-on-Insulator platform,we demonstrate an NOSP at a data rate approaching 40 gigabits per second with a record low pump power of one milliwatt.These findings pave the way for the development of fully chip-scale NOSP devices with pump light sources integrated together,potentially leading to a wide range of applications in optical communication networks and classical or quantum computation.The combination of PT symmetry and NOSP may also open up opportunities for amplification,detection,and sensing,where response speed and efficiency are equally important.展开更多
The sun and outer space are the ultimate heat and cold sources for the earth,respectively.They have significant potential for renewable energy harvesting.In this paper,a spectrally selective surface structure that has...The sun and outer space are the ultimate heat and cold sources for the earth,respectively.They have significant potential for renewable energy harvesting.In this paper,a spectrally selective surface structure that has a planar polydimethylsiloxane layer covering a solar absorber is conceptually proposed and optically designed for the combination of photothermic conversion(PT)and nighttime radiative sky cooling(RC).An optical simulation is conducted whose result shows that the designed surface structure(i.e.,PT-RC surface structure)has a strong solar absorption coefficient of 0.92 and simultaneously emits as a mid-infrared spectral-selective emitter with an average emissivity of 0.84 within the atmospheric window.A thermal analysis prediction reveals that the designed PTRC surface structure can be heated to 79.1℃higher than the ambient temperature in the daytime and passively cooled below the ambient temperature of approximately 10℃in the nighttime,indicating that the designed PT-RC surface structure has the potential for integrated PT conversion and nighttime RC utilization.展开更多
文摘This study examined how exploitative leadership undermines employees’experience of flow with work role overload and traditionalist values.Data were collected from 361 staff members across diverse industries in China(females=58.17%,mean age=32.14,SD=5.83).Structural equation modeling results indicated that exploitative leadership reduces employees’work-related flow via increased role overload.Furthermore,employees’traditionality level moderates the exploitative leadership effects on role overload.Specifically,employees with higher traditionality reported lower role overload when experiencing exploitative leadership,suggesting that cultural values may buffer its negative impact.This study contributes to understanding the mechanism and contextual factors linking exploitative leadership to work-related flow,filling a gap in the literature.Organizations are encouraged to reduce exploitative leadership behaviors through leadership development programs and to consider employees’value orientations when designing work environments.
基金supported by the Natural Science Foundation of Hunan Province(No.2020JJ4684)the Fundamental Research Funds for the Central Universities of Central South University(No.2021zzts0522)the Recruitment Program of Global Youth Experts。
文摘Rechargeable aqueous zinc-ion batteries are recently gaining incremental attention because of low cost and material abundance,but their development is plagued by limited choices of cathode materials with satisfactory cycling performance.The polyoxometalates perform formidable redox stability and able to participate in multi-electron transfer,which was well-suited for energy storage.Herein,a bicomponent polyoxometalate-derivative KNiVO(K_(2)[Ni(H_(2)O)_(6)]_(2)[V_(10)O_(28)]·_(4)H_(2)O polyoxometalates after annealing)is firstly demonstrated as a cathode material for aqueous ZIBs.The layered KV_(3)O_(8)(KVO)In the bi-component material constitutes Zn^(2+) migration and storage channels(K^(+) were substantially replaced by Zn^(2+) in the activation phase),and the three-dimensional NiV_(3)O_(8)(NiVO)part acts as skeleton to stabilize the ion channels,which assist the cell to demonstrate a high-rate capacity and specific energy of229.4 mAh/g and satisfactory cyclability(capacity retention of 99.1%after 4500 cycles at a current density of 4 A/g).These results prove the feasibility of POM as cathode materials precursor and put forward a novel pattern of the Zn^(2+)storage mechanism in the activated-KNiVO clusters,which also provide a new route for selecting or designing high-performance cathode for aqueous ZIBs and other advanced battery systems.
基金supported in part by the Strategic Priority Research Program of Chinese Academy of Sciences(XDA27030100)National Natural Science Foundation of China(72293575, 11832001)。
文摘The pursuit-evasion game models the strategic interaction among players, attracting attention in many realistic scenarios, such as missile guidance, unmanned aerial vehicles, and target defense. Existing studies mainly concentrate on the cooperative pursuit of multiple players in two-dimensional pursuit-evasion games. However, these approaches can hardly be applied to practical situations where players usually move in three-dimensional space with a three-degree-of-freedom control. In this paper,we make the first attempt to investigate the equilibrium strategy of the realistic pursuit-evasion game, in which the pursuer follows a three-degree-of-freedom control, and the evader moves freely. First, we describe the pursuer's three-degree-of-freedom control and the evader's relative coordinate. We then rigorously derive the equilibrium strategy by solving the retrogressive path equation according to the Hamilton-Jacobi-Bellman-Isaacs(HJBI) method, which divides the pursuit-evasion process into the navigation and acceleration phases. Besides, we analyze the maximum allowable speed for the pursuer to capture the evader successfully and provide the strategy with which the evader can escape when the pursuer's speed exceeds the threshold. We further conduct comparison tests with various unilateral deviations to verify that the proposed strategy forms a Nash equilibrium.
基金support from Key Program of National Natural Science Foundation of China(22133006)the National Natural Science Foundation of China(ZX20210286)+1 种基金the Fundamental Research Funds for the Central Universities(20CX06004A)Talent Introduction Program of China University of Petroleum(East China)(ZX20190162)and the Post-Graduate Innovation Project of China University of Petroluem(East China)(YCX2021140)are acknowledged.We also thank the support from the Yankuang Group 2019 Science and Technology Program(YKKJ2019AJ05JG-R60).Prof.X.Li and Dr.T.Zhang thank the Taishan Scholar Programof Shandong Province(ts201712019,tsnq201909069)for financial support.
文摘Due to the solution processable nature,the prepared perovskite films are polycrystalline with considerable number of defects.These defects,especially defects at interface accelerate the carrier recombination and reduce the carrier collection.Besides,the surface defects also affect the long-term stability of the perovskite solar cells(PVSCs).To solve this problem,surface passivation molecules are introduced at selective interface(the interface between perovskite and carrier selective layer).This review summarizes recent progress of small molecules used in PVSCs.Firstly,different types of defect states in perovskite films are introduced and their effects on device performance are discussed.Subsequently,surface passivation molecules are divided into four categories,and the interaction between the functional groups of the surface passivation molecules and selective defect states in perovskite films are highlighted.Finally,we look into the prospects and challenges in design noble small molecules for PVSCs applications.
基金The National Natural Science Foundation of China,Grant/Award Number:52178080Major Research Project of the Hospital Management Research Institute of the National Health Commission,Grant/Award Number:GY2023011National Institute of Hospital Administration Management of China,Grant/Award Number:GY2023049。
文摘Remarkable progress has been made in infection prevention and control(IPC)in many countries,but some gaps emerged in the context of the coronavirus disease 2019(COVID-19)pandemic.Core capabilities such as standard clinical precautions and tracing the source of infection were the focus of IPC in medical institutions during the pandemic.Therefore,the core competences of IPC professionals during the pandemic,and how these contributed to successful prevention and control of the epidemic,should be studied.To investigate,using a systematic review and cluster analysis,fundamental improvements in the competences of infection control and prevention professionals that may be emphasized in light of the COVID-19 pandemic.We searched the PubMed,Embase,Cochrane Library,Web of Science,CNKI,WanFang Data,and CBM databases for original articles exploring core competencies of IPC professionals during the COVID-19 pandemic(from January 1,2020 to February 7,2023).Weiciyun software was used for data extraction and the Donohue formula was followed to distinguish high-frequency technical terms.Cluster analysis was performed using the within-group linkage method and squared Euclidean distance as the metric to determine the priority competencies for development.We identified 46 studies with 29 high-frequency technical terms.The most common term was“infection prevention and control training”(184 times,17.3%),followed by“hand hygiene”(172 times,16.2%).“Infection prevention and control in clinical practice”was the most-reported core competency(367 times,34.5%),followed by“microbiology and surveillance”(292 times,27.5%).Cluster analysis showed two key areas of competence:Category 1(program management and leadership,patient safety and occupational health,education and microbiology and surveillance)and Category 2(IPC in clinical practice).During the COVID-19 pandemic,IPC program management and leadership,microbiology and surveillance,education,patient safety,and occupational health were the most important focus of development and should be given due consideration by IPC professionals.
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA25051000,XDA25010100,XDA25010300,XDA25030100,and XDA25030200)。
文摘The spherical crystal imaging system,noted for its high energy spectral resolution(monochromaticity)and spatial resolution,is extensively applied in high energy density physics and inertial confinement fusion research.This system supports studies on fast electron transport,hydrodynamic instabilities,and implosion dynamics.The x-ray source,produced through laser-plasma interaction,emits a limited number of photons within short time scales,resulting in predominantly photon-starved images.Through ray-tracing simulations,we investigated the impact of varying crystal dimensions on the performance of a spherical crystal self-emission imager.We observed that increasing the crystal dimension leads to higher imaging efficiency but at the expense of monochromaticity,causing broader spectral acceptance and reduced spatial resolution.Furthermore,we presented a theoretical model to estimate the spatial resolution of the imaging system within a specific energy spectrum range,detailing the expressions for the effective size of the crystal.The spatial resolution derived from the model closely matches the numerical simulations.
基金Supported by Innovation and Entrepreneurship Training Program for College Students (202310580018).
文摘[Objectives]To isolate and identify characteristics of the cellulose-degrading bacteria.[Methods]In view of the poor effect of crop straw composting,the strains which can degrade cellulose were isolated and purified from the soil piled with rice straw,and the strains A2 and A5 with high efficiency of cellulose degradation were finally screened through the transparent circle,cellulase activity and filter paper disintegration experiments.[Results]It was confirmed that the strains A2 and A5 could degrade cellulose well.The results of 16s rDNA showed that A2 was Pseudoxanthomonas mexicana and A5 was Bacillus cibi.[Conclusions]The results of this study are expected to provide high-quality strain resources for the degradation of cellulose in straw,and have important application value for improving the efficiency of straw composting.
基金This work was supported by the Hangzhou XUANs’Pediatric School Inheritance Studio Construction Project(No.[2012]228).
文摘Background:To investigate the clinical medication approach of Professor Guiqi Xuan(Prof.Xuan)in treating pediatric patients with attention-deficit hyperactivity disorder(ADHD)and the potential mechanism of the core herbal prescription.Methods:Following medical record information pretreatment,the Traditional Chinese Medicine(TCM)inheritance computing platform system V3.0 was utilized to analyze the standardized data.The associate rules were summarized to identify the core prescription for treating ADHD.The extracted core herbal prescription’s active compounds and potential targets were used to establish a protein-protein interaction network of active ingredient-disease targets.Cytoscape 3.9.1 software was used to analyze the network’s topological parameters to obtain the key active ingredients and their targets.The Bioconductor data package of R4.0.2 was used to analyze the gene ontology biological functions and Kyoto Encyclopedia of Genes and Genomes pathways of key targets.Results:Two hundred and twenty-seven entries derived from TCM record information were selected.Through data mining,it was found that 62.5%of pediatric patients had short-tempered behavior,nearly half had sleep problems,and 30%-40%had picky eating and polyphagia issues.The highest-frequency syndrome type was kidney deficiency and liver hyperactivity.Deficiency,fire,phlegm,and dyspeptic food were the main pathological factors for ADHD.Prof.Xuan’s treatment of ADHD mainly focused on replenishing kidney essence and subduing Yang(active,external,ascending,warm,bright,functional and excited pertain to Yang).The core herbal prescription for ADHD included Yuan-zhi,Yi-zhi,Gui-jia,Bai-shao,Long-chi,Ci-shi,Shi-chang-pu,Yu-jin,Fu-shen,and Huang-jing.The protein-protein interaction network showed that MAOA,ADRB2,FOS,MAOB,and SLC6A3 were the five key targets essential in treating ADHD with core herbal prescriptions.The gene ontology biological function of crucial targets mainly involved G protein-coupled amine receptor activity,catecholamine binding,and neurotransmitter transmembrane transporter activity.Analysis of Kyoto Encyclopedia of Genes and Genomes pathways showed that the dopaminergic synapse signaling and neuroactive ligand-receptor interaction pathways were significantly enriched and may be the primary routes for the main treatment of ADHD.Conclusion:Prof.Xuan’s treatment of ADHD has achieved satisfactory clinical effects by supplementing the kidney,replenishing the essence,opening the orifices,nourishing the Yin(static,internal,descending,cold,dim,organic,depressed and pertain to Yin),and subduing the Yang.The major prescription predominantly affects catecholamine binding,neuroactive ligand-receptor interaction,G protein-coupled amine receptor function,and signaling pathways for dopaminergic synapses.Our findings showed that the methodology and software used in this research could explore and analyze the mechanism behind Prof.Xuan’s clinical medication rule for treating ADHD in children.
基金the National Natural Science Foundation of China(W2411049,52303247,and 52173023)the Fundamental Research Funds for the Central Universities(xzy012023169)+2 种基金the Postdoctoral Research Project of Shaanxi Province(2023BSHEDZZ24)the 111 Project 2.0(BP0618008)the China Postdoctoral Science Foundation(2023TQ0273)。
文摘Slot-die coating with halogen-free solvents is a promising scalable fabrication strategy for organic solar cells(OSCs).However,the complex interplay between long-time-scale solute diffusion and microstructural evolution during the coating process remains poorly understood,limiting further optimization of morphology and device performance.In this study,we elucidate the critical role of solution viscosity in regulating phase separation and aggregation kinetics.Specifically,lower solution viscosity enhances solute diffusion,accelerating molecular aggregation while suppressing liquid-liquid phase separation(LLPS).Notably,we observe that in three different systems with varying crystallinity and immiscibility(PM6:Y6,PTQ10:Y6,and D18:Y6),the optimal processing conditions for peak device efficiency consistently correspond to a nearly identical solution viscosity(∼0.8 mPa s),despite variations in optimal processing temperatures.In situ characterizations reveal that at this viscosity,all three systems exhibit constrained LLPS and rapid molecular aggregation,promoting the formation of finely structured,continuous nanoscale domains.These findings establish solution viscosity as a universal governing parameter for morphology control in printed active layers.By providing a fundamental framework for understanding viscosity-mediated phase separation,this work offers valuable insights for advancing high-throughput,environmentally friendly printing techniques for high-efficiency OSCs.
基金supports of the National Key Research and Development Program of China(2022YFD2100703)the Guangdong Province Key Areas Research and Development Programs(2022B1111070006,China)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(2025A1515012225,China)the project of Guangdong Provincial Academy of Sciences(2022GDASZH-2022010101,China)for the financial support.
文摘The disturbance of the human microbiota influences the occurrence and progression of many diseases.Live therapeutic bacteria,with their genetic manipulability,anaerobic tendencies,and immunomodulatory properties,are emerging as promising therapeutic agents.However,their clinical applications face challenges in maintaining activity and achieving precise spatiotemporal release,particularly in the harsh gastrointestinal environment.This review highlights the innovative bacterial functionalized encapsulation strategies developed through advances in physicochemical and biological techniques.We comprehensively review how bacterial encapsulation strategies can be used to provide physical barriers and enhanced adhesion properties to live microorganisms,while introducing superior material properties to live bacteria.In addition,this review outlines how bacterial surface coating can facilitate targeted delivery and precise spatiotemporal release of live bacteria.Furthermore,it elucidates their potential applications for treating different diseases,along with critical perspectives on challenges in clinical translation.This review comprehensively analyzes the connection between functionalized bacterial encapsulation and innovative biomedical applications,providing a theoretical reference for the development of next-generation bacterial therapies.
基金supported by the National Natural Science Foundation of China(82101606,82173105,81771775,81971471,and 32270800)Shandong Excellent Young Scientists Fund Program(Overseas)(2022HWYQ-028)Shandong Provincial Natural Science Foundation(ZR2022MC012).
文摘Short-chain fatty acids(SCFAs)have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiota-gut-brain axis.However,the precise mechanism by which brain SCFAs extert multiple beneficial effects is not completely understood.Our previous research has demonstrated that the acetyl-coenzyme A synthetase short-chain family member 2(ACSS2)is a novel target of the rapid and long-lasting antidepressant responses.Here,we show that micromolar SCFAs significantly augment both total cellular and nuclear ACSS2 to trigger tryptophan hydroxylase 2(TPH2)promoter histone acetylation and its transcription in SH-SY5Y cells.In chronic-restraint-stress-induced depression mice,neuronal ACSS2 knockdown by stereotaxic injection of adeno-associated virus in the hippocampus abolished SCFA-mediated improvements in depressive-like behaviors of mice,supporting that ACSS2 is required for SCFA-mediated antidepressant responses.Mechanistically,the peroxisome-proliferator-activated receptor gamma(PPARγ)is identified as a novel partner of ACSS2 to activate TPH2 transcription.Importantly,PPARγis also responsible for SCFA-mediated antidepressant-like effects via ACSS2-TPH2 axis.To further support brain SCFAs as a therapeutic target for antidepressant effects,d-mannose,which is a naturally present hexose,can significantly reverse the dysbiosis of gut microbiota in the chronic-restraint-stress-exposure mice and augment brain SCFAs to protect against the depressive-like behaviors via ACSS2-PPARγ-TPH2 axis.In summary,brain SCFAs can activate ACSS2-PPARγ-TPH2 axis to play the antidepressive-like effects,and d-mannose is suggested to be an inducer of brain SCFAs in resisting depression.
基金supported by the Jiangsu Province University Basic Science(Natural Science)Research Major Project(24KJA360007)Nanjing University of Chinese Medicine TCM First-Class Discipline"Leading Plan”Scientific Research Project(ZYXYL2024-001)+3 种基金Jiangsu Provincial TCM Science and Technology Development Program Project(MS2021004)High Level Key Discipline Construction Project of the National Administration of Traditional Chinese Medicine-Resource Chemistry of Chinese Medicinal Materials(ZYYZDXK-2023083)National Administration of Traditional Chinese Medicine Chinese Medicine Innovation Team and Talent Support Program Project(ZYYCXTD-D-202005)2022 Student Innovation Training Program Project(103152022075).
文摘Food-derived polysaccharides are gaining popularity across diverse food applications due to their wideranging bioactivities and distinctive properties.The specific targeting of glycoside hydrolases towards glycosidic bonds lays the groundwork for synthesizing and exploring specific structural segments of polysaccharides,offering crucial implications in the food industry.However,macromolecular polysaccharides demonstrate limited biological activities as their active centers are tightly enveloped,posing challenges for traversing cell membrane barriers.By selectively cleaving partial glycosidic linkages in polysaccharides,glycoside hydrolases decrease the polymerization of polysaccharide molecules and effectively change the structural characteristics,where a series of smaller polysaccharide fragments can be generated for improving the bioactivities and properties in some respects.This review examines the role of glycoside hydrolases in degrading food-derived polysaccharides,the structure-function relationships,reaction conditions,and the current application status of degraded polysaccharides is discussed in particular.In addition,we also highlight challenges and future directions worth attention in the application of enzymes and polysaccharides.Overall,the present review will provide an efficient method for producing bioactivity-enhanced polysaccharides,which can improve the effectiveness and safety of functional foods to safeguard human wellness.
基金We thank the National Key R&D Program of China(No.2020YFA0710401)the National Natural Science Foundation of China(Nos.82225012,81922019,82071161,81991505,22122207,21988102,and 52075138)+1 种基金the Young Elite Scientist Sponsorship Program by CAST(No.2020QNRC001)the Beijing Nova Program(No.211100002121013).
文摘Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.
基金supported by“Pioneer”and“Leading Goose”R&D Program of Zhejiang(2022C01042)the National Natural Science Foundation of China(Grant No.92046011)+1 种基金Center for Balance Architecture Zhejiang UniversityAlibaba-Zhejiang University Joint Research Institute of Frontier Technologies.
文摘The outbreak and spreading of the COVID-19 pandemic have had a significant impact on transportation system.By analyzing the impact of the pandemic on the transportation system,the impact of the pandemic on the social economy can be reflected to a certain extent,and the effect of anti-pandemic policy implementation can also be evaluated.In addition,the analysis results are expected to provide support for policy optimization.Currently,most of the relevant studies analyze the impact of the pandemic on the overall transportation system from the macro perspective,while few studies quantitatively analyze the impact of the pandemic on individual spatiotemporal travel behavior.Based on the license plate recognition(LPR)data,this paper analyzes the spatiotemporal travel patterns of travelers in each stage of the pandemic progress,quantifies the change of travelers'spatiotemporal behaviors,and analyzes the adjustment of travelers'behaviors under the influence of the pandemic.There are three different behavior adjustment strategies under the influence of the pandemic,and the behavior adjustment is related to the individual's past travel habits.The paper quantitatively assesses the impact of the COVID-19 pandemic on individual travel behavior.And the method proposed in this paper can be used to quantitatively assess the impact of any long-term emergency on individual micro travel behavior.
文摘The authors regret that Eq.(5)in the paper is wrongly written and should be revised as follows:s_(p)(a_(i),a_(j))=len(a_(i))×Ratio(LCS(a_(i),a_(j)),a_(i))+len(a_(j))×Ratio(LCS(a_(i),a_(j)),a_(j))/len(a_(i))+len(a_(j))(5)The authors would like to apologise for any inconvenience caused.
基金supported in part by the National Key Research and Development Program of China(2019YFB2203100)the National Natural Science Foundation of China(NSFC)(No.62275087)+1 种基金the European Research Council(REFOCUS 853522),the Danish National Research Foundation,SPOC(ref.DNRF123)the Knowledge Innovation Program of Wuhan-Shuguang Project(No.2022010801010082).
文摘Nonlinear optical signal processing(NOSP)has the potential to significantly improve the throughput,flexibility,and cost-efficiency of optical communication networks by exploiting the intrinsically ultrafast optical nonlinear wave mixing.It can support digital signal processing speeds of up to terabits per second,far exceeding the line rate of the electronic counterpart.In NOSP,high-intensity light fields are used to generate nonlinear optical responses,which can be used to process optical signals.Great efforts have been devoted to developing new materials and structures for NOSP.However,one of the challenges in implementing NOSP is the requirement of high-intensity light fields,which is difficult to generate and maintain.This has been a major roadblock to realize practical NOSP systems for high-speed,high-capacity optical communications.Here,we propose using a parity-time(PT)symmetric microresonator system to significantly enhance the light intensity and support high-speed operation by relieving the bandwidth-efficiency limit imposed on conventional single resonator systems.The design concept is the coexistence of a PT symmetry broken regime for a narrow-linewidth pump wave and near-exceptional point operation for broadband signal and idler waves.This enables us to achieve a new NOSP system with two orders of magnitude improvement in efficiency compared to a single resonator.With a highly nonlinear AlGaAs-on-Insulator platform,we demonstrate an NOSP at a data rate approaching 40 gigabits per second with a record low pump power of one milliwatt.These findings pave the way for the development of fully chip-scale NOSP devices with pump light sources integrated together,potentially leading to a wide range of applications in optical communication networks and classical or quantum computation.The combination of PT symmetry and NOSP may also open up opportunities for amplification,detection,and sensing,where response speed and efficiency are equally important.
基金the National Natural Science Foundation of China(Grant Nos.51776193,51761145109,and 51906241).
文摘The sun and outer space are the ultimate heat and cold sources for the earth,respectively.They have significant potential for renewable energy harvesting.In this paper,a spectrally selective surface structure that has a planar polydimethylsiloxane layer covering a solar absorber is conceptually proposed and optically designed for the combination of photothermic conversion(PT)and nighttime radiative sky cooling(RC).An optical simulation is conducted whose result shows that the designed surface structure(i.e.,PT-RC surface structure)has a strong solar absorption coefficient of 0.92 and simultaneously emits as a mid-infrared spectral-selective emitter with an average emissivity of 0.84 within the atmospheric window.A thermal analysis prediction reveals that the designed PTRC surface structure can be heated to 79.1℃higher than the ambient temperature in the daytime and passively cooled below the ambient temperature of approximately 10℃in the nighttime,indicating that the designed PT-RC surface structure has the potential for integrated PT conversion and nighttime RC utilization.
